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Protein

Probable G-protein coupled receptor 75

Gene

GPR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.1 PublicationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 75
Gene namesi
Name:GPR75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4526. GPR75.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence analysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 8619CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 12013ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini142 – 16019CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 20524ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini227 – 31892CytoplasmicSequence analysisAdd
BLAST
Transmembranei319 – 33921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini340 – 35011ExtracellularSequence analysisAdd
BLAST
Transmembranei351 – 37121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini372 – 540169CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28919.

Chemistry

GuidetoPHARMACOLOGYi115.

Polymorphism and mutation databases

BioMutaiGPR75.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Probable G-protein coupled receptor 75PRO_0000069583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95800.
PRIDEiO95800.

Expressioni

Tissue specificityi

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).3 Publications

Gene expression databases

BgeeiO95800.
GenevisibleiO95800. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378195.

Structurei

3D structure databases

ProteinModelPortaliO95800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 12161Phe-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiO95800.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG7992Q7.
PhylomeDBiO95800.
TreeFamiTF331523.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTGHLQDA PNATSLHVPH SQEGNSTSLQ EGLQDLIHTA TLVTCTFLLA
60 70 80 90 100
VIFCLGSYGN FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM
110 120 130 140 150
FTFVLFFSSA SSIPDAFCFT FHLTSSGFII MSLKTVAVIA LHRLRMVLGK
160 170 180 190 200
QPNRTASFPC TVLLTLLLWA TSFTLATLAT LKTSKSHLCL PMSSLIAGKG
210 220 230 240 250
KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVRKCPP VITVDASRPQ
260 270 280 290 300
PFMGVPVQGG GDPIQCAMPA LYRNQNYNKL QHVQTRGYTK SPNQLVTPAA
310 320 330 340 350
SRLQLVSAIN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLSSNG
360 370 380 390 400
SFILYQFELF GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LQYIGLGFFC
410 420 430 440 450
CKQKTRLRAM GKGNLEVNRN KSSHHETNSA YMLSPKPQKK FVDQACGPSH
460 470 480 490 500
SKESMVSPKI SAGHQHCGQS SSTPINTRIE PYYSIYNSSP SQEESSPCNL
510 520 530 540
QPVNSFGFAN SYIAMHYHTT NDLVQEYDST SAKQIPVPSV
Length:540
Mass (Da):59,359
Last modified:May 1, 1999 - v1
Checksum:iB5BE87BB384190EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → P in AAH67475 (PubMed:15489334).Curated
Sequence conflicti278 – 2781N → D in AAH67475 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781N → K Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication
Corresponds to variant rs72799238 [ dbSNP | Ensembl ].
VAR_071258
Natural varianti99 – 991P → L Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication
VAR_071259
Natural varianti108 – 1081S → T Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication
Corresponds to variant rs763005023 [ dbSNP | Ensembl ].
VAR_071260
Natural varianti116 – 1161A → T.1 Publication
Corresponds to variant rs34000641 [ dbSNP | Ensembl ].
VAR_033471
Natural varianti135 – 1351T → P Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication
VAR_071261
Natural varianti160 – 1601C → G.
Corresponds to variant rs35349235 [ dbSNP | Ensembl ].
VAR_033472
Natural varianti433 – 4331L → V.
Corresponds to variant rs3731969 [ dbSNP | Ensembl ].
VAR_033473

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA. Translation: AAD19849.1.
AF101472 Genomic DNA. Translation: AAD22770.1.
AK314885 mRNA. Translation: BAG37399.1.
AC008068 Genomic DNA. Translation: AAY15018.1.
CH471053 Genomic DNA. Translation: EAX00162.1.
BC067475 mRNA. Translation: AAH67475.1.
BC067476 mRNA. Translation: AAH67476.1.
CCDSiCCDS1849.1.
RefSeqiNP_006785.1. NM_006794.3.
UniGeneiHs.40763.

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737.
GeneIDi10936.
KEGGihsa:10936.
UCSCiuc002rxo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA. Translation: AAD19849.1.
AF101472 Genomic DNA. Translation: AAD22770.1.
AK314885 mRNA. Translation: BAG37399.1.
AC008068 Genomic DNA. Translation: AAY15018.1.
CH471053 Genomic DNA. Translation: EAX00162.1.
BC067475 mRNA. Translation: AAH67475.1.
BC067476 mRNA. Translation: AAH67476.1.
CCDSiCCDS1849.1.
RefSeqiNP_006785.1. NM_006794.3.
UniGeneiHs.40763.

3D structure databases

ProteinModelPortaliO95800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378195.

Chemistry

GuidetoPHARMACOLOGYi115.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR75.

Proteomic databases

PaxDbiO95800.
PRIDEiO95800.

Protocols and materials databases

DNASUi10936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737.
GeneIDi10936.
KEGGihsa:10936.
UCSCiuc002rxo.4. human.

Organism-specific databases

CTDi10936.
GeneCardsiGPR75.
HGNCiHGNC:4526. GPR75.
MIMi606704. gene.
neXtProtiNX_O95800.
PharmGKBiPA28919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiO95800.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG7992Q7.
PhylomeDBiO95800.
TreeFamiTF331523.

Miscellaneous databases

GeneWikiiGPR75.
GenomeRNAii10936.
PROiO95800.
SOURCEiSearch...

Gene expression databases

BgeeiO95800.
GenevisibleiO95800. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16."
    Tarttelin E.E., Kirschner L.S., Bellingham J., Baffi J., Taymans S.E., Gregory-Evans K., Csaky K., Stratakis C.A., Gregory-Evans C.Y.
    Biochem. Biophys. Res. Commun. 260:174-180(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Retina.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis."
    Liu B., Hassan Z., Amisten S., King A.J., Bowe J.E., Huang G.C., Jones P.M., Persaud S.J.
    Diabetologia 56:2467-2476(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  7. "Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration."
    Sauer C.G., White K., Stohr H., Grimm T., Hutchinson A., Bernstein P.S., Lewis R.A., Simonelli F., Pauleikhoff D., Allikmets R., Weber B.H.
    Br. J. Ophthalmol. 85:969-975(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-78; LEU-99; THR-108; THR-116 AND PRO-135, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR75_HUMAN
AccessioniPrimary (citable) accession number: O95800
Secondary accession number(s): B2RC02, Q6NWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.