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Protein

Putative postmeiotic segregation increased 2-like protein 2

Gene

PMS2P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Biological processi

  1. mismatch repair Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative postmeiotic segregation increased 2-like protein 2
Alternative name(s):
Postmeiotic segregation increased 2-like protein 14
Postmeiotic segregation increased protein 4
Putative postmeiotic segregation increased 2 pseudogene 2
Gene namesi
Name:PMS2P2
Synonyms:PMS2L14, PMS2L2, PMS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9127. PMS2P2.

Subcellular locationi

GO - Cellular componenti

  1. mismatch repair complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative postmeiotic segregation increased 2-like protein 2PRO_0000311099Add
BLAST

Proteomic databases

PaxDbiO95744.
PRIDEiO95744.

Expressioni

Tissue specificityi

Highly expressed in kidney, spleen, adrenal gland, esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and to a lower extent in lung, liver, stomach, uterus and pancreas. Not expressed in heart.1 Publication

Gene expression databases

GenevestigatoriO95744.

Organism-specific databases

HPAiHPA043839.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369775.

Structurei

3D structure databases

ProteinModelPortaliO95744.
SMRiO95744. Positions 2-43, 91-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0323.
HOVERGENiHBG108275.
InParanoidiO95744.
PhylomeDBiO95744.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view]
PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
SUPFAMiSSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

O95744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC
60 70 80 90 100
RDCQFLEGSP AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA
110 120 130 140 150
VKKIVGNSLD AGATNIDLKL KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL
160 170 180 190 200
KHHTSKIREF ADLTRVETFG FQGKALSSLC ALSDVTISTC HVSAKVGTRL
210 220 230 240 250
VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR NIKKKRACFP
260 270 280 290
FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG
Length:297
Mass (Da):32,669
Last modified:May 1, 1999 - v1
Checksum:i9D05D86F583B917D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017005 mRNA. Translation: BAA74754.1.
UniGeneiHs.661055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017005 mRNA. Translation: BAA74754.1.
UniGeneiHs.661055.

3D structure databases

ProteinModelPortaliO95744.
SMRiO95744. Positions 2-43, 91-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369775.

Proteomic databases

PaxDbiO95744.
PRIDEiO95744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC07M074880.
HGNCiHGNC:9127. PMS2P2.
HPAiHPA043839.
neXtProtiNX_O95744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0323.
HOVERGENiHBG108275.
InParanoidiO95744.
PhylomeDBiO95744.

Miscellaneous databases

PROiO95744.

Gene expression databases

GenevestigatoriO95744.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view]
PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
SUPFAMiSSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein."
    Kondo E., Horii A., Fukushige S.
    J. Biochem. 125:818-825(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.

Entry informationi

Entry nameiPM2P2_HUMAN
AccessioniPrimary (citable) accession number: O95744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.