O95741 (CPNE6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Copine-6

Alternative name(s):
Copine VI
Neuronal-copine
Short name=N-copine

Gene names

Name:

CPNE6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May have a role in synaptic plasticity By similarity.
Sequence similarities	Belongs to the copine family. Contains 2 C2 domains. Contains 1 VWFA domain.

Ontologies

Keywords
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid metabolic process Traceable author statement Ref.1. Source: ProtInc nervous system development Traceable author statement Ref.1. Source: ProtInc synaptic transmission Traceable author statement Ref.1. Source: ProtInc vesicle-mediated transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	axon Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Traceable author statement Ref.1. Source: ProtInc phosphatidylserine binding Inferred from electronic annotation. Source: Compara transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Copine-6		PRO_0000144845
Regions
	Domain	24 – 111	88	C2 1
	Domain	138 – 243	106	C2 2
	Domain	306 – 526	221	VWFA
Amino acid modifications
	Modified residue	65	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	13	1	P → Q in AAH18046. Ref.5
	Sequence conflict	87	1	L → V in AAH18046. Ref.5
	Sequence conflict	331	1	P → H in BAD96395. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O95741 [UniParc]. Last modified June 7, 2005. Version 3. Checksum: CA1ECA3560926FC2	FASTA	557	61,991
	10 20 30 40 50 60 MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT 70 80 90 100 110 120 EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ 130 140 150 160 170 180 TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK 190 200 210 220 230 240 TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG 250 260 270 280 290 300 EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM 310 320 330 340 350 360 GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF 370 380 390 400 410 420 GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA 430 440 450 460 470 480 EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR 490 500 510 520 530 540 LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS 550 PGAPRPCTLA TTPSPSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression." Nakayama T., Yaoi T., Yasui M., Kuwajima G. FEBS Lett. 428:80-84(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009288 mRNA. Translation: BAA75899.1. AK222675 mRNA. Translation: BAD96395.1. AK314182 mRNA. Translation: BAG36863.1. CH471078 Genomic DNA. Translation: EAW66119.1. CH471078 Genomic DNA. Translation: EAW66120.1. BC018046 mRNA. Translation: AAH18046.1.
IPI	IPI01009428.
RefSeq	NP_006023.1. NM_006032.2.
UniGene	Hs.6132.
3D structure databases
ProteinModelPortal	O95741.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95741. 1 interaction.
MINT	MINT-1419837.
PTM databases
PhosphoSite	O95741.
Proteomic databases
PaxDb	O95741.
PeptideAtlas	O95741.
PRIDE	O95741.
Protocols and materials databases
DNASU	9362.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216775; ENSP00000216775; ENSG00000100884. ENST00000397016; ENSP00000380211; ENSG00000100884.
GeneID	9362.
KEGG	hsa:9362.
UCSC	uc001wll.3. human.
Organism-specific databases
CTD	9362.
GeneCards	GC14P024540.
HGNC	HGNC:2319. CPNE6.
HPA	HPA031636.
MIM	605688. gene.
neXtProt	NX_O95741.
PharmGKB	PA26836.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240062.
HOVERGEN	HBG066841.
InParanoid	O95741.
OrthoDB	EOG4M3986.
PhylomeDB	O95741.
Gene expression databases
ArrayExpress	O95741.
Bgee	O95741.
CleanEx	HS_CPNE6.
Genevestigator	O95741.
GermOnline	ENSG00000100884. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR010734. Copine. IPR002035. VWF_A. [Graphical view]
Pfam	PF00168. C2. 2 hits. PF07002. Copine. 1 hit. [Graphical view]
SMART	SM00239. C2. 2 hits. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 1 hit. PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9362.
NextBio	35059.
SOURCE	Search...

Entry information

Entry name

CPNE6_HUMAN

Accession

Primary (citable) accession number: O95741
Secondary accession number(s): B2RAG6 , D3DS55, Q53HA6, Q8WVG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.