O95825 (QORL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Quinone oxidoreductase-like protein 1
EC=1.-.-.-

Alternative name(s):
Protein 4P11
Quinone oxidoreductase homolog 1
Short name=QOH-1
Zeta-crystallin homolog

Gene names

Name:	CRYZL1
Synonyms:	4P11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Sequence caution	The sequence AAH13155.1 differs from that shown. Reason: The sequence BAA91605.1 differs from that shown. Reason: Frameshift at position 302.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	quinone cofactor metabolic process Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	cytosol Inferred from direct assay PubMed 16780588. Source: UniProtKB
Molecular_function	NADP binding Non-traceable author statement Ref.2. Source: UniProtKB NADPH:quinone reductase activity Non-traceable author statement Ref.2. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]

Isoform 1 (identifier: O95825-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95825-2)

The sequence of this isoform is not available.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Quinone oxidoreductase-like protein 1		PRO_0000160913
Natural variations
	Natural variant	39	1	A → T. Corresponds to variant rs13050238 [ dbSNP | Ensembl ].		VAR_027835
Experimental info
	Sequence conflict	78	1	S → P in BAA91605. Ref.3
	Sequence conflict	89	1	I → T in BAA91605. Ref.3
	Sequence conflict	276	1	F → L in AAD20219. Ref.1
	Sequence conflict	276	1	F → L in AAD22381. Ref.2
	Sequence conflict	276	1	F → L in AAH13155. Ref.4
	Sequence conflict	299	1	K → E in BAA91605. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: 7EC26B8852A5BD31	FASTA	349	38,697
	10 20 30 40 50 60 MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF 70 80 90 100 110 120 PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT 130 140 150 160 170 180 EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE 190 200 210 220 230 240 DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ 250 260 270 280 290 300 LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY 310 320 330 340 LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
	Isoform 2 (Sequence not available).		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel gene, 4P11, which maps to the D142H8 region of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-2 (AF-1) gene." Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S. Eur. Cytokine Netw. 9:504-504(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1." Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J. Genomics 57:156-159(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Testis.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098798 mRNA. Translation: AAD20219.1. AF029689 mRNA. Translation: AAD22381.1. AK001293 mRNA. Translation: BAA91605.1. Frameshift. AK315707 mRNA. Translation: BAG38068.1. BC013155 mRNA. Translation: AAH13155.1. Sequence problems. BC033023 mRNA. Translation: AAH33023.1.
IPI	IPI00438923.
RefSeq	NP_665857.2. NM_145858.2.
UniGene	Hs.352671.
3D structure databases
ProteinModelPortal	O95825.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000370966.
PTM databases
PhosphoSite	O95825.
Proteomic databases
PaxDb	O95825.
PRIDE	O95825.
Protocols and materials databases
DNASU	9946.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381554; ENSP00000370966; ENSG00000205758. ENST00000413017; ENSP00000389209; ENSG00000205758.
GeneID	9946.
KEGG	hsa:9946.
UCSC	uc021wio.1. human.
Organism-specific databases
CTD	9946.
GeneCards	GC21M034961.
HGNC	HGNC:2420. CRYZL1.
HPA	CAB034129. HPA019120. HPA029399.
MIM	603920. gene.
neXtProt	NX_O95825.
PharmGKB	PA26926.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0604.
HOGENOM	HOG000293267.
HOVERGEN	HBG009484.
InParanoid	O95825.
KO	K00540.
OMA	WTEAAGT.
OrthoDB	EOG4BZN2T.
Gene expression databases
ArrayExpress	O95825.
Bgee	O95825.
CleanEx	HS_CRYZL1.
Genevestigator	O95825.
GermOnline	ENSG00000205758. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.180.10. 1 hit.
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. PTHR11695. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS01162. QOR_ZETA_CRYSTAL. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9946.
NextBio	37524.
SOURCE	Search...

Entry information

Entry name

QORL1_HUMAN

Accession

Primary (citable) accession number: O95825
Secondary accession number(s): B2RDX1, Q96DY0, Q9NVY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 3, 2006
Last modified:	May 29, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.