O95777 (NAA38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 38, NatC auxiliary subunit

Alternative name(s):
U6 snRNA-associated Sm-like protein LSm8

Gene names

Name:	NAA38
Synonyms:	LSM8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.
Subunit structure	LSm subunits form a heteromer with a doughnut shape.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mRNA splicing, via spliceosome Non-traceable author statement. Source: UniProtKB
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	U6 snRNA binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM2	Q9Y333	5	EBI-347779,EBI-347416
LSM3	P62310	5	EBI-347779,EBI-348239
LSM4	Q9Y4Z0	4	EBI-347779,EBI-372521

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 96	95	N-alpha-acetyltransferase 38, NatC auxiliary subunit		PRO_0000125582
Amino acid modifications
	Modified residue	2	1	N-acetylthreonine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O95777 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 15D26E6B75AA2EE1	FASTA	96	10,403
	10 20 30 40 50 60 MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY 70 80 90 IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Uterus.
[4]	Bienvenut W.V. Submitted (JUL-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-11; 29-44 AND 88-96, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[5]	"A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates." Polevoda B., Arnesen T., Sherman F. BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF182294 mRNA. Translation: AAD56232.1. AC006389 Genomic DNA. Translation: AAD15542.1. BC002742 mRNA. Translation: AAH02742.1. BC022440 mRNA. Translation: AAH22440.1.
IPI	IPI00219871.
RefSeq	NP_057284.1. NM_016200.4.
UniGene	Hs.655046.
3D structure databases
ProteinModelPortal	O95777.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31195N.
IntAct	O95777. 46 interactions.
MINT	MINT-1032595.
STRING	9606.ENSP00000249299.
PTM databases
PhosphoSite	O95777.
Proteomic databases
PaxDb	O95777.
PeptideAtlas	O95777.
PRIDE	O95777.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249299; ENSP00000249299; ENSG00000128534.
GeneID	51691.
KEGG	hsa:51691.
UCSC	uc003vjg.3. human.
Organism-specific databases
CTD	51691.
GeneCards	GC07P117824.
HGNC	HGNC:20471. NAA38.
HPA	HPA020116.
MIM	607288. gene.
neXtProt	NX_O95777.
PharmGKB	PA165618166.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG235625.
HOVERGEN	HBG105578.
InParanoid	O95777.
KO	K12627.
OMA	NHTVSII.
OrthoDB	EOG48SGVN.
PhylomeDB	O95777.
Gene expression databases
ArrayExpress	O95777.
Bgee	O95777.
CleanEx	HS_LSM8.
Genevestigator	O95777.
GermOnline	ENSG00000128534. Homo sapiens.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. IPR006649. Ribonucl_LSM_euk/arc. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
SMART	SM00651. Sm. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	51691.
NextBio	55698.
SOURCE	Search...

Entry information

Entry name

NAA38_HUMAN

Accession

Primary (citable) accession number: O95777

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 121 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.