Reviewed,
UniProtKB/Swiss-Prot O95751 (LDOC1_HUMAN)
Last modified
December 15, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein LDOC1 Alternative name(s): Leucine zipper protein down-regulated in cancer cells | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 146 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May have an important role in the development and/or progression of some cancers. |
| Subcellular location | |
| Tissue specificity | Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined. Ref.1 |
| Sequence similarities | Belongs to the LDOC1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | nucleus Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ABLIM1 | O14639 | 1 | EBI-740738,EBI-487024 | |
| AP1M1 | Q9BXS5 | 2 | EBI-740738,EBI-541426 | |
| FOSL1 | P15407 | 2 | EBI-740738,EBI-744510 | |
| FXR2 | P51116 | 2 | EBI-740738,EBI-740459 | |
| NRIP1 | P48552 | 2 | EBI-740738,EBI-746484 | |
| ZNF408 | Q9H9D4 | 2 | EBI-740738,EBI-347633 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines." Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K. Cancer Lett. 140:227-234(1999) [PubMed: 10403563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Fetal brain. |
| [2] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB019527 mRNA. Translation: BAA34364.1. CR457088 mRNA. Translation: CAG33369.1. AL109799 Genomic DNA. Translation: CAC18891.1. BC003104 mRNA. Translation: AAH03104.1. | |
| IPI | IPI00032909. |
| RefSeq | NP_036449.1. |
| UniGene | Hs.45231 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O95751. 30 interactions. |
| STRING | O95751. |
Proteomic databases | |
| PRIDE | O95751. |
Genome annotation databases | |
| Ensembl | ENST00000370526; ENSP00000359557; ENSG00000182195; Homo sapiens. [Genome view] |
| GeneID | 23641. |
| KEGG | hsa:23641. |
| UCSC | uc004fbj.1. human. |
Organism-specific databases | |
| CTD | 23641. |
| GeneCards | GC0XM140097. |
| HGNC | HGNC:6548. LDOC1. |
| MIM | 300402. gene. |
| PharmGKB | PA30329. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG507242. |
| HOVERGEN | O95751. |
| InParanoid | O95751. |
| OMA | CNDAMKV. |
| OrthoDB | EOG9PK4T2. |
Gene expression databases | |
| ArrayExpress | O95751. |
| Bgee | O95751. |
| CleanEx | HS_LDOC1. |
| Genevestigator | O95751. |
| GermOnline | ENSG00000182195. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 46442. |
| SOURCE | Search... |
Entry information
| Entry name | LDOC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95751 Secondary accession number(s): Q6IAR6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


