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O95817

- BAG3_HUMAN

UniProt

O95817 - BAG3_HUMAN

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Protein
BAG family molecular chaperone regulator 3
Gene
BAG3, BIS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. brain development Source: Ensembl
  2. cellular response to mechanical stimulus Source: Ensembl
  3. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  4. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of striated muscle cell apoptotic process Source: Ensembl
  7. protein folding Source: UniProtKB
  8. protein stabilization Source: Ensembl
  9. spinal cord development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiO95817.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 3
Short name:
BAG-3
Alternative name(s):
Bcl-2-associated athanogene 3
Bcl-2-binding protein Bis
Docking protein CAIR-1
Gene namesi
Name:BAG3
Synonyms:BIS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:939. BAG3.

Subcellular locationi

GO - Cellular componenti

  1. Z disc Source: Ensembl
  2. cytoplasm Source: HPA
  3. cytosol Source: MGI
  4. neuron projection Source: Ensembl
  5. plasma membrane Source: HPA
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 3 Publications
Corresponds to variant rs121918312 [ dbSNP | Ensembl ].
VAR_063089
Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711R → W in CMD1HH. 1 Publication
VAR_065479
Natural varianti218 – 2181R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
VAR_066781
Natural varianti455 – 4551E → K in CMD1HH. 1 Publication
VAR_066785
Natural varianti462 – 4621L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
VAR_066786
Natural varianti468 – 4681V → M in CMD1HH. 1 Publication
VAR_066787
Natural varianti477 – 4771R → H in CMD1HH. 1 Publication
VAR_065480

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Myofibrillar myopathy

Organism-specific databases

MIMi612954. phenotype.
613881. phenotype.
Orphaneti154. Familial isolated dilated cardiomyopathy.
199340. Muscular dystrophy, Selcen type.
PharmGKBiPA25239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 575574BAG family molecular chaperone regulator 3
PRO_0000088868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei198 – 1981Phosphoserine1 Publication
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei275 – 2751Phosphoserine1 Publication
Modified residuei279 – 2791Phosphoserine1 Publication
Modified residuei285 – 2851Phosphothreonine1 Publication
Modified residuei289 – 2891Phosphoserine2 Publications
Modified residuei291 – 2911Phosphoserine1 Publication
Modified residuei377 – 3771Phosphoserine3 Publications
Modified residuei385 – 3851Phosphoserine By similarity
Modified residuei386 – 3861Phosphoserine2 Publications
Modified residuei406 – 4061Phosphothreonine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95817.
PaxDbiO95817.
PeptideAtlasiO95817.
PRIDEiO95817.

PTM databases

PhosphoSiteiO95817.

Miscellaneous databases

PMAP-CutDBO95817.

Expressioni

Gene expression databases

ArrayExpressiO95817.
BgeeiO95817.
CleanExiHS_BAG3.
GenevestigatoriO95817.

Organism-specific databases

HPAiHPA018493.
HPA020586.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SQSTM1Q135013EBI-747185,EBI-307104

Protein-protein interaction databases

BioGridi114907. 409 interactions.
DIPiDIP-41273N.
IntActiO95817. 14 interactions.
MINTiMINT-208995.
STRINGi9606.ENSP00000358081.

Structurei

3D structure databases

ProteinModelPortaliO95817.
SMRiO95817. Positions 19-55, 396-498.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 5435WW 1
Add
BLAST
Domaini124 – 15431WW 2
Add
BLAST
Domaini421 – 49878BAG
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi180 – 1878Poly-Ser

Sequence similaritiesi

Contains 1 BAG domain.
Contains 2 WW domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG238690.
HOGENOMiHOG000050234.
HOVERGENiHBG003419.
InParanoidiO95817.
KOiK09557.
OMAiVYPQLRP.
OrthoDBiEOG75B85S.
PhylomeDBiO95817.
TreeFamiTF102013.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95817-1 [UniParc]FASTAAdd to Basket

« Hide

MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN    50
DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH 100
EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ 150
CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ 200
LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI 250
QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD 300
RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP 350
VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST 400
APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK 450
YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID 500
VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ 550
QPEATAAATS NPSSMTDTPG NPAAP 575
Length:575
Mass (Da):61,595
Last modified:January 11, 2001 - v3
Checksum:iA6328A44F37A406A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711R → Q.1 Publication
Corresponds to variant rs35434411 [ dbSNP | Ensembl ].
VAR_048344
Natural varianti71 – 711R → W in CMD1HH. 1 Publication
VAR_065479
Natural varianti77 – 771P → L.1 Publication
Corresponds to variant rs141355480 [ dbSNP | Ensembl ].
VAR_066777
Natural varianti94 – 941I → F.1 Publication
Corresponds to variant rs145393807 [ dbSNP | Ensembl ].
VAR_066778
Natural varianti115 – 1151P → S.1 Publication
VAR_066779
Natural varianti151 – 1511C → R.2 Publications
Corresponds to variant rs2234962 [ dbSNP | Ensembl ].
VAR_048345
Natural varianti155 – 1551A → T.1 Publication
Corresponds to variant rs61756328 [ dbSNP | Ensembl ].
VAR_066780
Natural varianti209 – 2091P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 3 Publications
Corresponds to variant rs121918312 [ dbSNP | Ensembl ].
VAR_063089
Natural varianti218 – 2181R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
VAR_066781
Natural varianti258 – 2581R → W Polymorphism with no functional consequences. 2 Publications
Corresponds to variant rs117671123 [ dbSNP | Ensembl ].
VAR_066782
Natural varianti300 – 3001D → N.1 Publication
Corresponds to variant rs78439745 [ dbSNP | Ensembl ].
VAR_066783
Natural varianti380 – 3801P → S.1 Publication
Corresponds to variant rs144692954 [ dbSNP | Ensembl ].
VAR_066784
Natural varianti405 – 4051A → V.
Corresponds to variant rs11199064 [ dbSNP | Ensembl ].
VAR_048346
Natural varianti407 – 4071P → L.2 Publications
Corresponds to variant rs3858340 [ dbSNP | Ensembl ].
VAR_048347
Natural varianti455 – 4551E → K in CMD1HH. 1 Publication
VAR_066785
Natural varianti462 – 4621L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
VAR_066786
Natural varianti468 – 4681V → M in CMD1HH. 1 Publication
VAR_066787
Natural varianti477 – 4771R → H in CMD1HH. 1 Publication
VAR_065480
Natural varianti553 – 5531E → D.1 Publication
VAR_066788

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271Q → K in AAD16122. 1 Publication
Sequence conflicti237 – 2371Q → R in AAD16122. 1 Publication
Sequence conflicti304 – 3041Missing in CAB70824. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095193 mRNA. Translation: AAD16122.2.
AF127139 mRNA. Translation: AAF26839.1.
AF071218 mRNA. Translation: AAF69592.2.
AK291333 mRNA. Translation: BAF84022.1.
AL137582 mRNA. Translation: CAB70824.1.
BC006418 mRNA. Translation: AAH06418.1.
BC014656 mRNA. Translation: AAH14656.1.
BC107786 mRNA. Translation: AAI07787.1.
CCDSiCCDS7615.1.
RefSeqiNP_004272.2. NM_004281.3.
UniGeneiHs.523309.

Genome annotation databases

EnsembliENST00000369085; ENSP00000358081; ENSG00000151929.
GeneIDi9531.
KEGGihsa:9531.
UCSCiuc001lel.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095193 mRNA. Translation: AAD16122.2 .
AF127139 mRNA. Translation: AAF26839.1 .
AF071218 mRNA. Translation: AAF69592.2 .
AK291333 mRNA. Translation: BAF84022.1 .
AL137582 mRNA. Translation: CAB70824.1 .
BC006418 mRNA. Translation: AAH06418.1 .
BC014656 mRNA. Translation: AAH14656.1 .
BC107786 mRNA. Translation: AAI07787.1 .
CCDSi CCDS7615.1.
RefSeqi NP_004272.2. NM_004281.3.
UniGenei Hs.523309.

3D structure databases

ProteinModelPortali O95817.
SMRi O95817. Positions 19-55, 396-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114907. 409 interactions.
DIPi DIP-41273N.
IntActi O95817. 14 interactions.
MINTi MINT-208995.
STRINGi 9606.ENSP00000358081.

PTM databases

PhosphoSitei O95817.

Proteomic databases

MaxQBi O95817.
PaxDbi O95817.
PeptideAtlasi O95817.
PRIDEi O95817.

Protocols and materials databases

DNASUi 9531.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369085 ; ENSP00000358081 ; ENSG00000151929 .
GeneIDi 9531.
KEGGi hsa:9531.
UCSCi uc001lel.3. human.

Organism-specific databases

CTDi 9531.
GeneCardsi GC10P121400.
GeneReviewsi BAG3.
HGNCi HGNC:939. BAG3.
HPAi HPA018493.
HPA020586.
MIMi 603883. gene.
612954. phenotype.
613881. phenotype.
neXtProti NX_O95817.
Orphaneti 154. Familial isolated dilated cardiomyopathy.
199340. Muscular dystrophy, Selcen type.
PharmGKBi PA25239.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238690.
HOGENOMi HOG000050234.
HOVERGENi HBG003419.
InParanoidi O95817.
KOi K09557.
OMAi VYPQLRP.
OrthoDBi EOG75B85S.
PhylomeDBi O95817.
TreeFami TF102013.

Enzyme and pathway databases

SignaLinki O95817.

Miscellaneous databases

GeneWikii BAG3.
GenomeRNAii 9531.
NextBioi 35732.
PMAP-CutDB O95817.
PROi O95817.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95817.
Bgeei O95817.
CleanExi HS_BAG3.
Genevestigatori O95817.

Family and domain databases

Gene3Di 1.20.58.120. 1 hit.
InterProi IPR003103. BAG_domain.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF02179. BAG. 1 hit.
PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00264. BAG. 1 hit.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS51035. BAG. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
    Takayama S., Xie Z., Reed J.C.
    J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."
    Lee J.H., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y.
    Oncogene 18:6183-6190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-151.
  3. "CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70."
    Doong H., Price J., Kim Y.S., Gasbarre C., Probst J., Liotta L.A., Blanchette J., Rizzo K., Kohn E.
    Oncogene 19:4385-4395(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Placenta.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-275; SER-279; THR-285; SER-289; SER-291; SER-377; SER-386 AND THR-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-289; SER-377; SER-386 AND THR-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: INTERACTION WITH DNAJB6.
  15. "Mutation in BAG3 causes severe dominant childhood muscular dystrophy."
    Selcen D., Muntoni F., Burton B.K., Pegoraro E., Sewry C., Bite A.V., Engel A.G.
    Ann. Neurol. 65:83-89(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MFM6 LEU-209.
  16. "Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy."
    Norton N., Li D., Rieder M.J., Siegfried J.D., Rampersaud E., Zuchner S., Mangos S., Gonzalez-Quintana J., Wang L., McGee S., Reiser J., Martin E., Nickerson D.A., Hershberger R.E.
    Am. J. Hum. Genet. 88:273-282(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CMD1HH TRP-71 AND HIS-477.
  17. "BAG3-related myofibrillar myopathy in a Chinese family."
    Lee H., Cherk S., Chan S., Wong S., Tong T., Ho W., Chan A., Lee K., Mak C.
    Clin. Genet. 81:394-398(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MFM6 LEU-209, VARIANT TRP-258.
  18. Cited for: VARIANTS GLN-71; LEU-77; PHE-94; SER-115; ARG-151; THR-155; SER-380 AND LEU-407, VARIANTS CMD1HH LYS-455 AND MET-468.
  19. "Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes."
    Arimura T., Ishikawa T., Nunoda S., Kawai S., Kimura A.
    Hum. Mutat. 32:1481-1491(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CMD1HH TRP-218 AND PRO-462, VARIANTS TRP-258; ASN-300; LEU-407 AND ASP-553, CHARACTERIZATION OF VARIANTS CMD1HH TRP-218 AND PRO-462, CHARACTERIZATION OF VARIANT MFM6 LEU-209, CHARACTERIZATION OF VARIANT TRP-258.

Entry informationi

Entry nameiBAG3_HUMAN
AccessioniPrimary (citable) accession number: O95817
Secondary accession number(s): A8K5L8
, Q3B763, Q9NT20, Q9P120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: July 9, 2014
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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