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Protein

Transmembrane protein 50A

Gene

TMEM50A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi9.B.199.1.1. the 4tms pf05225 (pf0225) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 50A
Alternative name(s):
Small membrane protein 1
Gene namesi
Name:TMEM50A
Synonyms:SMP1
ORF Names:UNQ386/PRO718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30590. TMEM50A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183726.
PharmGKBiPA142670766.

Polymorphism and mutation databases

BioMutaiTMEM50A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001741812 – 157Transmembrane protein 50AAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95807.
PaxDbiO95807.
PeptideAtlasiO95807.
PRIDEiO95807.

PTM databases

iPTMnetiO95807.
PhosphoSitePlusiO95807.
SwissPalmiO95807.

Expressioni

Gene expression databases

BgeeiENSG00000183726.
CleanExiHS_TMEM50A.
ExpressionAtlasiO95807. baseline and differential.
GenevisibleiO95807. HS.

Organism-specific databases

HPAiHPA065192.

Interactioni

Protein-protein interaction databases

BioGridi117120. 2 interactors.
MINTiMINT-1384132.
STRINGi9606.ENSP00000363478.

Structurei

3D structure databases

ProteinModelPortaliO95807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0220 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3393. Eukaryota.
ENOG410YCSG. LUCA.
GeneTreeiENSGT00390000007434.
HOVERGENiHBG000997.
InParanoidiO95807.
OMAiEHISEEN.
OrthoDBiEOG091G0QWW.
PhylomeDBiO95807.
TreeFamiTF300282.

Family and domain databases

InterProiIPR007919. UPF0220.
[Graphical view]
PANTHERiPTHR13180. PTHR13180. 1 hit.
PfamiPF05255. UPF0220. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFLEGLRC SECIDWGEKR NTIASIAAGV LFFTGWWIII DAAVIYPTMK
60 70 80 90 100
DFNHSYHACG VIATIAFLMI NAVSNGQVRG DSYSEGCLGQ TGARIWLFVG
110 120 130 140 150
FMLAFGSLIA SMWILFGGYV AKEKDIVYPG IAVFFQNAFI FFGGLVFKFG

RTEDLWQ
Length:157
Mass (Da):17,400
Last modified:May 1, 1999 - v1
Checksum:i8CDF83AA23EBB1FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01312158A → V.1 PublicationCorresponds to variant rs3093647dbSNPEnsembl.1
Natural variantiVAR_007851141F → L.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081282 mRNA. Translation: AAD17754.1.
AL136627 mRNA. Translation: CAB66562.1.
AY358650 mRNA. Translation: AAQ89013.1.
AF458851 Genomic DNA. Translation: AAL51108.1.
BC007341 mRNA. Translation: AAH07341.1.
CCDSiCCDS264.1.
RefSeqiNP_055128.1. NM_014313.3.
XP_011539461.1. XM_011541159.1.
UniGeneiHs.705699.

Genome annotation databases

EnsembliENST00000374358; ENSP00000363478; ENSG00000183726.
GeneIDi23585.
KEGGihsa:23585.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081282 mRNA. Translation: AAD17754.1.
AL136627 mRNA. Translation: CAB66562.1.
AY358650 mRNA. Translation: AAQ89013.1.
AF458851 Genomic DNA. Translation: AAL51108.1.
BC007341 mRNA. Translation: AAH07341.1.
CCDSiCCDS264.1.
RefSeqiNP_055128.1. NM_014313.3.
XP_011539461.1. XM_011541159.1.
UniGeneiHs.705699.

3D structure databases

ProteinModelPortaliO95807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117120. 2 interactors.
MINTiMINT-1384132.
STRINGi9606.ENSP00000363478.

Protein family/group databases

TCDBi9.B.199.1.1. the 4tms pf05225 (pf0225) family.

PTM databases

iPTMnetiO95807.
PhosphoSitePlusiO95807.
SwissPalmiO95807.

Polymorphism and mutation databases

BioMutaiTMEM50A.

Proteomic databases

EPDiO95807.
PaxDbiO95807.
PeptideAtlasiO95807.
PRIDEiO95807.

Protocols and materials databases

DNASUi23585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374358; ENSP00000363478; ENSG00000183726.
GeneIDi23585.
KEGGihsa:23585.

Organism-specific databases

CTDi23585.
GeneCardsiTMEM50A.
HGNCiHGNC:30590. TMEM50A.
HPAiHPA065192.
MIMi605348. gene.
neXtProtiNX_O95807.
OpenTargetsiENSG00000183726.
PharmGKBiPA142670766.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3393. Eukaryota.
ENOG410YCSG. LUCA.
GeneTreeiENSGT00390000007434.
HOVERGENiHBG000997.
InParanoidiO95807.
OMAiEHISEEN.
OrthoDBiEOG091G0QWW.
PhylomeDBiO95807.
TreeFamiTF300282.

Miscellaneous databases

ChiTaRSiTMEM50A. human.
GeneWikiiTMEM50A.
GenomeRNAii23585.
PROiO95807.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183726.
CleanExiHS_TMEM50A.
ExpressionAtlasiO95807. baseline and differential.
GenevisibleiO95807. HS.

Family and domain databases

InterProiIPR007919. UPF0220.
[Graphical view]
PANTHERiPTHR13180. PTHR13180. 1 hit.
PfamiPF05255. UPF0220. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM50A_HUMAN
AccessioniPrimary (citable) accession number: O95807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.