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O95751

- LDOC1_HUMAN

UniProt

O95751 - LDOC1_HUMAN

Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have an important role in the development and/or progression of some cancers.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of cell proliferation Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LDOC1
    Alternative name(s):
    Leucine zipper protein down-regulated in cancer cells
    Gene namesi
    Name:LDOC1
    Synonyms:BCUR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6548. LDOC1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30329.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 146146Protein LDOC1PRO_0000084391Add
    BLAST

    Proteomic databases

    MaxQBiO95751.
    PaxDbiO95751.
    PRIDEiO95751.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

    Gene expression databases

    BgeeiO95751.
    CleanExiHS_LDOC1.
    GenevestigatoriO95751.

    Organism-specific databases

    HPAiHPA051768.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABLIM1O146392EBI-740738,EBI-487024
    AP1M1Q9BXS53EBI-740738,EBI-541426
    FOSL1P154073EBI-740738,EBI-744510
    FXR2P511163EBI-740738,EBI-740459
    HTTP428585EBI-740738,EBI-466029
    NRIP1P485523EBI-740738,EBI-746484
    ZNF408Q9H9D43EBI-740738,EBI-347633

    Protein-protein interaction databases

    BioGridi117169. 33 interactions.
    IntActiO95751. 36 interactions.
    MINTiMINT-1216573.
    STRINGi9606.ENSP00000359557.

    Structurei

    3D structure databases

    ProteinModelPortaliO95751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi132 – 14514Asp/Glu-rich (highly acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the LDOC1 family.Curated

    Phylogenomic databases

    eggNOGiNOG46550.
    HOGENOMiHOG000049195.
    HOVERGENiHBG052318.
    InParanoidiO95751.
    OMAiEFIVQTT.
    OrthoDBiEOG76HQ3K.
    PhylomeDBiO95751.
    TreeFamiTF337843.

    Family and domain databases

    InterProiIPR029750. LDOC1.
    [Graphical view]
    PANTHERiPTHR15503:SF3. PTHR15503:SF3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O95751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP    50
    VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA 100
    EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY 146
    Length:146
    Mass (Da):16,968
    Last modified:May 1, 1999 - v1
    Checksum:i3D02813B2DE52DBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019527 mRNA. Translation: BAA34364.1.
    CR457088 mRNA. Translation: CAG33369.1.
    AL109799 Genomic DNA. Translation: CAC18891.1.
    BC003104 mRNA. Translation: AAH03104.1.
    CCDSiCCDS14672.1.
    RefSeqiNP_036449.1. NM_012317.3.
    UniGeneiHs.45231.

    Genome annotation databases

    EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
    GeneIDi23641.
    KEGGihsa:23641.
    UCSCiuc004fbj.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019527 mRNA. Translation: BAA34364.1 .
    CR457088 mRNA. Translation: CAG33369.1 .
    AL109799 Genomic DNA. Translation: CAC18891.1 .
    BC003104 mRNA. Translation: AAH03104.1 .
    CCDSi CCDS14672.1.
    RefSeqi NP_036449.1. NM_012317.3.
    UniGenei Hs.45231.

    3D structure databases

    ProteinModelPortali O95751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117169. 33 interactions.
    IntActi O95751. 36 interactions.
    MINTi MINT-1216573.
    STRINGi 9606.ENSP00000359557.

    Proteomic databases

    MaxQBi O95751.
    PaxDbi O95751.
    PRIDEi O95751.

    Protocols and materials databases

    DNASUi 23641.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370526 ; ENSP00000359557 ; ENSG00000182195 .
    GeneIDi 23641.
    KEGGi hsa:23641.
    UCSCi uc004fbj.3. human.

    Organism-specific databases

    CTDi 23641.
    GeneCardsi GC0XM140269.
    HGNCi HGNC:6548. LDOC1.
    HPAi HPA051768.
    MIMi 300402. gene.
    neXtProti NX_O95751.
    PharmGKBi PA30329.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46550.
    HOGENOMi HOG000049195.
    HOVERGENi HBG052318.
    InParanoidi O95751.
    OMAi EFIVQTT.
    OrthoDBi EOG76HQ3K.
    PhylomeDBi O95751.
    TreeFami TF337843.

    Miscellaneous databases

    GeneWikii LDOC1.
    GenomeRNAii 23641.
    NextBioi 46442.
    PROi O95751.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95751.
    CleanExi HS_LDOC1.
    Genevestigatori O95751.

    Family and domain databases

    InterProi IPR029750. LDOC1.
    [Graphical view ]
    PANTHERi PTHR15503:SF3. PTHR15503:SF3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines."
      Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K.
      Cancer Lett. 140:227-234(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Fetal brain.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiLDOC1_HUMAN
    AccessioniPrimary (citable) accession number: O95751
    Secondary accession number(s): Q6IAR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3