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Reviewed, UniProtKB/Swiss-Prot O95741 (CPNE6_HUMAN)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Copine-6
Alternative name(s):
    Copine VI
    Neuronal-copine
      Short name=N-copine
Gene names
Name: CPNE6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May have a role in synaptic plasticity By similarity.

Sequence similarities

Belongs to the copine family.

Contains 2 C2 domains.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Copine-6
PRO_0000144845

Regions

Domain24 – 11188C2 1
Domain138 – 243106C2 2
Domain306 – 526221VWFA

Amino acid modifications

Modified residue651Phosphoserine By similarity

Experimental info

Sequence conflict131P → Q in AAH18046. Ref.3
Sequence conflict871L → V in AAH18046. Ref.3
Sequence conflict3311P → H in BAD96395. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O95741-1 [UniParc].

Last modified June 7, 2005. Version 3.
Checksum: CA1ECA3560926FC2

FASTA55761,991
        10         20         30         40         50         60 
MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT 

        70         80         90        100        110        120 
EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ 

       130        140        150        160        170        180 
TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK 

       190        200        210        220        230        240 
TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG 

       250        260        270        280        290        300 
EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM 

       310        320        330        340        350        360 
GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF 

       370        380        390        400        410        420 
GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA 

       430        440        450        460        470        480 
EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR 

       490        500        510        520        530        540 
LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS 

       550 
PGAPRPCTLA TTPSPSP 

« Hide

References

« Hide 'large scale' references
[1]"N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression."
Nakayama T., Yaoi T., Yasui M., Kuwajima G.
FEBS Lett. 428:80-84(1998) [PubMed: 9645480] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

AB009288 mRNA. Translation: BAA75899.1.
AK222675 mRNA. Translation: BAD96395.1.
BC018046 mRNA. Translation: AAH18046.1.
IPIIPI00295469.
RefSeqNP_006023.1.
UniGeneHs.6132

3D structure databases

HSSPHSSP built from PDB template 1DJH based on UniProtKB P10688.
ModBaseSearch...

Protein-protein interaction databases

IntActO95741. 1 interaction.

PTM databases

PhosphoSiteO95741.

Proteomic databases

PeptideAtlasO95741.
PRIDEO95741.

Genome annotation databases

EnsemblENSG00000100884. Homo sapiens. [Contig view]
GeneID9362.
KEGGhsa:9362.

Organism-specific databases

GeneCardsGC14P023609.
HGNCHGNC:2319. CPNE6.
MIM605688. gene.
PharmGKBPA26836.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO95741.
HOVERGENO95741.
OMAO95741. VITSYRR.

Gene expression databases

ArrayExpressO95741.
BgeeO95741.
CleanExHS_CPNE6.
GermOnlineENSG00000100884. Homo sapiens.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR018029. C2_membr_targeting.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS50004. C2. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio35059.
SOURCESearch...

Entry information

Entry nameCPNE6_HUMAN
AccessionPrimary (citable) accession number: O95741
Secondary accession number(s): Q53HA6, Q8WVG1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 7, 2005
Last modified: June 16, 2009
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents