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Protein

Cerberus

Gene

CER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).By similarity

GO - Molecular functioni

  • BMP binding Source: BHF-UCL
  • cytokine activity Source: UniProtKB-KW
  • morphogen activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • anterior/posterior axis specification Source: BHF-UCL
  • anterior/posterior pattern specification Source: BHF-UCL
  • BMP signaling pathway Source: Reactome
  • bone mineralization Source: BHF-UCL
  • cell migration involved in gastrulation Source: BHF-UCL
  • cellular response to BMP stimulus Source: BHF-UCL
  • determination of dorsal identity Source: BHF-UCL
  • determination of heart left/right asymmetry Source: GO_Central
  • gastrulation Source: BHF-UCL
  • growth plate cartilage chondrocyte proliferation Source: BHF-UCL
  • negative regulation of activin receptor signaling pathway Source: BHF-UCL
  • negative regulation of BMP signaling pathway Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of mesoderm development Source: BHF-UCL
  • negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
  • nervous system development Source: BHF-UCL
  • sequestering of BMP in extracellular matrix Source: BHF-UCL
  • signal transduction involved in regulation of gene expression Source: BHF-UCL
  • ureteric bud development Source: UniProtKB

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-1181150. Signaling by NODAL.
R-HSA-1433617. Regulation of signaling by NODAL.
R-HSA-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-related protein
DAN domain family member 4
Gene namesi
Name:CER1
Synonyms:DAND4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147869.4.
HGNCiHGNC:1862. CER1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9350.
OpenTargetsiENSG00000147869.
PharmGKBiPA26417.

Polymorphism and mutation databases

BioMutaiCER1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000000671118 – 267CerberusAdd BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 209
Disulfide bondi176 ↔ 223
Disulfide bondi186 ↔ 239
Disulfide bondi190 ↔ 241
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO95813.
PaxDbiO95813.
PeptideAtlasiO95813.
PRIDEiO95813.

PTM databases

iPTMnetiO95813.
PhosphoSitePlusiO95813.

Expressioni

Gene expression databases

BgeeiENSG00000147869.
CleanExiHS_CER1.
GenevisibleiO95813. HS.

Organism-specific databases

HPAiHPA019917.

Interactioni

Subunit structurei

Forms monomers and predominantly dimers.By similarity

GO - Molecular functioni

  • BMP binding Source: BHF-UCL
  • cytokine activity Source: UniProtKB-KW
  • morphogen activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi114753. 14 interactors.
STRINGi9606.ENSP00000370297.

Structurei

3D structure databases

ProteinModelPortaliO95813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 246CTCKAdd BLAST85

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR5. Eukaryota.
ENOG410YX4Y. LUCA.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000231309.
HOVERGENiHBG050902.
InParanoidiO95813.
KOiK01645.
OMAiCFGKCGS.
OrthoDBiEOG091G0IOA.
PhylomeDBiO95813.
TreeFamiTF106445.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
PANTHERiPTHR15273. PTHR15273. 1 hit.
PfamiView protein in Pfam
PF03045. DAN. 1 hit.
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiView protein in SMART
SM00041. CT. 1 hit.
PROSITEiView protein in PROSITE
PS01225. CTCK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA
60 70 80 90 100
EEKPDLFVAV PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS
110 120 130 140 150
DSEPFPPGTQ SLIQPIDGMK MEKSPLREEA KKFWHHFMFR KTPASQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV VQNNLCFGKC GSVHFPGAAQ
210 220 230 240 250
HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ CKVKTEHEDG
260
HILHAGSQDS FIPGVSA
Length:267
Mass (Da):30,084
Last modified:May 1, 1999 - v1
Checksum:iC9FB048CD8558ED7
GO

Sequence cautioni

The sequence AAH69503 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57F → L in AAH69503 (PubMed:15489334).Curated1
Sequence conflicti221L → V in AAH69405 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02159119R → W1 PublicationCorresponds to variant dbSNP:rs10115703Ensembl.1
Natural variantiVAR_02159265A → G1 PublicationCorresponds to variant dbSNP:rs3747532Ensembl.1
Natural variantiVAR_021593179V → I1 PublicationCorresponds to variant dbSNP:rs7036635Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090189 Genomic DNA. Translation: AAD19879.1.
AF400435 mRNA. Translation: AAK92484.1.
AL390732 Genomic DNA. No translation available.
BC069371 mRNA. Translation: AAH69371.1.
BC069405 mRNA. Translation: AAH69405.1.
BC069491 mRNA. Translation: AAH69491.1.
BC069503 mRNA. Translation: AAH69503.1. Sequence problems.
CCDSiCCDS6476.1.
RefSeqiNP_005445.1. NM_005454.2.
UniGeneiHs.248204.

Genome annotation databases

EnsembliENST00000380911; ENSP00000370297; ENSG00000147869.
GeneIDi9350.
KEGGihsa:9350.
UCSCiuc003zlj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCER1_HUMAN
AccessioniPrimary (citable) accession number: O95813
Secondary accession number(s): Q6ISJ1
, Q6ISJ6, Q6ISQ2, Q6ISS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families