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O95744

- PM2P2_HUMAN

UniProt

O95744 - PM2P2_HUMAN

Protein

Putative postmeiotic segregation increased 2-like protein 2

Gene

PMS2P2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative postmeiotic segregation increased 2-like protein 2
    Alternative name(s):
    Postmeiotic segregation increased 2-like protein 14
    Postmeiotic segregation increased protein 4
    Putative postmeiotic segregation increased 2 pseudogene 2
    Gene namesi
    Name:PMS2P2
    Synonyms:PMS2L14, PMS2L2, PMS4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:9127. PMS2P2.

    Subcellular locationi

    GO - Cellular componenti

    1. mismatch repair complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Putative postmeiotic segregation increased 2-like protein 2PRO_0000311099Add
    BLAST

    Proteomic databases

    PaxDbiO95744.
    PRIDEiO95744.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, spleen, adrenal gland, esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and to a lower extent in lung, liver, stomach, uterus and pancreas. Not expressed in heart.1 Publication

    Gene expression databases

    GenevestigatoriO95744.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369775.

    Structurei

    3D structure databases

    ProteinModelPortaliO95744.
    SMRiO95744. Positions 2-43, 91-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0323.
    HOVERGENiHBG108275.
    InParanoidiO95744.
    PhylomeDBiO95744.

    Family and domain databases

    Gene3Di3.30.565.10. 1 hit.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR028831. Pms1/Pms2/PMS2L.
    [Graphical view]
    PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
    SUPFAMiSSF55874. SSF55874. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O95744-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC    50
    RDCQFLEGSP AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA 100
    VKKIVGNSLD AGATNIDLKL KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL 150
    KHHTSKIREF ADLTRVETFG FQGKALSSLC ALSDVTISTC HVSAKVGTRL 200
    VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR NIKKKRACFP 250
    FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG 297
    Length:297
    Mass (Da):32,669
    Last modified:May 1, 1999 - v1
    Checksum:i9D05D86F583B917D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017005 mRNA. Translation: BAA74754.1.
    UniGeneiHs.661055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017005 mRNA. Translation: BAA74754.1 .
    UniGenei Hs.661055.

    3D structure databases

    ProteinModelPortali O95744.
    SMRi O95744. Positions 2-43, 91-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369775.

    Proteomic databases

    PaxDbi O95744.
    PRIDEi O95744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC07M074880.
    HGNCi HGNC:9127. PMS2P2.
    neXtProti NX_O95744.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0323.
    HOVERGENi HBG108275.
    InParanoidi O95744.
    PhylomeDBi O95744.

    Miscellaneous databases

    PROi O95744.

    Gene expression databases

    Genevestigatori O95744.

    Family and domain databases

    Gene3Di 3.30.565.10. 1 hit.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR028831. Pms1/Pms2/PMS2L.
    [Graphical view ]
    PANTHERi PTHR10073:SF9. PTHR10073:SF9. 1 hit.
    SUPFAMi SSF55874. SSF55874. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein."
      Kondo E., Horii A., Fukushige S.
      J. Biochem. 125:818-825(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiPM2P2_HUMAN
    AccessioniPrimary (citable) accession number: O95744
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3