O95755 (RAB36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-36

Gene names

Name:

RAB36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subcellular location	Golgi apparatus membrane; Lipid-anchor.
Tissue specificity	Ubiquitously present in all tissues examined.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Traceable author statement Ref.1. Source: ProtInc Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95755-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95755-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-142: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Ras-related protein Rab-36		PRO_0000121248
Regions
	Nucleotide binding	130 – 137	8	GTP By similarity
	Nucleotide binding	178 – 182	5	GTP By similarity
	Nucleotide binding	237 – 240	4	GTP By similarity
	Motif	152 – 160	9	Effector region By similarity
Amino acid modifications
	Lipidation	332	1	S-geranylgeranyl cysteine Potential
	Lipidation	333	1	S-geranylgeranyl cysteine Potential
Natural variations
	Alternative sequence	121 – 142	22	Missing in isoform 2.		VSP_010143
	Natural variant	50	1	P → L. Corresponds to variant rs9624036 [ dbSNP | Ensembl ].		VAR_034433
	Natural variant	308	1	N → D. Ref.1 Corresponds to variant rs5759612 [ dbSNP | Ensembl ].		VAR_024189
	Natural variant	320	1	E → K. Corresponds to variant rs9624038 [ dbSNP | Ensembl ].		VAR_051715
Experimental info
	Sequence conflict	42	1	I → N in AAQ16115. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: FFDD522F6DE40A2D	FASTA	333	36,322
	10 20 30 40 50 60 MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP GRAEPQLSQP 70 80 90 100 110 120 SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR EHFHGQVSAA CQRRNTGTVG 130 140 150 160 170 180 LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR DYKATIGVDF EIERFEIAGI PYSLQIWDTA 190 200 210 220 230 240 GQEKFKCIAS AYYRGAQVII TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD 250 260 270 280 290 300 LLSGAACEQA EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS 310 320 330 SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC
	Isoform 2 [UniParc]. Checksum: 03099737E46D6D13	FASTA	311	33,915
	10 20 30 40 50 60 MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP GRAEPQLSQP 70 80 90 100 110 120 SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR EHFHGQVSAA CQRRNTGTVG 130 140 150 160 170 180 FCKNVFDRDY KATIGVDFEI ERFEIAGIPY SLQIWDTAGQ EKFKCIASAY YRGAQVIITA 190 200 210 220 230 240 FDLTDVQTLE HTRQWLEDAL RENEAGSCFI FLVGTKKDLL SGAACEQAEA DAVHLAREMQ 250 260 270 280 290 300 AEYWSVSAKT GENVKAFFSR VAALAFEQSV LQDLERQSSA RLQVGNGDLI QMEGSPPETQ 310 ESKRPSSLGC C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors." Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T., Nakamura Y., Inazawa J. Biochem. Biophys. Res. Commun. 254:594-600(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-308.
[2]	"Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2." Zhou J.-Y., Fogelgren B., Wang Z., Roe B.A., Biegel J.A. Gene 241:133-141(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	Shen C., Zhong G., Zheng G., Li H., Zhou G., Ke R., Yu R., Lin L., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023061 mRNA. Translation: BAA75195.1. AF133588 mRNA. Translation: AAF02485.1. AY336745 mRNA. Translation: AAQ16115.1. CR456553 mRNA. Translation: CAG30439.1. BC104989 mRNA. Translation: AAI04990.1. BC104991 mRNA. Translation: AAI04992.1.
IPI	IPI00032916. IPI00410116.
RefSeq	NP_004905.2. NM_004914.2.
UniGene	Hs.369557.
3D structure databases
ProteinModelPortal	O95755.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000263116.
PTM databases
PhosphoSite	O95755.
2D gel databases
REPRODUCTION-2DPAGE	O95755.
Proteomic databases
PaxDb	O95755.
PRIDE	O95755.
Protocols and materials databases
DNASU	9609.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263116; ENSP00000263116; ENSG00000100228. ENST00000341989; ENSP00000343494; ENSG00000100228.
GeneID	9609.
KEGG	hsa:9609.
UCSC	uc002zwv.1. human. uc010gtw.1. human.
Organism-specific databases
CTD	9609.
GeneCards	GC22P023487.
H-InvDB	HIX0027922.
HGNC	HGNC:9775. RAB36.
MIM	605662. gene.
neXtProt	NX_O95755.
PharmGKB	PA34128.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233970.
HOVERGEN	HBG106693.
InParanoid	O95755.
KO	K07922.
OMA	PEACLQF.
OrthoDB	EOG49P9ZZ.
PhylomeDB	O95755.
Gene expression databases
Bgee	O95755.
CleanEx	HS_RAB36.
Genevestigator	O95755.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RAB36. human.
GenomeRNAi	9609.
NextBio	36047.
SOURCE	Search...

Entry information

Entry name

RAB36_HUMAN

Accession

Primary (citable) accession number: O95755
Secondary accession number(s): Q2M390, Q7Z4A9, Q9UHP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	April 26, 2004
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.