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Protein

Serine/threonine-protein kinase OSR1

Gene

OXSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.1 Publication1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

By autophosphorylation on threonine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPPROSITE-ProRule annotation1 Publication1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 31ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cellular hypotonic response Source: Ensembl
  • intracellular signal transduction Source: UniProtKB
  • negative regulation of potassium ion transmembrane transporter activity Source: Ensembl
  • negative regulation of rubidium ion transmembrane transporter activity Source: Ensembl
  • peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
  • protein phosphorylation Source: UniProtKB
  • response to oxidative stress Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10595-MONOMER.
SignaLinkiO95747.
SIGNORiO95747.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)
Alternative name(s):
Oxidative stress-responsive 1 protein
Gene namesi
Name:OXSR1Imported
Synonyms:KIAA1101Imported, OSR1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8508. OXSR1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46K → A: Loss of autophosphorylation and kinase activity. 2 Publications1
Mutagenesisi46K → M: Loss of RELT, RELL1 and RELL2 phosphorylation. Retention of some autophosphorylation activity may be due to complex formation with other endogenous kinases in the assay. 2 Publications1

Organism-specific databases

DisGeNETi9943.
OpenTargetsiENSG00000172939.
PharmGKBiPA134973207.

Chemistry databases

ChEMBLiCHEMBL1163104.
GuidetoPHARMACOLOGYi2132.

Polymorphism and mutation databases

BioMutaiOXSR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000864562 – 527Serine/threonine-protein kinase OSR1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95747.
MaxQBiO95747.
PaxDbiO95747.
PeptideAtlasiO95747.
PRIDEiO95747.

PTM databases

iPTMnetiO95747.
PhosphoSitePlusiO95747.
SwissPalmiO95747.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissue examined.1 Publication

Gene expression databases

BgeeiENSG00000172939.
CleanExiHS_OSR1.
HS_OXSR1.
ExpressionAtlasiO95747. baseline and differential.
GenevisibleiO95747. HS.

Organism-specific databases

HPAiCAB017181.
HPA008237.

Interactioni

Subunit structurei

Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB39Q9Y3763EBI-620853,EBI-306905
RELL2Q8NC245EBI-620853,EBI-10269209
SLC12A2P550112EBI-620853,EBI-2801449
WNK1Q9H4A32EBI-620853,EBI-457907
WNK4Q96J9211EBI-620853,EBI-766352

Protein-protein interaction databases

BioGridi115269. 32 interactors.
DIPiDIP-34977N.
IntActiO95747. 12 interactors.
MINTiMINT-5207465.
STRINGi9606.ENSP00000311713.

Chemistry databases

BindingDBiO95747.

Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 16Combined sources3
Beta strandi18 – 24Combined sources7
Beta strandi31 – 35Combined sources5
Turni37 – 40Combined sources4
Beta strandi42 – 46Combined sources5
Turni50 – 54Combined sources5
Helixi57 – 65Combined sources9
Beta strandi78 – 86Combined sources9
Beta strandi88 – 93Combined sources6
Helixi100 – 109Combined sources10
Turni110 – 115Combined sources6
Helixi120 – 139Combined sources20
Helixi149 – 151Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi160 – 162Combined sources3
Helixi166 – 170Combined sources5
Helixi195 – 202Combined sources8
Helixi207 – 222Combined sources16
Turni226 – 229Combined sources4
Helixi232 – 234Combined sources3
Helixi235 – 240Combined sources6
Turni247 – 250Combined sources4
Helixi254 – 257Combined sources4
Helixi262 – 271Combined sources10
Helixi276 – 278Combined sources3
Helixi282 – 286Combined sources5
Helixi289 – 293Combined sources5
Beta strandi434 – 441Combined sources8
Beta strandi447 – 454Combined sources8
Turni456 – 458Combined sources3
Helixi461 – 470Combined sources10
Helixi476 – 478Combined sources3
Helixi479 – 491Combined sources13
Turni493 – 495Combined sources3
Beta strandi497 – 502Combined sources6
Helixi504 – 506Combined sources3
Beta strandi507 – 511Combined sources5
Helixi515 – 517Combined sources3
Beta strandi519 – 526Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V3SX-ray1.70A/B433-527[»]
2VWIX-ray2.15A/B/C/D1-303[»]
3DAKX-ray2.25A/B/C/D6-295[»]
ProteinModelPortaliO95747.
SMRiO95747.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95747.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 291Protein kinasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiO95747.
KOiK08835.
OMAiEPCIATI.
OrthoDBiEOG091G0AKO.
PhylomeDBiO95747.
TreeFamiTF105339.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE STIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350
QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
KAAISQLRSP RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA
410 420 430 440 450
TQPTQVSLPP TAEPAKTAQA LSSGSGSQET KIPISLVLRL RNSKKELNDI
460 470 480 490 500
RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT
510 520
FKLASGVEGS DIPDDGKLIG FAQLSIS
Length:527
Mass (Da):58,022
Last modified:May 1, 1999 - v1
Checksum:iB46EC934E95A3A1F
GO

Sequence cautioni

The sequence AAP97192 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA83053 differs from that shown. Reason: Frameshift at position 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti316K → R in AAP97192 (Ref. 5) Curated1
Sequence conflicti325S → G in AAP97192 (Ref. 5) Curated1
Sequence conflicti363K → R in AAP97192 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023232304T → I.3 PublicationsCorresponds to variant rs6599079dbSNPEnsembl.1
Natural variantiVAR_025181425S → T.1 PublicationCorresponds to variant rs35295772dbSNPEnsembl.1
Natural variantiVAR_040969433P → S in a metastatic melanoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017642 mRNA. Translation: BAA75674.1.
AB029024 mRNA. Translation: BAA83053.2. Frameshift.
DQ201638 Genomic DNA. Translation: ABA27097.1.
BC008726 mRNA. Translation: AAH08726.1.
AF087893 mRNA. Translation: AAP97192.1. Different initiation.
CCDSiCCDS2675.1.
RefSeqiNP_005100.1. NM_005109.2.
UniGeneiHs.475970.

Genome annotation databases

EnsembliENST00000311806; ENSP00000311713; ENSG00000172939.
GeneIDi9943.
KEGGihsa:9943.
UCSCiuc003chy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017642 mRNA. Translation: BAA75674.1.
AB029024 mRNA. Translation: BAA83053.2. Frameshift.
DQ201638 Genomic DNA. Translation: ABA27097.1.
BC008726 mRNA. Translation: AAH08726.1.
AF087893 mRNA. Translation: AAP97192.1. Different initiation.
CCDSiCCDS2675.1.
RefSeqiNP_005100.1. NM_005109.2.
UniGeneiHs.475970.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V3SX-ray1.70A/B433-527[»]
2VWIX-ray2.15A/B/C/D1-303[»]
3DAKX-ray2.25A/B/C/D6-295[»]
ProteinModelPortaliO95747.
SMRiO95747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115269. 32 interactors.
DIPiDIP-34977N.
IntActiO95747. 12 interactors.
MINTiMINT-5207465.
STRINGi9606.ENSP00000311713.

Chemistry databases

BindingDBiO95747.
ChEMBLiCHEMBL1163104.
GuidetoPHARMACOLOGYi2132.

PTM databases

iPTMnetiO95747.
PhosphoSitePlusiO95747.
SwissPalmiO95747.

Polymorphism and mutation databases

BioMutaiOXSR1.

Proteomic databases

EPDiO95747.
MaxQBiO95747.
PaxDbiO95747.
PeptideAtlasiO95747.
PRIDEiO95747.

Protocols and materials databases

DNASUi9943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311806; ENSP00000311713; ENSG00000172939.
GeneIDi9943.
KEGGihsa:9943.
UCSCiuc003chy.4. human.

Organism-specific databases

CTDi9943.
DisGeNETi9943.
GeneCardsiOXSR1.
HGNCiHGNC:8508. OXSR1.
HPAiCAB017181.
HPA008237.
MIMi604046. gene.
neXtProtiNX_O95747.
OpenTargetsiENSG00000172939.
PharmGKBiPA134973207.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiO95747.
KOiK08835.
OMAiEPCIATI.
OrthoDBiEOG091G0AKO.
PhylomeDBiO95747.
TreeFamiTF105339.

Enzyme and pathway databases

BioCyciZFISH:HS10595-MONOMER.
SignaLinkiO95747.
SIGNORiO95747.

Miscellaneous databases

ChiTaRSiOXSR1. human.
EvolutionaryTraceiO95747.
GeneWikiiOXSR1.
GenomeRNAii9943.
PROiO95747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172939.
CleanExiHS_OSR1.
HS_OXSR1.
ExpressionAtlasiO95747. baseline and differential.
GenevisibleiO95747. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXSR1_HUMAN
AccessioniPrimary (citable) accession number: O95747
Secondary accession number(s): Q3LR53, Q7Z501, Q9UPQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.