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O95813

- CER1_HUMAN

UniProt

O95813 - CER1_HUMAN

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Protein
Cerberus
Gene
CER1, DAND4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak By similarity.

GO - Molecular functioni

  1. BMP binding Source: BHF-UCL
  2. morphogen activity Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. BMP signaling pathway Source: Reactome
  2. anterior/posterior axis specification Source: BHF-UCL
  3. anterior/posterior pattern specification Source: BHF-UCL
  4. bone mineralization Source: BHF-UCL
  5. cell migration involved in gastrulation Source: BHF-UCL
  6. cellular response to BMP stimulus Source: BHF-UCL
  7. determination of dorsal identity Source: BHF-UCL
  8. gastrulation Source: BHF-UCL
  9. growth plate cartilage chondrocyte proliferation Source: BHF-UCL
  10. negative regulation of BMP signaling pathway Source: BHF-UCL
  11. negative regulation of activin receptor signaling pathway Source: BHF-UCL
  12. negative regulation of cell proliferation Source: BHF-UCL
  13. negative regulation of mesoderm development Source: BHF-UCL
  14. nervous system development Source: BHF-UCL
  15. sequestering of BMP in extracellular matrix Source: BHF-UCL
  16. signal transduction involved in regulation of gene expression Source: BHF-UCL
  17. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_111059. Regulation of signaling by NODAL.
REACT_12034. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-related protein
DAN domain family member 4
Gene namesi
Name:CER1
Synonyms:DAND4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1862. CER1.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 Publication
Add
BLAST
Chaini18 – 267250Cerberus
PRO_0000006711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi162 ↔ 209 By similarity
Disulfide bondi176 ↔ 223 By similarity
Disulfide bondi186 ↔ 239 By similarity
Disulfide bondi190 ↔ 241 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95813.
PRIDEiO95813.

PTM databases

PhosphoSiteiO95813.

Expressioni

Gene expression databases

BgeeiO95813.
CleanExiHS_CER1.
GenevestigatoriO95813.

Organism-specific databases

HPAiHPA019917.

Interactioni

Subunit structurei

Forms monomers and predominantly dimers By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000370297.

Structurei

3D structure databases

ProteinModelPortaliO95813.
SMRiO95813. Positions 155-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24685CTCK
Add
BLAST

Sequence similaritiesi

Belongs to the DAN family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40714.
HOGENOMiHOG000231309.
HOVERGENiHBG050902.
InParanoidiO95813.
KOiK01645.
OMAiCFGKCGS.
OrthoDBiEOG7VX8X6.
PhylomeDBiO95813.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95813-1 [UniParc]FASTAAdd to Basket

« Hide

MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA    50
EEKPDLFVAV PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS 100
DSEPFPPGTQ SLIQPIDGMK MEKSPLREEA KKFWHHFMFR KTPASQGVIL 150
PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV VQNNLCFGKC GSVHFPGAAQ 200
HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ CKVKTEHEDG 250
HILHAGSQDS FIPGVSA 267
Length:267
Mass (Da):30,084
Last modified:May 1, 1999 - v1
Checksum:iC9FB048CD8558ED7
GO

Sequence cautioni

The sequence AAH69503.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191R → W.1 Publication
Corresponds to variant rs10115703 [ dbSNP | Ensembl ].
VAR_021591
Natural varianti65 – 651A → G.1 Publication
Corresponds to variant rs3747532 [ dbSNP | Ensembl ].
VAR_021592
Natural varianti179 – 1791V → I.1 Publication
Corresponds to variant rs7036635 [ dbSNP | Ensembl ].
VAR_021593

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571F → L in AAH69503. 1 Publication
Sequence conflicti221 – 2211L → V in AAH69405. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090189 Genomic DNA. Translation: AAD19879.1.
AF400435 mRNA. Translation: AAK92484.1.
AL390732 Genomic DNA. Translation: CAH73850.1.
BC069371 mRNA. Translation: AAH69371.1.
BC069405 mRNA. Translation: AAH69405.1.
BC069491 mRNA. Translation: AAH69491.1.
BC069503 mRNA. Translation: AAH69503.1. Sequence problems.
CCDSiCCDS6476.1.
RefSeqiNP_005445.1. NM_005454.2.
UniGeneiHs.248204.

Genome annotation databases

EnsembliENST00000380911; ENSP00000370297; ENSG00000147869.
GeneIDi9350.
KEGGihsa:9350.
UCSCiuc003zlj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090189 Genomic DNA. Translation: AAD19879.1 .
AF400435 mRNA. Translation: AAK92484.1 .
AL390732 Genomic DNA. Translation: CAH73850.1 .
BC069371 mRNA. Translation: AAH69371.1 .
BC069405 mRNA. Translation: AAH69405.1 .
BC069491 mRNA. Translation: AAH69491.1 .
BC069503 mRNA. Translation: AAH69503.1 . Sequence problems.
CCDSi CCDS6476.1.
RefSeqi NP_005445.1. NM_005454.2.
UniGenei Hs.248204.

3D structure databases

ProteinModelPortali O95813.
SMRi O95813. Positions 155-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000370297.

PTM databases

PhosphoSitei O95813.

Proteomic databases

PaxDbi O95813.
PRIDEi O95813.

Protocols and materials databases

DNASUi 9350.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380911 ; ENSP00000370297 ; ENSG00000147869 .
GeneIDi 9350.
KEGGi hsa:9350.
UCSCi uc003zlj.3. human.

Organism-specific databases

CTDi 9350.
GeneCardsi GC09M014710.
H-InvDB HIX0034784.
HGNCi HGNC:1862. CER1.
HPAi HPA019917.
MIMi 603777. gene.
neXtProti NX_O95813.
PharmGKBi PA26417.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40714.
HOGENOMi HOG000231309.
HOVERGENi HBG050902.
InParanoidi O95813.
KOi K01645.
OMAi CFGKCGS.
OrthoDBi EOG7VX8X6.
PhylomeDBi O95813.
TreeFami TF106445.

Enzyme and pathway databases

Reactomei REACT_111059. Regulation of signaling by NODAL.
REACT_12034. Signaling by BMP.

Miscellaneous databases

GeneWikii Cerberus_(protein).
GenomeRNAii 9350.
NextBioi 35013.
PROi O95813.
SOURCEi Search...

Gene expression databases

Bgeei O95813.
CleanExi HS_CER1.
Genevestigatori O95813.

Family and domain databases

InterProi IPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view ]
Pfami PF03045. DAN. 1 hit.
[Graphical view ]
PIRSFi PIRSF027807. Cerberus. 1 hit.
SMARTi SM00041. CT. 1 hit.
[Graphical view ]
PROSITEi PS01225. CTCK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human cerberus related gene CER1 maps to chromosome 9."
    Lah M., Brodnicki T., Maccarone P., Nash A., Stanley E., Harvey R.P.
    Genomics 55:364-366(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. Feng Z., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-19; GLY-65 AND ILE-179.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-32.

Entry informationi

Entry nameiCER1_HUMAN
AccessioniPrimary (citable) accession number: O95813
Secondary accession number(s): Q6ISJ1
, Q6ISJ6, Q6ISQ2, Q6ISS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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