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Protein

Probable G-protein coupled receptor 75

Gene

GPR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.1 PublicationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 75
Gene namesi
Name:GPR75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4526. GPR75.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 86CytoplasmicSequence analysisAdd BLAST19
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 120ExtracellularSequence analysisAdd BLAST13
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 160CytoplasmicSequence analysisAdd BLAST19
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 205ExtracellularSequence analysisAdd BLAST24
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 318CytoplasmicSequence analysisAdd BLAST92
Transmembranei319 – 339Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini340 – 350ExtracellularSequence analysisAdd BLAST11
Transmembranei351 – 371Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini372 – 540CytoplasmicSequence analysisAdd BLAST169

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10936.
OpenTargetsiENSG00000119737.
PharmGKBiPA28919.

Chemistry databases

GuidetoPHARMACOLOGYi115.

Polymorphism and mutation databases

BioMutaiGPR75.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695831 – 540Probable G-protein coupled receptor 75Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95800.
PRIDEiO95800.

Expressioni

Tissue specificityi

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000119737.
GenevisibleiO95800. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378195.

Structurei

3D structure databases

ProteinModelPortaliO95800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 121Phe-richAdd BLAST61

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiO95800.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG091G07SG.
PhylomeDBiO95800.
TreeFamiTF331523.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTGHLQDA PNATSLHVPH SQEGNSTSLQ EGLQDLIHTA TLVTCTFLLA
60 70 80 90 100
VIFCLGSYGN FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM
110 120 130 140 150
FTFVLFFSSA SSIPDAFCFT FHLTSSGFII MSLKTVAVIA LHRLRMVLGK
160 170 180 190 200
QPNRTASFPC TVLLTLLLWA TSFTLATLAT LKTSKSHLCL PMSSLIAGKG
210 220 230 240 250
KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVRKCPP VITVDASRPQ
260 270 280 290 300
PFMGVPVQGG GDPIQCAMPA LYRNQNYNKL QHVQTRGYTK SPNQLVTPAA
310 320 330 340 350
SRLQLVSAIN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLSSNG
360 370 380 390 400
SFILYQFELF GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LQYIGLGFFC
410 420 430 440 450
CKQKTRLRAM GKGNLEVNRN KSSHHETNSA YMLSPKPQKK FVDQACGPSH
460 470 480 490 500
SKESMVSPKI SAGHQHCGQS SSTPINTRIE PYYSIYNSSP SQEESSPCNL
510 520 530 540
QPVNSFGFAN SYIAMHYHTT NDLVQEYDST SAKQIPVPSV
Length:540
Mass (Da):59,359
Last modified:May 1, 1999 - v1
Checksum:iB5BE87BB384190EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → P in AAH67475 (PubMed:15489334).Curated1
Sequence conflicti278N → D in AAH67475 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07125878N → K Found in a patient with age-related macular degeneration; unknown pathological significance. 1 PublicationCorresponds to variant rs72799238dbSNPEnsembl.1
Natural variantiVAR_07125999P → L Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication1
Natural variantiVAR_071260108S → T Found in a patient with age-related macular degeneration; unknown pathological significance. 1 PublicationCorresponds to variant rs763005023dbSNPEnsembl.1
Natural variantiVAR_033471116A → T.1 PublicationCorresponds to variant rs34000641dbSNPEnsembl.1
Natural variantiVAR_071261135T → P Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication1
Natural variantiVAR_033472160C → G.Corresponds to variant rs35349235dbSNPEnsembl.1
Natural variantiVAR_033473433L → V.Corresponds to variant rs3731969dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA. Translation: AAD19849.1.
AF101472 Genomic DNA. Translation: AAD22770.1.
AK314885 mRNA. Translation: BAG37399.1.
AC008068 Genomic DNA. Translation: AAY15018.1.
CH471053 Genomic DNA. Translation: EAX00162.1.
BC067475 mRNA. Translation: AAH67475.1.
BC067476 mRNA. Translation: AAH67476.1.
CCDSiCCDS1849.1.
RefSeqiNP_006785.1. NM_006794.3.
UniGeneiHs.40763.

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737.
GeneIDi10936.
KEGGihsa:10936.
UCSCiuc002rxo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA. Translation: AAD19849.1.
AF101472 Genomic DNA. Translation: AAD22770.1.
AK314885 mRNA. Translation: BAG37399.1.
AC008068 Genomic DNA. Translation: AAY15018.1.
CH471053 Genomic DNA. Translation: EAX00162.1.
BC067475 mRNA. Translation: AAH67475.1.
BC067476 mRNA. Translation: AAH67476.1.
CCDSiCCDS1849.1.
RefSeqiNP_006785.1. NM_006794.3.
UniGeneiHs.40763.

3D structure databases

ProteinModelPortaliO95800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378195.

Chemistry databases

GuidetoPHARMACOLOGYi115.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR75.

Proteomic databases

PaxDbiO95800.
PRIDEiO95800.

Protocols and materials databases

DNASUi10936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737.
GeneIDi10936.
KEGGihsa:10936.
UCSCiuc002rxo.4. human.

Organism-specific databases

CTDi10936.
DisGeNETi10936.
GeneCardsiGPR75.
HGNCiHGNC:4526. GPR75.
MIMi606704. gene.
neXtProtiNX_O95800.
OpenTargetsiENSG00000119737.
PharmGKBiPA28919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiO95800.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG091G07SG.
PhylomeDBiO95800.
TreeFamiTF331523.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119737-MONOMER.

Miscellaneous databases

GeneWikiiGPR75.
GenomeRNAii10936.
PROiO95800.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119737.
GenevisibleiO95800. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR75_HUMAN
AccessioniPrimary (citable) accession number: O95800
Secondary accession number(s): B2RC02, Q6NWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.