ID   CPNE6_HUMAN             Reviewed;         557 AA.
AC   O95741; B2RAG6; Q53HA6; Q8WVG1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 3.
DT   19-JAN-2010, entry version 79.
DE   RecName: Full=Copine-6;
DE   AltName: Full=Copine VI;
DE   AltName: Full=Neuronal-copine;
DE            Short=N-copine;
GN   Name=CPNE6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=98307387; PubMed=9645480; DOI=10.1016/S0014-5793(98)00497-9;
RA   Nakayama T., Yaoi T., Yasui M., Kuwajima G.;
RT   "N-copine: a novel two C2-domain-containing protein with neuronal
RT   activity-regulated expression.";
RL   FEBS Lett. 428:80-84(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function in membrane trafficking. Exhibits calcium-
CC       dependent phospholipid binding properties. May have a role in
CC       synaptic plasticity (By similarity).
CC   -!- SIMILARITY: Belongs to the copine family.
CC   -!- SIMILARITY: Contains 2 C2 domains.
CC   -!- SIMILARITY: Contains 1 VWFA domain.
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DR   EMBL; AB009288; BAA75899.1; -; mRNA.
DR   EMBL; AK222675; BAD96395.1; -; mRNA.
DR   EMBL; AK314182; BAG36863.1; -; mRNA.
DR   EMBL; CH471078; EAW66119.1; -; Genomic_DNA.
DR   EMBL; BC018046; AAH18046.1; -; mRNA.
DR   IPI; IPI00295469; -.
DR   RefSeq; NP_006023.1; -.
DR   UniGene; Hs.6132; -.
DR   SMR; O95741; 27-267.
DR   IntAct; O95741; 1.
DR   STRING; O95741; -.
DR   PhosphoSite; O95741; -.
DR   PeptideAtlas; O95741; -.
DR   PRIDE; O95741; -.
DR   Ensembl; ENST00000216775; ENSP00000216775; ENSG00000100884; Homo sapiens.
DR   Ensembl; ENST00000397016; ENSP00000380211; ENSG00000100884; Homo sapiens.
DR   GeneID; 9362; -.
DR   KEGG; hsa:9362; -.
DR   UCSC; uc001wll.1; human.
DR   CTD; 9362; -.
DR   GeneCards; GC14P023609; -.
DR   HGNC; HGNC:2319; CPNE6.
DR   MIM; 605688; gene.
DR   PharmGKB; PA26836; -.
DR   eggNOG; prNOG18811; -.
DR   HOVERGEN; O95741; -.
DR   InParanoid; O95741; -.
DR   OMA; VITSYRR; -.
DR   OrthoDB; EOG95QKZW; -.
DR   PhylomeDB; O95741; -.
DR   NextBio; 35059; -.
DR   ArrayExpress; O95741; -.
DR   Bgee; O95741; -.
DR   CleanEx; HS_CPNE6; -.
DR   Genevestigator; O95741; -.
DR   GermOnline; ENSG00000100884; Homo sapiens.
DR   GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR   GO; GO:0005215; F:transporter activity; TAS:ProtInc.
DR   GO; GO:0006629; P:lipid metabolic process; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   GO; GO:0007268; P:synaptic transmission; TAS:ProtInc.
DR   GO; GO:0016192; P:vesicle-mediated transport; TAS:ProtInc.
DR   InterPro; IPR000008; C2_Ca-dep.
DR   InterPro; IPR008973; C2_Ca/lipid-bd_dom_CaLB.
DR   InterPro; IPR018029; C2_membr_targeting.
DR   InterPro; IPR010734; Copine.
DR   InterPro; IPR002035; VWF_A.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF07002; Copine; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00327; VWA; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Phosphoprotein; Repeat.
FT   CHAIN         1    557       Copine-6.
FT                                /FTId=PRO_0000144845.
FT   DOMAIN       24    111       C2 1.
FT   DOMAIN      138    243       C2 2.
FT   DOMAIN      306    526       VWFA.
FT   MOD_RES      65     65       Phosphoserine (By similarity).
FT   CONFLICT     13     13       P -> Q (in Ref. 5; AAH18046).
FT   CONFLICT     87     87       L -> V (in Ref. 5; AAH18046).
FT   CONFLICT    331    331       P -> H (in Ref. 3; BAD96395).
SQ   SEQUENCE   557 AA;  61991 MW;  CA1ECA3560926FC2 CRC64;
     MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT
     EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ
     TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK
     TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG
     EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM
     GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF
     GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA
     EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR
     LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS
     PGAPRPCTLA TTPSPSP
//