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Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in the development and/or progression of some cancers.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDOC1
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells
Gene namesi
Name:LDOC1
Synonyms:BCUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182195.7.
HGNCiHGNC:6548. LDOC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23641.
OpenTargetsiENSG00000182195.
PharmGKBiPA30329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843911 – 146Protein LDOC1Add BLAST146

Proteomic databases

EPDiO95751.
MaxQBiO95751.
PaxDbiO95751.
PeptideAtlasiO95751.
PRIDEiO95751.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

Gene expression databases

BgeeiENSG00000182195.
CleanExiHS_LDOC1.
GenevisibleiO95751. HS.

Organism-specific databases

HPAiHPA051768.
HPA061842.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABLIM1O146392EBI-740738,EBI-487024
AESQ081173EBI-740738,EBI-717810
AP1M1Q9BXS55EBI-740738,EBI-541426
ATF4P188487EBI-740738,EBI-492498
ATP6V1G1O753483EBI-740738,EBI-711802
BARD1A0AVN23EBI-740738,EBI-9977322
BARD1Q997285EBI-740738,EBI-473181
C1orf109Q9NX043EBI-740738,EBI-8643161
CTNNBL1Q8WYA63EBI-740738,EBI-748128
DPF2Q927855EBI-740738,EBI-359932
DPPA4Q7L1906EBI-740738,EBI-710457
FAM110AQ9BQ894EBI-740738,EBI-1752811
FAM208BQ5VWN6-23EBI-740738,EBI-10172380
FAM50BQ9Y2474EBI-740738,EBI-742802
FAM90A1Q86YD75EBI-740738,EBI-6658203
FAP7Q120553EBI-740738,EBI-22197From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
FAR7P435924EBI-740738,EBI-22932From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
FOSL1P154073EBI-740738,EBI-744510
FXR2P511163EBI-740738,EBI-740459
GNL3LQ9NVN83EBI-740738,EBI-746682
HAUS1Q96CS23EBI-740738,EBI-2514791
HDAC4P565243EBI-740738,EBI-308629
HGSO149648EBI-740738,EBI-740220
HTTP428585EBI-740738,EBI-466029
KRR1P255863EBI-740738,EBI-21773From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
LATS1Q6PJG33EBI-740738,EBI-10253976
LENG1Q96BZ87EBI-740738,EBI-726510
MEAF6Q9HAF13EBI-740738,EBI-399266
MFAP1P550815EBI-740738,EBI-1048159
MHR1Q066303EBI-740738,EBI-36794From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
MRP4P329023EBI-740738,EBI-16248From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NRD1P536173EBI-740738,EBI-12228From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NRIP1P485523EBI-740738,EBI-746484
NXF1Q9UBU93EBI-740738,EBI-398874
PEG10Q86TG73EBI-740738,EBI-2858265
PLEKHF2Q9H8W44EBI-740738,EBI-742388
PRP45P280043EBI-740738,EBI-20640From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PRPF31Q8WWY38EBI-740738,EBI-1567797
PSMA1P257867EBI-740738,EBI-359352
PSY3Q123183EBI-740738,EBI-37340From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RAB7L1Q6FGU73EBI-740738,EBI-10249635
SDCBPO005605EBI-740738,EBI-727004
SH2D4AQ9H7885EBI-740738,EBI-747035
SMARCD1Q96GM53EBI-740738,EBI-358489
TBC1D7Q9P0N95EBI-740738,EBI-3258000
TNNT1P138053EBI-740738,EBI-726527
TTC23Q5W5X93EBI-740738,EBI-6447954
YPL077CQ028313EBI-740738,EBI-31828From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ZBTB16Q055165EBI-740738,EBI-711925
ZBTB24O431677EBI-740738,EBI-744471
ZGPATQ8N5A53EBI-740738,EBI-3439227
ZGPATQ8N5A5-23EBI-740738,EBI-10183064
ZNF124Q159734EBI-740738,EBI-2555767
ZNF250P15622-34EBI-740738,EBI-10177272
ZNF253O753462EBI-740738,EBI-1047617
ZNF408Q9H9D43EBI-740738,EBI-347633
ZNF564Q8TBZ83EBI-740738,EBI-10273713
ZNF774Q6NX453EBI-740738,EBI-10251462

Protein-protein interaction databases

BioGridi117169. 63 interactors.
IntActiO95751. 108 interactors.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Structurei

3D structure databases

ProteinModelPortaliO95751.
SMRiO95751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 145Asp/Glu-rich (highly acidic)Add BLAST14

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3P7. Eukaryota.
ENOG410Y6K0. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiQTTSYML.
OrthoDBiEOG091G02TH.
PhylomeDBiO95751.
TreeFamiTF337843.

Family and domain databases

InterProiView protein in InterPro
IPR032549. DUF4939.
IPR029750. LDOC1.
IPR032567. LDOC1-rel.
PANTHERiPTHR15503. PTHR15503. 1 hit.
PTHR15503:SF13. PTHR15503:SF13. 1 hit.
PfamiView protein in Pfam
PF16297. DUF4939. 1 hit.

Sequencei

Sequence statusi: Complete.

O95751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Length:146
Mass (Da):16,968
Last modified:May 1, 1999 - v1
Checksum:i3D02813B2DE52DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.5. human.

Similar proteinsi

Entry informationi

Entry nameiLDOC1_HUMAN
AccessioniPrimary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families