##gff-version 3 O95835 UniProtKB Chain 1 1130 . . . ID=PRO_0000086232;Note=Serine/threonine-protein kinase LATS1 O95835 UniProtKB Domain 100 141 . . . Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 O95835 UniProtKB Domain 705 1010 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 O95835 UniProtKB Domain 1011 1090 . . . Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618 O95835 UniProtKB Region 1 71 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 149 276 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 294 321 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 365 405 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 432 484 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 515 631 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Region 526 655 . . . Note=Interaction with YAP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18158288;Dbxref=PMID:18158288 O95835 UniProtKB Region 1104 1130 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Motif 373 376 . . . Note=PPxY motif 1 O95835 UniProtKB Motif 556 559 . . . Note=PPxY motif 2 O95835 UniProtKB Compositional bias 17 38 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 39 59 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 163 183 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 200 215 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 232 270 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 295 310 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 381 405 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 515 537 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 549 565 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Compositional bias 583 631 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95835 UniProtKB Active site 828 828 . . . Note=Proton acceptor;Ontology_term=ECO:0000250,ECO:0000255,ECO:0000255;evidence=ECO:0000250|UniProtKB:P22612,ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 O95835 UniProtKB Binding site 711 719 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P22612,ECO:0000255|PROSITE-ProRule:PRU00159 O95835 UniProtKB Binding site 734 734 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15122335;Dbxref=PMID:15122335 O95835 UniProtKB Modified residue 246 246 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 O95835 UniProtKB Modified residue 278 278 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 O95835 UniProtKB Modified residue 464 464 . . . Note=Phosphoserine%3B by NUAK1 and NUAK2;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:19927127,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19927127,PMID:23186163 O95835 UniProtKB Modified residue 613 613 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95835 UniProtKB Modified residue 674 674 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17525332;Dbxref=PMID:17525332 O95835 UniProtKB Modified residue 909 909 . . . Note=Phosphoserine%3B by STK3/MST2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15688006;Dbxref=PMID:15688006 O95835 UniProtKB Modified residue 1079 1079 . . . Note=Phosphothreonine%3B by STK3/MST2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15688006,ECO:0000269|PubMed:28087714;Dbxref=PMID:15688006,PMID:28087714 O95835 UniProtKB Alternative sequence 672 690 . . . ID=VSP_051604;Note=In isoform 2. GLSQDAQDQMRKMLCQKES->KPFKMSIFILNHLFAWCLF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O95835 UniProtKB Alternative sequence 691 1130 . . . ID=VSP_051605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O95835 UniProtKB Natural variant 96 96 . . . ID=VAR_040660;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55945045,PMID:17344846 O95835 UniProtKB Natural variant 204 204 . . . ID=VAR_040661;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34793526,PMID:17344846 O95835 UniProtKB Natural variant 237 237 . . . ID=VAR_040662;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56149740,PMID:17344846 O95835 UniProtKB Natural variant 370 370 . . . ID=VAR_040663;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56348064,PMID:17344846 O95835 UniProtKB Natural variant 531 531 . . . ID=VAR_040664;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55874734,PMID:17344846 O95835 UniProtKB Natural variant 641 641 . . . ID=VAR_040665;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35163691,PMID:17344846 O95835 UniProtKB Natural variant 669 669 . . . ID=VAR_040666;Note=In a lung adenocarcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1390558952,PMID:17344846 O95835 UniProtKB Natural variant 806 806 . . . ID=VAR_040667;Note=In a lung large cell carcinoma sample%3B somatic mutation. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 O95835 UniProtKB Natural variant 1000 1000 . . . ID=VAR_040668;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56412005,PMID:17344846 O95835 UniProtKB Mutagenesis 464 464 . . . Note=Abolishes phosphorylation by NUAK1 and NUAK2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19927127;Dbxref=PMID:19927127 O95835 UniProtKB Mutagenesis 559 559 . . . Note=Loss of interaction with YAP1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18158288;Dbxref=PMID:18158288 O95835 UniProtKB Mutagenesis 734 734 . . . Note=Loss of kinase activity%2C autophosphorylation%2C increased ploidy%2C prolonged duration of mitosis and lack of p53 expression. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15122335;Dbxref=PMID:15122335 O95835 UniProtKB Helix 72 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7LWH O95835 UniProtKB Helix 75 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7LWH O95835 UniProtKB Helix 86 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7LWH O95835 UniProtKB Helix 637 671 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5BRK O95835 UniProtKB Helix 675 697 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5BRK