ID   IL33_HUMAN              Reviewed;         270 AA.
AC   O95760; Q2YEJ5;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   19-JAN-2010, entry version 66.
DE   RecName: Full=Interleukin-33;
DE            Short=IL-33;
DE   AltName: Full=Interleukin-1 family member 11;
DE            Short=IL-1F11;
DE   AltName: Full=Nuclear factor from high endothelial venules;
DE            Short=NF-HEV;
DE   Flags: Precursor;
GN   Name=IL33; Synonyms=C9orf26, IL1F11, NFHEV;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Endothelial cell;
RX   MEDLINE=22702309; PubMed=12819012;
RA   Baekkevold E.S., Roussigne M., Yamanaka T., Johansen F.-E.,
RA   Jahnsen F.L., Amalric F., Brandtzaeg P., Erard M., Haraldsen G.,
RA   Girard J.-P.;
RT   "Molecular characterization of NF-HEV, a nuclear factor preferentially
RT   expressed in human high endothelial venules.";
RL   Am. J. Pathol. 163:69-79(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20031251; PubMed=10566975;
RX   DOI=10.1097/00004647-199911000-00013;
RA   Onda H., Kasuya H., Takakura K., Hori T., Imaizumi T., Takeuchi T.,
RA   Inoue I., Takeda J.;
RT   "Identification of genes differentially expressed in canine
RT   vasospastic cerebral arteries after subarachnoid hemorrhage.";
RL   J. Cereb. Blood Flow Metab. 19:1279-1288(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PROTEOLYTIC
RP   PROCESSING, AND FUNCTION.
RX   PubMed=16286016; DOI=10.1016/j.immuni.2005.09.015;
RA   Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K.,
RA   Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F.,
RA   Kastelein R.A.;
RT   "IL-33, an interleukin-1-like cytokine that signals via the IL-1
RT   receptor-related protein ST 2 and induces T helper type 2-associated
RT   cytokines.";
RL   Immunity 23:479-490(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2
CC       and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6,
CC       followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,
CC       MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.
CC   -!- INTERACTION:
CC       Q01638:IL1RL1; NbExp=2; IntAct=EBI-724057, EBI-993762;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed at high level in high endothelial
CC       venules found in tonsils, Peyer patches and mesenteric lymph
CC       nodes. Almost undetectable in placenta.
CC   -!- PTM: Proteolytically converted to a mature form by CASP1.
CC   -!- SIMILARITY: Belongs to the IL-1 family. Highly divergent.
CC   -!- CAUTION: Was originally (PubMed:12819012) thought to one of the
CC       key factors that controls the specialized post-capillary high
CC       endothelial venules (HEV) phenotype found in organized secondary
CC       lymphoid tissue and to be nuclear localized.
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DR   EMBL; AB024518; BAA75892.1; -; mRNA.
DR   EMBL; AY905581; AAX86998.1; -; mRNA.
DR   EMBL; CR407619; CAG28547.1; -; mRNA.
DR   EMBL; AL353741; CAI16003.1; -; Genomic_DNA.
DR   EMBL; BC047085; AAH47085.1; -; mRNA.
DR   IPI; IPI00027628; -.
DR   RefSeq; NP_254274.1; -.
DR   UniGene; Hs.348390; -.
DR   PDB; 2KLL; NMR; -; A=111-270.
DR   PDBsum; 2KLL; -.
DR   IntAct; O95760; 2.
DR   STRING; O95760; -.
DR   Ensembl; ENST00000381434; ENSP00000370842; ENSG00000137033; Homo sapiens.
DR   Ensembl; ENST00000429607; ENSP00000399586; ENSG00000137033; Homo sapiens.
DR   GeneID; 90865; -.
DR   KEGG; hsa:90865; -.
DR   UCSC; uc003zjt.2; human.
DR   CTD; 90865; -.
DR   GeneCards; GC09P006206; -.
DR   H-InvDB; HIX0007907; -.
DR   HGNC; HGNC:16028; IL33.
DR   HPA; CAB007057; -.
DR   HPA; HPA024426; -.
DR   MIM; 608678; gene.
DR   eggNOG; prNOG19288; -.
DR   HOGENOM; HBG125786; -.
DR   HOVERGEN; O95760; -.
DR   InParanoid; O95760; -.
DR   OMA; GVKDNHL; -.
DR   OrthoDB; EOG94XN2Q; -.
DR   PhylomeDB; O95760; -.
DR   NextBio; 77016; -.
DR   ArrayExpress; O95760; -.
DR   Bgee; O95760; -.
DR   CleanEx; HS_IL33; -.
DR   Genevestigator; O95760; -.
DR   GermOnline; ENSG00000137033; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Polymorphism; Secreted.
FT   PROPEP        1      ?       Potential.
FT                                /FTId=PRO_0000248845.
FT   CHAIN         ?    270       Interleukin-33.
FT                                /FTId=PRO_0000096790.
FT   VARIANT     263    263       I -> M (in dbSNP:rs16924241).
FT                                /FTId=VAR_049576.
SQ   SEQUENCE   270 AA;  30759 MW;  7C158069196EF636 CRC64;
     MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG LMIKKEACYF
     RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG VQKYTRALHD SSITGISPIT
     EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK
     MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI
     GVKDNHLALI KVDSSENLCT ENILFKLSET
//