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O95751

- LDOC1_HUMAN

UniProt

O95751 - LDOC1_HUMAN

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Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May have an important role in the development and/or progression of some cancers.

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDOC1
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells
Gene namesi
Name:LDOC1
Synonyms:BCUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6548. LDOC1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Protein LDOC1PRO_0000084391Add
BLAST

Proteomic databases

MaxQBiO95751.
PaxDbiO95751.
PRIDEiO95751.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

Gene expression databases

BgeeiO95751.
CleanExiHS_LDOC1.
GenevestigatoriO95751.

Organism-specific databases

HPAiHPA051768.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABLIM1O146392EBI-740738,EBI-487024
AP1M1Q9BXS53EBI-740738,EBI-541426
FOSL1P154073EBI-740738,EBI-744510
FXR2P511163EBI-740738,EBI-740459
HTTP428585EBI-740738,EBI-466029
NRIP1P485523EBI-740738,EBI-746484
ZNF408Q9H9D43EBI-740738,EBI-347633

Protein-protein interaction databases

BioGridi117169. 35 interactions.
IntActiO95751. 36 interactions.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Structurei

3D structure databases

ProteinModelPortaliO95751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 14514Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Phylogenomic databases

eggNOGiNOG46550.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiEFIVQTT.
OrthoDBiEOG76HQ3K.
PhylomeDBiO95751.
TreeFamiTF337843.

Family and domain databases

InterProiIPR029750. LDOC1.
[Graphical view]
PANTHERiPTHR15503:SF3. PTHR15503:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

O95751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Length:146
Mass (Da):16,968
Last modified:May 1, 1999 - v1
Checksum:i3D02813B2DE52DBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019527 mRNA. Translation: BAA34364.1 .
CR457088 mRNA. Translation: CAG33369.1 .
AL109799 Genomic DNA. Translation: CAC18891.1 .
BC003104 mRNA. Translation: AAH03104.1 .
CCDSi CCDS14672.1.
RefSeqi NP_036449.1. NM_012317.3.
UniGenei Hs.45231.

3D structure databases

ProteinModelPortali O95751.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117169. 35 interactions.
IntActi O95751. 36 interactions.
MINTi MINT-1216573.
STRINGi 9606.ENSP00000359557.

Proteomic databases

MaxQBi O95751.
PaxDbi O95751.
PRIDEi O95751.

Protocols and materials databases

DNASUi 23641.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370526 ; ENSP00000359557 ; ENSG00000182195 .
GeneIDi 23641.
KEGGi hsa:23641.
UCSCi uc004fbj.3. human.

Organism-specific databases

CTDi 23641.
GeneCardsi GC0XM140269.
HGNCi HGNC:6548. LDOC1.
HPAi HPA051768.
MIMi 300402. gene.
neXtProti NX_O95751.
PharmGKBi PA30329.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46550.
GeneTreei ENSGT00510000047956.
HOGENOMi HOG000049195.
HOVERGENi HBG052318.
InParanoidi O95751.
OMAi EFIVQTT.
OrthoDBi EOG76HQ3K.
PhylomeDBi O95751.
TreeFami TF337843.

Miscellaneous databases

GeneWikii LDOC1.
GenomeRNAii 23641.
NextBioi 46442.
PROi O95751.
SOURCEi Search...

Gene expression databases

Bgeei O95751.
CleanExi HS_LDOC1.
Genevestigatori O95751.

Family and domain databases

InterProi IPR029750. LDOC1.
[Graphical view ]
PANTHERi PTHR15503:SF3. PTHR15503:SF3. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines."
    Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K.
    Cancer Lett. 140:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLDOC1_HUMAN
AccessioniPrimary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3