Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95816

- BAG2_HUMAN

UniProt

O95816 - BAG2_HUMAN

Protein

BAG family molecular chaperone regulator 2

Gene

BAG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. protein folding Source: ProtInc
    2. protein metabolic process Source: MGI

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BAG family molecular chaperone regulator 2
    Short name:
    BAG-2
    Alternative name(s):
    Bcl-2-associated athanogene 2
    Gene namesi
    Name:BAG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:938. BAG2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25238.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 211210BAG family molecular chaperone regulator 2PRO_0000088866Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei20 – 201Phosphoserine1 Publication
    Modified residuei73 – 731Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95816.
    PaxDbiO95816.
    PeptideAtlasiO95816.
    PRIDEiO95816.

    PTM databases

    PhosphoSiteiO95816.

    Expressioni

    Gene expression databases

    ArrayExpressiO95816.
    BgeeiO95816.
    CleanExiHS_BAG2.
    GenevestigatoriO95816.

    Organism-specific databases

    HPAiHPA018862.
    HPA019918.

    Interactioni

    Subunit structurei

    Binds to the ATPase domain of HSP/HSC70 chaperones.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-355275,EBI-355275
    A8K1F42EBI-355275,EBI-9357094
    Q96BE02EBI-355275,EBI-9356686
    EBNA-LPQ8AZK72EBI-355275,EBI-1185167From a different organism.
    HSPA8P111423EBI-355275,EBI-351896
    LRRK2Q5S0072EBI-355275,EBI-5323863
    SGTAO437652EBI-355275,EBI-347996
    STUB1Q9UNE74EBI-355275,EBI-357085

    Protein-protein interaction databases

    BioGridi114908. 46 interactions.
    IntActiO95816. 97 interactions.
    MINTiMINT-5002329.
    STRINGi9606.ENSP00000359727.

    Structurei

    3D structure databases

    ProteinModelPortaliO95816.
    SMRiO95816. Positions 108-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 18981BAGPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili20 – 6142Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAG domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG251652.
    HOGENOMiHOG000073529.
    HOVERGENiHBG004808.
    InParanoidiO95816.
    KOiK09556.
    OMAiKIQAKMN.
    PhylomeDBiO95816.
    TreeFamiTF102012.

    Family and domain databases

    InterProiIPR003103. BAG_domain.
    [Graphical view]
    PfamiPF02179. BAG. 1 hit.
    [Graphical view]
    SMARTiSM00264. BAG. 1 hit.
    [Graphical view]
    PROSITEiPS51035. BAG. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95816-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE    50
    QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET 100
    IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP 150
    VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK 200
    TLQQNAESRF N 211
    Length:211
    Mass (Da):23,772
    Last modified:May 1, 1999 - v1
    Checksum:iCAF631F4578FCCA3
    GO
    Isoform 2 (identifier: O95816-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELR → MPHMW

    Note: No experimental confirmation available.

    Show »
    Length:178
    Mass (Da):20,189
    Checksum:i548BFD3AB88A93DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801N → D in CAG38527. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3838MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationVSP_056462Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095192 mRNA. Translation: AAD16121.1.
    AL050287 mRNA. Translation: CAB43388.1.
    AK301934 mRNA. Translation: BAG63354.1.
    CR533496 mRNA. Translation: CAG38527.1.
    AL031321, AL136311 Genomic DNA. Translation: CAI21565.1.
    AL136311, AL031321 Genomic DNA. Translation: CAI20515.1.
    BC125039 mRNA. Translation: AAI25040.1.
    CCDSiCCDS4961.1.
    PIRiT08764.
    RefSeqiNP_004273.1. NM_004282.3.
    XP_005249547.1. XM_005249490.1.
    UniGeneiHs.745046.

    Genome annotation databases

    EnsembliENST00000370693; ENSP00000359727; ENSG00000112208.
    ENST00000545080; ENSP00000441795; ENSG00000112208.
    GeneIDi9532.
    KEGGihsa:9532.
    UCSCiuc003pdr.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095192 mRNA. Translation: AAD16121.1 .
    AL050287 mRNA. Translation: CAB43388.1 .
    AK301934 mRNA. Translation: BAG63354.1 .
    CR533496 mRNA. Translation: CAG38527.1 .
    AL031321 , AL136311 Genomic DNA. Translation: CAI21565.1 .
    AL136311 , AL031321 Genomic DNA. Translation: CAI20515.1 .
    BC125039 mRNA. Translation: AAI25040.1 .
    CCDSi CCDS4961.1.
    PIRi T08764.
    RefSeqi NP_004273.1. NM_004282.3.
    XP_005249547.1. XM_005249490.1.
    UniGenei Hs.745046.

    3D structure databases

    ProteinModelPortali O95816.
    SMRi O95816. Positions 108-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114908. 46 interactions.
    IntActi O95816. 97 interactions.
    MINTi MINT-5002329.
    STRINGi 9606.ENSP00000359727.

    PTM databases

    PhosphoSitei O95816.

    Proteomic databases

    MaxQBi O95816.
    PaxDbi O95816.
    PeptideAtlasi O95816.
    PRIDEi O95816.

    Protocols and materials databases

    DNASUi 9532.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370693 ; ENSP00000359727 ; ENSG00000112208 .
    ENST00000545080 ; ENSP00000441795 ; ENSG00000112208 .
    GeneIDi 9532.
    KEGGi hsa:9532.
    UCSCi uc003pdr.3. human.

    Organism-specific databases

    CTDi 9532.
    GeneCardsi GC06P057084.
    HGNCi HGNC:938. BAG2.
    HPAi HPA018862.
    HPA019918.
    MIMi 603882. gene.
    neXtProti NX_O95816.
    PharmGKBi PA25238.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251652.
    HOGENOMi HOG000073529.
    HOVERGENi HBG004808.
    InParanoidi O95816.
    KOi K09556.
    OMAi KIQAKMN.
    PhylomeDBi O95816.
    TreeFami TF102012.

    Miscellaneous databases

    GeneWikii BAG2.
    GenomeRNAii 9532.
    NextBioi 35736.
    PROi O95816.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95816.
    Bgeei O95816.
    CleanExi HS_BAG2.
    Genevestigatori O95816.

    Family and domain databases

    InterProi IPR003103. BAG_domain.
    [Graphical view ]
    Pfami PF02179. BAG. 1 hit.
    [Graphical view ]
    SMARTi SM00264. BAG. 1 hit.
    [Graphical view ]
    PROSITEi PS51035. BAG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
      Takayama S., Xie Z., Reed J.C.
      J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBAG2_HUMAN
    AccessioniPrimary (citable) accession number: O95816
    Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3