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Protein

MLN64 N-terminal domain homolog

Gene

STARD3NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MLN64 N-terminal domain homolog
Alternative name(s):
STARD3 N-terminal-like protein
Gene namesi
Name:STARD3NL
Synonyms:MENTHO
ORF Names:UNQ855/PRO1864
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19169. STARD3NL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini75 – 9723ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini119 – 1224CytoplasmicSequence analysis
Transmembranei123 – 14321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini144 – 1507ExtracellularSequence analysis
Transmembranei151 – 17121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini172 – 23463CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990065.

Polymorphism and mutation databases

BioMutaiSTARD3NL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234MLN64 N-terminal domain homologPRO_0000021666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei193 – 1931PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95772.
MaxQBiO95772.
PaxDbiO95772.
PRIDEiO95772.

PTM databases

iPTMnetiO95772.
PhosphoSiteiO95772.
SwissPalmiO95772.

Expressioni

Gene expression databases

BgeeiO95772.
CleanExiHS_STARD3NL.
ExpressionAtlasiO95772. baseline and differential.
GenevisibleiO95772. HS.

Organism-specific databases

HPAiHPA019204.

Interactioni

Subunit structurei

Can form homodimers. Interacts with STARD3.1 Publication

Protein-protein interaction databases

BioGridi123815. 2 interactions.
IntActiO95772. 3 interactions.
STRINGi9606.ENSP00000009041.

Structurei

3D structure databases

ProteinModelPortaliO95772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 218171MENTALPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MENTAL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPP0. Eukaryota.
ENOG4110JA9. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000252985.
HOVERGENiHBG052455.
InParanoidiO95772.
OMAiWWAIAFT.
OrthoDBiEOG74FF0Z.
PhylomeDBiO95772.
TreeFamiTF313869.

Family and domain databases

InterProiIPR019498. MENTAL.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: O95772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLPEDMEN ALTGSQSSHA SLRNIHSINP TQLMARIESY EGREKKGISD
60 70 80 90 100
VRRTFCLFVT FDLLFVTLLW IIELNVNGGI ENTLEKEVMQ YDYYSSYFDI
110 120 130 140 150
FLLAVFRFKV LILAYAVCRL RHWWAIALTT AVTSAFLLAK VILSKLFSQG
160 170 180 190 200
AFGYVLPIIS FILAWIETWF LDFKVLPQEA EEENRLLIVQ DASERAALIP
210 220 230
GGLSDGQFYS PPESEAGSEE AEEKQDSEKP LLEL
Length:234
Mass (Da):26,655
Last modified:May 1, 1999 - v1
Checksum:iAFB7DAE381983FB0
GO
Isoform 2 (identifier: O95772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:227
Mass (Da):25,818
Checksum:i1313F76EC5C9CA91
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. CuratedVSP_018819

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492267 mRNA. Translation: CAD37353.1.
AY358645 mRNA. Translation: AAQ89008.1.
AK315404 mRNA. Translation: BAG37796.1.
AC006033 Genomic DNA. Translation: AAS07552.1.
CH236951 Genomic DNA. Translation: EAL23983.1.
CH471073 Genomic DNA. Translation: EAW94088.1.
BC003074 mRNA. Translation: AAH03074.1.
BC005959 mRNA. Translation: AAH05959.1.
CCDSiCCDS5455.1. [O95772-1]
RefSeqiNP_114405.1. NM_032016.3. [O95772-1]
XP_005249937.1. XM_005249880.1. [O95772-1]
XP_006715852.1. XM_006715789.1. [O95772-1]
XP_011513874.1. XM_011515572.1. [O95772-1]
UniGeneiHs.309753.
Hs.744885.

Genome annotation databases

EnsembliENST00000009041; ENSP00000009041; ENSG00000010270. [O95772-1]
ENST00000396013; ENSP00000379334; ENSG00000010270. [O95772-1]
GeneIDi83930.
KEGGihsa:83930.
UCSCiuc003tfr.4. human. [O95772-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492267 mRNA. Translation: CAD37353.1.
AY358645 mRNA. Translation: AAQ89008.1.
AK315404 mRNA. Translation: BAG37796.1.
AC006033 Genomic DNA. Translation: AAS07552.1.
CH236951 Genomic DNA. Translation: EAL23983.1.
CH471073 Genomic DNA. Translation: EAW94088.1.
BC003074 mRNA. Translation: AAH03074.1.
BC005959 mRNA. Translation: AAH05959.1.
CCDSiCCDS5455.1. [O95772-1]
RefSeqiNP_114405.1. NM_032016.3. [O95772-1]
XP_005249937.1. XM_005249880.1. [O95772-1]
XP_006715852.1. XM_006715789.1. [O95772-1]
XP_011513874.1. XM_011515572.1. [O95772-1]
UniGeneiHs.309753.
Hs.744885.

3D structure databases

ProteinModelPortaliO95772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123815. 2 interactions.
IntActiO95772. 3 interactions.
STRINGi9606.ENSP00000009041.

PTM databases

iPTMnetiO95772.
PhosphoSiteiO95772.
SwissPalmiO95772.

Polymorphism and mutation databases

BioMutaiSTARD3NL.

Proteomic databases

EPDiO95772.
MaxQBiO95772.
PaxDbiO95772.
PRIDEiO95772.

Protocols and materials databases

DNASUi83930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000009041; ENSP00000009041; ENSG00000010270. [O95772-1]
ENST00000396013; ENSP00000379334; ENSG00000010270. [O95772-1]
GeneIDi83930.
KEGGihsa:83930.
UCSCiuc003tfr.4. human. [O95772-1]

Organism-specific databases

CTDi83930.
GeneCardsiSTARD3NL.
HGNCiHGNC:19169. STARD3NL.
HPAiHPA019204.
MIMi611759. gene.
neXtProtiNX_O95772.
PharmGKBiPA134990065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPP0. Eukaryota.
ENOG4110JA9. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000252985.
HOVERGENiHBG052455.
InParanoidiO95772.
OMAiWWAIAFT.
OrthoDBiEOG74FF0Z.
PhylomeDBiO95772.
TreeFamiTF313869.

Miscellaneous databases

ChiTaRSiSTARD3NL. human.
GeneWikiiSTARD3NL.
GenomeRNAii83930.
PROiO95772.
SOURCEiSearch...

Gene expression databases

BgeeiO95772.
CleanExiHS_STARD3NL.
ExpressionAtlasiO95772. baseline and differential.
GenevisibleiO95772. HS.

Family and domain databases

InterProiIPR019498. MENTAL.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MENTHO, a MLN64 homologue devoid of the START domain."
    Alpy F., Wendling C., Rio M.-C., Tomasetto C.
    J. Biol. Chem. 277:50780-50787(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TOPOLOGY, PHOSPHORYLATION, ALTERNATIVE INITIATION.
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Kidney.
  8. "MLN64 and MENTHO, two mediators of endosomal cholesterol transport."
    Alpy F., Tomasetto C.
    Biochem. Soc. Trans. 34:343-345(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, INTERACTION WITH STARD3.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMENTO_HUMAN
AccessioniPrimary (citable) accession number: O95772
Secondary accession number(s): A4D1X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.