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Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in the development and/or progression of some cancers.

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32807-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDOC1
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells
Gene namesi
Name:LDOC1
Synonyms:BCUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6548. LDOC1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23641.
OpenTargetsiENSG00000182195.
PharmGKBiPA30329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843911 – 146Protein LDOC1Add BLAST146

Proteomic databases

EPDiO95751.
MaxQBiO95751.
PaxDbiO95751.
PeptideAtlasiO95751.
PRIDEiO95751.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

Gene expression databases

BgeeiENSG00000182195.
CleanExiHS_LDOC1.
GenevisibleiO95751. HS.

Organism-specific databases

HPAiHPA051768.
HPA061842.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117169. 63 interactors.
IntActiO95751. 97 interactors.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Structurei

3D structure databases

ProteinModelPortaliO95751.
SMRiO95751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 145Asp/Glu-rich (highly acidic)Add BLAST14

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3P7. Eukaryota.
ENOG410Y6K0. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiQTTSYML.
OrthoDBiEOG091G02TH.
PhylomeDBiO95751.
TreeFamiTF337843.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR029750. LDOC1.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PTHR15503:SF3. PTHR15503:SF3. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Length:146
Mass (Da):16,968
Last modified:May 1, 1999 - v1
Checksum:i3D02813B2DE52DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA. Translation: BAA34364.1.
CR457088 mRNA. Translation: CAG33369.1.
AL109799 Genomic DNA. Translation: CAC18891.1.
BC003104 mRNA. Translation: AAH03104.1.
CCDSiCCDS14672.1.
RefSeqiNP_036449.1. NM_012317.3.
UniGeneiHs.45231.

3D structure databases

ProteinModelPortaliO95751.
SMRiO95751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117169. 63 interactors.
IntActiO95751. 97 interactors.
MINTiMINT-1216573.
STRINGi9606.ENSP00000359557.

Proteomic databases

EPDiO95751.
MaxQBiO95751.
PaxDbiO95751.
PeptideAtlasiO95751.
PRIDEiO95751.

Protocols and materials databases

DNASUi23641.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195.
GeneIDi23641.
KEGGihsa:23641.
UCSCiuc004fbj.5. human.

Organism-specific databases

CTDi23641.
DisGeNETi23641.
GeneCardsiLDOC1.
HGNCiHGNC:6548. LDOC1.
HPAiHPA051768.
HPA061842.
MIMi300402. gene.
neXtProtiNX_O95751.
OpenTargetsiENSG00000182195.
PharmGKBiPA30329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3P7. Eukaryota.
ENOG410Y6K0. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiO95751.
OMAiQTTSYML.
OrthoDBiEOG091G02TH.
PhylomeDBiO95751.
TreeFamiTF337843.

Enzyme and pathway databases

BioCyciZFISH:G66-32807-MONOMER.

Miscellaneous databases

ChiTaRSiLDOC1. human.
GeneWikiiLDOC1.
GenomeRNAii23641.
PROiO95751.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182195.
CleanExiHS_LDOC1.
GenevisibleiO95751. HS.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR029750. LDOC1.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PTHR15503:SF3. PTHR15503:SF3. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDOC1_HUMAN
AccessioniPrimary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.