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Protein

Mitogen-activated protein kinase kinase kinase kinase 4

Gene

MAP4K4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • creatine kinase activity Source: CACAO
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • negative regulation of apoptotic process Source: CACAO
  • protein phosphorylation Source: UniProtKB
  • regulation of JNK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01023-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiO95819.
SIGNORiO95819.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinase 4 (EC:2.7.11.1)
Alternative name(s):
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
Short name:
MEK kinase kinase 4
Short name:
MEKKK 4
Nck-interacting kinase
Gene namesi
Name:MAP4K4
Synonyms:HGK, KIAA0687, NIK
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6866. MAP4K4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9448.
OpenTargetsiENSG00000071054.
PharmGKBiPA30612.

Chemistry databases

ChEMBLiCHEMBL6166.
GuidetoPHARMACOLOGYi2088.

Polymorphism and mutation databases

BioMutaiMAP4K4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000862802 – 1239Mitogen-activated protein kinase kinase kinase kinase 4Add BLAST1238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei629PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei656PhosphoserineBy similarity1
Modified residuei700PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei791PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei828PhosphothreonineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei913PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95819.
MaxQBiO95819.
PaxDbiO95819.
PeptideAtlasiO95819.
PRIDEiO95819.

PTM databases

iPTMnetiO95819.
PhosphoSitePlusiO95819.

Expressioni

Tissue specificityi

Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.1 Publication

Gene expression databases

BgeeiENSG00000071054.
CleanExiHS_MAP4K4.
ExpressionAtlasiO95819. baseline and differential.
GenevisibleiO95819. HS.

Organism-specific databases

HPAiHPA008476.

Interactioni

Subunit structurei

Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GBP3Q9H0R54EBI-2511133,EBI-2798916

Protein-protein interaction databases

BioGridi114838. 45 interactors.
IntActiO95819. 23 interactors.
MINTiMINT-1172114.
STRINGi9606.ENSP00000314363.

Chemistry databases

BindingDBiO95819.

Structurei

Secondary structure

11239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 17Combined sources3
Turni22 – 24Combined sources3
Beta strandi25 – 33Combined sources9
Beta strandi35 – 44Combined sources10
Turni45 – 47Combined sources3
Beta strandi50 – 58Combined sources9
Helixi60 – 62Combined sources3
Helixi63 – 73Combined sources11
Helixi74 – 77Combined sources4
Beta strandi79 – 82Combined sources4
Beta strandi85 – 91Combined sources7
Beta strandi99 – 105Combined sources7
Helixi113 – 118Combined sources6
Helixi121 – 123Combined sources3
Helixi127 – 146Combined sources20
Helixi156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi167 – 170Combined sources4
Helixi174 – 180Combined sources7
Beta strandi182 – 184Combined sources3
Helixi197 – 199Combined sources3
Beta strandi205 – 207Combined sources3
Helixi214 – 228Combined sources15
Turni232 – 235Combined sources4
Helixi238 – 244Combined sources7
Turni245 – 247Combined sources3
Helixi260 – 269Combined sources10
Helixi274 – 276Combined sources3
Helixi280 – 284Combined sources5
Helixi287 – 290Combined sources4
Helixi295 – 310Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OBOX-ray2.10A/B2-328[»]
4OBPX-ray2.27A/B2-328[»]
4OBQX-ray2.19A/B2-328[»]
4RVTX-ray2.40A/B1-325[»]
4U3YX-ray1.45A/B2-328[»]
4U3ZX-ray2.09A/B2-328[»]
4U40X-ray2.30A/B2-328[»]
4U41X-ray2.20A/B2-328[»]
4U42X-ray2.50A/B2-328[»]
4U43X-ray2.18A/B2-328[»]
4U44X-ray2.43A/B2-328[»]
4U45X-ray2.58A/B2-328[»]
4ZK5X-ray2.89A/B2-328[»]
4ZP5X-ray2.29A/B1-309[»]
5DI1X-ray2.90A/B1-310[»]
ProteinModelPortaliO95819.
SMRiO95819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini926 – 1213CNHPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni858 – 1212Mediates interaction with RAP2A1 PublicationAdd BLAST355

Sequence similaritiesi

Contains 1 CNH domain.PROSITE-ProRule annotationCurated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410YBF5. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
InParanoidiO95819.
KOiK04407.
PhylomeDBiO95819.
TreeFamiTF105138.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: O95819-1) [UniParc]FASTAAdd to basket
Also known as: Tumor-associated

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ
110 120 130 140 150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP
260 270 280 290 300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES
360 370 380 390 400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE
410 420 430 440 450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE
460 470 480 490 500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLECRWRE
510 520 530 540 550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP PPQQERSKPS
560 570 580 590 600
FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS
610 620 630 640 650
ESFSNGNSES VHPALQRPAE PQVPVRTTSR SPVLSRRDSP LQGSGQQNSQ
660 670 680 690 700
AGQRNSTSIE PRLLWERVEK LVPRPGSGSS SGSSNSGSQP GSHPGSQSGS
710 720 730 740 750
GERFRVRSSS KSEGSPSQRL ENAVKKPEDK KEVFRPLKPA DLTALAKELR
760 770 780 790 800
AVEDVRPPHK VTDYSSSSEE SGTTDEEDDD VEQEGADEST SGPEDTRAAS
810 820 830 840 850
SLNLSNGETE SVKTMIVHDD VESEPAMTPS KEGTLIVRQT QSASSTLQKH
860 870 880 890 900
KSSSSFTPFI DPRLLQISPS SGTTVTSVVG FSCDGMRPEA IRQDPTRKGS
910 920 930 940 950
VVNVNPTNTR PQSDTPEIRK YKKRFNSEIL CAALWGVNLL VGTESGLMLL
960 970 980 990 1000
DRSGQGKVYP LINRRRFQQM DVLEGLNVLV TISGKKDKLR VYYLSWLRNK
1010 1020 1030 1040 1050
ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA LKSSVEVYAW
1060 1070 1080 1090 1100
APKPYHKFMA FKSFGELVHK PLLVDLTVEE GQRLKVIYGS CAGFHAVDVD
1110 1120 1130 1140 1150
SGSVYDIYLP THIQCSIKPH AIIILPNTDG MELLVCYEDE GVYVNTYGRI
1160 1170 1180 1190 1200
TKDVVLQWGE MPTSVAYIRS NQTMGWGEKA IEIRSVETGH LDGVFMHKRA
1210 1220 1230
QRLKFLCERN DKVFFASVRS GGSSQVYFMT LGRTSLLSW
Length:1,239
Mass (Da):142,101
Last modified:March 28, 2003 - v2
Checksum:i8FBBE2F9ABEEC757
GO
Isoform 21 Publication (identifier: O95819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     740-740: A → AGEV

Show »
Length:1,211
Mass (Da):138,418
Checksum:iFD4A41765D9719F7
GO
Isoform 31 Publication (identifier: O95819-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     740-740: A → AGEV

Show »
Length:1,319
Mass (Da):150,913
Checksum:i6DCBFA9AB27A8AD9
GO
Isoform 41 Publication (identifier: O95819-4) [UniParc]FASTAAdd to basket
Also known as: HGK-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

Show »
Length:1,165
Mass (Da):133,401
Checksum:i03D9E1A3D7F9415D
GO
Isoform 51 Publication (identifier: O95819-5) [UniParc]FASTAAdd to basket
Also known as: HGK-L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

Show »
Length:1,242
Mass (Da):141,929
Checksum:iAF0219B2CA816B5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti658S → SS (PubMed:9734811).Curated1
Sequence conflicti658S → SS (PubMed:17974005).Curated1
Sequence conflicti839Q → R in AAO32626 (PubMed:12612079).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040746712S → T.1 Publication1
Isoform 31 Publication (identifier: O95819-3)
Natural varianti682D → V.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007054495 – 525Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_007055569 – 622Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_007056623V → VQWSHLASLKNNVSPVSRSH SFSDPSPKFAHHHLRSQDPC PPSRSEVLSQSSDSKSEAPD PTQKAWSRSDSDEVPPRV in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_007057740A → AGEV in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_0070581112H → HVRKNPHSM in isoform 4 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096300 mRNA. Translation: AAD16137.1.
AY212247 mRNA. Translation: AAO32626.1.
AB014587 mRNA. Translation: BAA31662.1.
AL137755 mRNA. Translation: CAB70907.2.
AB013385 mRNA. Translation: BAA33714.1.
CCDSiCCDS56130.1. [O95819-1]
CCDS82487.1. [O95819-4]
PIRiT46481.
RefSeqiNP_001229488.1. NM_001242559.1. [O95819-1]
NP_004825.3. NM_004834.4. [O95819-4]
NP_663720.1. NM_145687.3.
XP_016860857.1. XM_017005368.1. [O95819-2]
UniGeneiHs.701013.

Genome annotation databases

EnsembliENST00000347699; ENSP00000314363; ENSG00000071054. [O95819-1]
ENST00000634702; ENSP00000489579; ENSG00000071054. [O95819-4]
GeneIDi9448.
KEGGihsa:9448.
UCSCiuc002tbg.4. human. [O95819-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096300 mRNA. Translation: AAD16137.1.
AY212247 mRNA. Translation: AAO32626.1.
AB014587 mRNA. Translation: BAA31662.1.
AL137755 mRNA. Translation: CAB70907.2.
AB013385 mRNA. Translation: BAA33714.1.
CCDSiCCDS56130.1. [O95819-1]
CCDS82487.1. [O95819-4]
PIRiT46481.
RefSeqiNP_001229488.1. NM_001242559.1. [O95819-1]
NP_004825.3. NM_004834.4. [O95819-4]
NP_663720.1. NM_145687.3.
XP_016860857.1. XM_017005368.1. [O95819-2]
UniGeneiHs.701013.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OBOX-ray2.10A/B2-328[»]
4OBPX-ray2.27A/B2-328[»]
4OBQX-ray2.19A/B2-328[»]
4RVTX-ray2.40A/B1-325[»]
4U3YX-ray1.45A/B2-328[»]
4U3ZX-ray2.09A/B2-328[»]
4U40X-ray2.30A/B2-328[»]
4U41X-ray2.20A/B2-328[»]
4U42X-ray2.50A/B2-328[»]
4U43X-ray2.18A/B2-328[»]
4U44X-ray2.43A/B2-328[»]
4U45X-ray2.58A/B2-328[»]
4ZK5X-ray2.89A/B2-328[»]
4ZP5X-ray2.29A/B1-309[»]
5DI1X-ray2.90A/B1-310[»]
ProteinModelPortaliO95819.
SMRiO95819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114838. 45 interactors.
IntActiO95819. 23 interactors.
MINTiMINT-1172114.
STRINGi9606.ENSP00000314363.

Chemistry databases

BindingDBiO95819.
ChEMBLiCHEMBL6166.
GuidetoPHARMACOLOGYi2088.

PTM databases

iPTMnetiO95819.
PhosphoSitePlusiO95819.

Polymorphism and mutation databases

BioMutaiMAP4K4.

Proteomic databases

EPDiO95819.
MaxQBiO95819.
PaxDbiO95819.
PeptideAtlasiO95819.
PRIDEiO95819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347699; ENSP00000314363; ENSG00000071054. [O95819-1]
ENST00000634702; ENSP00000489579; ENSG00000071054. [O95819-4]
GeneIDi9448.
KEGGihsa:9448.
UCSCiuc002tbg.4. human. [O95819-1]

Organism-specific databases

CTDi9448.
DisGeNETi9448.
GeneCardsiMAP4K4.
HGNCiHGNC:6866. MAP4K4.
HPAiHPA008476.
MIMi604666. gene.
neXtProtiNX_O95819.
OpenTargetsiENSG00000071054.
PharmGKBiPA30612.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410YBF5. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
InParanoidiO95819.
KOiK04407.
PhylomeDBiO95819.
TreeFamiTF105138.

Enzyme and pathway databases

BioCyciZFISH:HS01023-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiO95819.
SIGNORiO95819.

Miscellaneous databases

ChiTaRSiMAP4K4. human.
GeneWikiiMAP4K4.
GenomeRNAii9448.
PROiO95819.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000071054.
CleanExiHS_MAP4K4.
ExpressionAtlasiO95819. baseline and differential.
GenevisibleiO95819. HS.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM4K4_HUMAN
AccessioniPrimary (citable) accession number: O95819
Secondary accession number(s): O75172, Q9NST7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: November 30, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.