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O95819

- M4K4_HUMAN

UniProt

O95819 - M4K4_HUMAN

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Protein
Mitogen-activated protein kinase kinase kinase kinase 4
Gene
MAP4K4, HGK, KIAA0687, NIK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Magnesium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATP By similarityBy similarity
Active sitei153 – 1531Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB
  4. receptor signaling protein serine/threonine kinase activity Source: RefGenome
  5. small GTPase regulator activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. protein phosphorylation Source: UniProtKB
  3. regulation of JNK cascade Source: UniProtKB
  4. signal transduction by phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
SignaLinkiO95819.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinase 4 (EC:2.7.11.1)
Alternative name(s):
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
Short name:
MEK kinase kinase 4
Short name:
MEKKK 4
Nck-interacting kinase
Gene namesi
Name:MAP4K4
Synonyms:HGK, KIAA0687, NIK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6866. MAP4K4.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 12391238Mitogen-activated protein kinase kinase kinase kinase 4
PRO_0000086280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei5 – 51Phosphoserine1 Publication
Modified residuei629 – 6291Phosphoserine2 Publications
Modified residuei631 – 6311Phosphoserine2 Publications
Modified residuei639 – 6391Phosphoserine5 Publications
Modified residuei644 – 6441Phosphoserine2 Publications
Modified residuei712 – 7121Phosphoserine1 Publication
Modified residuei800 – 8001Phosphoserine1 Publication
Modified residuei805 – 8051Phosphoserine5 Publications
Modified residuei900 – 9001Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95819.
PaxDbiO95819.
PRIDEiO95819.

PTM databases

PhosphoSiteiO95819.

Expressioni

Tissue specificityi

Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.1 Publication

Gene expression databases

ArrayExpressiO95819.
BgeeiO95819.
CleanExiHS_MAP4K4.
GenevestigatoriO95819.

Organism-specific databases

HPAiHPA008476.

Interactioni

Subunit structurei

Interacts with the SH3 domain of the adapter proteins Nck By similarity. Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GBP3Q9H0R54EBI-2511133,EBI-2798916

Protein-protein interaction databases

BioGridi114838. 22 interactions.
IntActiO95819. 17 interactions.
MINTiMINT-1172114.
STRINGi9606.ENSP00000313644.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 173
Turni22 – 243
Beta strandi25 – 317
Turni32 – 354
Beta strandi36 – 449
Turni45 – 473
Beta strandi50 – 589
Helixi66 – 7712
Beta strandi85 – 917
Beta strandi99 – 1068
Helixi113 – 1186
Helixi121 – 1233
Helixi127 – 14620
Helixi156 – 1583
Beta strandi159 – 1613
Beta strandi167 – 1693
Helixi197 – 1993
Beta strandi205 – 2073
Helixi212 – 22817
Turni232 – 2354
Helixi238 – 24710
Helixi260 – 26910
Helixi274 – 2763
Helixi280 – 2845
Helixi287 – 2904
Helixi295 – 30814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4OBOX-ray2.10A/B2-328[»]
4OBPX-ray2.27A/B2-328[»]
4OBQX-ray2.19A/B2-328[»]
ProteinModelPortaliO95819.
SMRiO95819. Positions 13-408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 289265Protein kinase
Add
BLAST
Domaini926 – 1213288CNH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni858 – 1212355Mediates interaction with RAP2A
Add
BLAST

Sequence similaritiesi

Contains 1 CNH domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
KOiK04407.
PhylomeDBiO95819.
TreeFamiTF105138.

Family and domain databases

InterProiIPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: O95819-1) [UniParc]FASTAAdd to Basket

Also known as: Tumor-associated

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL     50
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 100
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 150
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 200
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 250
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 300
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 350
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 400
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 450
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLECRWRE 500
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP PPQQERSKPS 550
FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS 600
ESFSNGNSES VHPALQRPAE PQVPVRTTSR SPVLSRRDSP LQGSGQQNSQ 650
AGQRNSTSIE PRLLWERVEK LVPRPGSGSS SGSSNSGSQP GSHPGSQSGS 700
GERFRVRSSS KSEGSPSQRL ENAVKKPEDK KEVFRPLKPA DLTALAKELR 750
AVEDVRPPHK VTDYSSSSEE SGTTDEEDDD VEQEGADEST SGPEDTRAAS 800
SLNLSNGETE SVKTMIVHDD VESEPAMTPS KEGTLIVRQT QSASSTLQKH 850
KSSSSFTPFI DPRLLQISPS SGTTVTSVVG FSCDGMRPEA IRQDPTRKGS 900
VVNVNPTNTR PQSDTPEIRK YKKRFNSEIL CAALWGVNLL VGTESGLMLL 950
DRSGQGKVYP LINRRRFQQM DVLEGLNVLV TISGKKDKLR VYYLSWLRNK 1000
ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA LKSSVEVYAW 1050
APKPYHKFMA FKSFGELVHK PLLVDLTVEE GQRLKVIYGS CAGFHAVDVD 1100
SGSVYDIYLP THIQCSIKPH AIIILPNTDG MELLVCYEDE GVYVNTYGRI 1150
TKDVVLQWGE MPTSVAYIRS NQTMGWGEKA IEIRSVETGH LDGVFMHKRA 1200
QRLKFLCERN DKVFFASVRS GGSSQVYFMT LGRTSLLSW 1239
Length:1,239
Mass (Da):142,101
Last modified:March 28, 2003 - v2
Checksum:i8FBBE2F9ABEEC757
GO
Isoform 21 Publication (identifier: O95819-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     740-740: A → AGEV

Show »
Length:1,211
Mass (Da):138,418
Checksum:iFD4A41765D9719F7
GO
Isoform 31 Publication (identifier: O95819-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     740-740: A → AGEV

Show »
Length:1,319
Mass (Da):150,913
Checksum:i6DCBFA9AB27A8AD9
GO
Isoform 41 Publication (identifier: O95819-4) [UniParc]FASTAAdd to Basket

Also known as: HGK-S

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

Show »
Length:1,165
Mass (Da):133,401
Checksum:i03D9E1A3D7F9415D
GO
Isoform 51 Publication (identifier: O95819-5) [UniParc]FASTAAdd to Basket

Also known as: HGK-L

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

Show »
Length:1,242
Mass (Da):141,929
Checksum:iAF0219B2CA816B5B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti712 – 7121S → T.1 Publication
VAR_040746
Isoform 31 Publication (identifier: O95819-3)
Natural varianti682 – 6821D → V.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei495 – 52531Missing in isoform 2, isoform 4 and isoform 5. 1 Publication
VSP_007054Add
BLAST
Alternative sequencei569 – 62254Missing in isoform 4 and isoform 5. 1 Publication
VSP_007055Add
BLAST
Alternative sequencei623 – 6231V → VQWSHLASLKNNVSPVSRSH SFSDPSPKFAHHHLRSQDPC PPSRSEVLSQSSDSKSEAPD PTQKAWSRSDSDEVPPRV in isoform 3 and isoform 5. 1 Publication
VSP_007056
Alternative sequencei740 – 7401A → AGEV in isoform 2, isoform 3, isoform 4 and isoform 5. 1 Publication
VSP_007057
Alternative sequencei1112 – 11121H → HVRKNPHSM in isoform 4 and isoform 5. 1 Publication
VSP_007058

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti658 – 6581S → SS1 Publication
Sequence conflicti658 – 6581S → SS1 Publication
Sequence conflicti839 – 8391Q → R in AAO32626. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096300 mRNA. Translation: AAD16137.1.
AY212247 mRNA. Translation: AAO32626.1.
AB014587 mRNA. Translation: BAA31662.1.
AL137755 mRNA. Translation: CAB70907.2.
AB013385 mRNA. Translation: BAA33714.1.
CCDSiCCDS56130.1. [O95819-1]
PIRiT46481.
RefSeqiNP_001229488.1. NM_001242559.1. [O95819-1]
NP_004825.3. NM_004834.4. [O95819-4]
NP_663720.1. NM_145687.3.
UniGeneiHs.701013.

Genome annotation databases

EnsembliENST00000347699; ENSP00000314363; ENSG00000071054. [O95819-1]
GeneIDi9448.
KEGGihsa:9448.
UCSCiuc002tbc.3. human. [O95819-3]
uc002tbd.3. human. [O95819-2]
uc002tbg.3. human. [O95819-1]
uc002tbh.3. human. [O95819-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096300 mRNA. Translation: AAD16137.1 .
AY212247 mRNA. Translation: AAO32626.1 .
AB014587 mRNA. Translation: BAA31662.1 .
AL137755 mRNA. Translation: CAB70907.2 .
AB013385 mRNA. Translation: BAA33714.1 .
CCDSi CCDS56130.1. [O95819-1 ]
PIRi T46481.
RefSeqi NP_001229488.1. NM_001242559.1. [O95819-1 ]
NP_004825.3. NM_004834.4. [O95819-4 ]
NP_663720.1. NM_145687.3.
UniGenei Hs.701013.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4OBO X-ray 2.10 A/B 2-328 [» ]
4OBP X-ray 2.27 A/B 2-328 [» ]
4OBQ X-ray 2.19 A/B 2-328 [» ]
ProteinModelPortali O95819.
SMRi O95819. Positions 13-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114838. 22 interactions.
IntActi O95819. 17 interactions.
MINTi MINT-1172114.
STRINGi 9606.ENSP00000313644.

Chemistry

BindingDBi O95819.
ChEMBLi CHEMBL6166.
GuidetoPHARMACOLOGYi 2088.

PTM databases

PhosphoSitei O95819.

Proteomic databases

MaxQBi O95819.
PaxDbi O95819.
PRIDEi O95819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347699 ; ENSP00000314363 ; ENSG00000071054 . [O95819-1 ]
GeneIDi 9448.
KEGGi hsa:9448.
UCSCi uc002tbc.3. human. [O95819-3 ]
uc002tbd.3. human. [O95819-2 ]
uc002tbg.3. human. [O95819-1 ]
uc002tbh.3. human. [O95819-4 ]

Organism-specific databases

CTDi 9448.
GeneCardsi GC02P102313.
HGNCi HGNC:6866. MAP4K4.
HPAi HPA008476.
MIMi 604666. gene.
neXtProti NX_O95819.
PharmGKBi PA30612.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000290708.
HOVERGENi HBG036506.
KOi K04407.
PhylomeDBi O95819.
TreeFami TF105138.

Enzyme and pathway databases

Reactomei REACT_169436. Oxidative Stress Induced Senescence.
SignaLinki O95819.

Miscellaneous databases

ChiTaRSi MAP4K4. human.
GeneWikii MAP4K4.
GenomeRNAii 9448.
NextBioi 35392.
PROi O95819.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95819.
Bgeei O95819.
CleanExi HS_MAP4K4.
Genevestigatori O95819.

Family and domain databases

InterProi IPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway."
    Yao Z., Zhou G., Wang X.S., Brown A., Diener K., Gan H., Tan T.-H.
    J. Biol. Chem. 274:2118-2125(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Macrophage.
  2. "The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion."
    Wright J.H., Wang X., Manning G., LaMere B.J., Le P., Zhu S., Khatry D., Flanagan P.M., Buckley S.D., Whyte D.B., Howlett A.R., Bischoff J.R., Lipson K.E., Jallal B.
    Mol. Cell. Biol. 23:2068-2082(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Glioblastoma.
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-1239 (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-1239 (ISOFORM 3).
    Tissue: Testis.
  5. "Isolation, expression profile and chromosome assignment of a novel serine/threonine kinase gene."
    Saito T., Seki N., Hori T.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 700-1239.
    Tissue: Brain.
  6. "A novel GTP-binding protein hGBP3 interacts with NIK/HGK."
    Luan Z., Zhang Y., Liu A., Man Y., Cheng L., Hu G.
    FEBS Lett. 530:233-238(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATL1.
  7. "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase."
    Machida N., Umikawa M., Takei K., Sakima N., Myagmar B.E., Taira K., Uezato H., Ogawa Y., Kariya K.
    J. Biol. Chem. 279:15711-15714(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAP2A, SUBCELLULAR LOCATION.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639; SER-644; SER-712 AND SER-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629; SER-631; SER-639 AND SER-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-639; SER-644; SER-805 AND SER-900, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-800 AND SER-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: FUNCTION.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629; SER-631 AND SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-712, VARIANT [LARGE SCALE ANALYSIS] VAL-682 (ISOFORM 3).

Entry informationi

Entry nameiM4K4_HUMAN
AccessioniPrimary (citable) accession number: O95819
Secondary accession number(s): O75172, Q9NST7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: September 3, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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