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Protein

Cerberus

Gene

CER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).By similarity

GO - Molecular functioni

  1. BMP binding Source: BHF-UCL
  2. morphogen activity Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior axis specification Source: BHF-UCL
  2. anterior/posterior pattern specification Source: BHF-UCL
  3. BMP signaling pathway Source: Reactome
  4. bone mineralization Source: BHF-UCL
  5. cell migration involved in gastrulation Source: BHF-UCL
  6. cellular response to BMP stimulus Source: BHF-UCL
  7. determination of dorsal identity Source: BHF-UCL
  8. gastrulation Source: BHF-UCL
  9. growth plate cartilage chondrocyte proliferation Source: BHF-UCL
  10. negative regulation of activin receptor signaling pathway Source: BHF-UCL
  11. negative regulation of BMP signaling pathway Source: BHF-UCL
  12. negative regulation of cell proliferation Source: BHF-UCL
  13. negative regulation of mesoderm development Source: BHF-UCL
  14. nervous system development Source: BHF-UCL
  15. sequestering of BMP in extracellular matrix Source: BHF-UCL
  16. signal transduction involved in regulation of gene expression Source: BHF-UCL
  17. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.
REACT_12034. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-related protein
DAN domain family member 4
Gene namesi
Name:CER1
Synonyms:DAND4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1862. CER1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 267250CerberusPRO_0000006711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95813.
PRIDEiO95813.

PTM databases

PhosphoSiteiO95813.

Expressioni

Gene expression databases

BgeeiO95813.
CleanExiHS_CER1.
GenevestigatoriO95813.

Organism-specific databases

HPAiHPA019917.

Interactioni

Subunit structurei

Forms monomers and predominantly dimers.By similarity

Protein-protein interaction databases

BioGridi114753. 10 interactions.
STRINGi9606.ENSP00000370297.

Structurei

3D structure databases

ProteinModelPortaliO95813.
SMRiO95813. Positions 144-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24685CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40714.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000231309.
HOVERGENiHBG050902.
InParanoidiO95813.
KOiK01645.
OMAiCFGKCGS.
OrthoDBiEOG7VX8X6.
PhylomeDBiO95813.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA
60 70 80 90 100
EEKPDLFVAV PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS
110 120 130 140 150
DSEPFPPGTQ SLIQPIDGMK MEKSPLREEA KKFWHHFMFR KTPASQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV VQNNLCFGKC GSVHFPGAAQ
210 220 230 240 250
HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ CKVKTEHEDG
260
HILHAGSQDS FIPGVSA
Length:267
Mass (Da):30,084
Last modified:May 1, 1999 - v1
Checksum:iC9FB048CD8558ED7
GO

Sequence cautioni

The sequence AAH69503.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571F → L in AAH69503 (PubMed:15489334).Curated
Sequence conflicti221 – 2211L → V in AAH69405 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191R → W.1 Publication
Corresponds to variant rs10115703 [ dbSNP | Ensembl ].
VAR_021591
Natural varianti65 – 651A → G.1 Publication
Corresponds to variant rs3747532 [ dbSNP | Ensembl ].
VAR_021592
Natural varianti179 – 1791V → I.1 Publication
Corresponds to variant rs7036635 [ dbSNP | Ensembl ].
VAR_021593

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090189 Genomic DNA. Translation: AAD19879.1.
AF400435 mRNA. Translation: AAK92484.1.
AL390732 Genomic DNA. Translation: CAH73850.1.
BC069371 mRNA. Translation: AAH69371.1.
BC069405 mRNA. Translation: AAH69405.1.
BC069491 mRNA. Translation: AAH69491.1.
BC069503 mRNA. Translation: AAH69503.1. Sequence problems.
CCDSiCCDS6476.1.
RefSeqiNP_005445.1. NM_005454.2.
UniGeneiHs.248204.

Genome annotation databases

EnsembliENST00000380911; ENSP00000370297; ENSG00000147869.
GeneIDi9350.
KEGGihsa:9350.
UCSCiuc003zlj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090189 Genomic DNA. Translation: AAD19879.1.
AF400435 mRNA. Translation: AAK92484.1.
AL390732 Genomic DNA. Translation: CAH73850.1.
BC069371 mRNA. Translation: AAH69371.1.
BC069405 mRNA. Translation: AAH69405.1.
BC069491 mRNA. Translation: AAH69491.1.
BC069503 mRNA. Translation: AAH69503.1. Sequence problems.
CCDSiCCDS6476.1.
RefSeqiNP_005445.1. NM_005454.2.
UniGeneiHs.248204.

3D structure databases

ProteinModelPortaliO95813.
SMRiO95813. Positions 144-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114753. 10 interactions.
STRINGi9606.ENSP00000370297.

PTM databases

PhosphoSiteiO95813.

Proteomic databases

PaxDbiO95813.
PRIDEiO95813.

Protocols and materials databases

DNASUi9350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380911; ENSP00000370297; ENSG00000147869.
GeneIDi9350.
KEGGihsa:9350.
UCSCiuc003zlj.3. human.

Organism-specific databases

CTDi9350.
GeneCardsiGC09M014710.
H-InvDBHIX0034784.
HGNCiHGNC:1862. CER1.
HPAiHPA019917.
MIMi603777. gene.
neXtProtiNX_O95813.
PharmGKBiPA26417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40714.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000231309.
HOVERGENiHBG050902.
InParanoidiO95813.
KOiK01645.
OMAiCFGKCGS.
OrthoDBiEOG7VX8X6.
PhylomeDBiO95813.
TreeFamiTF106445.

Enzyme and pathway databases

ReactomeiREACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.
REACT_12034. Signaling by BMP.

Miscellaneous databases

GeneWikiiCerberus_(protein).
GenomeRNAii9350.
NextBioi35013.
PROiO95813.
SOURCEiSearch...

Gene expression databases

BgeeiO95813.
CleanExiHS_CER1.
GenevestigatoriO95813.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cerberus related gene CER1 maps to chromosome 9."
    Lah M., Brodnicki T., Maccarone P., Nash A., Stanley E., Harvey R.P.
    Genomics 55:364-366(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. Feng Z., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-19; GLY-65 AND ILE-179.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-32.

Entry informationi

Entry nameiCER1_HUMAN
AccessioniPrimary (citable) accession number: O95813
Secondary accession number(s): Q6ISJ1
, Q6ISJ6, Q6ISQ2, Q6ISS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.