O95744 (PM2P2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative postmeiotic segregation increased 2-like protein 2

Alternative name(s):
Postmeiotic segregation increased 2-like protein 14
Postmeiotic segregation increased protein 4
Putative postmeiotic segregation increased 2 pseudogene 2

Gene names

Name:	PMS2P2
Synonyms:	PMS2L14, PMS2L2, PMS4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Highly expressed in kidney, spleen, adrenal gland, esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and to a lower extent in lung, liver, stomach, uterus and pancreas. Not expressed in heart. Ref.1
Miscellaneous	Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.
Sequence similarities	Belongs to the DNA mismatch repair MutL/HexB family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from Biological aspect of Ancestor. Source: RefGenome reciprocal meiotic recombination Inferred from Biological aspect of Ancestor. Source: RefGenome somatic hypermutation of immunoglobulin genes Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	MutLalpha complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome MutSalpha complex binding Inferred from Biological aspect of Ancestor. Source: RefGenome mismatched DNA binding Inferred from electronic annotation. Source: InterPro single-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Putative postmeiotic segregation increased 2-like protein 2		PRO_0000311099

Sequences

	Sequence		Length	Mass (Da)
	O95744 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9D05D86F583B917D	FASTA	297	32,669
	10 20 30 40 50 60 MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC RDCQFLEGSP 70 80 90 100 110 120 AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA VKKIVGNSLD AGATNIDLKL 130 140 150 160 170 180 KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL KHHTSKIREF ADLTRVETFG FQGKALSSLC 190 200 210 220 230 240 ALSDVTISTC HVSAKVGTRL VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR 250 260 270 280 290 NIKKKRACFP FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG

References

[1]	"The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein." Kondo E., Horii A., Fukushige S. J. Biochem. 125:818-825(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB017005 mRNA. Translation: BAA74754.1.
IPI	IPI00032884.
3D structure databases
HSSP	HSSP built from PDB template 1H7U based on UniProtKB P54278.
ProteinModelPortal	O95744.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369775.
Proteomic databases
PaxDb	O95744.
PRIDE	O95744.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC07M074880.
HGNC	HGNC:9127. PMS2P2.
neXtProt	NX_O95744.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0323.
HOVERGEN	HBG108275.
InParanoid	O95744.
Gene expression databases
Genevestigator	O95744.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
InterPro	IPR002099. DNA_mismatch_repair. IPR003594. HATPase_ATP-bd. [Graphical view]
PANTHER	PTHR10073. PTHR10073. 1 hit.
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PM2P2_HUMAN

Accession

Primary (citable) accession number: O95744

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.