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O95825

- QORL1_HUMAN

UniProt

O95825 - QORL1_HUMAN

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Protein

Quinone oxidoreductase-like protein 1

Gene

CRYZL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. NADP binding Source: UniProtKB
  2. NADPH:quinone reductase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. quinone metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase-like protein 1 (EC:1.-.-.-)
Alternative name(s):
Protein 4P11
Quinone oxidoreductase homolog 1
Short name:
QOH-1
Zeta-crystallin homolog
Gene namesi
Name:CRYZL1
Synonyms:4P11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:2420. CRYZL1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Quinone oxidoreductase-like protein 1PRO_0000160913Add
BLAST

Proteomic databases

MaxQBiO95825.
PaxDbiO95825.
PRIDEiO95825.

PTM databases

PhosphoSiteiO95825.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO95825.
CleanExiHS_CRYZL1.
ExpressionAtlasiO95825. baseline and differential.
GenevestigatoriO95825.

Organism-specific databases

HPAiCAB034129.
HPA019120.
HPA029399.

Interactioni

Protein-protein interaction databases

BioGridi115271. 8 interactions.
STRINGi9606.ENSP00000370966.

Structurei

3D structure databases

ProteinModelPortaliO95825.
SMRiO95825. Positions 19-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00390000013113.
HOGENOMiHOG000293267.
HOVERGENiHBG009484.
InParanoidiO95825.
KOiK00540.
OMAiKVSMEIV.
OrthoDBiEOG7K0ZDM.
PhylomeDBiO95825.
TreeFamiTF328922.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95825-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL
60 70 80 90 100
AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC
110 120 130 140 150
EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI
160 170 180 190 200
MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN
210 220 230 240 250
GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT
260 270 280 290 300
LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
310 320 330 340
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
Length:349
Mass (Da):38,697
Last modified:October 3, 2006 - v2
Checksum:i7EC26B8852A5BD31
GO
Isoform 2 (identifier: O95825-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-198: ARVIDV → ENSTIA
     199-349: Missing.

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):21,928
Checksum:i55BE2194BCBEE6EB
GO

Sequence cautioni

The sequence AAH13155.1 differs from that shown. Reason: Curated
The sequence BAA91605.1 differs from that shown. Reason: Frameshift at position 302. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781S → P in BAA91605. (PubMed:14702039)Curated
Sequence conflicti89 – 891I → T in BAA91605. (PubMed:14702039)Curated
Sequence conflicti276 – 2761F → L in AAD20219. 1 PublicationCurated
Sequence conflicti276 – 2761F → L in AAD22381. (PubMed:10191096)Curated
Sequence conflicti276 – 2761F → L in AAH13155. (PubMed:10830953)Curated
Sequence conflicti299 – 2991K → E in BAA91605. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → T.
Corresponds to variant rs13050238 [ dbSNP | Ensembl ].
VAR_027835

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei193 – 1986ARVIDV → ENSTIA in isoform 2. 1 PublicationVSP_055792
Alternative sequencei199 – 349151Missing in isoform 2. 1 PublicationVSP_055793Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA. Translation: AAD20219.1.
AF029689 mRNA. Translation: AAD22381.1.
AK001293 mRNA. Translation: BAA91605.1. Frameshift.
AK057604 mRNA. Translation: BAG51939.1.
AK315707 mRNA. Translation: BAG38068.1.
AP000304 Genomic DNA. No translation available.
AP000305 Genomic DNA. No translation available.
AP000306 Genomic DNA. No translation available.
AP000307 Genomic DNA. No translation available.
AP000308 Genomic DNA. No translation available.
BC013155 mRNA. Translation: AAH13155.1. Sequence problems.
BC033023 mRNA. Translation: AAH33023.1.
CCDSiCCDS13633.2. [O95825-1]
RefSeqiNP_665857.2. NM_145858.2. [O95825-1]
UniGeneiHs.352671.

Genome annotation databases

EnsembliENST00000381554; ENSP00000370966; ENSG00000205758. [O95825-1]
ENST00000413017; ENSP00000389209; ENSG00000205758.
ENST00000420072; ENSP00000416315; ENSG00000205758. [O95825-2]
GeneIDi9946.
KEGGihsa:9946.
UCSCiuc021wio.1. human. [O95825-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA. Translation: AAD20219.1 .
AF029689 mRNA. Translation: AAD22381.1 .
AK001293 mRNA. Translation: BAA91605.1 . Frameshift.
AK057604 mRNA. Translation: BAG51939.1 .
AK315707 mRNA. Translation: BAG38068.1 .
AP000304 Genomic DNA. No translation available.
AP000305 Genomic DNA. No translation available.
AP000306 Genomic DNA. No translation available.
AP000307 Genomic DNA. No translation available.
AP000308 Genomic DNA. No translation available.
BC013155 mRNA. Translation: AAH13155.1 . Sequence problems.
BC033023 mRNA. Translation: AAH33023.1 .
CCDSi CCDS13633.2. [O95825-1 ]
RefSeqi NP_665857.2. NM_145858.2. [O95825-1 ]
UniGenei Hs.352671.

3D structure databases

ProteinModelPortali O95825.
SMRi O95825. Positions 19-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115271. 8 interactions.
STRINGi 9606.ENSP00000370966.

PTM databases

PhosphoSitei O95825.

Proteomic databases

MaxQBi O95825.
PaxDbi O95825.
PRIDEi O95825.

Protocols and materials databases

DNASUi 9946.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381554 ; ENSP00000370966 ; ENSG00000205758 . [O95825-1 ]
ENST00000413017 ; ENSP00000389209 ; ENSG00000205758 .
ENST00000420072 ; ENSP00000416315 ; ENSG00000205758 . [O95825-2 ]
GeneIDi 9946.
KEGGi hsa:9946.
UCSCi uc021wio.1. human. [O95825-1 ]

Organism-specific databases

CTDi 9946.
GeneCardsi GC21M034961.
HGNCi HGNC:2420. CRYZL1.
HPAi CAB034129.
HPA019120.
HPA029399.
MIMi 603920. gene.
neXtProti NX_O95825.
PharmGKBi PA26926.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00390000013113.
HOGENOMi HOG000293267.
HOVERGENi HBG009484.
InParanoidi O95825.
KOi K00540.
OMAi KVSMEIV.
OrthoDBi EOG7K0ZDM.
PhylomeDBi O95825.
TreeFami TF328922.

Miscellaneous databases

GeneWikii CRYZL1.
GenomeRNAii 9946.
NextBioi 35469323.
PROi O95825.
SOURCEi Search...

Gene expression databases

Bgeei O95825.
CleanExi HS_CRYZL1.
ExpressionAtlasi O95825. baseline and differential.
Genevestigatori O95825.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene, 4P11, which maps to the D142H8 region of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-2 (AF-1) gene."
    Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.
    Eur. Cytokine Netw. 9:504-504(1998)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1."
    Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.
    Genomics 57:156-159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis and Thymus.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Testis.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQORL1_HUMAN
AccessioniPrimary (citable) accession number: O95825
Secondary accession number(s): B2RDX1
, B3KQ77, Q96DY0, Q9NVY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: November 26, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3