Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit alpha-14

Gene

GNA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 49GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-399997. Acetylcholine regulates insulin secretion.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-14
Short name:
G alpha-14
Short name:
G-protein subunit alpha-14
Gene namesi
Name:GNA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000156049.6.
HGNCiHGNC:4382. GNA14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9630.
OpenTargetsiENSG00000156049.
PharmGKBiPA28767.

Polymorphism and mutation databases

BioMutaiGNA14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037521 – 355Guanine nucleotide-binding protein subunit alpha-14Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiO95837.
MaxQBiO95837.
PaxDbiO95837.
PeptideAtlasiO95837.
PRIDEiO95837.

PTM databases

iPTMnetiO95837.
PhosphoSitePlusiO95837.
SwissPalmiO95837.

Expressioni

Gene expression databases

BgeeiENSG00000156049.
CleanExiHS_GNA14.
GenevisibleiO95837. HS.

Organism-specific databases

HPAiHPA048886.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAL4O960153EBI-7951023,EBI-742362

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114989. 4 interactors.
CORUMiO95837.
IntActiO95837. 3 interactors.
MINTiMINT-7944128.
STRINGi9606.ENSP00000365807.

Structurei

3D structure databases

ProteinModelPortaliO95837.
SMRiO95837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0085. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiO95837.
KOiK04636.
OMAiDRIAMPS.
OrthoDBiEOG091G0VUT.
PhylomeDBiO95837.
TreeFamiTF300673.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
InterProiView protein in InterPro
IPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiView protein in Pfam
PF00503. G-alpha. 1 hit.
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiView protein in SMART
SM00275. G_alpha. 1 hit.
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

O95837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCCCLSAE EKESQRISAE IERQLRRDKK DARRELKLLL LGTGESGKST
60 70 80 90 100
FIKQMRIIHG SGYSDEDRKG FTKLVYQNIF TAMQAMIRAM DTLRIQYVCE
110 120 130 140 150
QNKENAQIIR EVEVDKVSML SREQVEAIKQ LWQDPGIQEC YDRRREYQLS
160 170 180 190 200
DSAKYYLTDI DRIATPSFVP TQQDVLRVRV PTTGIIEYPF DLENIIFRMV
210 220 230 240 250
DVGGQRSERR KWIHCFESVT SIIFLVALSE YDQVLAECDN ENRMEESKAL
260 270 280 290 300
FKTIITYPWF LNSSVILFLN KKDLLEEKIM YSHLISYFPE YTGPKQDVRA
310 320 330 340 350
ARDFILKLYQ DQNPDKEKVI YSHFTCATDT DNIRFVFAAV KDTILQLNLR

EFNLV
Length:355
Mass (Da):41,571
Last modified:May 1, 1999 - v1
Checksum:iEAB73A9876E9C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105201 mRNA. Translation: AAD17944.1.
AF493903 mRNA. Translation: AAM12617.1.
AK312460 mRNA. Translation: BAG35367.1.
CH471089 Genomic DNA. Translation: EAW62603.1.
BC027886 mRNA. Translation: AAH27886.1.
CCDSiCCDS6657.1.
RefSeqiNP_004288.1. NM_004297.3.
UniGeneiHs.657795.

Genome annotation databases

EnsembliENST00000341700; ENSP00000365807; ENSG00000156049.
GeneIDi9630.
KEGGihsa:9630.
UCSCiuc004aku.4. human.

Similar proteinsi

Entry informationi

Entry nameiGNA14_HUMAN
AccessioniPrimary (citable) accession number: O95837
Secondary accession number(s): B1ALW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families