Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O95777 (LSM8_HUMAN)

Last modified June 16, 2009. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    U6 snRNA-associated Sm-like protein LSm8
Gene names
Name: LSM8
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

Subunit structure

LSm subunits form a heteromer with a donut shape.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the snRNP Sm proteins family.

Hide | Top

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processnuclear mRNA splicing, via spliceosome

Non-traceable author statement. Source: UniProtKB

   Cellular componentnucleus

Non-traceable author statement. Source: UniProtKB

ribonucleoprotein complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionU6 snRNA binding Ref.1

Non-traceable author statement. Source: UniProtKB

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 9695U6 snRNA-associated Sm-like protein LSm8
PRO_0000125582

Amino acid modifications

Modified residue21N-acetylthreonine Ref.4

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O95777-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 15D26E6B75AA2EE1

FASTA9610,403
        10         20         30         40         50         60 
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY 

        70         80         90 
IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Uterus.
[4]Bienvenut W.V.
Submitted (JUL-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-11; 29-44 AND 88-96, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Hide | Top

Cross-references

Sequence databases

AF182294 mRNA. Translation: AAD56232.1.
AC006389 Genomic DNA. Translation: AAD15542.1.
BC002742 mRNA. Translation: AAH02742.1.
BC022440 mRNA. Translation: AAH22440.1.
IPIIPI00219871.
RefSeqNP_057284.1.
UniGeneHs.709757

3D structure databases

HSSPHSSP built from PDB template 1JBM based on UniProtKB O26745.
ModBaseSearch...

Protein-protein interaction databases

IntActO95777. 26 interactions.

PTM databases

PhosphoSiteO95777.

Proteomic databases

PeptideAtlasO95777.
PRIDEO95777.

Genome annotation databases

EnsemblENSG00000128534. Homo sapiens. [Contig view]
GeneID51691.
KEGGhsa:51691.

Organism-specific databases

GeneCardsGC07P117611.
H-InvDBHIX0007025.
HGNCHGNC:20471. LSM8.
MIM607288. gene.
PharmGKBPA134930584.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO95777.
HOVERGENO95777.
OMAO95777. TNDGRNI.

Gene expression databases

ArrayExpressO95777.
BgeeO95777.
CleanExHS_LSM8.
GermOnlineENSG00000128534. Homo sapiens.

Family and domain databases

InterProIPR006649. Euk_arc_LSM_core.
IPR001163. LSM_snRNP_core.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
ProDomPD020287. snRNP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio55698.
SOURCESearch...

Hide | Top

Entry information

Entry nameLSM8_HUMAN
AccessionPrimary (citable) accession number: O95777
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents