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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

LSM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • U6 snRNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:LSM8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20471. LSM8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618166.

Polymorphism and mutation databases

BioMutaiNAA38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 9695U6 snRNA-associated Sm-like protein LSm8PRO_0000125582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineCombined sources1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95777.
MaxQBiO95777.
PaxDbiO95777.
PeptideAtlasiO95777.
PRIDEiO95777.
TopDownProteomicsiO95777.

PTM databases

iPTMnetiO95777.
PhosphoSiteiO95777.

Expressioni

Gene expression databases

BgeeiENSG00000128534.
CleanExiHS_LSM8.
ExpressionAtlasiO95777. baseline and differential.
GenevisibleiO95777. HS.

Organism-specific databases

HPAiHPA020116.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM2Q9Y3336EBI-347779,EBI-347416
LSM3P623106EBI-347779,EBI-348239
LSM4Q9Y4Z04EBI-347779,EBI-372521

Protein-protein interaction databases

BioGridi119679. 65 interactions.
DIPiDIP-31195N.
IntActiO95777. 52 interactions.
MINTiMINT-1032595.
STRINGi9606.ENSP00000249299.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0081-96[»]
ProteinModelPortaliO95777.
SMRiO95777. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiO95777.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG091G126L.
PhylomeDBiO95777.
TreeFamiTF314555.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182294 mRNA. Translation: AAD56232.1.
AC006389 Genomic DNA. Translation: AAD15542.1.
BC002742 mRNA. Translation: AAH02742.1.
BC022440 mRNA. Translation: AAH22440.1.
CCDSiCCDS5775.1.
RefSeqiNP_057284.1. NM_016200.4.
UniGeneiHs.655046.

Genome annotation databases

EnsembliENST00000249299; ENSP00000249299; ENSG00000128534.
GeneIDi51691.
KEGGihsa:51691.
UCSCiuc003vjg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182294 mRNA. Translation: AAD56232.1.
AC006389 Genomic DNA. Translation: AAD15542.1.
BC002742 mRNA. Translation: AAH02742.1.
BC022440 mRNA. Translation: AAH22440.1.
CCDSiCCDS5775.1.
RefSeqiNP_057284.1. NM_016200.4.
UniGeneiHs.655046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0081-96[»]
ProteinModelPortaliO95777.
SMRiO95777. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119679. 65 interactions.
DIPiDIP-31195N.
IntActiO95777. 52 interactions.
MINTiMINT-1032595.
STRINGi9606.ENSP00000249299.

PTM databases

iPTMnetiO95777.
PhosphoSiteiO95777.

Polymorphism and mutation databases

BioMutaiNAA38.

Proteomic databases

EPDiO95777.
MaxQBiO95777.
PaxDbiO95777.
PeptideAtlasiO95777.
PRIDEiO95777.
TopDownProteomicsiO95777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249299; ENSP00000249299; ENSG00000128534.
GeneIDi51691.
KEGGihsa:51691.
UCSCiuc003vjg.4. human.

Organism-specific databases

CTDi51691.
GeneCardsiLSM8.
HGNCiHGNC:20471. LSM8.
HPAiHPA020116.
MIMi607288. gene.
neXtProtiNX_O95777.
PharmGKBiPA165618166.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiO95777.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG091G126L.
PhylomeDBiO95777.
TreeFamiTF314555.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

GeneWikiiLSM8.
GenomeRNAii51691.
PROiO95777.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128534.
CleanExiHS_LSM8.
ExpressionAtlasiO95777. baseline and differential.
GenevisibleiO95777. HS.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM8_HUMAN
AccessioniPrimary (citable) accession number: O95777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.