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O95754

- SEM4F_HUMAN

UniProt

O95754 - SEM4F_HUMAN

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Protein

Semaphorin-4F

Gene

SEMA4F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons.By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. negative regulation of axon extension Source: Ensembl
  4. nervous system development Source: ProtInc
  5. retinal ganglion cell axon guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-M
Short name:
Sema M
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:SEMA4F
Synonyms:SEMAM, SEMAW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10734. SEMA4F.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 659625ExtracellularSequence AnalysisAdd
BLAST
Transmembranei660 – 68021HelicalSequence AnalysisAdd
BLAST
Topological domaini681 – 77090CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: ProtInc
  5. postsynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 770736Semaphorin-4FPRO_0000032330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 122PROSITE-ProRule annotation
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi140 ↔ 149PROSITE-ProRule annotation
Disulfide bondi273 ↔ 384PROSITE-ProRule annotation
Disulfide bondi297 ↔ 343PROSITE-ProRule annotation
Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi513 ↔ 530PROSITE-ProRule annotation
Disulfide bondi522 ↔ 539PROSITE-ProRule annotation
Disulfide bondi587 ↔ 628PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95754.
PRIDEiO95754.

PTM databases

PhosphoSiteiO95754.

Expressioni

Gene expression databases

BgeeiO95754.
CleanExiHS_SEMA4F.
ExpressionAtlasiO95754. baseline and differential.
GenevestigatoriO95754.

Interactioni

Protein-protein interaction databases

BioGridi115764. 5 interactions.
MINTiMINT-3003200.
STRINGi9606.ENSP00000350547.

Structurei

3D structure databases

ProteinModelPortaliO95754.
SMRiO95754. Positions 40-632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 510469SemaPROSITE-ProRule annotationAdd
BLAST
Domaini512 – 56352PSIAdd
BLAST
Domaini580 – 63556Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258001.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG093234.
InParanoidiO95754.
KOiK06521.
OMAiCNRGLPV.
OrthoDBiEOG7KM5S4.
PhylomeDBiO95754.
TreeFamiTF352903.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: O95754-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA
60 70 80 90 100
DSCLTRFAVP HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI
110 120 130 140 150
DWMVPEAHRQ NCRKKGKKED ECHNFVQILA IANASHLLTC GTFAFDPKCG
160 170 180 190 200
VIDVSRFQQV ERLESGRGKC PFEPAQRSAA VMAGGVLYAA TVKNYLGTEP
210 220 230 240 250
IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD EDGDDEIYFF
260 270 280 290 300
FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP
310 320 330 340 350
EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI
360 370 380 390 400
RTVLNGPFRE LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL
410 420 430 440 450
PDRVLTFIRD HPLMDRPVFP ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY
460 470 480 490 500
DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL FPEPQPVENM KLYHSWLLVG
510 520 530 540 550
SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV AHAGEHRGLV
560 570 580 590 600
QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ
610 620 630 640 650
PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR
660 670 680 690 700
DAPSRAHTVG AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL
710 720 730 740 750
DLGAPPSGTT SYSQDPPSPS PEDERLPLAL AKRGSGFGGF SPPFLLDPCP
760 770
SPAHIRLTGA PLATCDETSI
Length:770
Mass (Da):83,511
Last modified:May 30, 2000 - v2
Checksum:iCFBB74B41DF0E9C8
GO
Isoform Short (identifier: O95754-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-274: Missing.

Show »
Length:615
Mass (Da):66,477
Checksum:i43FBD465AFC6AEAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti533 – 5331S → N in BAA75631. (PubMed:10051670)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 274155Missing in isoform Short. 2 PublicationsVSP_006043Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022317 mRNA. Translation: BAA75631.1.
AL136552 mRNA. Translation: CAB66487.1.
AK075384 mRNA. Translation: BAC11584.1.
AC006544 Genomic DNA. No translation available.
BC018361 mRNA. Translation: AAH18361.1.
BC038411 mRNA. Translation: AAH38411.1.
AF053369 mRNA. Translation: AAF80660.1.
CCDSiCCDS1955.1. [O95754-1]
CCDS62942.1. [O95754-2]
RefSeqiNP_001258590.1. NM_001271661.1. [O95754-2]
NP_001258591.1. NM_001271662.1.
NP_004254.2. NM_004263.4. [O95754-1]
UniGeneiHs.25887.

Genome annotation databases

EnsembliENST00000339773; ENSP00000342675; ENSG00000135622. [O95754-2]
ENST00000357877; ENSP00000350547; ENSG00000135622. [O95754-1]
GeneIDi10505.
KEGGihsa:10505.
UCSCiuc002sna.2. human. [O95754-1]
uc002snb.2. human. [O95754-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022317 mRNA. Translation: BAA75631.1 .
AL136552 mRNA. Translation: CAB66487.1 .
AK075384 mRNA. Translation: BAC11584.1 .
AC006544 Genomic DNA. No translation available.
BC018361 mRNA. Translation: AAH18361.1 .
BC038411 mRNA. Translation: AAH38411.1 .
AF053369 mRNA. Translation: AAF80660.1 .
CCDSi CCDS1955.1. [O95754-1 ]
CCDS62942.1. [O95754-2 ]
RefSeqi NP_001258590.1. NM_001271661.1. [O95754-2 ]
NP_001258591.1. NM_001271662.1.
NP_004254.2. NM_004263.4. [O95754-1 ]
UniGenei Hs.25887.

3D structure databases

ProteinModelPortali O95754.
SMRi O95754. Positions 40-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115764. 5 interactions.
MINTi MINT-3003200.
STRINGi 9606.ENSP00000350547.

PTM databases

PhosphoSitei O95754.

Proteomic databases

PaxDbi O95754.
PRIDEi O95754.

Protocols and materials databases

DNASUi 10505.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339773 ; ENSP00000342675 ; ENSG00000135622 . [O95754-2 ]
ENST00000357877 ; ENSP00000350547 ; ENSG00000135622 . [O95754-1 ]
GeneIDi 10505.
KEGGi hsa:10505.
UCSCi uc002sna.2. human. [O95754-1 ]
uc002snb.2. human. [O95754-2 ]

Organism-specific databases

CTDi 10505.
GeneCardsi GC02P074793.
HGNCi HGNC:10734. SEMA4F.
MIMi 603706. gene.
neXtProti NX_O95754.
PharmGKBi PA35656.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258001.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000116087.
HOVERGENi HBG093234.
InParanoidi O95754.
KOi K06521.
OMAi CNRGLPV.
OrthoDBi EOG7KM5S4.
PhylomeDBi O95754.
TreeFami TF352903.

Miscellaneous databases

GeneWikii SEMA4F.
GenomeRNAii 10505.
NextBioi 39852.
PROi O95754.
SOURCEi Search...

Gene expression databases

Bgeei O95754.
CleanExi HS_SEMA4F.
ExpressionAtlasi O95754. baseline and differential.
Genevestigatori O95754.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
    Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
    Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Amygdala.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.
  6. "Large-scale comparative sequence analysis of human and mouse genomic DNA in the mnd2 region of mouse chromosome 6 reveals coding regions of three new genes."
    Jang W., Spilson S.V., Hua A., Roe B., Meisler M.H.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-770.

Entry informationi

Entry nameiSEM4F_HUMAN
AccessioniPrimary (citable) accession number: O95754
Secondary accession number(s): Q542Y7, Q9NS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3