O95837 (GNA14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein subunit alpha-14
Short name=G alpha-14
Short name=G-protein subunit alpha-14

Gene names

Name:

GNA14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Sequence similarities	Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Transducer
PTM	ADP-ribosylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome phospholipase C-activating dopamine receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome platelet activation Traceable author statement. Source: Reactome
Cellular_component	heterotrimeric G-protein complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	G-protein beta/gamma-subunit complex binding Inferred from Biological aspect of Ancestor. Source: RefGenome G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.1. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Guanine nucleotide-binding protein subunit alpha-14		PRO_0000203752
Regions
	Nucleotide binding	42 – 49	8	GTP By similarity
	Nucleotide binding	176 – 182	7	GTP By similarity
	Nucleotide binding	201 – 205	5	GTP By similarity
	Nucleotide binding	270 – 273	4	GTP By similarity
Sites
	Metal binding	49	1	Magnesium By similarity
	Metal binding	182	1	Magnesium By similarity
	Binding site	327	1	GTP; via amide nitrogen By similarity
Amino acid modifications
	Modified residue	179	1	ADP-ribosylarginine; by cholera toxin By similarity

Sequences

	Sequence		Length	Mass (Da)
	O95837 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EAB73A9876E9C47E	FASTA	355	41,571
	10 20 30 40 50 60 MAGCCCLSAE EKESQRISAE IERQLRRDKK DARRELKLLL LGTGESGKST FIKQMRIIHG 70 80 90 100 110 120 SGYSDEDRKG FTKLVYQNIF TAMQAMIRAM DTLRIQYVCE QNKENAQIIR EVEVDKVSML 130 140 150 160 170 180 SREQVEAIKQ LWQDPGIQEC YDRRREYQLS DSAKYYLTDI DRIATPSFVP TQQDVLRVRV 190 200 210 220 230 240 PTTGIIEYPF DLENIIFRMV DVGGQRSERR KWIHCFESVT SIIFLVALSE YDQVLAECDN 250 260 270 280 290 300 ENRMEESKAL FKTIITYPWF LNSSVILFLN KKDLLEEKIM YSHLISYFPE YTGPKQDVRA 310 320 330 340 350 ARDFILKLYQ DQNPDKEKVI YSHFTCATDT DNIRFVFAAV KDTILQLNLR EFNLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the human G-alpha-14 and G-alpha-Q genes and mutation analysis in chorea-acanthocytosis (CHAC)." Rubio J.P., Levy E.R., Dobson-Stone C., Monaco A.P. Genomics 57:84-93(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF105201 mRNA. Translation: AAD17944.1. AF493903 mRNA. Translation: AAM12617.1. BC027886 mRNA. Translation: AAH27886.1.
IPI	IPI00000695.
RefSeq	NP_004288.1. NM_004297.3.
UniGene	Hs.657795.
3D structure databases
ProteinModelPortal	O95837.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7944128.
STRING	9606.ENSP00000365807.
PTM databases
PhosphoSite	O95837.
Proteomic databases
PaxDb	O95837.
PRIDE	O95837.
Protocols and materials databases
DNASU	9630.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341700; ENSP00000365807; ENSG00000156049.
GeneID	9630.
KEGG	hsa:9630.
UCSC	uc004aku.3. human.
Organism-specific databases
CTD	9630.
GeneCards	GC09M080037.
HGNC	HGNC:4382. GNA14.
HPA	HPA048886.
MIM	604397. gene.
neXtProt	NX_O95837.
PharmGKB	PA28767.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322962.
HOGENOM	HOG000038729.
HOVERGEN	HBG063184.
InParanoid	O95837.
KO	K04636.
OMA	IDRIAMP.
OrthoDB	EOG4S4PGD.
PhylomeDB	O95837.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6cyclingpathway. Arf6 signaling events. endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. er_nongenomic_pathway. Plasma membrane estrogen receptor signaling. s1p_s1p2_pathway. S1P2 pathway. s1p_s1p3_pathway. S1P3 pathway. s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway. txa2pathway. Thromboxane A2 receptor signaling.
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	O95837.
Bgee	O95837.
CleanEx	HS_GNA14.
Genevestigator	O95837.
GermOnline	ENSG00000156049. Homo sapiens.
Family and domain databases
Gene3D	1.10.400.10. 1 hit.
InterPro	IPR000654. Gprotein_alpha_Q. IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR10218. PTHR10218. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00442. GPROTEINAQ.
SMART	SM00275. G_alpha. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit. SSF47895. Transducn_insert. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	GNA14. human.
GenomeRNAi	9630.
NextBio	36139.
SOURCE	Search...

Entry information

Entry name

GNA14_HUMAN

Accession

Primary (citable) accession number: O95837

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.