Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O95744 (PM2P2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative postmeiotic segregation increased 2-like protein 2
Alternative name(s):
Postmeiotic segregation increased 2-like protein 14
Postmeiotic segregation increased protein 4
Putative postmeiotic segregation increased 2 pseudogene 2
Gene names
Name:PMS2P2
Synonyms:PMS2L14, PMS2L2, PMS4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Tissue specificity

Highly expressed in kidney, spleen, adrenal gland, esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and to a lower extent in lung, liver, stomach, uterus and pancreas. Not expressed in heart. Ref.1

Miscellaneous

Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Caution

Could be the product of a pseudogene.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Putative postmeiotic segregation increased 2-like protein 2
PRO_0000311099

Sequences

Sequence LengthMass (Da)Tools
O95744 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9D05D86F583B917D

FASTA29732,669
        10         20         30         40         50         60 
MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC RDCQFLEGSP 

        70         80         90        100        110        120 
AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA VKKIVGNSLD AGATNIDLKL 

       130        140        150        160        170        180 
KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL KHHTSKIREF ADLTRVETFG FQGKALSSLC 

       190        200        210        220        230        240 
ALSDVTISTC HVSAKVGTRL VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR 

       250        260        270        280        290 
NIKKKRACFP FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG 

« Hide

References

[1]"The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein."
Kondo E., Horii A., Fukushige S.
J. Biochem. 125:818-825(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017005 mRNA. Translation: BAA74754.1.
UniGeneHs.661055.

3D structure databases

ProteinModelPortalO95744.
SMRO95744. Positions 2-43, 91-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369775.

Proteomic databases

PaxDbO95744.
PRIDEO95744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC07M074880.
HGNCHGNC:9127. PMS2P2.
neXtProtNX_O95744.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0323.
HOVERGENHBG108275.
InParanoidO95744.
PhylomeDBO95744.

Gene expression databases

GenevestigatorO95744.

Family and domain databases

Gene3D3.30.565.10. 1 hit.
InterProIPR002099. DNA_mismatch_repair_fam.
IPR003594. HATPase_ATP-bd.
IPR028831. PMS2/PMS2L.
[Graphical view]
PANTHERPTHR10073. PTHR10073. 1 hit.
PTHR10073:SF2. PTHR10073:SF2. 1 hit.
SUPFAMSSF55874. SSF55874. 1 hit.
ProtoNetSearch...

Other

PROO95744.

Entry information

Entry namePM2P2_HUMAN
AccessionPrimary (citable) accession number: O95744
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM