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O95816

- BAG2_HUMAN

UniProt

O95816 - BAG2_HUMAN

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Protein

BAG family molecular chaperone regulator 2

Gene
BAG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. protein folding Source: ProtInc
  2. protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:BAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:938. BAG2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 211210BAG family molecular chaperone regulator 2PRO_0000088866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei20 – 201Phosphoserine1 Publication
Modified residuei73 – 731Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95816.
PaxDbiO95816.
PeptideAtlasiO95816.
PRIDEiO95816.

PTM databases

PhosphoSiteiO95816.

Expressioni

Gene expression databases

ArrayExpressiO95816.
BgeeiO95816.
CleanExiHS_BAG2.
GenevestigatoriO95816.

Organism-specific databases

HPAiHPA018862.
HPA019918.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones.

Binary interactionsi

WithEntry#Exp.IntActNotes
EBNA-LPQ8AZK72EBI-355275,EBI-1185167From a different organism.

Protein-protein interaction databases

BioGridi114908. 45 interactions.
IntActiO95816. 28 interactions.
MINTiMINT-5002329.
STRINGi9606.ENSP00000359727.

Structurei

3D structure databases

ProteinModelPortaliO95816.
SMRiO95816. Positions 108-188.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 18981BAGAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 6142 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG251652.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiO95816.
KOiK09556.
OMAiKIQAKMN.
PhylomeDBiO95816.
TreeFamiTF102012.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95816-1 [UniParc]FASTAAdd to Basket

« Hide

MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE    50
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET 100
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP 150
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK 200
TLQQNAESRF N 211
Length:211
Mass (Da):23,772
Last modified:May 1, 1999 - v1
Checksum:iCAF631F4578FCCA3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801N → D in CAG38527. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095192 mRNA. Translation: AAD16121.1.
AL050287 mRNA. Translation: CAB43388.1.
CR533496 mRNA. Translation: CAG38527.1.
AL031321, AL136311 Genomic DNA. Translation: CAI21565.1.
AL136311, AL031321 Genomic DNA. Translation: CAI20515.1.
BC125039 mRNA. Translation: AAI25040.1.
CCDSiCCDS4961.1.
PIRiT08764.
RefSeqiNP_004273.1. NM_004282.3.
UniGeneiHs.745046.

Genome annotation databases

EnsembliENST00000370693; ENSP00000359727; ENSG00000112208.
GeneIDi9532.
KEGGihsa:9532.
UCSCiuc003pdr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095192 mRNA. Translation: AAD16121.1 .
AL050287 mRNA. Translation: CAB43388.1 .
CR533496 mRNA. Translation: CAG38527.1 .
AL031321 , AL136311 Genomic DNA. Translation: CAI21565.1 .
AL136311 , AL031321 Genomic DNA. Translation: CAI20515.1 .
BC125039 mRNA. Translation: AAI25040.1 .
CCDSi CCDS4961.1.
PIRi T08764.
RefSeqi NP_004273.1. NM_004282.3.
UniGenei Hs.745046.

3D structure databases

ProteinModelPortali O95816.
SMRi O95816. Positions 108-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114908. 45 interactions.
IntActi O95816. 28 interactions.
MINTi MINT-5002329.
STRINGi 9606.ENSP00000359727.

PTM databases

PhosphoSitei O95816.

Proteomic databases

MaxQBi O95816.
PaxDbi O95816.
PeptideAtlasi O95816.
PRIDEi O95816.

Protocols and materials databases

DNASUi 9532.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370693 ; ENSP00000359727 ; ENSG00000112208 .
GeneIDi 9532.
KEGGi hsa:9532.
UCSCi uc003pdr.3. human.

Organism-specific databases

CTDi 9532.
GeneCardsi GC06P057084.
HGNCi HGNC:938. BAG2.
HPAi HPA018862.
HPA019918.
MIMi 603882. gene.
neXtProti NX_O95816.
PharmGKBi PA25238.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251652.
HOGENOMi HOG000073529.
HOVERGENi HBG004808.
InParanoidi O95816.
KOi K09556.
OMAi KIQAKMN.
PhylomeDBi O95816.
TreeFami TF102012.

Miscellaneous databases

GeneWikii BAG2.
GenomeRNAii 9532.
NextBioi 35736.
PROi O95816.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95816.
Bgeei O95816.
CleanExi HS_BAG2.
Genevestigatori O95816.

Family and domain databases

InterProi IPR003103. BAG_domain.
[Graphical view ]
Pfami PF02179. BAG. 1 hit.
[Graphical view ]
SMARTi SM00264. BAG. 1 hit.
[Graphical view ]
PROSITEi PS51035. BAG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
    Takayama S., Xie Z., Reed J.C.
    J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBAG2_HUMAN
AccessioniPrimary (citable) accession number: O95816
Secondary accession number(s): Q08AS9, Q6FID0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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