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Protein

STARD3 N-terminal-like protein

Gene

STARD3NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263).1 Publication

GO - Molecular functioni

  • cholesterol binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-196108. Pregnenolone biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
STARD3 N-terminal-like protein1 Publication
Alternative name(s):
MLN64 N-terminal domain homolog
Gene namesi
Name:STARD3NL1 PublicationImported
Synonyms:MENTHO1 Publication
ORF Names:UNQ855/PRO1864
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000010270.13.
HGNCiHGNC:19169. STARD3NL.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53Cytoplasmic1 PublicationAdd BLAST53
Transmembranei54 – 74HelicalAdd BLAST21
Topological domaini75 – 97ExtracellularSequence analysisAdd BLAST23
Transmembranei98 – 118HelicalAdd BLAST21
Topological domaini119 – 122CytoplasmicSequence analysis4
Transmembranei123 – 143HelicalAdd BLAST21
Topological domaini144 – 150ExtracellularSequence analysis7
Transmembranei151 – 171HelicalAdd BLAST21
Topological domaini172 – 234Cytoplasmic1 PublicationAdd BLAST63

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83930.
OpenTargetsiENSG00000010270.
PharmGKBiPA134990065.

Polymorphism and mutation databases

BioMutaiSTARD3NL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000216661 – 234STARD3 N-terminal-like proteinAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95772.
MaxQBiO95772.
PaxDbiO95772.
PeptideAtlasiO95772.
PRIDEiO95772.

PTM databases

iPTMnetiO95772.
PhosphoSitePlusiO95772.
SwissPalmiO95772.

Expressioni

Gene expression databases

BgeeiENSG00000010270.
CleanExiHS_STARD3NL.
ExpressionAtlasiO95772. baseline and differential.
GenevisibleiO95772. HS.

Organism-specific databases

HPAiHPA019204.

Interactioni

Subunit structurei

Homodimer (PubMed:16709157). Interacts (via the MENTAL domain) with STARD3NL (PubMed:16709157). Interacts (via FFAT motif) with VAPA. Interacts (via FFAT motif) with VAPB (PubMed:24105263).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi123815. 7 interactors.
IntActiO95772. 4 interactors.
STRINGi9606.ENSP00000009041.

Structurei

3D structure databases

ProteinModelPortaliO95772.
SMRiO95772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 218MENTALAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi208 – 213FFAT1 Publication6

Domaini

The FFAT motif mediates interaction with VAPA and VAPB.By similarity
The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (By similarity). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).By similarity2 Publications

Sequence similaritiesi

Belongs to the STARD3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPP0. Eukaryota.
ENOG4110JA9. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000252985.
HOVERGENiHBG052455.
InParanoidiO95772.
OMAiWWAIAFT.
OrthoDBiEOG091G06RM.
PhylomeDBiO95772.
TreeFamiTF313869.

Family and domain databases

InterProiView protein in InterPro
IPR019498. MENTAL.
PfamiView protein in Pfam
PF10457. MENTAL. 1 hit.
PROSITEiView protein in PROSITE
PS51439. MENTAL. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: O95772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLPEDMEN ALTGSQSSHA SLRNIHSINP TQLMARIESY EGREKKGISD
60 70 80 90 100
VRRTFCLFVT FDLLFVTLLW IIELNVNGGI ENTLEKEVMQ YDYYSSYFDI
110 120 130 140 150
FLLAVFRFKV LILAYAVCRL RHWWAIALTT AVTSAFLLAK VILSKLFSQG
160 170 180 190 200
AFGYVLPIIS FILAWIETWF LDFKVLPQEA EEENRLLIVQ DASERAALIP
210 220 230
GGLSDGQFYS PPESEAGSEE AEEKQDSEKP LLEL
Length:234
Mass (Da):26,655
Last modified:May 1, 1999 - v1
Checksum:iAFB7DAE381983FB0
GO
Isoform 2 (identifier: O95772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:227
Mass (Da):25,818
Checksum:i1313F76EC5C9CA91
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188191 – 7Missing in isoform 2. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492267 mRNA. Translation: CAD37353.1.
AY358645 mRNA. Translation: AAQ89008.1.
AK315404 mRNA. Translation: BAG37796.1.
AC006033 Genomic DNA. Translation: AAS07552.1.
CH236951 Genomic DNA. Translation: EAL23983.1.
CH471073 Genomic DNA. Translation: EAW94088.1.
BC003074 mRNA. Translation: AAH03074.1.
BC005959 mRNA. Translation: AAH05959.1.
CCDSiCCDS5455.1. [O95772-1]
RefSeqiNP_114405.1. NM_032016.3. [O95772-1]
XP_005249937.1. XM_005249880.1. [O95772-1]
XP_011513874.1. XM_011515572.1. [O95772-1]
XP_016868181.1. XM_017012692.1. [O95772-1]
XP_016868182.1. XM_017012693.1. [O95772-1]
XP_016868183.1. XM_017012694.1. [O95772-1]
UniGeneiHs.309753.
Hs.744885.

Genome annotation databases

EnsembliENST00000009041; ENSP00000009041; ENSG00000010270. [O95772-1]
ENST00000396013; ENSP00000379334; ENSG00000010270. [O95772-1]
GeneIDi83930.
KEGGihsa:83930.
UCSCiuc003tfr.4. human. [O95772-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiSTR3N_HUMAN
AccessioniPrimary (citable) accession number: O95772
Secondary accession number(s): A4D1X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families