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Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in the development and/or progression of some cancers.

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDOC1
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells
Gene namesi
Name:LDOC1
Synonyms:BCUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6548. LDOC1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Protein LDOC1PRO_0000084391Add
BLAST

Proteomic databases

MaxQBiO95751.
PaxDbiO95751.
PRIDEiO95751.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

Gene expression databases

BgeeiO95751.
CleanExiHS_LDOC1.
GenevestigatoriO95751.

Organism-specific databases

HPAiHPA051768.
HPA061842.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABLIM1O146392EBI-740738,EBI-487024
AP1M1Q9BXS53EBI-740738,EBI-541426
FOSL1P154073EBI-740738,EBI-744510
FXR2P511163EBI-740738,EBI-740459
HTTP428585EBI-740738,EBI-466029
NRIP1P485523EBI-740738,EBI-746484
ZNF408Q9H9D43EBI-740738,EBI-347633

Protein-protein interaction databases

BioGridi117169. 63 interactions.
IntActiO95751. 36 interactions.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Structurei

3D structure databases

ProteinModelPortaliO95751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 14514Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Phylogenomic databases

eggNOGiNOG46550.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiEFIVQTT.
OrthoDBiEOG76HQ3K.
PhylomeDBiO95751.
TreeFamiTF337843.

Family and domain databases

InterProiIPR029750. LDOC1.
[Graphical view]
PANTHERiPTHR15503:SF3. PTHR15503:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

O95751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Length:146
Mass (Da):16,968
Last modified:May 1, 1999 - v1
Checksum:i3D02813B2DE52DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

3D structure databases

ProteinModelPortaliO95751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117169. 63 interactions.
IntActiO95751. 36 interactions.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Proteomic databases

MaxQBiO95751.
PaxDbiO95751.
PRIDEiO95751.

Protocols and materials databases

DNASUi23641.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.3. human.

Organism-specific databases

CTDi23641.
GeneCardsiGC0XM140269.
HGNCiHGNC:6548. LDOC1.
HPAiHPA051768.
HPA061842.
MIMi300402. gene.
neXtProtiNX_O95751.
PharmGKBiPA30329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46550.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiEFIVQTT.
OrthoDBiEOG76HQ3K.
PhylomeDBiO95751.
TreeFamiTF337843.

Miscellaneous databases

ChiTaRSiLDOC1. human.
GeneWikiiLDOC1.
GenomeRNAii23641.
NextBioi46442.
PROiO95751.
SOURCEiSearch...

Gene expression databases

BgeeiO95751.
CleanExiHS_LDOC1.
GenevestigatoriO95751.

Family and domain databases

InterProiIPR029750. LDOC1.
[Graphical view]
PANTHERiPTHR15503:SF3. PTHR15503:SF3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines."
    Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K.
    Cancer Lett. 140:227-234(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLDOC1_HUMAN
AccessioniPrimary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.