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O95755

- RAB36_HUMAN

UniProt

O95755 - RAB36_HUMAN

Protein

Ras-related protein Rab-36

Gene

RAB36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi130 – 1378GTPBy similarity
    Nucleotide bindingi178 – 1825GTPBy similarity
    Nucleotide bindingi237 – 2404GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-36
    Gene namesi
    Name:RAB36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:9775. RAB36.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: ProtInc
    2. Golgi membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34128.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Ras-related protein Rab-36PRO_0000121248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi332 – 3321S-geranylgeranyl cysteineSequence Analysis
    Lipidationi333 – 3331S-geranylgeranyl cysteineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiO95755.
    PaxDbiO95755.
    PRIDEiO95755.

    2D gel databases

    REPRODUCTION-2DPAGEO95755.

    PTM databases

    PhosphoSiteiO95755.

    Expressioni

    Tissue specificityi

    Ubiquitously present in all tissues examined.

    Gene expression databases

    BgeeiO95755.
    CleanExiHS_RAB36.
    GenevestigatoriO95755.

    Interactioni

    Protein-protein interaction databases

    BioGridi114971. 2 interactions.
    STRINGi9606.ENSP00000263116.

    Structurei

    3D structure databases

    ProteinModelPortaliO95755.
    SMRiO95755. Positions 123-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi152 – 1609Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233970.
    HOVERGENiHBG106693.
    InParanoidiO95755.
    KOiK07922.
    OMAiCLQLREH.
    OrthoDBiEOG7MH10M.
    PhylomeDBiO95755.
    TreeFamiTF326626.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95755-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP    50
    GRAEPQLSQP SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR 100
    EHFHGQVSAA CQRRNTGTVG LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR 150
    DYKATIGVDF EIERFEIAGI PYSLQIWDTA GQEKFKCIAS AYYRGAQVII 200
    TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD LLSGAACEQA 250
    EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS 300
    SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC 333
    Length:333
    Mass (Da):36,322
    Last modified:April 26, 2004 - v2
    Checksum:iFFDD522F6DE40A2D
    GO
    Isoform 2 (identifier: O95755-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-142: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:311
    Mass (Da):33,915
    Checksum:i03099737E46D6D13
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421I → N in AAQ16115. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501P → L.
    Corresponds to variant rs9624036 [ dbSNP | Ensembl ].
    VAR_034433
    Natural varianti308 – 3081N → D.1 Publication
    Corresponds to variant rs5759612 [ dbSNP | Ensembl ].
    VAR_024189
    Natural varianti320 – 3201E → K.
    Corresponds to variant rs9624038 [ dbSNP | Ensembl ].
    VAR_051715

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei121 – 14222Missing in isoform 2. 1 PublicationVSP_010143Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023061 mRNA. Translation: BAA75195.1.
    AF133588 mRNA. Translation: AAF02485.1.
    AY336745 mRNA. Translation: AAQ16115.1.
    CR456553 mRNA. Translation: CAG30439.1.
    BC104989 mRNA. Translation: AAI04990.1.
    BC104991 mRNA. Translation: AAI04992.1.
    CCDSiCCDS13805.1. [O95755-1]
    RefSeqiNP_004905.2. NM_004914.2. [O95755-1]
    UniGeneiHs.369557.

    Genome annotation databases

    EnsembliENST00000263116; ENSP00000263116; ENSG00000100228. [O95755-1]
    ENST00000341989; ENSP00000343494; ENSG00000100228. [O95755-2]
    GeneIDi9609.
    KEGGihsa:9609.
    UCSCiuc002zwv.1. human. [O95755-1]
    uc010gtw.1. human. [O95755-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023061 mRNA. Translation: BAA75195.1 .
    AF133588 mRNA. Translation: AAF02485.1 .
    AY336745 mRNA. Translation: AAQ16115.1 .
    CR456553 mRNA. Translation: CAG30439.1 .
    BC104989 mRNA. Translation: AAI04990.1 .
    BC104991 mRNA. Translation: AAI04992.1 .
    CCDSi CCDS13805.1. [O95755-1 ]
    RefSeqi NP_004905.2. NM_004914.2. [O95755-1 ]
    UniGenei Hs.369557.

    3D structure databases

    ProteinModelPortali O95755.
    SMRi O95755. Positions 123-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114971. 2 interactions.
    STRINGi 9606.ENSP00000263116.

    PTM databases

    PhosphoSitei O95755.

    2D gel databases

    REPRODUCTION-2DPAGE O95755.

    Proteomic databases

    MaxQBi O95755.
    PaxDbi O95755.
    PRIDEi O95755.

    Protocols and materials databases

    DNASUi 9609.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263116 ; ENSP00000263116 ; ENSG00000100228 . [O95755-1 ]
    ENST00000341989 ; ENSP00000343494 ; ENSG00000100228 . [O95755-2 ]
    GeneIDi 9609.
    KEGGi hsa:9609.
    UCSCi uc002zwv.1. human. [O95755-1 ]
    uc010gtw.1. human. [O95755-2 ]

    Organism-specific databases

    CTDi 9609.
    GeneCardsi GC22P023487.
    H-InvDB HIX0027922.
    HGNCi HGNC:9775. RAB36.
    MIMi 605662. gene.
    neXtProti NX_O95755.
    PharmGKBi PA34128.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233970.
    HOVERGENi HBG106693.
    InParanoidi O95755.
    KOi K07922.
    OMAi CLQLREH.
    OrthoDBi EOG7MH10M.
    PhylomeDBi O95755.
    TreeFami TF326626.

    Miscellaneous databases

    ChiTaRSi RAB36. human.
    GeneWikii RAB36.
    GenomeRNAii 9609.
    NextBioi 36047.
    PROi O95755.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95755.
    CleanExi HS_RAB36.
    Genevestigatori O95755.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors."
      Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T., Nakamura Y., Inazawa J.
      Biochem. Biophys. Res. Commun. 254:594-600(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-308.
    2. "Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2."
      Zhou J.-Y., Fogelgren B., Wang Z., Roe B.A., Biegel J.A.
      Gene 241:133-141(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Shen C., Zhong G., Zheng G., Li H., Zhou G., Ke R., Yu R., Lin L., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiRAB36_HUMAN
    AccessioniPrimary (citable) accession number: O95755
    Secondary accession number(s): Q2M390, Q7Z4A9, Q9UHP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3