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Protein

Cytotoxic and regulatory T-cell molecule

Gene

CRTAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109943-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytotoxic and regulatory T-cell molecule
Alternative name(s):
Class-I MHC-restricted T-cell-associated molecule
CD_antigen: CD355
Gene namesi
Name:CRTAMImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24313. CRTAM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 287ExtracellularSequence analysisAdd BLAST270
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 393CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56253.
OpenTargetsiENSG00000109943.
PharmGKBiPA145149072.

Polymorphism and mutation databases

BioMutaiCRTAM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000029260218 – 393Cytotoxic and regulatory T-cell moleculeAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi38 ↔ 98PROSITE-ProRule annotation1 Publication
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 196PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95727.
PeptideAtlasiO95727.
PRIDEiO95727.

PTM databases

iPTMnetiO95727.
PhosphoSitePlusiO95727.

Expressioni

Tissue specificityi

In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.3 Publications

Gene expression databases

BgeeiENSG00000109943.
CleanExiHS_CRTAM.
GenevisibleiO95727. HS.

Organism-specific databases

HPAiHPA054595.

Interactioni

Subunit structurei

Interacts with CADM1.2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-60155N.
STRINGi9606.ENSP00000227348.

Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi34 – 39Combined sources6
Beta strandi47 – 51Combined sources5
Beta strandi57 – 60Combined sources4
Beta strandi72 – 77Combined sources6
Beta strandi80 – 85Combined sources6
Helixi90 – 92Combined sources3
Beta strandi94 – 115Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBGX-ray2.30A/B/C/D18-117[»]
4H5SX-ray1.70A18-117[»]
ProteinModelPortaliO95727.
SMRiO95727.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 114Ig-like V-typeSequence analysisAdd BLAST97
Domaini118 – 210Ig-like C2-typeSequence analysisAdd BLAST93

Sequence similaritiesi

Belongs to the nectin family.1 Publication
Contains 1 Ig-like V-type (immunoglobulin-like) domain.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IESB. Eukaryota.
ENOG4111KGD. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000008690.
HOVERGENiHBG053014.
InParanoidiO95727.
KOiK16361.
OMAiHVIWKKE.
OrthoDBiEOG091G0BHE.
PhylomeDBiO95727.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: O95727-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW
60 70 80 90 100
LTPSGFTIFL NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH
110 120 130 140 150
YSDSVSTKEV KVIVLATPFK PILEASVIRK QNGEEHVVLM CSTMRSKPPP
160 170 180 190 200
QITWLLGNSM EVSGGTLHEF ETDGKKCNTT STLIIHTYGK NSTVDCIIRH
210 220 230 240 250
RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ PTSTVSVTED
260 270 280 290 300
SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI
310 320 330 340 350
LFIIVQLFIM KLRKAHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ
360 370 380 390
SSHPMRCMNY ITKLYSEAKT KRKENVQHSK LEEKHIQVPE SIV
Length:393
Mass (Da):44,641
Last modified:June 26, 2007 - v2
Checksum:iCB8173032EE45F03
GO
Isoform 2 (identifier: O95727-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.
     200-216: HRGLQGRKLVAPFRFED → MWVKLLSIVAEFCFSPF

Note: No experimental confirmation available.Curated
Show »
Length:194
Mass (Da):22,256
Checksum:i2CD6A68172F93C8B
GO

Sequence cautioni

The sequence BAD93067 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65A → V in AAH70266 (PubMed:15489334).Curated1
Sequence conflicti315A → T in AAH70266 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04986816E → A.Corresponds to variant rs35411582dbSNPEnsembl.1
Natural variantiVAR_04986978A → D.Corresponds to variant rs34397316dbSNPEnsembl.1
Natural variantiVAR_049870173D → G.Corresponds to variant rs35136295dbSNPEnsembl.1
Natural variantiVAR_032999321K → R.1 PublicationCorresponds to variant rs2272094dbSNPEnsembl.1
Natural variantiVAR_033000368A → G.1 PublicationCorresponds to variant rs1916036dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524711 – 199Missing in isoform 2. 1 PublicationAdd BLAST199
Alternative sequenceiVSP_052472200 – 216HRGLQ…FRFED → MWVKLLSIVAEFCFSPF in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001622 mRNA. Translation: AAC80267.1.
AB209830 mRNA. Translation: BAD93067.1. Different initiation.
BC070266 mRNA. Translation: AAH70266.1.
CCDSiCCDS76489.1. [O95727-2]
CCDS8437.1. [O95727-1]
RefSeqiNP_001291711.1. NM_001304782.1. [O95727-2]
NP_062550.2. NM_019604.3. [O95727-1]
UniGeneiHs.159523.

Genome annotation databases

EnsembliENST00000227348; ENSP00000227348; ENSG00000109943. [O95727-1]
ENST00000533709; ENSP00000433728; ENSG00000109943. [O95727-2]
GeneIDi56253.
KEGGihsa:56253.
UCSCiuc001pyj.4. human. [O95727-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001622 mRNA. Translation: AAC80267.1.
AB209830 mRNA. Translation: BAD93067.1. Different initiation.
BC070266 mRNA. Translation: AAH70266.1.
CCDSiCCDS76489.1. [O95727-2]
CCDS8437.1. [O95727-1]
RefSeqiNP_001291711.1. NM_001304782.1. [O95727-2]
NP_062550.2. NM_019604.3. [O95727-1]
UniGeneiHs.159523.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBGX-ray2.30A/B/C/D18-117[»]
4H5SX-ray1.70A18-117[»]
ProteinModelPortaliO95727.
SMRiO95727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60155N.
STRINGi9606.ENSP00000227348.

PTM databases

iPTMnetiO95727.
PhosphoSitePlusiO95727.

Polymorphism and mutation databases

BioMutaiCRTAM.

Proteomic databases

PaxDbiO95727.
PeptideAtlasiO95727.
PRIDEiO95727.

Protocols and materials databases

DNASUi56253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227348; ENSP00000227348; ENSG00000109943. [O95727-1]
ENST00000533709; ENSP00000433728; ENSG00000109943. [O95727-2]
GeneIDi56253.
KEGGihsa:56253.
UCSCiuc001pyj.4. human. [O95727-1]

Organism-specific databases

CTDi56253.
DisGeNETi56253.
GeneCardsiCRTAM.
H-InvDBHIX0035844.
HGNCiHGNC:24313. CRTAM.
HPAiHPA054595.
MIMi612597. gene.
neXtProtiNX_O95727.
OpenTargetsiENSG00000109943.
PharmGKBiPA145149072.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IESB. Eukaryota.
ENOG4111KGD. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000008690.
HOVERGENiHBG053014.
InParanoidiO95727.
KOiK16361.
OMAiHVIWKKE.
OrthoDBiEOG091G0BHE.
PhylomeDBiO95727.
TreeFamiTF326804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109943-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCRTAM. human.
EvolutionaryTraceiO95727.
GenomeRNAii56253.
PROiO95727.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109943.
CleanExiHS_CRTAM.
GenevisibleiO95727. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRTAM_HUMAN
AccessioniPrimary (citable) accession number: O95727
Secondary accession number(s): Q59EI1, Q6IRX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.