O95750 (FGF19_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 123.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fibroblast growth factor 19 Short name=FGF-19 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Ref.7 Ref.8 Ref.9 Ref.11 |
| Subunit structure | Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Ref.2 Ref.8 Ref.9 Ref.10 Ref.14 |
| Subcellular location | |
| Tissue specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. Ref.2 |
| Induction | Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2. Ref.7 |
| Miscellaneous | Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Ref.6 | ||||||||||||||||||||||||||||||||||||
| Chain | 25 – 216 | 192 | Fibroblast growth factor 19 | PRO_0000008993 | |||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||
| Disulfide bond | 58 ↔ 70 | Ref.13 | |||||||||||||||||||||||||||||||||||||
| Disulfide bond | 102 ↔ 120 | Ref.13 | |||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 42 – 49 | 8 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 58 – 62 | 5 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 66 – 73 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 76 – 78 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 80 – 86 | 7 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 89 – 94 | 6 | |||||||||||||||||||||||||||||||||||||
| Turn | 95 – 97 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 100 – 103 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 105 – 107 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 109 – 114 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 117 – 120 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 121 – 126 | 6 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 132 – 136 | 5 | |||||||||||||||||||||||||||||||||||||
| Turn | 137 – 140 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 150 – 152 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 153 – 156 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 165 – 168 | 4 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain." Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., Itoh N. Biochim. Biophys. Acta 1444:148-151(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4." Xie M.-H., Holcomb I., Deuel B., Dowd P., Huang A., Vagts A., Foster J., Liang J., Brush J., Gu Q., Hillan K., Goddard A., Gurney A.L. Cytokine 11:729-735(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH FGFR4, RECEPTOR SPECIFICITY. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39. |
| [7] | "Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis." Holt J.A., Luo G., Billin A.N., Bisi J., McNeill Y.Y., Kozarsky K.F., Donahee M., Wang D.Y., Mansfield T.A., Kliewer S.A., Goodwin B., Jones S.A. Genes Dev. 17:1581-1591(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY NR1H4, FUNCTION. |
| [8] | "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION. |
| [9] | "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21." Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M. J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGFR4 AND KLB. |
| [10] | "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors." Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y. J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR4; KL AND KLB. |
| [11] | "Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression." Song K.H., Li T., Owsley E., Strom S., Chiang J.Y. Hepatology 49:297-305(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| [12] | "Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW. |
| [13] | "The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity." Harmer N.J., Pellegrini L., Chirgadze D., Fernandez-Recio J., Blundell T.L. Biochemistry 43:629-640(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 39-196, DISULFIDE BONDS. |
| [14] | "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members." Goetz R., Beenken A., Ibrahimi O.A., Kalinina J., Olsen S.K., Eliseenkova A.V., Xu C., Neubert T.A., Zhang F., Linhardt R.J., Yu X., White K.E., Inagaki T., Kliewer S.A., Yamamoto M., Kurosu H., Ogawa Y., Kuro-o M. Mohammadi M.Mol. Cell. Biol. 27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 23-216, INTERACTION WITH KLB. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB018122 mRNA. Translation: BAA75500.1. AF110400 mRNA. Translation: AAD45973.1. AY358302 mRNA. Translation: AAQ88669.1. BT006729 mRNA. Translation: AAP35375.1. BC017664 mRNA. Translation: AAH17664.1. | ||||||||||||||||||
| IPI | IPI00032908. | ||||||||||||||||||
| RefSeq | NP_005108.1. NM_005117.2. | ||||||||||||||||||
| UniGene | Hs.249200. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | O95750. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-6039N. | ||||||||||||||||||
| STRING | 9606.ENSP00000294312. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | O95750. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PaxDb | O95750. | ||||||||||||||||||
| PRIDE | O95750. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| DNASU | 9965. | ||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000294312; ENSP00000294312; ENSG00000162344. | ||||||||||||||||||
| GeneID | 9965. | ||||||||||||||||||
| KEGG | hsa:9965. | ||||||||||||||||||
| UCSC | uc001opf.3. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 9965. | ||||||||||||||||||
| GeneCards | GC11M069513. | ||||||||||||||||||
| HGNC | HGNC:3675. FGF19. | ||||||||||||||||||
| HPA | HPA036082. | ||||||||||||||||||
| MIM | 603891. gene. | ||||||||||||||||||
| neXtProt | NX_O95750. | ||||||||||||||||||
| PharmGKB | PA28114. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | NOG294039. | ||||||||||||||||||
| HOGENOM | HOG000112572. | ||||||||||||||||||
| HOVERGEN | HBG051611. | ||||||||||||||||||
| InParanoid | O95750. | ||||||||||||||||||
| KO | K04358. | ||||||||||||||||||
| OMA | DGYNVYR. | ||||||||||||||||||
| OrthoDB | EOG45X7X5. | ||||||||||||||||||
| PhylomeDB | O95750. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Pathway_Interaction_DB | fgf_pathway. FGF signaling pathway. | ||||||||||||||||||
| Reactome | REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| Bgee | O95750. | ||||||||||||||||||
| CleanEx | HS_FGF19. | ||||||||||||||||||
| Genevestigator | O95750. | ||||||||||||||||||
| GermOnline | ENSG00000162344. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR008996. Cytokine_IL1-like. IPR017338. Fibroblast_GF_15/19/21. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR11486. PTHR11486. 1 hit. | ||||||||||||||||||
| Pfam | PF00167. FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| PIRSF | PIRSF037961. FGF-19_FGF-21. 1 hit. | ||||||||||||||||||
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. | ||||||||||||||||||
| SMART | SM00442. FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF50353. Cytok_IL1_like. 1 hit. | ||||||||||||||||||
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| EvolutionaryTrace | O95750. | ||||||||||||||||||
| GenomeRNAi | 9965. | ||||||||||||||||||
| NextBio | 37606. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | FGF19_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95750 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
