Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95803

- NDST3_HUMAN

UniProt

O95803 - NDST3_HUMAN

Protein

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Gene

NDST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.1 Publication

    Catalytic activityi

    3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei605 – 6051For sulfotransferase activityBy similarity
    Binding sitei703 – 7031PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi605 – 6095PAPSBy similarity
    Nucleotide bindingi824 – 8285PAPSBy similarity

    GO - Molecular functioni

    1. [heparan sulfate]-glucosamine N-sulfotransferase activity Source: UniProtKB-EC
    2. deacetylase activity Source: Ensembl

    GO - Biological processi

    1. heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. heparin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS09011-MONOMER.
    BRENDAi2.8.2.8. 2681.
    ReactomeiREACT_121248. HS-GAG biosynthesis.
    UniPathwayiUPA00756.
    UPA00862.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (EC:2.8.2.8)
    Alternative name(s):
    Glucosaminyl N-deacetylase/N-sulfotransferase 3
    Short name:
    NDST-3
    Short name:
    hNDST-3
    N-heparan sulfate sulfotransferase 3
    Short name:
    N-HSST 3
    Including the following 2 domains:
    Heparan sulfate N-deacetylase 3 (EC:3.-.-.-)
    Heparan sulfate N-sulfotransferase 3 (EC:2.8.2.-)
    Gene namesi
    Name:NDST3
    Synonyms:HSST3
    ORF Names:UNQ2544/PRO4998
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7682. NDST3.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31488.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3PRO_0000225659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi794 – 7941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi809 ↔ 819By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95803.
    PRIDEiO95803.

    PTM databases

    PhosphoSiteiO95803.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiO95803.
    BgeeiO95803.
    CleanExiHS_NDST3.
    GenevestigatoriO95803.

    Organism-specific databases

    HPAiHPA056189.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296499.

    Structurei

    3D structure databases

    ProteinModelPortaliO95803.
    SMRiO95803. Positions 570-870.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 873839LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni36 – 589554Heparan sulfate N-deacetylase 3Add
    BLAST
    Regioni590 – 873284Heparan sulfate N-sulfotransferase 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267831.
    HOGENOMiHOG000008010.
    HOVERGENiHBG082011.
    InParanoidiO95803.
    KOiK02578.
    OMAiTVIHDLG.
    OrthoDBiEOG7FXZXJ.
    PhylomeDBiO95803.
    TreeFamiTF313193.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR021930. Heparan_SO4_deacetylase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF12062. HSNSD. 1 hit.
    PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95803-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFIMKLHRH FQRTVILLAT FCMVSIIISA YYLYSGYKQE NELSETASEV    50
    DCGDLQHLPY QLMEVKAMKL FDASRTDPTV LVFVESQYSS LGQDIIMILE 100
    SSRFQYHIEI APGKGDLPVL IDKMKGKYIL IIYENILKYI NMDSWNRSLL 150
    DKYCVEYGVG VIGFHKTSEK SVQSFQLKGF PFSIYGNLAV KDCCINPHSP 200
    LIRVTKSSKL EKGSLPGTDW TVFQINHSAY QPVIFAKVKT PENLSPSISK 250
    GAFYATIIHD LGLHDGIQRV LFGNNLNFWL HKLIFIDAIS FLSGKRLTLS 300
    LDRYILVDID DIFVGKEGTR MNTNDVKALL DTQNLLRAQI TNFTFNLGFS 350
    GKFYHTGTEE EDEGDDCLLG SVDEFWWFPH MWSHMQPHLF HNESSLVEQM 400
    ILNKKFALEH GIPTDMGYAV APHHSGVYPV HVQLYEAWKK VWNIKITSTE 450
    EYPHLKPARY RRGFIHKNIM VLPRQTCGLF THTIFYKEYP GGPKELDKSI 500
    QGGELFFTVV LNPISIFMTH LSNYGNDRLG LYTFVNLANF VKSWTNLRLQ 550
    TLPPVQLAHK YFELFPDQKD PLWQNPCDDK RHRDIWSKEK TCDRLPKFLV 600
    IGPQKTGTTA LYLFLVMHPS ILSNSPSPKT FEEVQFFNRN NYHRGIDWYM 650
    DFFPVPSNVT TDFLFEKSAN YFHSEEAPKR AASLVPKAKI ITILIDPSDR 700
    AYSWYQHQRS HEDPAALKFS FYEVISAGPR APSELRALQK RCLVPGWYAS 750
    HIERWLVYFP PFQLLIIDGQ QLRTDPATVM DEVQKFLGVL PHYNYSEALT 800
    FDSHKGFWCQ LLEEGKTKCL GKSKGRKYPP MDSDSRTFLS SYYRDHNVEL 850
    SKLLHKLGQP LPSWLRQELQ KVR 873
    Length:873
    Mass (Da):100,902
    Last modified:May 1, 1999 - v1
    Checksum:i4DDE39257CAC0D36
    GO
    Isoform 2 (identifier: O95803-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         328-385: ALLDTQNLLR...WWFPHMWSHM → VRLYFLKFQS...NQLRRLCISI
         386-873: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:385
    Mass (Da):43,766
    Checksum:i55EAC286AA742C09
    GO
    Isoform 3 (identifier: O95803-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         328-408: Missing.
         635-642: QFFNRNNY → YGFLPSPI
         643-873: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:561
    Mass (Da):64,297
    Checksum:i644886B36ADFA6FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 1710HRHFQRTVIL → STEQLSKEPVISW in AAD46061. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti264 – 2641H → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036131

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei328 – 40881Missing in isoform 3. 1 PublicationVSP_054350Add
    BLAST
    Alternative sequencei328 – 38558ALLDT…MWSHM → VRLYFLKFQSSVHLPAGIQL SQFVLQLGYPGHGIYWESLG NLGLSLTLNQLRRLCISI in isoform 2. 1 PublicationVSP_017405Add
    BLAST
    Alternative sequencei386 – 873488Missing in isoform 2. 1 PublicationVSP_017406Add
    BLAST
    Alternative sequencei635 – 6428QFFNRNNY → YGFLPSPI in isoform 3. 1 PublicationVSP_054351
    Alternative sequencei643 – 873231Missing in isoform 3. 1 PublicationVSP_054352Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074924 mRNA. Translation: AAD15978.1.
    AF076605 mRNA. Translation: AAD46061.1.
    AY358852 mRNA. Translation: AAQ89211.1.
    AK295439 mRNA. Translation: BAG58379.1.
    AC096762 Genomic DNA. No translation available.
    AC108201 Genomic DNA. Translation: AAY41001.1.
    AC110999 Genomic DNA. Translation: AAY41056.1.
    AC116639 Genomic DNA. No translation available.
    BC109309 mRNA. Translation: AAI09310.1.
    BC109310 mRNA. Translation: AAI09311.1.
    CCDSiCCDS3708.1. [O95803-1]
    RefSeqiNP_004775.1. NM_004784.2. [O95803-1]
    XP_006714479.1. XM_006714416.1. [O95803-1]
    UniGeneiHs.480596.

    Genome annotation databases

    EnsembliENST00000296499; ENSP00000296499; ENSG00000164100. [O95803-1]
    GeneIDi9348.
    KEGGihsa:9348.
    UCSCiuc003ibw.3. human. [O95803-2]
    uc003ibx.3. human. [O95803-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074924 mRNA. Translation: AAD15978.1 .
    AF076605 mRNA. Translation: AAD46061.1 .
    AY358852 mRNA. Translation: AAQ89211.1 .
    AK295439 mRNA. Translation: BAG58379.1 .
    AC096762 Genomic DNA. No translation available.
    AC108201 Genomic DNA. Translation: AAY41001.1 .
    AC110999 Genomic DNA. Translation: AAY41056.1 .
    AC116639 Genomic DNA. No translation available.
    BC109309 mRNA. Translation: AAI09310.1 .
    BC109310 mRNA. Translation: AAI09311.1 .
    CCDSi CCDS3708.1. [O95803-1 ]
    RefSeqi NP_004775.1. NM_004784.2. [O95803-1 ]
    XP_006714479.1. XM_006714416.1. [O95803-1 ]
    UniGenei Hs.480596.

    3D structure databases

    ProteinModelPortali O95803.
    SMRi O95803. Positions 570-870.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296499.

    PTM databases

    PhosphoSitei O95803.

    Proteomic databases

    PaxDbi O95803.
    PRIDEi O95803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296499 ; ENSP00000296499 ; ENSG00000164100 . [O95803-1 ]
    GeneIDi 9348.
    KEGGi hsa:9348.
    UCSCi uc003ibw.3. human. [O95803-2 ]
    uc003ibx.3. human. [O95803-1 ]

    Organism-specific databases

    CTDi 9348.
    GeneCardsi GC04P118954.
    HGNCi HGNC:7682. NDST3.
    HPAi HPA056189.
    MIMi 603950. gene.
    neXtProti NX_O95803.
    PharmGKBi PA31488.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267831.
    HOGENOMi HOG000008010.
    HOVERGENi HBG082011.
    InParanoidi O95803.
    KOi K02578.
    OMAi TVIHDLG.
    OrthoDBi EOG7FXZXJ.
    PhylomeDBi O95803.
    TreeFami TF313193.

    Enzyme and pathway databases

    UniPathwayi UPA00756 .
    UPA00862 .
    BioCyci MetaCyc:HS09011-MONOMER.
    BRENDAi 2.8.2.8. 2681.
    Reactomei REACT_121248. HS-GAG biosynthesis.

    Miscellaneous databases

    GeneWikii NDST3.
    GenomeRNAii 9348.
    NextBioi 35005.
    PROi O95803.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95803.
    Bgeei O95803.
    CleanExi HS_NDST3.
    Genevestigatori O95803.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR021930. Heparan_SO4_deacetylase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF12062. HSNSD. 1 hit.
    PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family."
      Aikawa J., Esko J.D.
      J. Biol. Chem. 274:2690-2695(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. Sakakibara Y., Sanematsu F., Takami Y., Yanagisawa K., Nakayama T., Suiko M., Liu M.-C.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Corpus callosum.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-264.

    Entry informationi

    Entry nameiNDST3_HUMAN
    AccessioniPrimary (citable) accession number: O95803
    Secondary accession number(s): B4DI67
    , Q4W5C1, Q4W5D0, Q6UWC5, Q9UP21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3