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O95760

- IL33_HUMAN

UniProt

O95760 - IL33_HUMAN

Protein

Interleukin-33

Gene

IL33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).3 Publications
    In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei94 – 952Cleavage; by CTSG
    Sitei98 – 992Cleavage; by ELANE
    Sitei108 – 1092Cleavage; by CTSG

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of immunoglobulin secretion Source: Ensembl
    2. negative regulation of interferon-gamma production Source: Ensembl
    3. negative regulation of leukocyte migration Source: Ensembl
    4. negative regulation of T-helper 1 type immune response Source: Ensembl
    5. positive regulation of chemokine secretion Source: BHF-UCL
    6. positive regulation of immunoglobulin secretion Source: Ensembl
    7. positive regulation of inflammatory response Source: BHF-UCL
    8. positive regulation of interleukin-13 production Source: Ensembl
    9. positive regulation of interleukin-4 production Source: Ensembl
    10. positive regulation of interleukin-5 production Source: Ensembl
    11. positive regulation of interleukin-6 production Source: Ensembl
    12. positive regulation of macrophage activation Source: BHF-UCL
    13. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    14. positive regulation of type 2 immune response Source: Ensembl
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-33
    Short name:
    IL-33
    Alternative name(s):
    Interleukin-1 family member 11
    Short name:
    IL-1F11
    Nuclear factor from high endothelial venules
    Short name:
    NF-HEV
    Cleaved into the following 3 chains:
    Gene namesi
    Name:IL33
    Synonyms:C9orf26, IL1F11, NFHEV
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16028. IL33.

    Subcellular locationi

    Nucleus. Chromosome. Cytoplasmic vesiclesecretory vesicle. Secreted
    Note: Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. extracellular space Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell
    4. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Cytoplasmic vesicle, Nucleus, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi144 – 1441E → K: Decreases affinity for IL1RL1. 1 Publication
    Mutagenesisi148 – 1481E → K: 7-fold decrease in affinity for IL1RL1. 1 Publication
    Mutagenesisi149 – 1491D → K: Almost abolishes binding to IL1RL1. 1 Publication
    Mutagenesisi165 – 1651E → K: 8-fold decrease in affinity for IL1RL1. 1 Publication
    Mutagenesisi244 – 2441D → K: Decreases affinity for IL1RL1. 1 Publication

    Organism-specific databases

    PharmGKBiPA162392005.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Interleukin-33PRO_0000096790Add
    BLAST
    Propeptidei1 – 94941 PublicationPRO_0000430083Add
    BLAST
    Chaini95 – 270176Interleukin-33 (95-270)PRO_0000430084Add
    BLAST
    Chaini99 – 270172Interleukin-33 (99-270)PRO_0000430085Add
    BLAST
    Chaini109 – 270162Interleukin-33 (109-270)PRO_0000430086Add
    BLAST

    Post-translational modificationi

    The full length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.6 Publications

    Proteomic databases

    PaxDbiO95760.
    PRIDEiO95760.

    PTM databases

    PhosphoSiteiO95760.

    Expressioni

    Tissue specificityi

    Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.1 Publication

    Gene expression databases

    BgeeiO95760.
    CleanExiHS_IL33.
    GenevestigatoriO95760.

    Organism-specific databases

    HPAiCAB007057.
    HPA024426.

    Interactioni

    Subunit structurei

    Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HIST1H2AMP0C0S83EBI-724057,EBI-1390628
    IL1RL1Q016382EBI-724057,EBI-993762

    Protein-protein interaction databases

    BioGridi124776. 3 interactions.
    DIPiDIP-37862N.
    IntActiO95760. 4 interactions.
    MINTiMINT-1423224.
    STRINGi9606.ENSP00000370842.

    Structurei

    Secondary structure

    1
    270
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi112 – 1154
    Beta strandi119 – 1279
    Turni129 – 1313
    Beta strandi133 – 1386
    Beta strandi140 – 1489
    Beta strandi158 – 16912
    Turni170 – 1723
    Beta strandi180 – 18910
    Beta strandi193 – 1975
    Turni198 – 2014
    Beta strandi202 – 2065
    Helixi214 – 2163
    Beta strandi218 – 2247
    Beta strandi228 – 2358
    Beta strandi238 – 2436
    Beta strandi246 – 2516
    Helixi261 – 2633
    Beta strandi265 – 2673

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KLLNMR-A111-270[»]
    4KC3X-ray3.27A112-270[»]
    ProteinModelPortaliO95760.
    SMRiO95760. Positions 111-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95760.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6565Homeodomain-like HTH domainAdd
    BLAST
    Regioni66 – 11146Interaction with RELABy similarityAdd
    BLAST

    Domaini

    The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.

    Sequence similaritiesi

    Belongs to the IL-1 family. Highly divergent.Curated

    Phylogenomic databases

    eggNOGiNOG41297.
    HOGENOMiHOG000070215.
    HOVERGENiHBG081791.
    InParanoidiO95760.
    KOiK12967.
    OMAiDPGVFIG.
    OrthoDBiEOG7TQV1R.
    PhylomeDBiO95760.
    TreeFamiTF338120.

    Family and domain databases

    InterProiIPR026145. IL-33.
    [Graphical view]
    PANTHERiPTHR21114. PTHR21114. 1 hit.
    PfamiPF15095. IL33. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95760-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG    50
    LMIKKEACYF RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG 100
    VQKYTRALHD SSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL 150
    KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE 200
    HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI 250
    KVDSSENLCT ENILFKLSET 270
    Length:270
    Mass (Da):30,759
    Last modified:May 1, 1999 - v1
    Checksum:i7C158069196EF636
    GO
    Isoform 2 (identifier: O95760-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-156: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):25,930
    Checksum:iD48B2E3078CFA6C8
    GO
    Isoform 3 (identifier: O95760-3) [UniParc]FASTAAdd to Basket

    Also known as: spIL-33

    The sequence of this isoform differs from the canonical sequence as follows:
         72-113: Missing.

    Note: Constitutively active.

    Show »
    Length:228
    Mass (Da):26,104
    Checksum:iA982BD564D8FEC0E
    GO
    Isoform 4 (identifier: O95760-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         31-157: KSQQKAKEVC...EDLKKDEKKD → N

    Show »
    Length:144
    Mass (Da):16,250
    Checksum:i1B73431981DFFF46
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391E → G in BAG36208. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631I → M.
    Corresponds to variant rs16924241 [ dbSNP | Ensembl ].
    VAR_049576

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei31 – 157127KSQQK…DEKKD → N in isoform 4. 1 PublicationVSP_045440Add
    BLAST
    Alternative sequencei72 – 11342Missing in isoform 3. 1 PublicationVSP_044948Add
    BLAST
    Alternative sequencei115 – 15642Missing in isoform 2. 1 PublicationVSP_042728Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024518 mRNA. Translation: BAA75892.1.
    AY905581 mRNA. Translation: AAX86998.1.
    HQ641439 mRNA. Translation: ADR77828.1.
    AK295908 mRNA. Translation: BAG58697.1.
    AK303943 mRNA. Translation: BAG64871.1.
    AK313414 mRNA. Translation: BAG36208.1.
    CR407619 mRNA. Translation: CAG28547.1.
    AL353741 Genomic DNA. Translation: CAI16003.1.
    CH471071 Genomic DNA. Translation: EAW58748.1.
    CH471071 Genomic DNA. Translation: EAW58750.1.
    CH471071 Genomic DNA. Translation: EAW58751.1.
    BC047085 mRNA. Translation: AAH47085.1.
    CCDSiCCDS56563.1. [O95760-2]
    CCDS56564.1. [O95760-4]
    CCDS6468.1. [O95760-1]
    RefSeqiNP_001186569.1. NM_001199640.1. [O95760-2]
    NP_001186570.1. NM_001199641.1. [O95760-4]
    NP_254274.1. NM_033439.3. [O95760-1]
    XP_005251683.1. XM_005251626.2. [O95760-1]
    XP_005251684.1. XM_005251627.1. [O95760-1]
    UniGeneiHs.731660.

    Genome annotation databases

    EnsembliENST00000381434; ENSP00000370842; ENSG00000137033. [O95760-1]
    ENST00000417746; ENSP00000394039; ENSG00000137033. [O95760-4]
    ENST00000456383; ENSP00000414238; ENSG00000137033. [O95760-2]
    GeneIDi90865.
    KEGGihsa:90865.
    UCSCiuc003zjt.3. human. [O95760-1]
    uc011lmg.2. human. [O95760-2]
    uc011lmh.2. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024518 mRNA. Translation: BAA75892.1 .
    AY905581 mRNA. Translation: AAX86998.1 .
    HQ641439 mRNA. Translation: ADR77828.1 .
    AK295908 mRNA. Translation: BAG58697.1 .
    AK303943 mRNA. Translation: BAG64871.1 .
    AK313414 mRNA. Translation: BAG36208.1 .
    CR407619 mRNA. Translation: CAG28547.1 .
    AL353741 Genomic DNA. Translation: CAI16003.1 .
    CH471071 Genomic DNA. Translation: EAW58748.1 .
    CH471071 Genomic DNA. Translation: EAW58750.1 .
    CH471071 Genomic DNA. Translation: EAW58751.1 .
    BC047085 mRNA. Translation: AAH47085.1 .
    CCDSi CCDS56563.1. [O95760-2 ]
    CCDS56564.1. [O95760-4 ]
    CCDS6468.1. [O95760-1 ]
    RefSeqi NP_001186569.1. NM_001199640.1. [O95760-2 ]
    NP_001186570.1. NM_001199641.1. [O95760-4 ]
    NP_254274.1. NM_033439.3. [O95760-1 ]
    XP_005251683.1. XM_005251626.2. [O95760-1 ]
    XP_005251684.1. XM_005251627.1. [O95760-1 ]
    UniGenei Hs.731660.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KLL NMR - A 111-270 [» ]
    4KC3 X-ray 3.27 A 112-270 [» ]
    ProteinModelPortali O95760.
    SMRi O95760. Positions 111-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124776. 3 interactions.
    DIPi DIP-37862N.
    IntActi O95760. 4 interactions.
    MINTi MINT-1423224.
    STRINGi 9606.ENSP00000370842.

    PTM databases

    PhosphoSitei O95760.

    Proteomic databases

    PaxDbi O95760.
    PRIDEi O95760.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381434 ; ENSP00000370842 ; ENSG00000137033 . [O95760-1 ]
    ENST00000417746 ; ENSP00000394039 ; ENSG00000137033 . [O95760-4 ]
    ENST00000456383 ; ENSP00000414238 ; ENSG00000137033 . [O95760-2 ]
    GeneIDi 90865.
    KEGGi hsa:90865.
    UCSCi uc003zjt.3. human. [O95760-1 ]
    uc011lmg.2. human. [O95760-2 ]
    uc011lmh.2. human.

    Organism-specific databases

    CTDi 90865.
    GeneCardsi GC09P006206.
    HGNCi HGNC:16028. IL33.
    HPAi CAB007057.
    HPA024426.
    MIMi 608678. gene.
    neXtProti NX_O95760.
    PharmGKBi PA162392005.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41297.
    HOGENOMi HOG000070215.
    HOVERGENi HBG081791.
    InParanoidi O95760.
    KOi K12967.
    OMAi DPGVFIG.
    OrthoDBi EOG7TQV1R.
    PhylomeDBi O95760.
    TreeFami TF338120.

    Miscellaneous databases

    EvolutionaryTracei O95760.
    GenomeRNAii 90865.
    NextBioi 35467794.
    PROi O95760.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95760.
    CleanExi HS_IL33.
    Genevestigatori O95760.

    Family and domain databases

    InterProi IPR026145. IL-33.
    [Graphical view ]
    PANTHERi PTHR21114. PTHR21114. 1 hit.
    Pfami PF15095. IL33. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules."
      Baekkevold E.S., Roussigne M., Yamanaka T., Johansen F.-E., Jahnsen F.L., Amalric F., Brandtzaeg P., Erard M., Haraldsen G., Girard J.-P.
      Am. J. Pathol. 163:69-79(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Endothelial cell.
    2. "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage."
      Onda H., Kasuya H., Takakura K., Hori T., Imaizumi T., Takeuchi T., Inoue I., Takeda J.
      J. Cereb. Blood Flow Metab. 19:1279-1288(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
      Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A.
      Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING.
    4. "Identification of constitutively active interleukin 33 (IL-33) splice variant."
      Hong J., Bae S., Jhun H., Lee S., Choi J., Kang T., Kwak A., Hong K., Kim E., Jo S., Kim S.
      J. Biol. Chem. 286:20078-20086(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Adrenal gland and Trachea.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. "IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G."
      Lefrancais E., Roga S., Gautier V., Gonzalez-de-Peredo A., Monsarrat B., Girard J.P., Cayrol C.
      Proc. Natl. Acad. Sci. U.S.A. 109:1673-1678(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 95-121, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, PROTEOLYTIC PROCESSING, CLEAVAGE AT PHE-94 AND LEU-108 BY CSTG, CLEAVAGE AT ILE-98 BY ELANE.
    11. Cited for: FUNCTION.
    12. "IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo."
      Carriere V., Roussel L., Ortega N., Lacorre D.A., Americh L., Aguilar L., Bouche G., Girard J.P.
      Proc. Natl. Acad. Sci. U.S.A. 104:282-287(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR TARGETING DOMAIN.
    13. "Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation."
      Kuchler A.M., Pollheimer J., Balogh J., Sponheim J., Manley L., Sorensen D.R., De Angelis P.M., Scott H., Haraldsen G.
      Am. J. Pathol. 173:1229-1242(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    14. "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?"
      Moussion C., Ortega N., Girard J.P.
      PLoS ONE 3:E3331-E3331(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    15. "Mature interleukin-33 is produced by calpain-mediated cleavage in vivo."
      Hayakawa M., Hayakawa H., Matsuyama Y., Tamemoto H., Okazaki H., Tominaga S.
      Biochem. Biophys. Res. Commun. 387:218-222(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    16. Cited for: PROTEOLYTIC PROCESSING.
    17. "Interleukin-33 is biologically active independently of caspase-1 cleavage."
      Talabot-Ayer D., Lamacchia C., Gabay C., Palmer G.
      J. Biol. Chem. 284:19420-19426(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
    18. "The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1."
      Cayrol C., Girard J.P.
      Proc. Natl. Acad. Sci. U.S.A. 106:9021-9026(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    19. "The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription."
      Ali S., Mohs A., Thomas M., Klare J., Ross R., Schmitz M.L., Martin M.U.
      J. Immunol. 187:1609-1616(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    20. "Interleukin 33 as a mechanically responsive cytokine secreted by living cells."
      Kakkar R., Hei H., Dobner S., Lee R.T.
      J. Biol. Chem. 287:6941-6948(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    21. "Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes."
      Lingel A., Weiss T.M., Niebuhr M., Pan B., Appleton B.A., Wiesmann C., Bazan J.F., Fairbrother W.J.
      Structure 17:1398-1410(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 111-270, INTERACTION WITH IL1RL1 AND IL1RAP, SUBUNIT.
    22. "Structural insights into the interaction of IL-33 with its receptors."
      Liu X., Hammel M., He Y., Tainer J.A., Jeng U.S., Zhang L., Wang S., Wang X.
      Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.27 ANGSTROMS) OF 112-270 IN COMPLEX WITH IL1RL1/ST2, MUTAGENESIS OF GLU-144; GLU-148; ASP-149; GLU-165 AND ASP-244.

    Entry informationi

    Entry nameiIL33_HUMAN
    AccessioniPrimary (citable) accession number: O95760
    Secondary accession number(s): B2R8L1
    , B4DJ35, B4E1Q9, D3DRI5, E7EAX4, Q2YEJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3