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Protein

Tetratricopeptide repeat protein 4

Gene

TTC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 4
Short name:
TPR repeat protein 4
Gene namesi
Name:TTC4
ORF Names:My044
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12394. TTC4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37059.

Polymorphism and mutation databases

BioMutaiTTC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Tetratricopeptide repeat protein 4PRO_0000106379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei243 – 2431PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95801.
MaxQBiO95801.
PaxDbiO95801.
PeptideAtlasiO95801.
PRIDEiO95801.

PTM databases

iPTMnetiO95801.
PhosphoSiteiO95801.

Expressioni

Gene expression databases

BgeeiENSG00000243725.
CleanExiHS_TTC4.
GenevisibleiO95801. HS.

Organism-specific databases

HPAiHPA041608.
HPA042459.

Interactioni

Protein-protein interaction databases

BioGridi113119. 49 interactions.
IntActiO95801. 19 interactions.
STRINGi9606.ENSP00000360329.

Structurei

3D structure databases

ProteinModelPortaliO95801.
SMRiO95801. Positions 77-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 11234TPR 1Add
BLAST
Repeati117 – 15034TPR 2Add
BLAST
Repeati151 – 18434TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC4 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0551. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00510000049371.
HOGENOMiHOG000230541.
HOVERGENiHBG030742.
InParanoidiO95801.
OMAiDRWQEEM.
OrthoDBiEOG091G0B2R.
PhylomeDBiO95801.
TreeFamiTF314657.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPGQDPTS DDVMDSFLEK FQSQPYRGGF HEDQWEKEFE KVPLFMSRAP
60 70 80 90 100
SEIDPRENPD LACLQSIIFD EERSPEEQAK TYKDEGNDYF KEKDYKKAVI
110 120 130 140 150
SYTEGLKKKC ADPDLNAVLY TNRAAAQYYL GNFRSALNDV TAARKLKPCH
160 170 180 190 200
LKAIIRGALC HLELKHFAEA VNWCDEGLQI DAKEKKLLEM RAKADKLKRI
210 220 230 240 250
EQRDVRKANL KEKKERNQNE ALLQAIKARN IRLSEAACED EDSASEGLGE
260 270 280 290 300
LFLDGLSTEN PHGARLSLDG QGRLSWPVLF LYPEYAQSDF ISAFHEDSRF
310 320 330 340 350
IDHLMVMFGE TPSWDLEQKY CPDNLEVYFE DEDRAELYRV PAKSTLLQVL
360 370 380
QHQRYFVKAL TPAFLVCVGS SPFCKNFLRG RKVYQIR
Length:387
Mass (Da):44,679
Last modified:April 17, 2007 - v3
Checksum:i4FA45889C4C9E427
GO

Sequence cautioni

The sequence AAD19853 differs from that shown. Reason: Frameshift at position 322. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651K → I in AAD19853 (PubMed:9933562).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471S → T.4 Publications
Corresponds to variant rs1147990 [ dbSNP | Ensembl ].
VAR_031713

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073887 mRNA. Translation: AAD19853.1. Frameshift.
AF063602 mRNA. Translation: AAG43161.1.
AK292426 mRNA. Translation: BAF85115.1.
BT006817 mRNA. Translation: AAP35463.1.
AK222562 mRNA. Translation: BAD96282.1.
AL139244 Genomic DNA. Translation: CAI18994.1.
CH471059 Genomic DNA. Translation: EAX06671.1.
BC001276 mRNA. Translation: AAH01276.1.
CCDSiCCDS596.1.
RefSeqiNP_004614.3. NM_004623.4.
UniGeneiHs.412482.
Hs.729029.

Genome annotation databases

EnsembliENST00000371281; ENSP00000360329; ENSG00000243725.
GeneIDi7268.
KEGGihsa:7268.
UCSCiuc001cxx.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073887 mRNA. Translation: AAD19853.1. Frameshift.
AF063602 mRNA. Translation: AAG43161.1.
AK292426 mRNA. Translation: BAF85115.1.
BT006817 mRNA. Translation: AAP35463.1.
AK222562 mRNA. Translation: BAD96282.1.
AL139244 Genomic DNA. Translation: CAI18994.1.
CH471059 Genomic DNA. Translation: EAX06671.1.
BC001276 mRNA. Translation: AAH01276.1.
CCDSiCCDS596.1.
RefSeqiNP_004614.3. NM_004623.4.
UniGeneiHs.412482.
Hs.729029.

3D structure databases

ProteinModelPortaliO95801.
SMRiO95801. Positions 77-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113119. 49 interactions.
IntActiO95801. 19 interactions.
STRINGi9606.ENSP00000360329.

PTM databases

iPTMnetiO95801.
PhosphoSiteiO95801.

Polymorphism and mutation databases

BioMutaiTTC4.

Proteomic databases

EPDiO95801.
MaxQBiO95801.
PaxDbiO95801.
PeptideAtlasiO95801.
PRIDEiO95801.

Protocols and materials databases

DNASUi7268.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371281; ENSP00000360329; ENSG00000243725.
GeneIDi7268.
KEGGihsa:7268.
UCSCiuc001cxx.5. human.

Organism-specific databases

CTDi7268.
GeneCardsiTTC4.
H-InvDBHIX0020481.
HGNCiHGNC:12394. TTC4.
HPAiHPA041608.
HPA042459.
MIMi606753. gene.
neXtProtiNX_O95801.
PharmGKBiPA37059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0551. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00510000049371.
HOGENOMiHOG000230541.
HOVERGENiHBG030742.
InParanoidiO95801.
OMAiDRWQEEM.
OrthoDBiEOG091G0B2R.
PhylomeDBiO95801.
TreeFamiTF314657.

Miscellaneous databases

GeneWikiiTTC4.
GenomeRNAii7268.
PROiO95801.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243725.
CleanExiHS_TTC4.
GenevisibleiO95801. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC4_HUMAN
AccessioniPrimary (citable) accession number: O95801
Secondary accession number(s): Q53Y95, Q5TA96, Q9H3I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.