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O95813

- CER1_HUMAN

UniProt

O95813 - CER1_HUMAN

Protein

Cerberus

Gene

CER1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak By similarity.By similarity

    GO - Molecular functioni

    1. BMP binding Source: BHF-UCL
    2. morphogen activity Source: BHF-UCL
    3. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior axis specification Source: BHF-UCL
    2. anterior/posterior pattern specification Source: BHF-UCL
    3. BMP signaling pathway Source: Reactome
    4. bone mineralization Source: BHF-UCL
    5. cell migration involved in gastrulation Source: BHF-UCL
    6. cellular response to BMP stimulus Source: BHF-UCL
    7. determination of dorsal identity Source: BHF-UCL
    8. gastrulation Source: BHF-UCL
    9. growth plate cartilage chondrocyte proliferation Source: BHF-UCL
    10. negative regulation of activin receptor signaling pathway Source: BHF-UCL
    11. negative regulation of BMP signaling pathway Source: BHF-UCL
    12. negative regulation of cell proliferation Source: BHF-UCL
    13. negative regulation of mesoderm development Source: BHF-UCL
    14. nervous system development Source: BHF-UCL
    15. sequestering of BMP in extracellular matrix Source: BHF-UCL
    16. signal transduction involved in regulation of gene expression Source: BHF-UCL
    17. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_111059. Regulation of signaling by NODAL.
    REACT_12034. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cerberus
    Alternative name(s):
    Cerberus-related protein
    DAN domain family member 4
    Gene namesi
    Name:CER1
    Synonyms:DAND4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:1862. CER1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: BHF-UCL
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 267250CerberusPRO_0000006711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
    Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
    Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95813.
    PRIDEiO95813.

    PTM databases

    PhosphoSiteiO95813.

    Expressioni

    Gene expression databases

    BgeeiO95813.
    CleanExiHS_CER1.
    GenevestigatoriO95813.

    Organism-specific databases

    HPAiHPA019917.

    Interactioni

    Subunit structurei

    Forms monomers and predominantly dimers.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000370297.

    Structurei

    3D structure databases

    ProteinModelPortaliO95813.
    SMRiO95813. Positions 155-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 24685CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DAN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40714.
    HOGENOMiHOG000231309.
    HOVERGENiHBG050902.
    InParanoidiO95813.
    KOiK01645.
    OMAiCFGKCGS.
    OrthoDBiEOG7VX8X6.
    PhylomeDBiO95813.
    TreeFamiTF106445.

    Family and domain databases

    InterProiIPR016860. Cerberus.
    IPR006207. Cys_knot_C.
    IPR004133. DAN.
    [Graphical view]
    PfamiPF03045. DAN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027807. Cerberus. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    [Graphical view]
    PROSITEiPS01225. CTCK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95813-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA    50
    EEKPDLFVAV PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS 100
    DSEPFPPGTQ SLIQPIDGMK MEKSPLREEA KKFWHHFMFR KTPASQGVIL 150
    PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV VQNNLCFGKC GSVHFPGAAQ 200
    HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ CKVKTEHEDG 250
    HILHAGSQDS FIPGVSA 267
    Length:267
    Mass (Da):30,084
    Last modified:May 1, 1999 - v1
    Checksum:iC9FB048CD8558ED7
    GO

    Sequence cautioni

    The sequence AAH69503.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571F → L in AAH69503. (PubMed:15489334)Curated
    Sequence conflicti221 – 2211L → V in AAH69405. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191R → W.1 Publication
    Corresponds to variant rs10115703 [ dbSNP | Ensembl ].
    VAR_021591
    Natural varianti65 – 651A → G.1 Publication
    Corresponds to variant rs3747532 [ dbSNP | Ensembl ].
    VAR_021592
    Natural varianti179 – 1791V → I.1 Publication
    Corresponds to variant rs7036635 [ dbSNP | Ensembl ].
    VAR_021593

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090189 Genomic DNA. Translation: AAD19879.1.
    AF400435 mRNA. Translation: AAK92484.1.
    AL390732 Genomic DNA. Translation: CAH73850.1.
    BC069371 mRNA. Translation: AAH69371.1.
    BC069405 mRNA. Translation: AAH69405.1.
    BC069491 mRNA. Translation: AAH69491.1.
    BC069503 mRNA. Translation: AAH69503.1. Sequence problems.
    CCDSiCCDS6476.1.
    RefSeqiNP_005445.1. NM_005454.2.
    UniGeneiHs.248204.

    Genome annotation databases

    EnsembliENST00000380911; ENSP00000370297; ENSG00000147869.
    GeneIDi9350.
    KEGGihsa:9350.
    UCSCiuc003zlj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090189 Genomic DNA. Translation: AAD19879.1 .
    AF400435 mRNA. Translation: AAK92484.1 .
    AL390732 Genomic DNA. Translation: CAH73850.1 .
    BC069371 mRNA. Translation: AAH69371.1 .
    BC069405 mRNA. Translation: AAH69405.1 .
    BC069491 mRNA. Translation: AAH69491.1 .
    BC069503 mRNA. Translation: AAH69503.1 . Sequence problems.
    CCDSi CCDS6476.1.
    RefSeqi NP_005445.1. NM_005454.2.
    UniGenei Hs.248204.

    3D structure databases

    ProteinModelPortali O95813.
    SMRi O95813. Positions 155-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000370297.

    PTM databases

    PhosphoSitei O95813.

    Proteomic databases

    PaxDbi O95813.
    PRIDEi O95813.

    Protocols and materials databases

    DNASUi 9350.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380911 ; ENSP00000370297 ; ENSG00000147869 .
    GeneIDi 9350.
    KEGGi hsa:9350.
    UCSCi uc003zlj.3. human.

    Organism-specific databases

    CTDi 9350.
    GeneCardsi GC09M014710.
    H-InvDB HIX0034784.
    HGNCi HGNC:1862. CER1.
    HPAi HPA019917.
    MIMi 603777. gene.
    neXtProti NX_O95813.
    PharmGKBi PA26417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40714.
    HOGENOMi HOG000231309.
    HOVERGENi HBG050902.
    InParanoidi O95813.
    KOi K01645.
    OMAi CFGKCGS.
    OrthoDBi EOG7VX8X6.
    PhylomeDBi O95813.
    TreeFami TF106445.

    Enzyme and pathway databases

    Reactomei REACT_111059. Regulation of signaling by NODAL.
    REACT_12034. Signaling by BMP.

    Miscellaneous databases

    GeneWikii Cerberus_(protein).
    GenomeRNAii 9350.
    NextBioi 35013.
    PROi O95813.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95813.
    CleanExi HS_CER1.
    Genevestigatori O95813.

    Family and domain databases

    InterProi IPR016860. Cerberus.
    IPR006207. Cys_knot_C.
    IPR004133. DAN.
    [Graphical view ]
    Pfami PF03045. DAN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027807. Cerberus. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    [Graphical view ]
    PROSITEi PS01225. CTCK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cerberus related gene CER1 maps to chromosome 9."
      Lah M., Brodnicki T., Maccarone P., Nash A., Stanley E., Harvey R.P.
      Genomics 55:364-366(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    2. Feng Z., Zhang B., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-19; GLY-65 AND ILE-179.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-32.

    Entry informationi

    Entry nameiCER1_HUMAN
    AccessioniPrimary (citable) accession number: O95813
    Secondary accession number(s): Q6ISJ1
    , Q6ISJ6, Q6ISQ2, Q6ISS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3