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O95817

- BAG3_HUMAN

UniProt

O95817 - BAG3_HUMAN

Protein

BAG family molecular chaperone regulator 3

Gene

BAG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 3 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cellular response to mechanical stimulus Source: Ensembl
    3. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    4. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of striated muscle cell apoptotic process Source: Ensembl
    7. protein folding Source: UniProtKB
    8. protein stabilization Source: Ensembl
    9. spinal cord development Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    SignaLinkiO95817.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BAG family molecular chaperone regulator 3
    Short name:
    BAG-3
    Alternative name(s):
    Bcl-2-associated athanogene 3
    Bcl-2-binding protein Bis
    Docking protein CAIR-1
    Gene namesi
    Name:BAG3
    Synonyms:BIS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:939. BAG3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: MGI
    3. neuron projection Source: Ensembl
    4. plasma membrane Source: HPA
    5. Z disc Source: Ensembl

    Pathology & Biotechi

    Involvement in diseasei

    Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti209 – 2091P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 2 Publications
    Corresponds to variant rs121918312 [ dbSNP | Ensembl ].
    VAR_063089
    Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → W in CMD1HH. 1 Publication
    VAR_065479
    Natural varianti218 – 2181R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
    VAR_066781
    Natural varianti455 – 4551E → K in CMD1HH. 1 Publication
    VAR_066785
    Natural varianti462 – 4621L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
    VAR_066786
    Natural varianti468 – 4681V → M in CMD1HH. 1 Publication
    VAR_066787
    Natural varianti477 – 4771R → H in CMD1HH. 1 Publication
    VAR_065480

    Keywords - Diseasei

    Cardiomyopathy, Disease mutation, Myofibrillar myopathy

    Organism-specific databases

    MIMi612954. phenotype.
    613881. phenotype.
    Orphaneti154. Familial isolated dilated cardiomyopathy.
    199340. Muscular dystrophy, Selcen type.
    PharmGKBiPA25239.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 575574BAG family molecular chaperone regulator 3PRO_0000088868Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei198 – 1981Phosphoserine1 Publication
    Modified residuei274 – 2741Phosphoserine1 Publication
    Modified residuei275 – 2751Phosphoserine1 Publication
    Modified residuei279 – 2791Phosphoserine1 Publication
    Modified residuei285 – 2851Phosphothreonine1 Publication
    Modified residuei289 – 2891Phosphoserine2 Publications
    Modified residuei291 – 2911Phosphoserine1 Publication
    Modified residuei377 – 3771Phosphoserine3 Publications
    Modified residuei385 – 3851PhosphoserineBy similarity
    Modified residuei386 – 3861Phosphoserine2 Publications
    Modified residuei406 – 4061Phosphothreonine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95817.
    PaxDbiO95817.
    PeptideAtlasiO95817.
    PRIDEiO95817.

    PTM databases

    PhosphoSiteiO95817.

    Miscellaneous databases

    PMAP-CutDBO95817.

    Expressioni

    Gene expression databases

    ArrayExpressiO95817.
    BgeeiO95817.
    CleanExiHS_BAG3.
    GenevestigatoriO95817.

    Organism-specific databases

    HPAiHPA018493.
    HPA020586.

    Interactioni

    Subunit structurei

    Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q96BE02EBI-747185,EBI-9356686
    HSPB1P047922EBI-747185,EBI-352682
    HSPB8Q9UJY14EBI-747185,EBI-739074
    LRRK2Q5S0072EBI-747185,EBI-5323863
    SQSTM1Q135013EBI-747185,EBI-307104
    STUB1Q9UNE72EBI-747185,EBI-357085

    Protein-protein interaction databases

    BioGridi114907. 409 interactions.
    DIPiDIP-41273N.
    IntActiO95817. 33 interactions.
    MINTiMINT-208995.
    STRINGi9606.ENSP00000358081.

    Structurei

    3D structure databases

    ProteinModelPortaliO95817.
    SMRiO95817. Positions 19-55, 396-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 5435WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 15431WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 49878BAGPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi180 – 1878Poly-Ser

    Sequence similaritiesi

    Contains 1 BAG domain.PROSITE-ProRule annotation
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG238690.
    HOGENOMiHOG000050234.
    HOVERGENiHBG003419.
    InParanoidiO95817.
    KOiK09557.
    OMAiVYPQLRP.
    OrthoDBiEOG75B85S.
    PhylomeDBiO95817.
    TreeFamiTF102013.

    Family and domain databases

    Gene3Di1.20.58.120. 1 hit.
    InterProiIPR003103. BAG_domain.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF02179. BAG. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00264. BAG. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS51035. BAG. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN    50
    DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH 100
    EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ 150
    CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ 200
    LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI 250
    QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD 300
    RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP 350
    VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST 400
    APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK 450
    YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID 500
    VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ 550
    QPEATAAATS NPSSMTDTPG NPAAP 575
    Length:575
    Mass (Da):61,595
    Last modified:January 11, 2001 - v3
    Checksum:iA6328A44F37A406A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271Q → K in AAD16122. (PubMed:9873016)Curated
    Sequence conflicti237 – 2371Q → R in AAD16122. (PubMed:9873016)Curated
    Sequence conflicti304 – 3041Missing in CAB70824. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → Q.1 Publication
    Corresponds to variant rs35434411 [ dbSNP | Ensembl ].
    VAR_048344
    Natural varianti71 – 711R → W in CMD1HH. 1 Publication
    VAR_065479
    Natural varianti77 – 771P → L.1 Publication
    Corresponds to variant rs141355480 [ dbSNP | Ensembl ].
    VAR_066777
    Natural varianti94 – 941I → F.1 Publication
    Corresponds to variant rs145393807 [ dbSNP | Ensembl ].
    VAR_066778
    Natural varianti115 – 1151P → S.1 Publication
    VAR_066779
    Natural varianti151 – 1511C → R.2 Publications
    Corresponds to variant rs2234962 [ dbSNP | Ensembl ].
    VAR_048345
    Natural varianti155 – 1551A → T.1 Publication
    Corresponds to variant rs61756328 [ dbSNP | Ensembl ].
    VAR_066780
    Natural varianti209 – 2091P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 2 Publications
    Corresponds to variant rs121918312 [ dbSNP | Ensembl ].
    VAR_063089
    Natural varianti218 – 2181R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
    VAR_066781
    Natural varianti258 – 2581R → W Polymorphism with no functional consequences. 2 Publications
    Corresponds to variant rs117671123 [ dbSNP | Ensembl ].
    VAR_066782
    Natural varianti300 – 3001D → N.1 Publication
    Corresponds to variant rs78439745 [ dbSNP | Ensembl ].
    VAR_066783
    Natural varianti380 – 3801P → S.1 Publication
    Corresponds to variant rs144692954 [ dbSNP | Ensembl ].
    VAR_066784
    Natural varianti405 – 4051A → V.
    Corresponds to variant rs11199064 [ dbSNP | Ensembl ].
    VAR_048346
    Natural varianti407 – 4071P → L.2 Publications
    Corresponds to variant rs3858340 [ dbSNP | Ensembl ].
    VAR_048347
    Natural varianti455 – 4551E → K in CMD1HH. 1 Publication
    VAR_066785
    Natural varianti462 – 4621L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 Publication
    VAR_066786
    Natural varianti468 – 4681V → M in CMD1HH. 1 Publication
    VAR_066787
    Natural varianti477 – 4771R → H in CMD1HH. 1 Publication
    VAR_065480
    Natural varianti553 – 5531E → D.1 Publication
    VAR_066788

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095193 mRNA. Translation: AAD16122.2.
    AF127139 mRNA. Translation: AAF26839.1.
    AF071218 mRNA. Translation: AAF69592.2.
    AK291333 mRNA. Translation: BAF84022.1.
    AL137582 mRNA. Translation: CAB70824.1.
    BC006418 mRNA. Translation: AAH06418.1.
    BC014656 mRNA. Translation: AAH14656.1.
    BC107786 mRNA. Translation: AAI07787.1.
    CCDSiCCDS7615.1.
    RefSeqiNP_004272.2. NM_004281.3.
    UniGeneiHs.523309.

    Genome annotation databases

    EnsembliENST00000369085; ENSP00000358081; ENSG00000151929.
    GeneIDi9531.
    KEGGihsa:9531.
    UCSCiuc001lel.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095193 mRNA. Translation: AAD16122.2 .
    AF127139 mRNA. Translation: AAF26839.1 .
    AF071218 mRNA. Translation: AAF69592.2 .
    AK291333 mRNA. Translation: BAF84022.1 .
    AL137582 mRNA. Translation: CAB70824.1 .
    BC006418 mRNA. Translation: AAH06418.1 .
    BC014656 mRNA. Translation: AAH14656.1 .
    BC107786 mRNA. Translation: AAI07787.1 .
    CCDSi CCDS7615.1.
    RefSeqi NP_004272.2. NM_004281.3.
    UniGenei Hs.523309.

    3D structure databases

    ProteinModelPortali O95817.
    SMRi O95817. Positions 19-55, 396-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114907. 409 interactions.
    DIPi DIP-41273N.
    IntActi O95817. 33 interactions.
    MINTi MINT-208995.
    STRINGi 9606.ENSP00000358081.

    PTM databases

    PhosphoSitei O95817.

    Proteomic databases

    MaxQBi O95817.
    PaxDbi O95817.
    PeptideAtlasi O95817.
    PRIDEi O95817.

    Protocols and materials databases

    DNASUi 9531.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369085 ; ENSP00000358081 ; ENSG00000151929 .
    GeneIDi 9531.
    KEGGi hsa:9531.
    UCSCi uc001lel.3. human.

    Organism-specific databases

    CTDi 9531.
    GeneCardsi GC10P121400.
    GeneReviewsi BAG3.
    HGNCi HGNC:939. BAG3.
    HPAi HPA018493.
    HPA020586.
    MIMi 603883. gene.
    612954. phenotype.
    613881. phenotype.
    neXtProti NX_O95817.
    Orphaneti 154. Familial isolated dilated cardiomyopathy.
    199340. Muscular dystrophy, Selcen type.
    PharmGKBi PA25239.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238690.
    HOGENOMi HOG000050234.
    HOVERGENi HBG003419.
    InParanoidi O95817.
    KOi K09557.
    OMAi VYPQLRP.
    OrthoDBi EOG75B85S.
    PhylomeDBi O95817.
    TreeFami TF102013.

    Enzyme and pathway databases

    SignaLinki O95817.

    Miscellaneous databases

    GeneWikii BAG3.
    GenomeRNAii 9531.
    NextBioi 35732.
    PMAP-CutDB O95817.
    PROi O95817.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95817.
    Bgeei O95817.
    CleanExi HS_BAG3.
    Genevestigatori O95817.

    Family and domain databases

    Gene3Di 1.20.58.120. 1 hit.
    InterProi IPR003103. BAG_domain.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF02179. BAG. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00264. BAG. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS51035. BAG. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
      Takayama S., Xie Z., Reed J.C.
      J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."
      Lee J.H., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y.
      Oncogene 18:6183-6190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-151.
    3. "CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70."
      Doong H., Price J., Kim Y.S., Gasbarre C., Probst J., Liotta L.A., Blanchette J., Rizzo K., Kohn E.
      Oncogene 19:4385-4395(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Placenta.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-275; SER-279; THR-285; SER-289; SER-291; SER-377; SER-386 AND THR-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-289; SER-377; SER-386 AND THR-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: INTERACTION WITH DNAJB6.
    15. "Mutation in BAG3 causes severe dominant childhood muscular dystrophy."
      Selcen D., Muntoni F., Burton B.K., Pegoraro E., Sewry C., Bite A.V., Engel A.G.
      Ann. Neurol. 65:83-89(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MFM6 LEU-209.
    16. "Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy."
      Norton N., Li D., Rieder M.J., Siegfried J.D., Rampersaud E., Zuchner S., Mangos S., Gonzalez-Quintana J., Wang L., McGee S., Reiser J., Martin E., Nickerson D.A., Hershberger R.E.
      Am. J. Hum. Genet. 88:273-282(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CMD1HH TRP-71 AND HIS-477.
    17. "BAG3-related myofibrillar myopathy in a Chinese family."
      Lee H., Cherk S., Chan S., Wong S., Tong T., Ho W., Chan A., Lee K., Mak C.
      Clin. Genet. 81:394-398(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MFM6 LEU-209, VARIANT TRP-258.
    18. Cited for: VARIANTS GLN-71; LEU-77; PHE-94; SER-115; ARG-151; THR-155; SER-380 AND LEU-407, VARIANTS CMD1HH LYS-455 AND MET-468.
    19. "Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes."
      Arimura T., Ishikawa T., Nunoda S., Kawai S., Kimura A.
      Hum. Mutat. 32:1481-1491(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CMD1HH TRP-218 AND PRO-462, VARIANTS TRP-258; ASN-300; LEU-407 AND ASP-553, CHARACTERIZATION OF VARIANTS CMD1HH TRP-218 AND PRO-462, CHARACTERIZATION OF VARIANT MFM6 LEU-209, CHARACTERIZATION OF VARIANT TRP-258.

    Entry informationi

    Entry nameiBAG3_HUMAN
    AccessioniPrimary (citable) accession number: O95817
    Secondary accession number(s): A8K5L8
    , Q3B763, Q9NT20, Q9P120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 146 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3