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O95754

- SEM4F_HUMAN

UniProt

O95754 - SEM4F_HUMAN

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Protein
Semaphorin-4F
Gene
SEMA4F, SEMAM, SEMAW
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. negative regulation of axon extension Source: Ensembl
  4. nervous system development Source: ProtInc
  5. retinal ganglion cell axon guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-M
Short name:
Sema M
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:SEMA4F
Synonyms:SEMAM, SEMAW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10734. SEMA4F.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 659625Extracellular Reviewed prediction
Add
BLAST
Transmembranei660 – 68021Helical; Reviewed prediction
Add
BLAST
Topological domaini681 – 77090Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: ProtInc
  5. postsynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 770736Semaphorin-4F
PRO_0000032330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 122 By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 149 By similarity
Disulfide bondi273 ↔ 384 By similarity
Disulfide bondi297 ↔ 343 By similarity
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi513 ↔ 530 By similarity
Disulfide bondi522 ↔ 539 By similarity
Disulfide bondi587 ↔ 628 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95754.
PRIDEiO95754.

PTM databases

PhosphoSiteiO95754.

Expressioni

Gene expression databases

ArrayExpressiO95754.
BgeeiO95754.
CleanExiHS_SEMA4F.
GenevestigatoriO95754.

Interactioni

Protein-protein interaction databases

MINTiMINT-3003200.
STRINGi9606.ENSP00000350547.

Structurei

3D structure databases

ProteinModelPortaliO95754.
SMRiO95754. Positions 40-632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 510469Sema
Add
BLAST
Domaini512 – 56352PSI
Add
BLAST
Domaini580 – 63556Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258001.
HOGENOMiHOG000116087.
HOVERGENiHBG093234.
InParanoidiO95754.
KOiK06521.
OMAiCNRGLPV.
OrthoDBiEOG7KM5S4.
PhylomeDBiO95754.
TreeFamiTF352903.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: O95754-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA    50
DSCLTRFAVP HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI 100
DWMVPEAHRQ NCRKKGKKED ECHNFVQILA IANASHLLTC GTFAFDPKCG 150
VIDVSRFQQV ERLESGRGKC PFEPAQRSAA VMAGGVLYAA TVKNYLGTEP 200
IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD EDGDDEIYFF 250
FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP 300
EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI 350
RTVLNGPFRE LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL 400
PDRVLTFIRD HPLMDRPVFP ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY 450
DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL FPEPQPVENM KLYHSWLLVG 500
SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV AHAGEHRGLV 550
QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ 600
PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR 650
DAPSRAHTVG AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL 700
DLGAPPSGTT SYSQDPPSPS PEDERLPLAL AKRGSGFGGF SPPFLLDPCP 750
SPAHIRLTGA PLATCDETSI 770
Length:770
Mass (Da):83,511
Last modified:May 30, 2000 - v2
Checksum:iCFBB74B41DF0E9C8
GO
Isoform Short (identifier: O95754-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-274: Missing.

Show »
Length:615
Mass (Da):66,477
Checksum:i43FBD465AFC6AEAD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 274155Missing in isoform Short.
VSP_006043Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti533 – 5331S → N in BAA75631. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022317 mRNA. Translation: BAA75631.1.
AL136552 mRNA. Translation: CAB66487.1.
AK075384 mRNA. Translation: BAC11584.1.
AC006544 Genomic DNA. No translation available.
BC018361 mRNA. Translation: AAH18361.1.
BC038411 mRNA. Translation: AAH38411.1.
AF053369 mRNA. Translation: AAF80660.1.
CCDSiCCDS1955.1. [O95754-1]
CCDS62942.1. [O95754-2]
RefSeqiNP_001258590.1. NM_001271661.1. [O95754-2]
NP_001258591.1. NM_001271662.1.
NP_004254.2. NM_004263.4. [O95754-1]
UniGeneiHs.25887.

Genome annotation databases

EnsembliENST00000339773; ENSP00000342675; ENSG00000135622. [O95754-2]
ENST00000357877; ENSP00000350547; ENSG00000135622. [O95754-1]
GeneIDi10505.
KEGGihsa:10505.
UCSCiuc002sna.2. human. [O95754-1]
uc002snb.2. human. [O95754-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022317 mRNA. Translation: BAA75631.1 .
AL136552 mRNA. Translation: CAB66487.1 .
AK075384 mRNA. Translation: BAC11584.1 .
AC006544 Genomic DNA. No translation available.
BC018361 mRNA. Translation: AAH18361.1 .
BC038411 mRNA. Translation: AAH38411.1 .
AF053369 mRNA. Translation: AAF80660.1 .
CCDSi CCDS1955.1. [O95754-1 ]
CCDS62942.1. [O95754-2 ]
RefSeqi NP_001258590.1. NM_001271661.1. [O95754-2 ]
NP_001258591.1. NM_001271662.1.
NP_004254.2. NM_004263.4. [O95754-1 ]
UniGenei Hs.25887.

3D structure databases

ProteinModelPortali O95754.
SMRi O95754. Positions 40-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-3003200.
STRINGi 9606.ENSP00000350547.

PTM databases

PhosphoSitei O95754.

Proteomic databases

PaxDbi O95754.
PRIDEi O95754.

Protocols and materials databases

DNASUi 10505.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339773 ; ENSP00000342675 ; ENSG00000135622 . [O95754-2 ]
ENST00000357877 ; ENSP00000350547 ; ENSG00000135622 . [O95754-1 ]
GeneIDi 10505.
KEGGi hsa:10505.
UCSCi uc002sna.2. human. [O95754-1 ]
uc002snb.2. human. [O95754-2 ]

Organism-specific databases

CTDi 10505.
GeneCardsi GC02P074793.
HGNCi HGNC:10734. SEMA4F.
MIMi 603706. gene.
neXtProti NX_O95754.
PharmGKBi PA35656.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258001.
HOGENOMi HOG000116087.
HOVERGENi HBG093234.
InParanoidi O95754.
KOi K06521.
OMAi CNRGLPV.
OrthoDBi EOG7KM5S4.
PhylomeDBi O95754.
TreeFami TF352903.

Miscellaneous databases

GeneWikii SEMA4F.
GenomeRNAii 10505.
NextBioi 39852.
PROi O95754.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95754.
Bgeei O95754.
CleanExi HS_SEMA4F.
Genevestigatori O95754.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
    Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
    Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Amygdala.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.
  6. "Large-scale comparative sequence analysis of human and mouse genomic DNA in the mnd2 region of mouse chromosome 6 reveals coding regions of three new genes."
    Jang W., Spilson S.V., Hua A., Roe B., Meisler M.H.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-770.

Entry informationi

Entry nameiSEM4F_HUMAN
AccessioniPrimary (citable) accession number: O95754
Secondary accession number(s): Q542Y7, Q9NS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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