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O95777

- LSM8_HUMAN

UniProt

O95777 - LSM8_HUMAN

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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

LSM8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. U6 snRNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:LSM8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:20471. LSM8.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618166.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 9695U6 snRNA-associated Sm-like protein LSm8PRO_0000125582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO95777.
PaxDbiO95777.
PeptideAtlasiO95777.
PRIDEiO95777.

PTM databases

PhosphoSiteiO95777.

Expressioni

Gene expression databases

BgeeiO95777.
CleanExiHS_LSM8.
ExpressionAtlasiO95777. baseline and differential.
GenevestigatoriO95777.

Organism-specific databases

HPAiHPA020116.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM2Q9Y3336EBI-347779,EBI-347416
LSM3P623106EBI-347779,EBI-348239
LSM4Q9Y4Z04EBI-347779,EBI-372521

Protein-protein interaction databases

BioGridi119679. 62 interactions.
DIPiDIP-31195N.
IntActiO95777. 51 interactions.
MINTiMINT-1032595.
STRINGi9606.ENSP00000249299.

Structurei

3D structure databases

ProteinModelPortaliO95777.
SMRiO95777. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiNOG235625.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiO95777.
KOiK12627.
OMAiECHERVF.
OrthoDBiEOG7SV0XS.
PhylomeDBiO95777.
TreeFamiTF314555.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95777-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182294 mRNA. Translation: AAD56232.1.
AC006389 Genomic DNA. Translation: AAD15542.1.
BC002742 mRNA. Translation: AAH02742.1.
BC022440 mRNA. Translation: AAH22440.1.
CCDSiCCDS5775.1.
RefSeqiNP_057284.1. NM_016200.4.
UniGeneiHs.655046.

Genome annotation databases

EnsembliENST00000249299; ENSP00000249299; ENSG00000128534.
GeneIDi51691.
KEGGihsa:51691.
UCSCiuc003vjg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182294 mRNA. Translation: AAD56232.1 .
AC006389 Genomic DNA. Translation: AAD15542.1 .
BC002742 mRNA. Translation: AAH02742.1 .
BC022440 mRNA. Translation: AAH22440.1 .
CCDSi CCDS5775.1.
RefSeqi NP_057284.1. NM_016200.4.
UniGenei Hs.655046.

3D structure databases

ProteinModelPortali O95777.
SMRi O95777. Positions 2-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119679. 62 interactions.
DIPi DIP-31195N.
IntActi O95777. 51 interactions.
MINTi MINT-1032595.
STRINGi 9606.ENSP00000249299.

PTM databases

PhosphoSitei O95777.

Proteomic databases

MaxQBi O95777.
PaxDbi O95777.
PeptideAtlasi O95777.
PRIDEi O95777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249299 ; ENSP00000249299 ; ENSG00000128534 .
GeneIDi 51691.
KEGGi hsa:51691.
UCSCi uc003vjg.3. human.

Organism-specific databases

CTDi 51691.
GeneCardsi GC07P117825.
HGNCi HGNC:20471. LSM8.
HPAi HPA020116.
MIMi 607288. gene.
neXtProti NX_O95777.
PharmGKBi PA165618166.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235625.
GeneTreei ENSGT00730000111212.
HOVERGENi HBG105578.
InParanoidi O95777.
KOi K12627.
OMAi ECHERVF.
OrthoDBi EOG7SV0XS.
PhylomeDBi O95777.
TreeFami TF314555.

Miscellaneous databases

GeneWikii LSM8.
GenomeRNAii 51691.
NextBioi 55698.
PROi O95777.
SOURCEi Search...

Gene expression databases

Bgeei O95777.
CleanExi HS_LSM8.
ExpressionAtlasi O95777. baseline and differential.
Genevestigatori O95777.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
    Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
    EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  4. Bienvenut W.V.
    Submitted (JUL-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 29-44 AND 88-96, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSM8_HUMAN
AccessioniPrimary (citable) accession number: O95777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3