O95751 (LDOC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LDOC1

Alternative name(s):
Leucine zipper protein down-regulated in cancer cells

Gene names

Name:	LDOC1
Synonyms:	BCUR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have an important role in the development and/or progression of some cancers.
Subcellular location	Nucleus Ref.1.
Tissue specificity	Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined. Ref.1
Sequence similarities	Belongs to the LDOC1 family.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleus Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABLIM1	O14639	2	EBI-740738,EBI-487024
AP1M1	Q9BXS5	3	EBI-740738,EBI-541426
FOSL1	P15407	3	EBI-740738,EBI-744510
FXR2	P51116	3	EBI-740738,EBI-740459
NRIP1	P48552	3	EBI-740738,EBI-746484
ZNF408	Q9H9D4	3	EBI-740738,EBI-347633

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Protein LDOC1		PRO_0000084391
Regions
	Compositional bias	132 – 145	14	Asp/Glu-rich (highly acidic)

Sequences

	Sequence		Length	Mass (Da)
	O95751 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3D02813B2DE52DBE	FASTA	146	16,968
	10 20 30 40 50 60 MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP VPFPETFNGE 70 80 90 100 110 120 SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA EEWVVPYIEM DSPILGDYRA 130 140 FLDEMKQCFG WDDDEDDDDE EEEDDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel gene, LDOC1, down-regulated in cancer cell lines." Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K. Cancer Lett. 140:227-234(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Fetal brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB019527 mRNA. Translation: BAA34364.1. CR457088 mRNA. Translation: CAG33369.1. AL109799 Genomic DNA. Translation: CAC18891.1. BC003104 mRNA. Translation: AAH03104.1.
IPI	IPI00032909.
RefSeq	NP_036449.1. NM_012317.2.
UniGene	Hs.45231.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95751. 33 interactions.
MINT	MINT-1216573.
STRING	9606.ENSP00000359557.
Proteomic databases
PaxDb	O95751.
PRIDE	O95751.
Protocols and materials databases
DNASU	23641.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370526; ENSP00000359557; ENSG00000182195. ENST00000601624; ENSP00000473205; ENSG00000268691.
GeneID	23641.
KEGG	hsa:23641.
UCSC	uc004fbj.3. human.
Organism-specific databases
CTD	23641.
GeneCards	GC0XM140269.
HGNC	HGNC:6548. LDOC1.
HPA	HPA051768.
MIM	300402. gene.
neXtProt	NX_O95751.
PharmGKB	PA30329.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46550.
HOGENOM	HOG000049195.
HOVERGEN	HBG052318.
InParanoid	O95751.
OMA	EFIVQTT.
OrthoDB	EOG4H9XMZ.
PhylomeDB	O95751.
Gene expression databases
Bgee	O95751.
CleanEx	HS_LDOC1.
Genevestigator	O95751.
GermOnline	ENSG00000182195. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	23641.
NextBio	46442.
SOURCE	Search...

Entry information

Entry name

LDOC1_HUMAN

Accession

Primary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.