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Protein

Zinc finger MYM-type protein 6

Gene

ZMYM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 151MYM-type 1Add BLAST39
Zinc fingeri163 – 206MYM-type 2Add BLAST44
Zinc fingeri213 – 248MYM-type 3Add BLAST36
Zinc fingeri296 – 334MYM-type 4Add BLAST39
Zinc fingeri342 – 443MYM-type 5Add BLAST102
Zinc fingeri451 – 485MYM-type 6Add BLAST35
Zinc fingeri492 – 531MYM-type 7Add BLAST40
Zinc fingeri538 – 572MYM-type 8Add BLAST35

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • regulation of cell morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 6
Alternative name(s):
Transposon-derived Buster2 transposase-like protein
Zinc finger protein 258
Gene namesi
Name:ZMYM6
Synonyms:Buster2, KIAA1353, ZNF258
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13050. ZMYM6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163867.
ENSG00000271741.
PharmGKBiPA37628.

Polymorphism and mutation databases

BioMutaiZMYM6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913811 – 1325Zinc finger MYM-type protein 6Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei397PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95789.
PaxDbiO95789.
PeptideAtlasiO95789.
PRIDEiO95789.

PTM databases

iPTMnetiO95789.
PhosphoSitePlusiO95789.

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle, kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000163867.
CleanExiHS_ZMYM6.
ExpressionAtlasiO95789. baseline and differential.
GenevisibleiO95789. HS.

Organism-specific databases

HPAiHPA011004.

Interactioni

Protein-protein interaction databases

BioGridi114638. 31 interactors.
IntActiO95789. 3 interactors.
MINTiMINT-4658180.
STRINGi9606.ENSP00000349708.

Structurei

3D structure databases

ProteinModelPortaliO95789.
SMRiO95789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 8 MYM-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 151MYM-type 1Add BLAST39
Zinc fingeri163 – 206MYM-type 2Add BLAST44
Zinc fingeri213 – 248MYM-type 3Add BLAST36
Zinc fingeri296 – 334MYM-type 4Add BLAST39
Zinc fingeri342 – 443MYM-type 5Add BLAST102
Zinc fingeri451 – 485MYM-type 6Add BLAST35
Zinc fingeri492 – 531MYM-type 7Add BLAST40
Zinc fingeri538 – 572MYM-type 8Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOVERGENiHBG058050.
InParanoidiO95789.
OMAiLQGTMTT.
OrthoDBiEOG091G0BE1.
PhylomeDBiO95789.
TreeFamiTF336988.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR012337. RNaseH-like_dom.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF14291. DUF4371. 1 hit.
PF06467. zf-FCS. 3 hits.
[Graphical view]
SMARTiSM00746. TRASH. 9 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: O95789-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEPLDGECG KAVVPQQELL DKIKEEPDNA QEYGCVQQPK TQESKLKIGG
60 70 80 90 100
VSSVNERPIA QQLNPGFQLS FASSGPSVLL PSVPAVAIKV FCSGCKKMLY
110 120 130 140 150
KGQTAYHKTG STQLFCSTRC ITRHSSPACL PPPPKKTCTN CSKDILNPKD
160 170 180 190 200
VITTRFENSY PSKDFCSQSC LSSYELKKKP VVTIYTKSIS TKCSMCQKNA
210 220 230 240 250
DTRFEVKYQN VVHGLCSDAC FSKFHSTNNL TMNCCENCGS YCYSSSGPCQ
260 270 280 290 300
SQKVFSSTSV TAYKQNSAQI PPYALGKSLR PSAEMIETTN DSGKTELFCS
310 320 330 340 350
INCLSAYRVK TVTSSGVQVS CHSCKTSAIP QYHLAMSNGT IYSFCSSSCV
360 370 380 390 400
VAFQNVFSKP KGTNSSAVPL SQGQVVVSPP SSRSAVSIGG GNTSAVSPSS
410 420 430 440 450
IRGSAAASLQ PLAEQSQQVA LTHTVVKLKC QHCNHLFATK PELLFYKGKM
460 470 480 490 500
FLFCGKNCSD EYKKKNKVVA MCDYCKLQKI IKETVRFSGV DKPFCSEVCK
510 520 530 540 550
FLSARDFGER WGNYCKMCSY CSQTSPNLVE NRLEGKLEEF CCEDCMSKFT
560 570 580 590 600
VLFYQMAKCD GCKRQGKLSE SIKWRGNIKH FCNLFCVLEF CHQQIMNDCL
610 620 630 640 650
PQNKVNISKA KTAVTELPSA RTDTTPVITS VMSLAKIPAT LSTGNTNSVL
660 670 680 690 700
KGAVTKEAAK IIQDESTQED AMKFPSSQSS QPSRLLKNKG ISCKPVTQTK
710 720 730 740 750
ATSCKPHTQH KECQTDLPMP NEKNDAELDS PPSKKKRLGF FQTYDTEYLK
760 770 780 790 800
VGFIICPGSK ESSPRPQCVI CGEILSSENM KPANLSHHLK TKHSELENKP
810 820 830 840 850
VDFFEQKSLE MECQNSSLKK CLLVEKSLVK ASYLIAFQTA ASKKPFSIAE
860 870 880 890 900
ELIKPYLVEM CSEVLGSSAG DKMKTIPLSN VTIQHRIDEL SADIEDQLIQ
910 920 930 940 950
KVRESKWFAL QIDESSEISN ITLLLCYIRF IDYDCRDVKE ELLFCIEMPT
960 970 980 990 1000
QITGFEIFEL INKYIDSKSL NWKHCVGLCT DGAASMTGRY SGLKAKIQEV
1010 1020 1030 1040 1050
AMNTAAFTHC FIHRERLVAE KLSPCLHKIL LQSAQILSFI KSNALNSRML
1060 1070 1080 1090 1100
TILCEEMGSE HVSLPLHAEV RWISRGRMLK RLFELRHEIE IFLSQKHSDL
1110 1120 1130 1140 1150
AKYFHDEEWV GKLAYLSDIF SLINELNLSL QGTLTTFFNL CNKIDVFKRK
1160 1170 1180 1190 1200
LKMWLKRTQE NDYDMFPSFS EFSNSSGLNM TDITRIIFEH LEGLSQVFSD
1210 1220 1230 1240 1250
CFPPEQDLRS GNLWIIHPFM NHQNNNLTDF EEEKLTELSS DLGLQALFKS
1260 1270 1280 1290 1300
VSVTQFWINA KTSYPELHER AMKFLLPFST VYLCDAAFSA LTESKQKNLL
1310 1320
GSGPALRLAV TSLIPRIEKL VKEKE
Length:1,325
Mass (Da):148,089
Last modified:July 22, 2008 - v2
Checksum:i1BC8ADE286A27F5A
GO
Isoform 2 (identifier: O95789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-156: DILNPKDVITTRF → YKILNIPFYFTFF
     157-1325: Missing.

Show »
Length:156
Mass (Da):17,121
Checksum:iFC5EF17AD7116337
GO
Isoform 1 (identifier: O95789-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-723: DLPMPNEK → ECPVRAVC
     724-1325: Missing.

Show »
Length:723
Mass (Da):79,113
Checksum:iF2F654CA86A24660
GO
Isoform 4 (identifier: O95789-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-170: DILNPKDVITTRFENSYPSKDFCSQSC → YKILNIPFYFTFFLVCILFSSNILLIL
     171-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,664
Checksum:i66B082068291909A
GO
Isoform 5 (identifier: O95789-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-687: Missing.
     688-715: NKGISCKPVTQTKATSCKPHTQHKECQT → MNFKYVGRYIKNIAYLFLKITVIQIFHS

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):73,255
Checksum:i147A835A111ADCFD
GO

Sequence cautioni

The sequence AAH33903 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI07881 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA92591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44S → G in AAI07881 (PubMed:15489334).Curated1
Sequence conflicti413A → G in AAD15797 (PubMed:10486218).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044432660K → R.Corresponds to variant rs10158256dbSNPEnsembl.1
Natural variantiVAR_0444331233E → K.Corresponds to variant rs16837147dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0352871 – 687Missing in isoform 5. 1 PublicationAdd BLAST687
Alternative sequenceiVSP_034680144 – 170DILNP…CSQSC → YKILNIPFYFTFFLVCILFS SNILLIL in isoform 4. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_011446144 – 156DILNP…ITTRF → YKILNIPFYFTFF in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_011447157 – 1325Missing in isoform 2. 1 PublicationAdd BLAST1169
Alternative sequenceiVSP_034681171 – 1325Missing in isoform 4. 2 PublicationsAdd BLAST1155
Alternative sequenceiVSP_035288688 – 715NKGIS…KECQT → MNFKYVGRYIKNIAYLFLKI TVIQIFHS in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_034682716 – 723DLPMPNEK → ECPVRAVC in isoform 1. 1 Publication8
Alternative sequenceiVSP_034683724 – 1325Missing in isoform 1. 1 PublicationAdd BLAST602

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055470 mRNA. Translation: AAD15797.1.
AB037774 mRNA. Translation: BAA92591.1. Different initiation.
AK299293 mRNA. Translation: BAG61308.1.
BT007117 mRNA. Translation: AAP35781.1.
AL832911 mRNA. Translation: CAH10638.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12897.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12898.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12899.1.
BC033903 mRNA. Translation: AAH33903.1. Sequence problems.
BC068534 mRNA. Translation: AAH68534.1.
BC107880 mRNA. Translation: AAI07881.1. Sequence problems.
BC117463 mRNA. Translation: AAI17464.1.
CCDSiCCDS387.2. [O95789-3]
RefSeqiNP_009098.3. NM_007167.3. [O95789-3]
UniGeneiHs.533986.
Hs.623978.
Hs.729053.

Genome annotation databases

EnsembliENST00000317538; ENSP00000326695; ENSG00000163867. [O95789-4]
ENST00000357182; ENSP00000349708; ENSG00000163867. [O95789-3]
ENST00000373333; ENSP00000362430; ENSG00000163867. [O95789-4]
GeneIDi9204.
KEGGihsa:9204.
UCSCiuc001byh.4. human. [O95789-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055470 mRNA. Translation: AAD15797.1.
AB037774 mRNA. Translation: BAA92591.1. Different initiation.
AK299293 mRNA. Translation: BAG61308.1.
BT007117 mRNA. Translation: AAP35781.1.
AL832911 mRNA. Translation: CAH10638.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12897.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12898.1.
AL607089, AC114490 Genomic DNA. Translation: CAI12899.1.
BC033903 mRNA. Translation: AAH33903.1. Sequence problems.
BC068534 mRNA. Translation: AAH68534.1.
BC107880 mRNA. Translation: AAI07881.1. Sequence problems.
BC117463 mRNA. Translation: AAI17464.1.
CCDSiCCDS387.2. [O95789-3]
RefSeqiNP_009098.3. NM_007167.3. [O95789-3]
UniGeneiHs.533986.
Hs.623978.
Hs.729053.

3D structure databases

ProteinModelPortaliO95789.
SMRiO95789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114638. 31 interactors.
IntActiO95789. 3 interactors.
MINTiMINT-4658180.
STRINGi9606.ENSP00000349708.

PTM databases

iPTMnetiO95789.
PhosphoSitePlusiO95789.

Polymorphism and mutation databases

BioMutaiZMYM6.

Proteomic databases

EPDiO95789.
PaxDbiO95789.
PeptideAtlasiO95789.
PRIDEiO95789.

Protocols and materials databases

DNASUi9204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317538; ENSP00000326695; ENSG00000163867. [O95789-4]
ENST00000357182; ENSP00000349708; ENSG00000163867. [O95789-3]
ENST00000373333; ENSP00000362430; ENSG00000163867. [O95789-4]
GeneIDi9204.
KEGGihsa:9204.
UCSCiuc001byh.4. human. [O95789-3]

Organism-specific databases

CTDi9204.
GeneCardsiZMYM6.
HGNCiHGNC:13050. ZMYM6.
HPAiHPA011004.
MIMi613567. gene.
neXtProtiNX_O95789.
OpenTargetsiENSG00000163867.
ENSG00000271741.
PharmGKBiPA37628.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOVERGENiHBG058050.
InParanoidiO95789.
OMAiLQGTMTT.
OrthoDBiEOG091G0BE1.
PhylomeDBiO95789.
TreeFamiTF336988.

Miscellaneous databases

ChiTaRSiZMYM6. human.
GenomeRNAii9204.
PROiO95789.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163867.
CleanExiHS_ZMYM6.
ExpressionAtlasiO95789. baseline and differential.
GenevisibleiO95789. HS.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR012337. RNaseH-like_dom.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF14291. DUF4371. 1 hit.
PF06467. zf-FCS. 3 hits.
[Graphical view]
SMARTiSM00746. TRASH. 9 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZMYM6_HUMAN
AccessioniPrimary (citable) accession number: O95789
Secondary accession number(s): B4DRJ6
, Q32Q23, Q4G108, Q5SVZ9, Q5SW00, Q69YL4, Q96IY0, Q9NWF1, Q9P2J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.