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Protein

Zinc finger protein 682

Gene

ZNF682

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 682
Gene namesi
Name:ZNF682
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28857. ZNF682.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197124.
PharmGKBiPA142670483.

Polymorphism and mutation databases

BioMutaiZNF682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340011 – 498Zinc finger protein 682Add BLAST498

Proteomic databases

EPDiO95780.
PaxDbiO95780.
PeptideAtlasiO95780.
PRIDEiO95780.

PTM databases

iPTMnetiO95780.
PhosphoSitePlusiO95780.

Expressioni

Gene expression databases

BgeeiENSG00000197124.
CleanExiHS_ZNF682.
ExpressionAtlasiO95780. baseline and differential.
GenevisibleiO95780. HS.

Organism-specific databases

HPAiHPA055998.

Interactioni

Protein-protein interaction databases

IntActiO95780. 1 interactor.
STRINGi9606.ENSP00000380351.

Structurei

3D structure databases

ProteinModelPortaliO95780.
SMRiO95780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiO95780.
KOiK09228.
PhylomeDBiO95780.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95780-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLTFRDVT IEFSLEEWEF LNPAQQSLYR KVMLENYRNL VSLGLTVSKP
60 70 80 90 100
ELISRLEQRQ EPWNVKRHET IAKPPAMSSH YTEDLLPEQC MQDSFQKVIL
110 120 130 140 150
RRYGSCGLED LHLRKDGENV GECKDQKEIY NGLNQCLSTL PSKIFPYNKC
160 170 180 190 200
VKVFSKSSNL NRENIRHTTE KLFKCMQCGK VFKSHSGLSY HKIIHTEEKL
210 220 230 240 250
CICEECGKTF KWFSYLTKHK RIHTGEKPYK CEECGKAFNW CSSLTKHKRI
260 270 280 290 300
HTGEKPYKCE ECGKAFHWCS PFVRHKKIHT GEKPYTCEDC GRAFNRHSHL
310 320 330 340 350
TKHKTIHTGK KPYKCKECGK AFNHCSLLTI HERTHTGEKP YKCEECGKAF
360 370 380 390 400
NSSSILTEHK VIHSGEKPYK CEKCDKVFKR FSYLTKHKRI HTGEKPYKCE
410 420 430 440 450
ECGKAFNWSS ILTEHKRIHT GEKPYNCEEC GKAFNRCSHL TRHKKIHTAV
460 470 480 490
KRYKCEECGK AFKRCSHLNE HKRVQRGEKS CKYKKCGEAF NHCSNLTT
Note: Gene prediction based on EST data.
Length:498
Mass (Da):58,361
Last modified:May 1, 1999 - v1
Checksum:i77993708F2E809BD
GO
Isoform 2 (identifier: O95780-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):49,321
Checksum:i659F000F385D15E4
GO
Isoform 3 (identifier: O95780-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):54,446
Checksum:i5BA1220CA4DA484E
GO

Sequence cautioni

The sequence BAB55408 differs from that shown. Reason: Frameshift at position 441.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05289165V → M.Corresponds to variant rs7255165dbSNPEnsembl.1
Natural variantiVAR_052892209T → I.1 PublicationCorresponds to variant rs2075090dbSNPEnsembl.1
Natural variantiVAR_052893450V → I.Corresponds to variant rs17679334dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0181661 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0445631 – 32Missing in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027845 mRNA. Translation: BAB55408.1. Frameshift.
AK096571 mRNA. Translation: BAG53326.1.
DA787253 mRNA. No translation available.
AC006539 Genomic DNA. Translation: AAD14472.1.
CCDSiCCDS42533.1. [O95780-1]
CCDS42534.1. [O95780-3]
RefSeqiNP_149973.1. NM_033196.2. [O95780-1]
XP_016882945.1. XM_017027456.1. [O95780-2]
UniGeneiHs.306298.

Genome annotation databases

EnsembliENST00000358523; ENSP00000351324; ENSG00000197124. [O95780-3]
ENST00000397162; ENSP00000380348; ENSG00000197124. [O95780-3]
ENST00000397165; ENSP00000380351; ENSG00000197124. [O95780-1]
ENST00000595736; ENSP00000471717; ENSG00000197124. [O95780-2]
GeneIDi91120.
KEGGihsa:91120.
UCSCiuc002noo.3. human. [O95780-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027845 mRNA. Translation: BAB55408.1. Frameshift.
AK096571 mRNA. Translation: BAG53326.1.
DA787253 mRNA. No translation available.
AC006539 Genomic DNA. Translation: AAD14472.1.
CCDSiCCDS42533.1. [O95780-1]
CCDS42534.1. [O95780-3]
RefSeqiNP_149973.1. NM_033196.2. [O95780-1]
XP_016882945.1. XM_017027456.1. [O95780-2]
UniGeneiHs.306298.

3D structure databases

ProteinModelPortaliO95780.
SMRiO95780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95780. 1 interactor.
STRINGi9606.ENSP00000380351.

PTM databases

iPTMnetiO95780.
PhosphoSitePlusiO95780.

Polymorphism and mutation databases

BioMutaiZNF682.

Proteomic databases

EPDiO95780.
PaxDbiO95780.
PeptideAtlasiO95780.
PRIDEiO95780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358523; ENSP00000351324; ENSG00000197124. [O95780-3]
ENST00000397162; ENSP00000380348; ENSG00000197124. [O95780-3]
ENST00000397165; ENSP00000380351; ENSG00000197124. [O95780-1]
ENST00000595736; ENSP00000471717; ENSG00000197124. [O95780-2]
GeneIDi91120.
KEGGihsa:91120.
UCSCiuc002noo.3. human. [O95780-1]

Organism-specific databases

CTDi91120.
GeneCardsiZNF682.
HGNCiHGNC:28857. ZNF682.
HPAiHPA055998.
neXtProtiNX_O95780.
OpenTargetsiENSG00000197124.
PharmGKBiPA142670483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiO95780.
KOiK09228.
PhylomeDBiO95780.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF682. human.
GenomeRNAii91120.
PROiO95780.

Gene expression databases

BgeeiENSG00000197124.
CleanExiHS_ZNF682.
ExpressionAtlasiO95780. baseline and differential.
GenevisibleiO95780. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN682_HUMAN
AccessioniPrimary (citable) accession number: O95780
Secondary accession number(s): B3KU64, E9PFJ5, Q96JV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.