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O95803

- NDST3_HUMAN

UniProt

O95803 - NDST3_HUMAN

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Protein

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Gene

NDST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.1 Publication

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei605 – 6051For sulfotransferase activityBy similarity
Binding sitei703 – 7031PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi605 – 6095PAPSBy similarity
Nucleotide bindingi824 – 8285PAPSBy similarity

GO - Molecular functioni

  1. [heparan sulfate]-glucosamine N-sulfotransferase activity Source: UniProtKB-EC
  2. deacetylase activity Source: Ensembl

GO - Biological processi

  1. heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. heparin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS09011-MONOMER.
BRENDAi2.8.2.8. 2681.
ReactomeiREACT_121248. HS-GAG biosynthesis.
UniPathwayiUPA00756.
UPA00862.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (EC:2.8.2.8)
Alternative name(s):
Glucosaminyl N-deacetylase/N-sulfotransferase 3
Short name:
NDST-3
Short name:
hNDST-3
N-heparan sulfate sulfotransferase 3
Short name:
N-HSST 3
Including the following 2 domains:
Heparan sulfate N-deacetylase 3 (EC:3.-.-.-)
Heparan sulfate N-sulfotransferase 3 (EC:2.8.2.-)
Gene namesi
Name:NDST3
Synonyms:HSST3
ORF Names:UNQ2544/PRO4998
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7682. NDST3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3PRO_0000225659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi794 – 7941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi809 ↔ 819By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95803.
PRIDEiO95803.

PTM databases

PhosphoSiteiO95803.

Expressioni

Tissue specificityi

Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiO95803.
CleanExiHS_NDST3.
GenevestigatoriO95803.

Organism-specific databases

HPAiHPA056189.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000296499.

Structurei

3D structure databases

ProteinModelPortaliO95803.
SMRiO95803. Positions 570-870.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini35 – 873839LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 589554Heparan sulfate N-deacetylase 3Add
BLAST
Regioni590 – 873284Heparan sulfate N-sulfotransferase 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267831.
GeneTreeiENSGT00760000119023.
HOGENOMiHOG000008010.
HOVERGENiHBG082011.
InParanoidiO95803.
KOiK02578.
OMAiTVIHDLG.
OrthoDBiEOG7FXZXJ.
PhylomeDBiO95803.
TreeFamiTF313193.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR021930. Heparan_SO4_deacetylase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF12062. HSNSD. 1 hit.
PF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95803-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFIMKLHRH FQRTVILLAT FCMVSIIISA YYLYSGYKQE NELSETASEV
60 70 80 90 100
DCGDLQHLPY QLMEVKAMKL FDASRTDPTV LVFVESQYSS LGQDIIMILE
110 120 130 140 150
SSRFQYHIEI APGKGDLPVL IDKMKGKYIL IIYENILKYI NMDSWNRSLL
160 170 180 190 200
DKYCVEYGVG VIGFHKTSEK SVQSFQLKGF PFSIYGNLAV KDCCINPHSP
210 220 230 240 250
LIRVTKSSKL EKGSLPGTDW TVFQINHSAY QPVIFAKVKT PENLSPSISK
260 270 280 290 300
GAFYATIIHD LGLHDGIQRV LFGNNLNFWL HKLIFIDAIS FLSGKRLTLS
310 320 330 340 350
LDRYILVDID DIFVGKEGTR MNTNDVKALL DTQNLLRAQI TNFTFNLGFS
360 370 380 390 400
GKFYHTGTEE EDEGDDCLLG SVDEFWWFPH MWSHMQPHLF HNESSLVEQM
410 420 430 440 450
ILNKKFALEH GIPTDMGYAV APHHSGVYPV HVQLYEAWKK VWNIKITSTE
460 470 480 490 500
EYPHLKPARY RRGFIHKNIM VLPRQTCGLF THTIFYKEYP GGPKELDKSI
510 520 530 540 550
QGGELFFTVV LNPISIFMTH LSNYGNDRLG LYTFVNLANF VKSWTNLRLQ
560 570 580 590 600
TLPPVQLAHK YFELFPDQKD PLWQNPCDDK RHRDIWSKEK TCDRLPKFLV
610 620 630 640 650
IGPQKTGTTA LYLFLVMHPS ILSNSPSPKT FEEVQFFNRN NYHRGIDWYM
660 670 680 690 700
DFFPVPSNVT TDFLFEKSAN YFHSEEAPKR AASLVPKAKI ITILIDPSDR
710 720 730 740 750
AYSWYQHQRS HEDPAALKFS FYEVISAGPR APSELRALQK RCLVPGWYAS
760 770 780 790 800
HIERWLVYFP PFQLLIIDGQ QLRTDPATVM DEVQKFLGVL PHYNYSEALT
810 820 830 840 850
FDSHKGFWCQ LLEEGKTKCL GKSKGRKYPP MDSDSRTFLS SYYRDHNVEL
860 870
SKLLHKLGQP LPSWLRQELQ KVR
Length:873
Mass (Da):100,902
Last modified:May 1, 1999 - v1
Checksum:i4DDE39257CAC0D36
GO
Isoform 2 (identifier: O95803-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-385: ALLDTQNLLR...WWFPHMWSHM → VRLYFLKFQS...NQLRRLCISI
     386-873: Missing.

Note: No experimental confirmation available.

Show »
Length:385
Mass (Da):43,766
Checksum:i55EAC286AA742C09
GO
Isoform 3 (identifier: O95803-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-408: Missing.
     635-642: QFFNRNNY → YGFLPSPI
     643-873: Missing.

Note: No experimental confirmation available.

Show »
Length:561
Mass (Da):64,297
Checksum:i644886B36ADFA6FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 1710HRHFQRTVIL → STEQLSKEPVISW in AAD46061. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti264 – 2641H → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036131

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei328 – 40881Missing in isoform 3. 1 PublicationVSP_054350Add
BLAST
Alternative sequencei328 – 38558ALLDT…MWSHM → VRLYFLKFQSSVHLPAGIQL SQFVLQLGYPGHGIYWESLG NLGLSLTLNQLRRLCISI in isoform 2. 1 PublicationVSP_017405Add
BLAST
Alternative sequencei386 – 873488Missing in isoform 2. 1 PublicationVSP_017406Add
BLAST
Alternative sequencei635 – 6428QFFNRNNY → YGFLPSPI in isoform 3. 1 PublicationVSP_054351
Alternative sequencei643 – 873231Missing in isoform 3. 1 PublicationVSP_054352Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF074924 mRNA. Translation: AAD15978.1.
AF076605 mRNA. Translation: AAD46061.1.
AY358852 mRNA. Translation: AAQ89211.1.
AK295439 mRNA. Translation: BAG58379.1.
AC096762 Genomic DNA. No translation available.
AC108201 Genomic DNA. Translation: AAY41001.1.
AC110999 Genomic DNA. Translation: AAY41056.1.
AC116639 Genomic DNA. No translation available.
BC109309 mRNA. Translation: AAI09310.1.
BC109310 mRNA. Translation: AAI09311.1.
CCDSiCCDS3708.1. [O95803-1]
RefSeqiNP_004775.1. NM_004784.2. [O95803-1]
XP_006714479.1. XM_006714416.1. [O95803-1]
UniGeneiHs.480596.

Genome annotation databases

EnsembliENST00000296499; ENSP00000296499; ENSG00000164100. [O95803-1]
GeneIDi9348.
KEGGihsa:9348.
UCSCiuc003ibw.3. human. [O95803-2]
uc003ibx.3. human. [O95803-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF074924 mRNA. Translation: AAD15978.1 .
AF076605 mRNA. Translation: AAD46061.1 .
AY358852 mRNA. Translation: AAQ89211.1 .
AK295439 mRNA. Translation: BAG58379.1 .
AC096762 Genomic DNA. No translation available.
AC108201 Genomic DNA. Translation: AAY41001.1 .
AC110999 Genomic DNA. Translation: AAY41056.1 .
AC116639 Genomic DNA. No translation available.
BC109309 mRNA. Translation: AAI09310.1 .
BC109310 mRNA. Translation: AAI09311.1 .
CCDSi CCDS3708.1. [O95803-1 ]
RefSeqi NP_004775.1. NM_004784.2. [O95803-1 ]
XP_006714479.1. XM_006714416.1. [O95803-1 ]
UniGenei Hs.480596.

3D structure databases

ProteinModelPortali O95803.
SMRi O95803. Positions 570-870.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000296499.

PTM databases

PhosphoSitei O95803.

Proteomic databases

PaxDbi O95803.
PRIDEi O95803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296499 ; ENSP00000296499 ; ENSG00000164100 . [O95803-1 ]
GeneIDi 9348.
KEGGi hsa:9348.
UCSCi uc003ibw.3. human. [O95803-2 ]
uc003ibx.3. human. [O95803-1 ]

Organism-specific databases

CTDi 9348.
GeneCardsi GC04P118954.
HGNCi HGNC:7682. NDST3.
HPAi HPA056189.
MIMi 603950. gene.
neXtProti NX_O95803.
PharmGKBi PA31488.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267831.
GeneTreei ENSGT00760000119023.
HOGENOMi HOG000008010.
HOVERGENi HBG082011.
InParanoidi O95803.
KOi K02578.
OMAi TVIHDLG.
OrthoDBi EOG7FXZXJ.
PhylomeDBi O95803.
TreeFami TF313193.

Enzyme and pathway databases

UniPathwayi UPA00756 .
UPA00862 .
BioCyci MetaCyc:HS09011-MONOMER.
BRENDAi 2.8.2.8. 2681.
Reactomei REACT_121248. HS-GAG biosynthesis.

Miscellaneous databases

GeneWikii NDST3.
GenomeRNAii 9348.
NextBioi 35005.
PROi O95803.
SOURCEi Search...

Gene expression databases

Bgeei O95803.
CleanExi HS_NDST3.
Genevestigatori O95803.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR021930. Heparan_SO4_deacetylase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF12062. HSNSD. 1 hit.
PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family."
    Aikawa J., Esko J.D.
    J. Biol. Chem. 274:2690-2695(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Sakakibara Y., Sanematsu F., Takami Y., Yanagisawa K., Nakayama T., Suiko M., Liu M.-C.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Corpus callosum.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-264.

Entry informationi

Entry nameiNDST3_HUMAN
AccessioniPrimary (citable) accession number: O95803
Secondary accession number(s): B4DI67
, Q4W5C1, Q4W5D0, Q6UWC5, Q9UP21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3