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Reviewed, UniProtKB/Swiss-Prot O95750 (FGF19_HUMAN)

Last modified June 16, 2009. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fibroblast growth factor 19
      Short name=FGF-19
Gene names
Name: FGF19
ORF Names: UNQ334/PRO533
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in brain development during embryogenesis.

Subcellular location

Secreted.

Tissue specificity

Expressed in fetal brain, cartilage, retina, and adult gall bladder. Ref.2

Miscellaneous

Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological processnervous system development Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from Experiment. Source: Reactome

   Molecular functiongrowth factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.6
Chain25 – 216192Fibroblast growth factor 19
PRO_0000008993

Amino acid modifications

Disulfide bond58 ↔ 70 Ref.7
Disulfide bond102 ↔ 120 Ref.7

Secondary structure

............................ 216
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95750-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: E0BCBC9C220F9832

FASTA21624,003
        10         20         30         40         50         60 
MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL 

        70         80         90        100        110        120 
RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC 

       130        140        150        160        170        180 
AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR 

       190        200        210 
GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain."
Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., Itoh N.
Biochim. Biophys. Acta 1444:148-151(1999) [PubMed: 9931477] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4."
Xie M.-H., Holcomb I., Deuel B., Dowd P., Huang A., Vagts A., Foster J., Liang J., Brush J., Gu Q., Hillan K., Goddard A., Gurney A.L.
Cytokine 11:729-735(1999) [PubMed: 10525310] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, RECEPTOR SPECIFICITY.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-39.
[7]"The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity."
Harmer N.J., Pellegrini L., Chirgadze D., Fernandez-Recio J., Blundell T.L.
Biochemistry 43:629-640(2004) [PubMed: 14730967] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 39-196, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

AB018122 mRNA. Translation: BAA75500.1.
AF110400 mRNA. Translation: AAD45973.1.
AY358302 mRNA. Translation: AAQ88669.1.
BT006729 mRNA. Translation: AAP35375.1.
BC017664 mRNA. Translation: AAH17664.1.
IPIIPI00032908.
RefSeqNP_005108.1.
UniGeneHs.249200

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1PWAX-ray1.30A39-196[»]
2P23X-ray1.80A/B23-216[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6039N.

Proteomic databases

PRIDEO95750.

Genome annotation databases

EnsemblENSG00000162344. Homo sapiens. [Contig view]
GeneID9965.
KEGGhsa:9965.

Organism-specific databases

GeneCardsGC11M069222.
H-InvDBHIX0009891.
HGNCHGNC:3675. FGF19.
MIM603891. gene.
PharmGKBPA28114.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO95750.
HOVERGENO95750.
OMAO95750. TDSMDPF.

Enzyme and pathway databases

Pathway_Interaction_DBfgf_pathway. FGF signaling pathway.
ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressO95750.
BgeeO95750.
CleanExHS_FGF19.
GermOnlineENSG00000162344. Homo sapiens.

Family and domain databases

InterProIPR017338. Fibroblast_GF_15/19/21.
IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PIRSFPIRSF037961. FGF-19_FGF-21. 1 hit.
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio37606.
SOURCESearch...

Entry information

Entry nameFGF19_HUMAN
AccessionPrimary (citable) accession number: O95750
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents