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Protein

Quinone oxidoreductase-like protein 1

Gene

CRYZL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • NADP binding Source: UniProtKB
  • NADPH:quinone reductase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • quinone metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:HS08360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase-like protein 1 (EC:1.-.-.-)
Alternative name(s):
Protein 4P11
Quinone oxidoreductase homolog 1
Short name:
QOH-1
Zeta-crystallin homolog
Gene namesi
Name:CRYZL1
Synonyms:4P11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:2420. CRYZL1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9946.
OpenTargetsiENSG00000205758.
PharmGKBiPA26926.

Polymorphism and mutation databases

BioMutaiCRYZL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609131 – 349Quinone oxidoreductase-like protein 1Add BLAST349

Proteomic databases

EPDiO95825.
MaxQBiO95825.
PaxDbiO95825.
PeptideAtlasiO95825.
PRIDEiO95825.

PTM databases

iPTMnetiO95825.
PhosphoSitePlusiO95825.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000205758.
CleanExiHS_CRYZL1.
ExpressionAtlasiO95825. baseline and differential.
GenevisibleiO95825. HS.

Organism-specific databases

HPAiCAB034129.
HPA019120.
HPA029399.

Interactioni

Protein-protein interaction databases

BioGridi115271. 13 interactors.
IntActiO95825. 3 interactors.
STRINGi9606.ENSP00000370966.

Structurei

3D structure databases

ProteinModelPortaliO95825.
SMRiO95825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00390000013113.
HOGENOMiHOG000293267.
HOVERGENiHBG009484.
InParanoidiO95825.
OMAiSNGKAHV.
OrthoDBiEOG091G08LX.
PhylomeDBiO95825.
TreeFamiTF328922.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL
60 70 80 90 100
AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC
110 120 130 140 150
EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI
160 170 180 190 200
MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN
210 220 230 240 250
GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT
260 270 280 290 300
LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
310 320 330 340
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
Length:349
Mass (Da):38,697
Last modified:October 3, 2006 - v2
Checksum:i7EC26B8852A5BD31
GO
Isoform 2 (identifier: O95825-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-198: ARVIDV → ENSTIA
     199-349: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):21,928
Checksum:i55BE2194BCBEE6EB
GO

Sequence cautioni

The sequence AAH13155 differs from that shown.Curated
The sequence BAA91605 differs from that shown. Reason: Frameshift at position 302.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78S → P in BAA91605 (PubMed:14702039).Curated1
Sequence conflicti89I → T in BAA91605 (PubMed:14702039).Curated1
Sequence conflicti276F → L in AAD20219 (Ref. 1) Curated1
Sequence conflicti276F → L in AAD22381 (PubMed:10191096).Curated1
Sequence conflicti276F → L in AAH13155 (PubMed:10830953).Curated1
Sequence conflicti299K → E in BAA91605 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02783539A → T.Corresponds to variant rs13050238dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055792193 – 198ARVIDV → ENSTIA in isoform 2. 1 Publication6
Alternative sequenceiVSP_055793199 – 349Missing in isoform 2. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA. Translation: AAD20219.1.
AF029689 mRNA. Translation: AAD22381.1.
AK001293 mRNA. Translation: BAA91605.1. Frameshift.
AK057604 mRNA. Translation: BAG51939.1.
AK315707 mRNA. Translation: BAG38068.1.
AP000304 Genomic DNA. No translation available.
AP000305 Genomic DNA. No translation available.
AP000306 Genomic DNA. No translation available.
AP000307 Genomic DNA. No translation available.
AP000308 Genomic DNA. No translation available.
BC013155 mRNA. Translation: AAH13155.1. Sequence problems.
BC033023 mRNA. Translation: AAH33023.1.
CCDSiCCDS13633.2. [O95825-1]
RefSeqiNP_665857.2. NM_145858.2. [O95825-1]
UniGeneiHs.352671.

Genome annotation databases

EnsembliENST00000381554; ENSP00000370966; ENSG00000205758. [O95825-1]
ENST00000420072; ENSP00000416315; ENSG00000205758. [O95825-2]
GeneIDi9946.
KEGGihsa:9946.
UCSCiuc002yss.2. human. [O95825-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA. Translation: AAD20219.1.
AF029689 mRNA. Translation: AAD22381.1.
AK001293 mRNA. Translation: BAA91605.1. Frameshift.
AK057604 mRNA. Translation: BAG51939.1.
AK315707 mRNA. Translation: BAG38068.1.
AP000304 Genomic DNA. No translation available.
AP000305 Genomic DNA. No translation available.
AP000306 Genomic DNA. No translation available.
AP000307 Genomic DNA. No translation available.
AP000308 Genomic DNA. No translation available.
BC013155 mRNA. Translation: AAH13155.1. Sequence problems.
BC033023 mRNA. Translation: AAH33023.1.
CCDSiCCDS13633.2. [O95825-1]
RefSeqiNP_665857.2. NM_145858.2. [O95825-1]
UniGeneiHs.352671.

3D structure databases

ProteinModelPortaliO95825.
SMRiO95825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115271. 13 interactors.
IntActiO95825. 3 interactors.
STRINGi9606.ENSP00000370966.

PTM databases

iPTMnetiO95825.
PhosphoSitePlusiO95825.

Polymorphism and mutation databases

BioMutaiCRYZL1.

Proteomic databases

EPDiO95825.
MaxQBiO95825.
PaxDbiO95825.
PeptideAtlasiO95825.
PRIDEiO95825.

Protocols and materials databases

DNASUi9946.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381554; ENSP00000370966; ENSG00000205758. [O95825-1]
ENST00000420072; ENSP00000416315; ENSG00000205758. [O95825-2]
GeneIDi9946.
KEGGihsa:9946.
UCSCiuc002yss.2. human. [O95825-1]

Organism-specific databases

CTDi9946.
DisGeNETi9946.
GeneCardsiCRYZL1.
HGNCiHGNC:2420. CRYZL1.
HPAiCAB034129.
HPA019120.
HPA029399.
MIMi603920. gene.
neXtProtiNX_O95825.
OpenTargetsiENSG00000205758.
PharmGKBiPA26926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00390000013113.
HOGENOMiHOG000293267.
HOVERGENiHBG009484.
InParanoidiO95825.
OMAiSNGKAHV.
OrthoDBiEOG091G08LX.
PhylomeDBiO95825.
TreeFamiTF328922.

Enzyme and pathway databases

BioCyciZFISH:HS08360-MONOMER.

Miscellaneous databases

GeneWikiiCRYZL1.
GenomeRNAii9946.
PROiO95825.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205758.
CleanExiHS_CRYZL1.
ExpressionAtlasiO95825. baseline and differential.
GenevisibleiO95825. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQORL1_HUMAN
AccessioniPrimary (citable) accession number: O95825
Secondary accession number(s): B2RDX1
, B3KQ77, Q96DY0, Q9NVY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.