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Protein

BAG family molecular chaperone regulator 2

Gene

BAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).2 Publications

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

  • protein folding Source: ProtInc
  • protein metabolic process Source: MGI
  • regulation of cellular response to heat Source: Reactome

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.
SIGNORiO95816.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:BAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:938. BAG2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112208.
PharmGKBiPA25238.

Polymorphism and mutation databases

BioMutaiBAG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000888662 – 211BAG family molecular chaperone regulator 2Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95816.
MaxQBiO95816.
PaxDbiO95816.
PeptideAtlasiO95816.
PRIDEiO95816.
TopDownProteomicsiO95816-1. [O95816-1]

PTM databases

iPTMnetiO95816.
PhosphoSitePlusiO95816.
SwissPalmiO95816.

Expressioni

Gene expression databases

BgeeiENSG00000112208.
CleanExiHS_BAG2.
GenevisibleiO95816. HS.

Organism-specific databases

HPAiHPA018862.
HPA019918.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi114908. 106 interactors.
IntActiO95816. 148 interactors.
MINTiMINT-5002329.
STRINGi9606.ENSP00000359727.

Structurei

3D structure databases

ProteinModelPortaliO95816.
SMRiO95816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 189BAGPROSITE-ProRule annotationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 61Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiO95816.
KOiK09556.
OMAiQLEMRVE.
OrthoDBiEOG091G0G1G.
PhylomeDBiO95816.
TreeFamiTF102012.

Family and domain databases

InterProiView protein in InterPro
IPR003103. BAG_domain.
SMARTiView protein in SMART
SM00264. BAG. 1 hit.
PROSITEiView protein in PROSITE
PS51035. BAG. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK
210
TLQQNAESRF N
Length:211
Mass (Da):23,772
Last modified:May 1, 1999 - v1
Checksum:iCAF631F4578FCCA3
GO
Isoform 2 (identifier: O95816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELR → MPHMW

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,189
Checksum:i548BFD3AB88A93DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180N → D in CAG38527 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564621 – 38MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095192 mRNA. Translation: AAD16121.1.
AL050287 mRNA. Translation: CAB43388.1.
AK301934 mRNA. Translation: BAG63354.1.
CR533496 mRNA. Translation: CAG38527.1.
AL031321, AL136311 Genomic DNA. Translation: CAI21565.1.
AL136311, AL031321 Genomic DNA. Translation: CAI20515.1.
BC125039 mRNA. Translation: AAI25040.1.
CCDSiCCDS4961.1. [O95816-1]
PIRiT08764.
RefSeqiNP_004273.1. NM_004282.3. [O95816-1]
XP_005249547.1. XM_005249490.3. [O95816-2]
XP_011513300.1. XM_011514998.2. [O95816-2]
XP_011513301.1. XM_011514999.2. [O95816-2]
UniGeneiHs.745046.

Genome annotation databases

EnsembliENST00000370693; ENSP00000359727; ENSG00000112208. [O95816-1]
GeneIDi9532.
KEGGihsa:9532.
UCSCiuc003pdr.4. human. [O95816-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095192 mRNA. Translation: AAD16121.1.
AL050287 mRNA. Translation: CAB43388.1.
AK301934 mRNA. Translation: BAG63354.1.
CR533496 mRNA. Translation: CAG38527.1.
AL031321, AL136311 Genomic DNA. Translation: CAI21565.1.
AL136311, AL031321 Genomic DNA. Translation: CAI20515.1.
BC125039 mRNA. Translation: AAI25040.1.
CCDSiCCDS4961.1. [O95816-1]
PIRiT08764.
RefSeqiNP_004273.1. NM_004282.3. [O95816-1]
XP_005249547.1. XM_005249490.3. [O95816-2]
XP_011513300.1. XM_011514998.2. [O95816-2]
XP_011513301.1. XM_011514999.2. [O95816-2]
UniGeneiHs.745046.

3D structure databases

ProteinModelPortaliO95816.
SMRiO95816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114908. 106 interactors.
IntActiO95816. 148 interactors.
MINTiMINT-5002329.
STRINGi9606.ENSP00000359727.

PTM databases

iPTMnetiO95816.
PhosphoSitePlusiO95816.
SwissPalmiO95816.

Polymorphism and mutation databases

BioMutaiBAG2.

Proteomic databases

EPDiO95816.
MaxQBiO95816.
PaxDbiO95816.
PeptideAtlasiO95816.
PRIDEiO95816.
TopDownProteomicsiO95816-1. [O95816-1]

Protocols and materials databases

DNASUi9532.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370693; ENSP00000359727; ENSG00000112208. [O95816-1]
GeneIDi9532.
KEGGihsa:9532.
UCSCiuc003pdr.4. human. [O95816-1]

Organism-specific databases

CTDi9532.
GeneCardsiBAG2.
HGNCiHGNC:938. BAG2.
HPAiHPA018862.
HPA019918.
MIMi603882. gene.
neXtProtiNX_O95816.
OpenTargetsiENSG00000112208.
PharmGKBiPA25238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiO95816.
KOiK09556.
OMAiQLEMRVE.
OrthoDBiEOG091G0G1G.
PhylomeDBiO95816.
TreeFamiTF102012.

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.
SIGNORiO95816.

Miscellaneous databases

ChiTaRSiBAG2. human.
GeneWikiiBAG2.
GenomeRNAii9532.
PROiO95816.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112208.
CleanExiHS_BAG2.
GenevisibleiO95816. HS.

Family and domain databases

InterProiView protein in InterPro
IPR003103. BAG_domain.
SMARTiView protein in SMART
SM00264. BAG. 1 hit.
PROSITEiView protein in PROSITE
PS51035. BAG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBAG2_HUMAN
AccessioniPrimary (citable) accession number: O95816
Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: March 15, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.