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O95825 (QORL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinone oxidoreductase-like protein 1

EC=1.-.-.-
Alternative name(s):
Protein 4P11
Quinone oxidoreductase homolog 1
Short name=QOH-1
Zeta-crystallin homolog
Gene names
Name:CRYZL1
Synonyms:4P11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence caution

The sequence AAH13155.1 differs from that shown. Reason:

The sequence BAA91605.1 differs from that shown. Reason: Frameshift at position 302.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processquinone metabolic process

Non-traceable author statement Ref.2. Source: UniProtKB

   Cellular_componentcytosol

Inferred from direct assay PubMed 16780588. Source: UniProtKB

   Molecular_functionNADP binding

Non-traceable author statement Ref.2. Source: UniProtKB

NADPH:quinone reductase activity

Non-traceable author statement Ref.2. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]
Isoform 1 (identifier: O95825-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95825-2)

The sequence of this isoform is not available.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Quinone oxidoreductase-like protein 1
PRO_0000160913

Natural variations

Natural variant391A → T.
Corresponds to variant rs13050238 [ dbSNP | Ensembl ].
VAR_027835

Experimental info

Sequence conflict781S → P in BAA91605. Ref.3
Sequence conflict891I → T in BAA91605. Ref.3
Sequence conflict2761F → L in AAD20219. Ref.1
Sequence conflict2761F → L in AAD22381. Ref.2
Sequence conflict2761F → L in AAH13155. Ref.4
Sequence conflict2991K → E in BAA91605. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 7EC26B8852A5BD31

FASTA34938,697
        10         20         30         40         50         60 
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF 

        70         80         90        100        110        120 
PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT 

       130        140        150        160        170        180 
EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE 

       190        200        210        220        230        240 
DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ 

       250        260        270        280        290        300 
LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY 

       310        320        330        340 
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF 

« Hide

Isoform 2 (Sequence not available).

References

« Hide 'large scale' references
[1]"Identification of a novel gene, 4P11, which maps to the D142H8 region of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-2 (AF-1) gene."
Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.
Eur. Cytokine Netw. 9:504-504(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1."
Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.
Genomics 57:156-159(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Testis.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098798 mRNA. Translation: AAD20219.1.
AF029689 mRNA. Translation: AAD22381.1.
AK001293 mRNA. Translation: BAA91605.1. Frameshift.
AK315707 mRNA. Translation: BAG38068.1.
BC013155 mRNA. Translation: AAH13155.1. Sequence problems.
BC033023 mRNA. Translation: AAH33023.1.
CCDSCCDS13633.2. [O95825-1]
RefSeqNP_665857.2. NM_145858.2. [O95825-1]
UniGeneHs.352671.

3D structure databases

ProteinModelPortalO95825.
SMRO95825. Positions 19-272.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115271. 4 interactions.
STRING9606.ENSP00000370966.

PTM databases

PhosphoSiteO95825.

Proteomic databases

MaxQBO95825.
PaxDbO95825.
PRIDEO95825.

Protocols and materials databases

DNASU9946.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381554; ENSP00000370966; ENSG00000205758. [O95825-1]
ENST00000413017; ENSP00000389209; ENSG00000205758.
GeneID9946.
KEGGhsa:9946.
UCSCuc021wio.1. human. [O95825-1]

Organism-specific databases

CTD9946.
GeneCardsGC21M034961.
HGNCHGNC:2420. CRYZL1.
HPACAB034129.
HPA019120.
HPA029399.
MIM603920. gene.
neXtProtNX_O95825.
PharmGKBPA26926.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000293267.
HOVERGENHBG009484.
InParanoidO95825.
KOK00540.
OMAKVSMEIV.
OrthoDBEOG7K0ZDM.
PhylomeDBO95825.
TreeFamTF328922.

Gene expression databases

ArrayExpressO95825.
BgeeO95825.
CleanExHS_CRYZL1.
GenevestigatorO95825.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Other

GeneWikiCRYZL1.
GenomeRNAi9946.
NextBio37524.
PROO95825.
SOURCESearch...

Entry information

Entry nameQORL1_HUMAN
AccessionPrimary (citable) accession number: O95825
Secondary accession number(s): B2RDX1, Q96DY0, Q9NVY7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM