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O95825

- QORL1_HUMAN

UniProt

O95825 - QORL1_HUMAN

Protein

Quinone oxidoreductase-like protein 1

Gene

CRYZL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. NADP binding Source: UniProtKB
    2. NADPH:quinone reductase activity Source: UniProtKB
    3. oxidoreductase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. quinone metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinone oxidoreductase-like protein 1 (EC:1.-.-.-)
    Alternative name(s):
    Protein 4P11
    Quinone oxidoreductase homolog 1
    Short name:
    QOH-1
    Zeta-crystallin homolog
    Gene namesi
    Name:CRYZL1
    Synonyms:4P11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:2420. CRYZL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26926.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Quinone oxidoreductase-like protein 1PRO_0000160913Add
    BLAST

    Proteomic databases

    MaxQBiO95825.
    PaxDbiO95825.
    PRIDEiO95825.

    PTM databases

    PhosphoSiteiO95825.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO95825.
    BgeeiO95825.
    CleanExiHS_CRYZL1.
    GenevestigatoriO95825.

    Organism-specific databases

    HPAiCAB034129.
    HPA019120.
    HPA029399.

    Interactioni

    Protein-protein interaction databases

    BioGridi115271. 6 interactions.
    STRINGi9606.ENSP00000370966.

    Structurei

    3D structure databases

    ProteinModelPortaliO95825.
    SMRiO95825. Positions 19-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000293267.
    HOVERGENiHBG009484.
    InParanoidiO95825.
    KOiK00540.
    OMAiKVSMEIV.
    OrthoDBiEOG7K0ZDM.
    PhylomeDBiO95825.
    TreeFamiTF328922.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95825-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL    50
    AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC 100
    EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI 150
    MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN 200
    GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT 250
    LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY 300
    LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF 349
    Length:349
    Mass (Da):38,697
    Last modified:October 3, 2006 - v2
    Checksum:i7EC26B8852A5BD31
    GO
    Isoform 2 (identifier: O95825-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         193-198: ARVIDV → ENSTIA
         199-349: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:198
    Mass (Da):21,928
    Checksum:i55BE2194BCBEE6EB
    GO

    Sequence cautioni

    The sequence AAH13155.1 differs from that shown. Reason:
    The sequence BAA91605.1 differs from that shown. Reason: Frameshift at position 302.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781S → P in BAA91605. (PubMed:14702039)Curated
    Sequence conflicti89 – 891I → T in BAA91605. (PubMed:14702039)Curated
    Sequence conflicti276 – 2761F → L in AAD20219. 1 PublicationCurated
    Sequence conflicti276 – 2761F → L in AAD22381. (PubMed:10191096)Curated
    Sequence conflicti276 – 2761F → L in AAH13155. (PubMed:10830953)Curated
    Sequence conflicti299 – 2991K → E in BAA91605. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391A → T.
    Corresponds to variant rs13050238 [ dbSNP | Ensembl ].
    VAR_027835

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei193 – 1986ARVIDV → ENSTIA in isoform 2. 1 PublicationVSP_055792
    Alternative sequencei199 – 349151Missing in isoform 2. 1 PublicationVSP_055793Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098798 mRNA. Translation: AAD20219.1.
    AF029689 mRNA. Translation: AAD22381.1.
    AK001293 mRNA. Translation: BAA91605.1. Frameshift.
    AK057604 mRNA. Translation: BAG51939.1.
    AK315707 mRNA. Translation: BAG38068.1.
    AP000304 Genomic DNA. No translation available.
    AP000305 Genomic DNA. No translation available.
    AP000306 Genomic DNA. No translation available.
    AP000307 Genomic DNA. No translation available.
    AP000308 Genomic DNA. No translation available.
    BC013155 mRNA. Translation: AAH13155.1. Sequence problems.
    BC033023 mRNA. Translation: AAH33023.1.
    CCDSiCCDS13633.2. [O95825-1]
    RefSeqiNP_665857.2. NM_145858.2. [O95825-1]
    UniGeneiHs.352671.

    Genome annotation databases

    EnsembliENST00000381554; ENSP00000370966; ENSG00000205758. [O95825-1]
    ENST00000413017; ENSP00000389209; ENSG00000205758.
    ENST00000420072; ENSP00000416315; ENSG00000205758. [O95825-2]
    GeneIDi9946.
    KEGGihsa:9946.
    UCSCiuc021wio.1. human. [O95825-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098798 mRNA. Translation: AAD20219.1 .
    AF029689 mRNA. Translation: AAD22381.1 .
    AK001293 mRNA. Translation: BAA91605.1 . Frameshift.
    AK057604 mRNA. Translation: BAG51939.1 .
    AK315707 mRNA. Translation: BAG38068.1 .
    AP000304 Genomic DNA. No translation available.
    AP000305 Genomic DNA. No translation available.
    AP000306 Genomic DNA. No translation available.
    AP000307 Genomic DNA. No translation available.
    AP000308 Genomic DNA. No translation available.
    BC013155 mRNA. Translation: AAH13155.1 . Sequence problems.
    BC033023 mRNA. Translation: AAH33023.1 .
    CCDSi CCDS13633.2. [O95825-1 ]
    RefSeqi NP_665857.2. NM_145858.2. [O95825-1 ]
    UniGenei Hs.352671.

    3D structure databases

    ProteinModelPortali O95825.
    SMRi O95825. Positions 19-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115271. 6 interactions.
    STRINGi 9606.ENSP00000370966.

    PTM databases

    PhosphoSitei O95825.

    Proteomic databases

    MaxQBi O95825.
    PaxDbi O95825.
    PRIDEi O95825.

    Protocols and materials databases

    DNASUi 9946.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381554 ; ENSP00000370966 ; ENSG00000205758 . [O95825-1 ]
    ENST00000413017 ; ENSP00000389209 ; ENSG00000205758 .
    ENST00000420072 ; ENSP00000416315 ; ENSG00000205758 . [O95825-2 ]
    GeneIDi 9946.
    KEGGi hsa:9946.
    UCSCi uc021wio.1. human. [O95825-1 ]

    Organism-specific databases

    CTDi 9946.
    GeneCardsi GC21M034961.
    HGNCi HGNC:2420. CRYZL1.
    HPAi CAB034129.
    HPA019120.
    HPA029399.
    MIMi 603920. gene.
    neXtProti NX_O95825.
    PharmGKBi PA26926.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000293267.
    HOVERGENi HBG009484.
    InParanoidi O95825.
    KOi K00540.
    OMAi KVSMEIV.
    OrthoDBi EOG7K0ZDM.
    PhylomeDBi O95825.
    TreeFami TF328922.

    Miscellaneous databases

    GeneWikii CRYZL1.
    GenomeRNAii 9946.
    NextBioi 37524.
    PROi O95825.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95825.
    Bgeei O95825.
    CleanExi HS_CRYZL1.
    Genevestigatori O95825.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene, 4P11, which maps to the D142H8 region of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-2 (AF-1) gene."
      Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.
      Eur. Cytokine Netw. 9:504-504(1998)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1."
      Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.
      Genomics 57:156-159(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis and Thymus.
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Testis.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQORL1_HUMAN
    AccessioniPrimary (citable) accession number: O95825
    Secondary accession number(s): B2RDX1
    , B3KQ77, Q96DY0, Q9NVY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3