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O95755 (RAB36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-36
Gene names
Name:RAB36
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein transport. Probably involved in vesicular traffic By similarity.

Subcellular location

Golgi apparatus membrane; Lipid-anchor.

Tissue specificity

Ubiquitously present in all tissues examined.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandGTP-binding
Nucleotide-binding
   PTMLipoprotein
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentGolgi apparatus

Traceable author statement Ref.1. Source: ProtInc

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95755-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95755-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-142: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Ras-related protein Rab-36
PRO_0000121248

Regions

Nucleotide binding130 – 1378GTP By similarity
Nucleotide binding178 – 1825GTP By similarity
Nucleotide binding237 – 2404GTP By similarity
Motif152 – 1609Effector region By similarity

Amino acid modifications

Lipidation3321S-geranylgeranyl cysteine Potential
Lipidation3331S-geranylgeranyl cysteine Potential

Natural variations

Alternative sequence121 – 14222Missing in isoform 2.
VSP_010143
Natural variant501P → L.
Corresponds to variant rs9624036 [ dbSNP | Ensembl ].
VAR_034433
Natural variant3081N → D. Ref.1
Corresponds to variant rs5759612 [ dbSNP | Ensembl ].
VAR_024189
Natural variant3201E → K.
Corresponds to variant rs9624038 [ dbSNP | Ensembl ].
VAR_051715

Experimental info

Sequence conflict421I → N in AAQ16115. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2004. Version 2.
Checksum: FFDD522F6DE40A2D

FASTA33336,322
        10         20         30         40         50         60 
MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP GRAEPQLSQP 

        70         80         90        100        110        120 
SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR EHFHGQVSAA CQRRNTGTVG 

       130        140        150        160        170        180 
LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR DYKATIGVDF EIERFEIAGI PYSLQIWDTA 

       190        200        210        220        230        240 
GQEKFKCIAS AYYRGAQVII TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD 

       250        260        270        280        290        300 
LLSGAACEQA EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS 

       310        320        330 
SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC 

« Hide

Isoform 2 [UniParc].

Checksum: 03099737E46D6D13
Show »

FASTA31133,915

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors."
Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T., Nakamura Y., Inazawa J.
Biochem. Biophys. Res. Commun. 254:594-600(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-308.
[2]"Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2."
Zhou J.-Y., Fogelgren B., Wang Z., Roe B.A., Biegel J.A.
Gene 241:133-141(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]Shen C., Zhong G., Zheng G., Li H., Zhou G., Ke R., Yu R., Lin L., Yang S.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023061 mRNA. Translation: BAA75195.1.
AF133588 mRNA. Translation: AAF02485.1.
AY336745 mRNA. Translation: AAQ16115.1.
CR456553 mRNA. Translation: CAG30439.1.
BC104989 mRNA. Translation: AAI04990.1.
BC104991 mRNA. Translation: AAI04992.1.
CCDSCCDS13805.1. [O95755-1]
RefSeqNP_004905.2. NM_004914.2. [O95755-1]
UniGeneHs.369557.

3D structure databases

ProteinModelPortalO95755.
SMRO95755. Positions 123-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114971. 2 interactions.
STRING9606.ENSP00000263116.

PTM databases

PhosphoSiteO95755.

2D gel databases

REPRODUCTION-2DPAGEO95755.

Proteomic databases

MaxQBO95755.
PaxDbO95755.
PRIDEO95755.

Protocols and materials databases

DNASU9609.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263116; ENSP00000263116; ENSG00000100228. [O95755-1]
ENST00000341989; ENSP00000343494; ENSG00000100228. [O95755-2]
GeneID9609.
KEGGhsa:9609.
UCSCuc002zwv.1. human. [O95755-1]
uc010gtw.1. human. [O95755-2]

Organism-specific databases

CTD9609.
GeneCardsGC22P023487.
H-InvDBHIX0027922.
HGNCHGNC:9775. RAB36.
MIM605662. gene.
neXtProtNX_O95755.
PharmGKBPA34128.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233970.
HOVERGENHBG106693.
InParanoidO95755.
KOK07922.
OMACLQLREH.
OrthoDBEOG7MH10M.
PhylomeDBO95755.
TreeFamTF326626.

Gene expression databases

BgeeO95755.
CleanExHS_RAB36.
GenevestigatorO95755.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRAB36. human.
GeneWikiRAB36.
GenomeRNAi9609.
NextBio36047.
PROO95755.
SOURCESearch...

Entry information

Entry nameRAB36_HUMAN
AccessionPrimary (citable) accession number: O95755
Secondary accession number(s): Q2M390, Q7Z4A9, Q9UHP5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM