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O95782

- AP2A1_HUMAN

UniProt

O95782 - AP2A1_HUMAN

Protein

AP-2 complex subunit alpha-1

Gene

AP2A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: ParkinsonsUK-UCL
    3. protein transporter activity Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. axon guidance Source: Reactome
    3. endocytosis Source: UniProtKB
    4. epidermal growth factor receptor signaling pathway Source: Reactome
    5. Golgi to endosome transport Source: UniProtKB
    6. intracellular protein transport Source: UniProtKB
    7. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
    8. negative regulation of hyaluronan biosynthetic process Source: UniProtKB
    9. neurotrophin TRK receptor signaling pathway Source: Reactome
    10. regulation of defense response to virus by virus Source: Reactome
    11. synaptic transmission Source: Reactome
    12. viral process Source: Reactome

    Keywords - Biological processi

    Endocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11166. Nef Mediated CD4 Down-regulation.
    REACT_11200. Nef Mediated CD8 Down-regulation.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_18422. Trafficking of GluR2-containing AMPA receptors.
    REACT_22365. Recycling pathway of L1.
    SignaLinkiO95782.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-2 complex subunit alpha-1
    Alternative name(s):
    100 kDa coated vesicle protein A
    Adaptor protein complex AP-2 subunit alpha-1
    Adaptor-related protein complex 2 subunit alpha-1
    Alpha-adaptin A
    Alpha1-adaptin
    Clathrin assembly protein complex 2 alpha-A large chain
    Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
    Gene namesi
    Name:AP2A1
    Synonyms:ADTAA, CLAPA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:561. AP2A1.

    Subcellular locationi

    Cell membrane By similarity. Membranecoated pit By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.By similarity

    GO - Cellular componenti

    1. AP-2 adaptor complex Source: UniProtKB
    2. apical plasma membrane Source: Ensembl
    3. basolateral plasma membrane Source: Ensembl
    4. clathrin-coated endocytic vesicle membrane Source: Reactome
    5. clathrin coat of trans-Golgi network vesicle Source: UniProtKB
    6. cytosol Source: Reactome
    7. endocytic vesicle membrane Source: Reactome
    8. membrane Source: UniProtKB
    9. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Coated pit, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24852.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 977977AP-2 complex subunit alpha-1PRO_0000193730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei626 – 6261Phosphoserine1 Publication
    Modified residuei652 – 6521Phosphoserine1 Publication
    Modified residuei653 – 6531Phosphothreonine2 Publications
    Modified residuei655 – 6551Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95782.
    PaxDbiO95782.
    PRIDEiO95782.

    PTM databases

    PhosphoSiteiO95782.

    Expressioni

    Tissue specificityi

    Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.

    Gene expression databases

    ArrayExpressiO95782.
    BgeeiO95782.
    CleanExiHS_AP2A1.
    GenevestigatoriO95782.

    Organism-specific databases

    HPAiCAB004306.

    Interactioni

    Subunit structurei

    Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with SGIP1 By similarity. Interacts with HIP1 and RAB11FIP2. Interacts with SLC12A5. Interacts with clathrin.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi106669. 49 interactions.
    IntActiO95782. 21 interactions.
    MINTiMINT-5002322.
    STRINGi9606.ENSP00000351926.

    Structurei

    3D structure databases

    ProteinModelPortaliO95782.
    SMRiO95782. Positions 3-621, 746-977.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG303101.
    HOGENOMiHOG000170596.
    HOVERGENiHBG050518.
    InParanoidiO95782.
    KOiK11824.
    OMAiNYVGAGI.
    OrthoDBiEOG7GQXV2.
    PhylomeDBiO95782.
    TreeFamiTF300308.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: O95782-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL    50
    DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV 100
    LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD 150
    IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH 200
    MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY 250
    FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 300
    QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL 350
    ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS 400
    NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI 450
    RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG 500
    GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN 550
    LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 600
    EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST 650
    VSTPSPSADL LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE 700
    EAFLSELEPP APESPMALLA DPAPAADPGP EDIGPPIPEA DELLNKFVCK 750
    NNGVLFENQL LQIGVKSEFR QNLGRMYLFY GNKTSVQFQN FSPTVVHPGD 800
    LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL SVRFRYGGAP 850
    QALTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPQQEAQ KIFKANHPMD 900
    AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ 950
    AQMYRLTLRT SKEPVSRHLC ELLAQQF 977
    Length:977
    Mass (Da):107,546
    Last modified:November 3, 2009 - v3
    Checksum:iD9FB569E7EDDF6ED
    GO
    Isoform B (identifier: O95782-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         706-727: Missing.

    Show »
    Length:955
    Mass (Da):105,361
    Checksum:iFCE1AEC87453B17F
    GO

    Sequence cautioni

    The sequence AAD15564.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti804 – 8041Q → H in AAL11039. (PubMed:12036598)Curated
    Sequence conflicti804 – 8041Q → H in AAL11040. (PubMed:12036598)Curated
    Sequence conflicti924 – 97754ENFVG…LAQQF → GDREDTRVWGMPGTFLRPFV FLFLFICCCLHSGGLGGVPL PPFPPQAQRGEGPGKWMSPP LPPHPVVAPPTPSPSRGCVL L in AAH14214. (PubMed:15489334)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti270 – 2701P → L.1 Publication
    Corresponds to variant rs17851121 [ dbSNP | Ensembl ].
    VAR_060544

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei706 – 72722Missing in isoform B. 2 PublicationsVSP_000161Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289221 Genomic DNA. Translation: AAL11039.1.
    AF289221 Genomic DNA. Translation: AAL11040.1.
    AL136925 mRNA. Translation: CAB66859.1.
    AC006942 Genomic DNA. Translation: AAD15564.1. Sequence problems.
    AC011495 Genomic DNA. No translation available.
    AC098783 Genomic DNA. No translation available.
    BC014214 mRNA. Translation: AAH14214.1.
    CCDSiCCDS46148.1. [O95782-1]
    CCDS46149.1. [O95782-2]
    RefSeqiNP_055018.2. NM_014203.2. [O95782-1]
    NP_570603.2. NM_130787.2. [O95782-2]
    UniGeneiHs.467125.

    Genome annotation databases

    EnsembliENST00000354293; ENSP00000346246; ENSG00000196961. [O95782-2]
    ENST00000359032; ENSP00000351926; ENSG00000196961. [O95782-1]
    GeneIDi160.
    KEGGihsa:160.
    UCSCiuc002ppn.3. human. [O95782-1]
    uc002ppo.3. human. [O95782-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289221 Genomic DNA. Translation: AAL11039.1 .
    AF289221 Genomic DNA. Translation: AAL11040.1 .
    AL136925 mRNA. Translation: CAB66859.1 .
    AC006942 Genomic DNA. Translation: AAD15564.1 . Sequence problems.
    AC011495 Genomic DNA. No translation available.
    AC098783 Genomic DNA. No translation available.
    BC014214 mRNA. Translation: AAH14214.1 .
    CCDSi CCDS46148.1. [O95782-1 ]
    CCDS46149.1. [O95782-2 ]
    RefSeqi NP_055018.2. NM_014203.2. [O95782-1 ]
    NP_570603.2. NM_130787.2. [O95782-2 ]
    UniGenei Hs.467125.

    3D structure databases

    ProteinModelPortali O95782.
    SMRi O95782. Positions 3-621, 746-977.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106669. 49 interactions.
    IntActi O95782. 21 interactions.
    MINTi MINT-5002322.
    STRINGi 9606.ENSP00000351926.

    PTM databases

    PhosphoSitei O95782.

    Proteomic databases

    MaxQBi O95782.
    PaxDbi O95782.
    PRIDEi O95782.

    Protocols and materials databases

    DNASUi 160.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354293 ; ENSP00000346246 ; ENSG00000196961 . [O95782-2 ]
    ENST00000359032 ; ENSP00000351926 ; ENSG00000196961 . [O95782-1 ]
    GeneIDi 160.
    KEGGi hsa:160.
    UCSCi uc002ppn.3. human. [O95782-1 ]
    uc002ppo.3. human. [O95782-2 ]

    Organism-specific databases

    CTDi 160.
    GeneCardsi GC19P050270.
    HGNCi HGNC:561. AP2A1.
    HPAi CAB004306.
    MIMi 601026. gene.
    neXtProti NX_O95782.
    PharmGKBi PA24852.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303101.
    HOGENOMi HOG000170596.
    HOVERGENi HBG050518.
    InParanoidi O95782.
    KOi K11824.
    OMAi NYVGAGI.
    OrthoDBi EOG7GQXV2.
    PhylomeDBi O95782.
    TreeFami TF300308.

    Enzyme and pathway databases

    Reactomei REACT_11166. Nef Mediated CD4 Down-regulation.
    REACT_11200. Nef Mediated CD8 Down-regulation.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_18422. Trafficking of GluR2-containing AMPA receptors.
    REACT_22365. Recycling pathway of L1.
    SignaLinki O95782.

    Miscellaneous databases

    ChiTaRSi AP2A1. human.
    GeneWikii Adaptor-related_protein_complex_2,_alpha_1.
    GenomeRNAii 160.
    NextBioi 637.
    PROi O95782.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95782.
    Bgeei O95782.
    CleanExi HS_AP2A1.
    Genevestigatori O95782.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene."
      Scorilas A., Levesque M.A., Ashworth L.K., Diamandis E.P.
      Gene 289:191-199(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Uterus.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), VARIANT LEU-270.
      Tissue: Muscle.
    5. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."
      Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E.
      Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIP1.
    6. "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors."
      Cullis D.N., Philip B., Baleja J.D., Feig L.A.
      J. Biol. Chem. 277:49158-49166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB11FIP2.
    7. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
      Nakatsu F., Ohno H.
      Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
    8. "Adaptors for clathrin coats: structure and function."
      Owen D.J., Collins B.M., Evans P.R.
      Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
    9. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
      Lau A.W., Chou M.M.
      J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652; THR-653 AND SER-655, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-653, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAP2A1_HUMAN
    AccessioniPrimary (citable) accession number: O95782
    Secondary accession number(s): Q96CI7
    , Q96PP6, Q96PP7, Q9H070
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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