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O95744

- PM2P2_HUMAN

UniProt

O95744 - PM2P2_HUMAN

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Protein

Putative postmeiotic segregation increased 2-like protein 2

Gene

PMS2P2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

GO - Biological processi

  1. mismatch repair Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative postmeiotic segregation increased 2-like protein 2
Alternative name(s):
Postmeiotic segregation increased 2-like protein 14
Postmeiotic segregation increased protein 4
Putative postmeiotic segregation increased 2 pseudogene 2
Gene namesi
Name:PMS2P2
Synonyms:PMS2L14, PMS2L2, PMS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:9127. PMS2P2.

Subcellular locationi

GO - Cellular componenti

  1. mismatch repair complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative postmeiotic segregation increased 2-like protein 2PRO_0000311099Add
BLAST

Proteomic databases

PaxDbiO95744.
PRIDEiO95744.

Expressioni

Tissue specificityi

Highly expressed in kidney, spleen, adrenal gland, esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and to a lower extent in lung, liver, stomach, uterus and pancreas. Not expressed in heart.1 Publication

Gene expression databases

GenevestigatoriO95744.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369775.

Structurei

3D structure databases

ProteinModelPortaliO95744.
SMRiO95744. Positions 2-43, 91-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0323.
HOVERGENiHBG108275.
InParanoidiO95744.
PhylomeDBiO95744.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view]
PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
SUPFAMiSSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

O95744-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC
60 70 80 90 100
RDCQFLEGSP AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA
110 120 130 140 150
VKKIVGNSLD AGATNIDLKL KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL
160 170 180 190 200
KHHTSKIREF ADLTRVETFG FQGKALSSLC ALSDVTISTC HVSAKVGTRL
210 220 230 240 250
VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR NIKKKRACFP
260 270 280 290
FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG
Length:297
Mass (Da):32,669
Last modified:May 1, 1999 - v1
Checksum:i9D05D86F583B917D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017005 mRNA. Translation: BAA74754.1.
UniGeneiHs.661055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017005 mRNA. Translation: BAA74754.1 .
UniGenei Hs.661055.

3D structure databases

ProteinModelPortali O95744.
SMRi O95744. Positions 2-43, 91-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369775.

Proteomic databases

PaxDbi O95744.
PRIDEi O95744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC07M074880.
HGNCi HGNC:9127. PMS2P2.
neXtProti NX_O95744.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0323.
HOVERGENi HBG108275.
InParanoidi O95744.
PhylomeDBi O95744.

Miscellaneous databases

PROi O95744.

Gene expression databases

Genevestigatori O95744.

Family and domain databases

Gene3Di 3.30.565.10. 1 hit.
InterProi IPR003594. HATPase_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view ]
PANTHERi PTHR10073:SF9. PTHR10073:SF9. 1 hit.
SUPFAMi SSF55874. SSF55874. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein."
    Kondo E., Horii A., Fukushige S.
    J. Biochem. 125:818-825(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.

Entry informationi

Entry nameiPM2P2_HUMAN
AccessioniPrimary (citable) accession number: O95744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3