Reviewed, UniProtKB/Swiss-Prot O95816 (BAG2_HUMAN)

Names and origin

Protein names

Recommended name:
    BAG family molecular chaperone regulator 2
      Short name=BAG-2
Alternative name(s):
    Bcl-2-associated athanogene 2

Gene names

Name:

BAG2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Subunit structure	Binds to the ATPase domain of HSP/HSC70 chaperones.
Sequence similarities	Contains 1 BAG domain.

Ontologies

Keywords
Domain	Coiled coil
Molecular function	Chaperone
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: InterPro protein folding Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MLF2	Q15773	1	EBI-355275,EBI-1051875
PSMC4	P43686	1	EBI-355275,EBI-743997

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	BAG family molecular chaperone regulator 2		PRO_0000088866
Regions
	Domain	109 – 189	81	BAG
	Coiled coil	20 – 61	42	Potential
Amino acid modifications
	Modified residue	73	1	Phosphoserine Ref.6
	Modified residue	111	1	N6-acetyllysine Ref.8
Experimental info
	Sequence conflict	180	1	N → D in CAG38527. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O95816-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: CAF631F4578FCCA3	FASTA	211	23,772
	10 20 30 40 50 60 MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI 70 80 90 100 110 120 HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV 130 140 150 160 170 180 VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN 190 200 210 IENSDKAIKL LEHSKGAGSK TLQQNAESRF N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." Takayama S., Xie Z., Reed J.C. J. Biol. Chem. 274:781-786(1999) [PubMed: 9873016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-111, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF095192 mRNA. Translation: AAD16121.1. AL050287 mRNA. Translation: CAB43388.1. CR533496 mRNA. Translation: CAG38527.1. AL031321, AL136311 Genomic DNA. Translation: CAI21565.1. AL136311, AL031321 Genomic DNA. Translation: CAI20515.1. BC125039 mRNA. Translation: AAI25040.1.
IPI	IPI00000643.
PIR	T08764.
RefSeq	NP_004273.1.
UniGene	Hs.719303
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95816. 22 interactions.
STRING	O95816.
PTM databases
PhosphoSite	O95816.
Proteomic databases
PeptideAtlas	O95816.
PRIDE	O95816.
Genome annotation databases
Ensembl	ENST00000370693; ENSP00000359727; ENSG00000112208; Homo sapiens. [Genome view]
GeneID	9532.
KEGG	hsa:9532.
UCSC	uc003pdr.1. human.
Organism-specific databases
CTD	9532.
GeneCards	GC06P057145.
H-InvDB	HIX0022299.
HGNC	HGNC:938. BAG2.
MIM	603882. gene.
PharmGKB	PA25238.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG714212.
HOVERGEN	O95816.
InParanoid	O95816.
OMA	VVSKFLD.
OrthoDB	EOG91NX66.
PhylomeDB	O95816.
Gene expression databases
ArrayExpress	O95816.
Bgee	O95816.
CleanEx	HS_BAG2.
Genevestigator	O95816.
GermOnline	ENSG00000112208. Homo sapiens.
Family and domain databases
InterPro	IPR003103. Apoptosis_reg_Bcl-2_prot_BAG. [Graphical view]
Pfam	PF02179. BAG. 1 hit. [Graphical view]
SMART	SM00264. BAG. 1 hit. [Graphical view]
PROSITE	PS51035. BAG. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	35736.
SOURCE	Search...

Entry information

Entry name

BAG2_HUMAN

Accession

Primary (citable) accession number: O95816
Secondary accession number(s): Q08AS9, Q6FID0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.