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Protein

Heat shock 70 kDa protein 4L

Gene

HSPA4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164070-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4L
Alternative name(s):
Heat shock 70-related protein APG-1
Osmotic stress protein 94
Gene namesi
Name:HSPA4L
Synonyms:APG1, OSP94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17041. HSPA4L.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: May translocate to the nucleus after heat shock.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22824.
OpenTargetsiENSG00000164070.
PharmGKBiPA134905749.

Polymorphism and mutation databases

BioMutaiHSPA4L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782801 – 839Heat shock 70 kDa protein 4LAdd BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei74PhosphoserineCombined sources1
Modified residuei89PhosphotyrosineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei430N6-acetyllysineBy similarity1
Modified residuei508PhosphoserineCombined sources1
Modified residuei545PhosphothreonineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei663PhosphotyrosineBy similarity1
Modified residuei682N6-acetyllysineBy similarity1
Modified residuei759PhosphoserineBy similarity1
Modified residuei761PhosphothreonineCombined sources1
Modified residuei776N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO95757.
MaxQBiO95757.
PaxDbiO95757.
PeptideAtlasiO95757.
PRIDEiO95757.

2D gel databases

REPRODUCTION-2DPAGEIPI00295485.

PTM databases

iPTMnetiO95757.
PhosphoSitePlusiO95757.

Expressioni

Inductioni

By heat shock and osmotic imbalance.1 Publication

Gene expression databases

BgeeiENSG00000164070.
CleanExiHS_HSPA4L.
ExpressionAtlasiO95757. baseline and differential.
GenevisibleiO95757. HS.

Organism-specific databases

HPAiCAB034450.
HPA039149.
HPA061446.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi116500. 59 interactors.
IntActiO95757. 21 interactors.
MINTiMINT-1135179.
STRINGi9606.ENSP00000296464.

Structurei

3D structure databases

ProteinModelPortaliO95757.
SMRiO95757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiO95757.
KOiK09485.
OMAiETINQYM.
OrthoDBiEOG091G04Y6.
PhylomeDBiO95757.
TreeFamiTF105043.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN
60 70 80 90 100
AAKSQIVTNV RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSAG
110 120 130 140 150
VKVRYLEEER PFAIEQVTGM LLAKLKETSE NALKKPVADC VISIPSFFTD
160 170 180 190 200
AERRSVMAAA QVAGLNCLRL MNETTAVALA YGIYKQDLPP LDEKPRNVVF
210 220 230 240 250
IDMGHSAYQV LVCAFNKGKL KVLATTFDPY LGGRNFDEAL VDYFCDEFKT
260 270 280 290 300
KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMNDLDVSSK
310 320 330 340 350
MNRAQFEQLC ASLLARVEPP LKAVMEQANL QREDISSIEI VGGATRIPAV
360 370 380 390 400
KEQITKFFLK DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLVPY
410 420 430 440 450
SITLRWKTSF EDGSGECEVF CKNHPAPFSK VITFHKKEPF ELEAFYTNLH
460 470 480 490 500
EVPYPDARIG SFTIQNVFPQ SDGDSSKVKV KVRVNIHGIF SVASASVIEK
510 520 530 540 550
QNLEGDHSDA PMETETSFKN ENKDNMDKMQ VDQEEGHQKC HAEHTPEEEI
560 570 580 590 600
DHTGAKTKSA VSDKQDRLNQ TLKKGKVKSI DLPIQSSLCR QLGQDLLNSY
610 620 630 640 650
IENEGKMIMQ DKLEKERNDA KNAVEEYVYD FRDRLGTVYE KFITPEDLSK
660 670 680 690 700
LSAVLEDTEN WLYEDGEDQP KQVYVDKLQE LKKYGQPIQM KYMEHEERPK
710 720 730 740 750
ALNDLGKKIQ LVMKVIEAYR NKDERYDHLD PTEMEKVEKC ISDAMSWLNS
760 770 780 790 800
KMNAQNKLSL TQDPVVKVSE IVAKSKELDN FCNPIIYKPK PKAEVPEDKP
810 820 830
KANSEHNGPM DGQSGTETKS DSTKDSSQHT KSSGEMEVD
Length:839
Mass (Da):94,512
Last modified:November 2, 2010 - v3
Checksum:i549933AECFF4369A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti806H → R in BAA75063 (PubMed:10524232).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025405211L → S.1 PublicationCorresponds to variant rs1380154dbSNPEnsembl.1
Natural variantiVAR_031214216N → T.Corresponds to variant rs12507229dbSNPEnsembl.1
Natural variantiVAR_055966601I → T.Corresponds to variant rs35518193dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023421 mRNA. Translation: BAA75063.1.
EF197155 mRNA. Translation: ABM69040.1.
AC093591 Genomic DNA. Translation: AAY40975.1.
CH471056 Genomic DNA. Translation: EAX05198.1.
BC040560 mRNA. Translation: AAH40560.1.
CCDSiCCDS3734.1.
RefSeqiNP_001304310.1. NM_001317381.1.
NP_001304311.1. NM_001317382.1.
NP_001304312.1. NM_001317383.1.
NP_055093.2. NM_014278.3.
UniGeneiHs.135554.

Genome annotation databases

EnsembliENST00000296464; ENSP00000296464; ENSG00000164070.
ENST00000508776; ENSP00000422482; ENSG00000164070.
GeneIDi22824.
KEGGihsa:22824.
UCSCiuc003ifm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023421 mRNA. Translation: BAA75063.1.
EF197155 mRNA. Translation: ABM69040.1.
AC093591 Genomic DNA. Translation: AAY40975.1.
CH471056 Genomic DNA. Translation: EAX05198.1.
BC040560 mRNA. Translation: AAH40560.1.
CCDSiCCDS3734.1.
RefSeqiNP_001304310.1. NM_001317381.1.
NP_001304311.1. NM_001317382.1.
NP_001304312.1. NM_001317383.1.
NP_055093.2. NM_014278.3.
UniGeneiHs.135554.

3D structure databases

ProteinModelPortaliO95757.
SMRiO95757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116500. 59 interactors.
IntActiO95757. 21 interactors.
MINTiMINT-1135179.
STRINGi9606.ENSP00000296464.

PTM databases

iPTMnetiO95757.
PhosphoSitePlusiO95757.

Polymorphism and mutation databases

BioMutaiHSPA4L.

2D gel databases

REPRODUCTION-2DPAGEIPI00295485.

Proteomic databases

EPDiO95757.
MaxQBiO95757.
PaxDbiO95757.
PeptideAtlasiO95757.
PRIDEiO95757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296464; ENSP00000296464; ENSG00000164070.
ENST00000508776; ENSP00000422482; ENSG00000164070.
GeneIDi22824.
KEGGihsa:22824.
UCSCiuc003ifm.4. human.

Organism-specific databases

CTDi22824.
DisGeNETi22824.
GeneCardsiHSPA4L.
HGNCiHGNC:17041. HSPA4L.
HPAiCAB034450.
HPA039149.
HPA061446.
neXtProtiNX_O95757.
OpenTargetsiENSG00000164070.
PharmGKBiPA134905749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiO95757.
KOiK09485.
OMAiETINQYM.
OrthoDBiEOG091G04Y6.
PhylomeDBiO95757.
TreeFamiTF105043.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164070-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA4L. human.
GeneWikiiHSPA4L.
GenomeRNAii22824.
PROiO95757.

Gene expression databases

BgeeiENSG00000164070.
CleanExiHS_HSPA4L.
ExpressionAtlasiO95757. baseline and differential.
GenevisibleiO95757. HS.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS74L_HUMAN
AccessioniPrimary (citable) accession number: O95757
Secondary accession number(s): A2ICT2, Q4W5M5, Q8IWA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.