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O95834 (EMAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Echinoderm microtubule-associated protein-like 2

Short name=EMAP-2
Short name=HuEMAP-2
Gene names
Name:EML2
Synonyms:EMAP2, EMAPL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length649 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic By similarity.

Subcellular location

Cytoplasmcytoskeleton Potential.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the WD repeat EMAP family.

Contains 11 WD repeats.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95834-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95834-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MSSFGA → MSLDDNLSGT...SSSNCSAKKE
Note: No experimental confirmation available.
Isoform 3 (identifier: O95834-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MSSFGA → MLERRALLWQ...SSSNCSAKKE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 649649Echinoderm microtubule-associated protein-like 2
PRO_0000050962

Regions

Repeat103 – 15250WD 1
Repeat157 – 20044WD 2
Repeat203 – 24240WD 3
Repeat250 – 28839WD 4
Repeat292 – 33140WD 5
Repeat375 – 41440WD 6
Repeat416 – 45540WD 7
Repeat458 – 49740WD 8
Repeat504 – 54340WD 9
Repeat571 – 61040WD 10
Repeat616 – 64833WD 11

Natural variations

Alternative sequence1 – 66MSSFGA → MSLDDNLSGTSGMEVDDRVS ALEQRLQLQEDELAVLKAAL ADALRRLRACEEQGAALRAR GTPKGRAPPRLGTTASVCQL LKGLPTRTPLNGSGPPRRVG GYATSPSSPKKEATSGRSSV RRYLSPERLASVRREDPRSR TTSSSSNCSAKKE in isoform 2.
VSP_042541
Alternative sequence1 – 66MSSFGA → MLERRALLWQREAGPGWGDR ARAGTGGAGGGCGGAMAERG PAFCGLYDTSSLLRYCNDDN LSGTSGMEVDDRVSALEQRL QLQEDELAVLKAALADALRR LRACEEQGAALRARGTPKGR APPRLGTTASVCQLLKGLPT RTPLNGSGPPRRVGGYATSP SSPKKEATSGRSSVRRYLSP ERLASVRREDPRSRTTSSSS NCSAKKE in isoform 3.
VSP_047538
Natural variant331M → V.
Corresponds to variant rs12151009 [ dbSNP | Ensembl ].
VAR_031723
Natural variant1871L → F.
Corresponds to variant rs7252175 [ dbSNP | Ensembl ].
VAR_031724
Natural variant2351E → D. Ref.6
Corresponds to variant rs1545040 [ dbSNP | Ensembl ].
VAR_024697
Natural variant3571R → H.
Corresponds to variant rs3816045 [ dbSNP | Ensembl ].
VAR_022026
Natural variant4841V → L in a colorectal cancer sample; somatic mutation. Ref.7
VAR_035879

Experimental info

Sequence conflict2941D → G in CAB46373. Ref.3
Sequence conflict419 – 4279DPARSAGFH → MAAAGHGDP in AAH32630. Ref.3
Sequence conflict5821S → F in CAB46373. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F356D3D974D208C9

FASTA64970,679
        10         20         30         40         50         60 
MSSFGAGKTK EVIFSVEDGS VKMFLRGRPV PMMIPDELAP TYSLDTRSEL PSCRLKLEWV 

        70         80         90        100        110        120 
YGYRGRDCRA NLYLLPTGEI VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAIHPDMVTI 

       130        140        150        160        170        180 
ATGQVAGTTK EGKPLPPHVR IWDSVSLSTL HVLGLGVFDR AVCCVGFSKS NGGNLLCAVD 

       190        200        210        220        230        240 
ESNDHMLSVW DWAKETKVVD VKCSNEAVLV ATFHPTDPTV LITCGKSHIY FWTLEGGSLS 

       250        260        270        280        290        300 
KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQAVL GAHDGGVFGL 

       310        320        330        340        350        360 
CALRDGTLVS GGGRDRRVVL WGSDYSKLQE VEVPEDFGPV RTVAEGHGDT LYVGTTRNSI 

       370        380        390        400        410        420 
LQGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSDSHQ PLWSRIIEDP 

       430        440        450        460        470        480 
ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH 

       490        500        510        520        530        540 
DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSSC FVTNSGDYEI LYWDPATCKQ 

       550        560        570        580        590        600 
ITSADAVRNM EWATATCVLG FGVFGIWSEG ADGTDINAVA RSHDGKLLAS ADDFGKVHLF 

       610        620        630        640 
SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVV 

« Hide

Isoform 2 [UniParc].

Checksum: 458459038BB78DE9
Show »

FASTA79686,471
Isoform 3 [UniParc].

Checksum: 3314BC538A339D66
Show »

FASTA85092,070

References

« Hide 'large scale' references
[1]"Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2)."
Lepley D.M., Palange J.M., Suprenant K.A.
Gene 237:343-349(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-850 (ISOFORM 3).
Tissue: Substantia nigra and Thalamus.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427 (ISOFORM 1).
Tissue: Liver.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-649 (ISOFORM 1), VARIANT ASP-235.
Tissue: Brain.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-484.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF103939 mRNA. Translation: AAD19904.1.
AL096717 mRNA. Translation: CAB46373.2.
AK295905 mRNA. Translation: BAH12218.1.
AK296258 mRNA. Translation: BAH12295.1.
AC006132 Genomic DNA. No translation available.
AC011480 Genomic DNA. No translation available.
AC098776 Genomic DNA. No translation available.
BC032630 mRNA. Translation: AAH32630.1.
AB209773 mRNA. Translation: BAD93010.1.
RefSeqNP_001180197.1. NM_001193268.1.
NP_001180198.1. NM_001193269.1.
NP_036287.1. NM_012155.2.
UniGeneHs.24178.

3D structure databases

ProteinModelPortalO95834.
SMRO95834. Positions 157-648.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117290. 4 interactions.
MINTMINT-4527842.

PTM databases

PhosphoSiteO95834.

Proteomic databases

PaxDbO95834.
PRIDEO95834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245925; ENSP00000245925; ENSG00000125746. [O95834-1]
ENST00000536630; ENSP00000442365; ENSG00000125746. [O95834-2]
ENST00000587152; ENSP00000468312; ENSG00000125746. [O95834-3]
ENST00000588308; ENSP00000468329; ENSG00000125746.
GeneID24139.
KEGGhsa:24139.
UCSCuc002pcn.3. human. [O95834-1]
uc010xxl.2. human. [O95834-2]

Organism-specific databases

CTD24139.
GeneCardsGC19M046112.
HGNCHGNC:18035. EML2.
HPAHPA012757.
neXtProtNX_O95834.
PharmGKBPA27768.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG051470.
InParanoidO95834.
OMADANDHIL.
PhylomeDBO95834.
TreeFamTF317832.

Enzyme and pathway databases

SignaLinkO95834.

Gene expression databases

ArrayExpressO95834.
BgeeO95834.
CleanExHS_EML2.
GenevestigatorO95834.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR005108. HELP.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 3 hits.
PROSITEPS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEML2. human.
GenomeRNAi24139.
NextBio46809.
PROO95834.

Entry information

Entry nameEMAL2_HUMAN
AccessionPrimary (citable) accession number: O95834
Secondary accession number(s): B7Z3I2 expand/collapse secondary AC list , B7Z3Q9, K7ERL7, Q59EN8, Q8N5A2, Q9UG50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM