ID   FGF19_HUMAN             Reviewed;         216 AA.
AC   O95750;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 88.
DE   RecName: Full=Fibroblast growth factor 19;
DE            Short=FGF-19;
DE   Flags: Precursor;
GN   Name=FGF19; ORFNames=UNQ334/PRO533;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=99132028; PubMed=9931477; DOI=10.1016/S0167-4781(98)00255-3;
RA   Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., Itoh N.;
RT   "Structure and expression of a novel human FGF, FGF-19, expressed in
RT   the fetal brain.";
RL   Biochim. Biophys. Acta 1444:148-151(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND RECEPTOR
RP   SPECIFICITY.
RX   PubMed=10525310; DOI=10.1006/cyto.1999.0485;
RA   Xie M.-H., Holcomb I., Deuel B., Dowd P., Huang A., Vagts A.,
RA   Foster J., Liang J., Brush J., Gu Q., Hillan K., Goddard A.,
RA   Gurney A.L.;
RT   "FGF-19, a novel fibroblast growth factor with unique specificity for
RT   FGFR4.";
RL   Cytokine 11:729-735(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 25-39.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [7]
RP   X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 39-196, AND DISULFIDE BONDS.
RX   PubMed=14730967; DOI=10.1021/bi035320k;
RA   Harmer N.J., Pellegrini L., Chirgadze D., Fernandez-Recio J.,
RA   Blundell T.L.;
RT   "The crystal structure of fibroblast growth factor (FGF) 19 reveals
RT   novel features of the FGF family and offers a structural basis for its
RT   unusual receptor affinity.";
RL   Biochemistry 43:629-640(2004).
CC   -!- FUNCTION: May be involved in brain development during
CC       embryogenesis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in fetal brain, cartilage, retina,
CC       and adult gall bladder.
CC   -!- MISCELLANEOUS: Contrarily to other members of the family that can
CC       bind several FGF receptors FGF19 is specific for FGFR4.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; AB018122; BAA75500.1; -; mRNA.
DR   EMBL; AF110400; AAD45973.1; -; mRNA.
DR   EMBL; AY358302; AAQ88669.1; -; mRNA.
DR   EMBL; BT006729; AAP35375.1; -; mRNA.
DR   EMBL; BC017664; AAH17664.1; -; mRNA.
DR   IPI; IPI00032908; -.
DR   RefSeq; NP_005108.1; -.
DR   UniGene; Hs.249200; -.
DR   PDB; 1PWA; X-ray; 1.30 A; A=39-196.
DR   PDB; 2P23; X-ray; 1.80 A; A/B=23-216.
DR   PDBsum; 1PWA; -.
DR   PDBsum; 2P23; -.
DR   DIP; DIP:6039N; -.
DR   PRIDE; O95750; -.
DR   Ensembl; ENSG00000162344; Homo sapiens.
DR   GeneID; 9965; -.
DR   KEGG; hsa:9965; -.
DR   GeneCards; GC11M069222; -.
DR   H-InvDB; HIX0009891; -.
DR   HGNC; HGNC:3675; FGF19.
DR   MIM; 603891; gene.
DR   PharmGKB; PA28114; -.
DR   HOGENOM; O95750; -.
DR   HOVERGEN; O95750; -.
DR   OMA; O95750; TDSMDPF.
DR   Pathway_Interaction_DB; fgf_pathway; FGF signaling pathway.
DR   Reactome; REACT_9470; Signaling by FGFR.
DR   NextBio; 37606; -.
DR   ArrayExpress; O95750; -.
DR   Bgee; O95750; -.
DR   CleanEx; HS_FGF19; -.
DR   GermOnline; ENSG00000162344; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; EXP:Reactome.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   InterPro; IPR017338; Fibroblast_GF_15/19/21.
DR   InterPro; IPR002209; GF_heparin_bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PIRSF; PIRSF037961; FGF-19_FGF-21; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL        1     24
FT   CHAIN        25    216       Fibroblast growth factor 19.
FT                                /FTId=PRO_0000008993.
FT   DISULFID     58     70
FT   DISULFID    102    120
FT   STRAND       42     49
FT   STRAND       58     62
FT   STRAND       66     73
FT   HELIX        76     78
FT   STRAND       80     86
FT   STRAND       89     94
FT   TURN         95     97
FT   STRAND      100    103
FT   HELIX       105    107
FT   STRAND      109    114
FT   HELIX       117    120
FT   STRAND      121    126
FT   STRAND      132    136
FT   TURN        137    140
FT   STRAND      165    168
SQ   SEQUENCE   216 AA;  24003 MW;  E0BCBC9C220F9832 CRC64;
     MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL
     RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC
     AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR
     GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK
//