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O95816

- BAG2_HUMAN

UniProt

O95816 - BAG2_HUMAN

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Protein

BAG family molecular chaperone regulator 2

Gene

BAG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. protein folding Source: ProtInc
  2. protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:BAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:938. BAG2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 211210BAG family molecular chaperone regulator 2PRO_0000088866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei20 – 201Phosphoserine1 Publication
Modified residuei73 – 731Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95816.
PaxDbiO95816.
PeptideAtlasiO95816.
PRIDEiO95816.

PTM databases

PhosphoSiteiO95816.

Expressioni

Gene expression databases

BgeeiO95816.
CleanExiHS_BAG2.
GenevestigatoriO95816.

Organism-specific databases

HPAiHPA018862.
HPA019918.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-355275,EBI-355275
A8K1F42EBI-355275,EBI-9357094
Q96BE02EBI-355275,EBI-9356686
EBNA-LPQ8AZK72EBI-355275,EBI-1185167From a different organism.
HSPA8P111423EBI-355275,EBI-351896
LRRK2Q5S0072EBI-355275,EBI-5323863
SGTAO437652EBI-355275,EBI-347996
STUB1Q9UNE74EBI-355275,EBI-357085

Protein-protein interaction databases

BioGridi114908. 57 interactions.
IntActiO95816. 97 interactions.
MINTiMINT-5002329.
STRINGi9606.ENSP00000359727.

Structurei

3D structure databases

ProteinModelPortaliO95816.
SMRiO95816. Positions 108-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 18981BAGPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 6142Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG251652.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiO95816.
KOiK09556.
OMAiKIQAKMN.
PhylomeDBiO95816.
TreeFamiTF102012.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95816-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK
210
TLQQNAESRF N
Length:211
Mass (Da):23,772
Last modified:May 1, 1999 - v1
Checksum:iCAF631F4578FCCA3
GO
Isoform 2 (identifier: O95816-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELR → MPHMW

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):20,189
Checksum:i548BFD3AB88A93DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801N → D in CAG38527. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationVSP_056462Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095192 mRNA. Translation: AAD16121.1.
AL050287 mRNA. Translation: CAB43388.1.
AK301934 mRNA. Translation: BAG63354.1.
CR533496 mRNA. Translation: CAG38527.1.
AL031321, AL136311 Genomic DNA. Translation: CAI21565.1.
AL136311, AL031321 Genomic DNA. Translation: CAI20515.1.
BC125039 mRNA. Translation: AAI25040.1.
CCDSiCCDS4961.1. [O95816-1]
PIRiT08764.
RefSeqiNP_004273.1. NM_004282.3. [O95816-1]
XP_005249547.1. XM_005249490.1. [O95816-2]
UniGeneiHs.745046.

Genome annotation databases

EnsembliENST00000370693; ENSP00000359727; ENSG00000112208. [O95816-1]
GeneIDi9532.
KEGGihsa:9532.
UCSCiuc003pdr.3. human. [O95816-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095192 mRNA. Translation: AAD16121.1 .
AL050287 mRNA. Translation: CAB43388.1 .
AK301934 mRNA. Translation: BAG63354.1 .
CR533496 mRNA. Translation: CAG38527.1 .
AL031321 , AL136311 Genomic DNA. Translation: CAI21565.1 .
AL136311 , AL031321 Genomic DNA. Translation: CAI20515.1 .
BC125039 mRNA. Translation: AAI25040.1 .
CCDSi CCDS4961.1. [O95816-1 ]
PIRi T08764.
RefSeqi NP_004273.1. NM_004282.3. [O95816-1 ]
XP_005249547.1. XM_005249490.1. [O95816-2 ]
UniGenei Hs.745046.

3D structure databases

ProteinModelPortali O95816.
SMRi O95816. Positions 108-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114908. 57 interactions.
IntActi O95816. 97 interactions.
MINTi MINT-5002329.
STRINGi 9606.ENSP00000359727.

PTM databases

PhosphoSitei O95816.

Proteomic databases

MaxQBi O95816.
PaxDbi O95816.
PeptideAtlasi O95816.
PRIDEi O95816.

Protocols and materials databases

DNASUi 9532.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370693 ; ENSP00000359727 ; ENSG00000112208 . [O95816-1 ]
GeneIDi 9532.
KEGGi hsa:9532.
UCSCi uc003pdr.3. human. [O95816-1 ]

Organism-specific databases

CTDi 9532.
GeneCardsi GC06P057084.
HGNCi HGNC:938. BAG2.
HPAi HPA018862.
HPA019918.
MIMi 603882. gene.
neXtProti NX_O95816.
PharmGKBi PA25238.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251652.
GeneTreei ENSGT00390000017590.
HOGENOMi HOG000073529.
HOVERGENi HBG004808.
InParanoidi O95816.
KOi K09556.
OMAi KIQAKMN.
PhylomeDBi O95816.
TreeFami TF102012.

Miscellaneous databases

ChiTaRSi BAG2. human.
GeneWikii BAG2.
GenomeRNAii 9532.
NextBioi 35475952.
PROi O95816.
SOURCEi Search...

Gene expression databases

Bgeei O95816.
CleanExi HS_BAG2.
Genevestigatori O95816.

Family and domain databases

InterProi IPR003103. BAG_domain.
[Graphical view ]
Pfami PF02179. BAG. 1 hit.
[Graphical view ]
SMARTi SM00264. BAG. 1 hit.
[Graphical view ]
PROSITEi PS51035. BAG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
    Takayama S., Xie Z., Reed J.C.
    J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBAG2_HUMAN
AccessioniPrimary (citable) accession number: O95816
Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3