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O95755

- RAB36_HUMAN

UniProt

O95755 - RAB36_HUMAN

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Protein

Ras-related protein Rab-36

Gene
RAB36
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 1378GTP By similarity
Nucleotide bindingi178 – 1825GTP By similarity
Nucleotide bindingi237 – 2404GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-36
Gene namesi
Name:RAB36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:9775. RAB36.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: ProtInc
  2. Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Ras-related protein Rab-36PRO_0000121248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi332 – 3321S-geranylgeranyl cysteine Reviewed prediction
Lipidationi333 – 3331S-geranylgeranyl cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiO95755.
PaxDbiO95755.
PRIDEiO95755.

2D gel databases

REPRODUCTION-2DPAGEO95755.

PTM databases

PhosphoSiteiO95755.

Expressioni

Tissue specificityi

Ubiquitously present in all tissues examined.

Gene expression databases

BgeeiO95755.
CleanExiHS_RAB36.
GenevestigatoriO95755.

Interactioni

Protein-protein interaction databases

BioGridi114971. 2 interactions.
STRINGi9606.ENSP00000263116.

Structurei

3D structure databases

ProteinModelPortaliO95755.
SMRiO95755. Positions 123-284.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi152 – 1609Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiO95755.
KOiK07922.
OMAiCLQLREH.
OrthoDBiEOG7MH10M.
PhylomeDBiO95755.
TreeFamiTF326626.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95755-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP    50
GRAEPQLSQP SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR 100
EHFHGQVSAA CQRRNTGTVG LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR 150
DYKATIGVDF EIERFEIAGI PYSLQIWDTA GQEKFKCIAS AYYRGAQVII 200
TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD LLSGAACEQA 250
EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS 300
SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC 333
Length:333
Mass (Da):36,322
Last modified:April 26, 2004 - v2
Checksum:iFFDD522F6DE40A2D
GO
Isoform 2 (identifier: O95755-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-142: Missing.

Note: No experimental confirmation available.

Show »
Length:311
Mass (Da):33,915
Checksum:i03099737E46D6D13
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501P → L.
Corresponds to variant rs9624036 [ dbSNP | Ensembl ].
VAR_034433
Natural varianti308 – 3081N → D.1 Publication
Corresponds to variant rs5759612 [ dbSNP | Ensembl ].
VAR_024189
Natural varianti320 – 3201E → K.
Corresponds to variant rs9624038 [ dbSNP | Ensembl ].
VAR_051715

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 14222Missing in isoform 2. VSP_010143Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421I → N in AAQ16115. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023061 mRNA. Translation: BAA75195.1.
AF133588 mRNA. Translation: AAF02485.1.
AY336745 mRNA. Translation: AAQ16115.1.
CR456553 mRNA. Translation: CAG30439.1.
BC104989 mRNA. Translation: AAI04990.1.
BC104991 mRNA. Translation: AAI04992.1.
CCDSiCCDS13805.1. [O95755-1]
RefSeqiNP_004905.2. NM_004914.2. [O95755-1]
UniGeneiHs.369557.

Genome annotation databases

EnsembliENST00000263116; ENSP00000263116; ENSG00000100228. [O95755-1]
ENST00000341989; ENSP00000343494; ENSG00000100228. [O95755-2]
GeneIDi9609.
KEGGihsa:9609.
UCSCiuc002zwv.1. human. [O95755-1]
uc010gtw.1. human. [O95755-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023061 mRNA. Translation: BAA75195.1 .
AF133588 mRNA. Translation: AAF02485.1 .
AY336745 mRNA. Translation: AAQ16115.1 .
CR456553 mRNA. Translation: CAG30439.1 .
BC104989 mRNA. Translation: AAI04990.1 .
BC104991 mRNA. Translation: AAI04992.1 .
CCDSi CCDS13805.1. [O95755-1 ]
RefSeqi NP_004905.2. NM_004914.2. [O95755-1 ]
UniGenei Hs.369557.

3D structure databases

ProteinModelPortali O95755.
SMRi O95755. Positions 123-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114971. 2 interactions.
STRINGi 9606.ENSP00000263116.

PTM databases

PhosphoSitei O95755.

2D gel databases

REPRODUCTION-2DPAGE O95755.

Proteomic databases

MaxQBi O95755.
PaxDbi O95755.
PRIDEi O95755.

Protocols and materials databases

DNASUi 9609.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263116 ; ENSP00000263116 ; ENSG00000100228 . [O95755-1 ]
ENST00000341989 ; ENSP00000343494 ; ENSG00000100228 . [O95755-2 ]
GeneIDi 9609.
KEGGi hsa:9609.
UCSCi uc002zwv.1. human. [O95755-1 ]
uc010gtw.1. human. [O95755-2 ]

Organism-specific databases

CTDi 9609.
GeneCardsi GC22P023487.
H-InvDB HIX0027922.
HGNCi HGNC:9775. RAB36.
MIMi 605662. gene.
neXtProti NX_O95755.
PharmGKBi PA34128.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233970.
HOVERGENi HBG106693.
InParanoidi O95755.
KOi K07922.
OMAi CLQLREH.
OrthoDBi EOG7MH10M.
PhylomeDBi O95755.
TreeFami TF326626.

Miscellaneous databases

ChiTaRSi RAB36. human.
GeneWikii RAB36.
GenomeRNAii 9609.
NextBioi 36047.
PROi O95755.
SOURCEi Search...

Gene expression databases

Bgeei O95755.
CleanExi HS_RAB36.
Genevestigatori O95755.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors."
    Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T., Nakamura Y., Inazawa J.
    Biochem. Biophys. Res. Commun. 254:594-600(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-308.
  2. "Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2."
    Zhou J.-Y., Fogelgren B., Wang Z., Roe B.A., Biegel J.A.
    Gene 241:133-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Shen C., Zhong G., Zheng G., Li H., Zhou G., Ke R., Yu R., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRAB36_HUMAN
AccessioniPrimary (citable) accession number: O95755
Secondary accession number(s): Q2M390, Q7Z4A9, Q9UHP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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