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Protein

Synaptosomal-associated protein 29

Gene

SNAP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.3 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: ProtInc
  • syntaxin binding Source: GO_Central

GO - Biological processi

  • autophagosome maturation Source: UniProtKB
  • cilium assembly Source: UniProtKB
  • exocytosis Source: ProtInc
  • membrane fusion Source: ProtInc
  • protein transport Source: UniProtKB-KW
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • synaptic vesicle priming Source: GO_Central
  • vesicle targeting Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Autophagy, Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29Imported
Short name:
SNAP-29Imported
Alternative name(s):
Soluble 29 kDa NSF attachment proteinImported
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:SNAP29Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11133. SNAP29.

Subcellular locationi

GO - Cellular componenti

  • autophagosome membrane Source: UniProtKB-SubCell
  • centrosome Source: HPA
  • ciliary pocket membrane Source: UniProtKB
  • cytoplasm Source: BHF-UCL
  • cytoplasmic vesicle Source: UniProtKB-KW
  • Golgi membrane Source: Reactome
  • plasma membrane Source: ProtInc
  • presynapse Source: GOC
  • SNARE complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma.
See also OMIM:609528

Keywords - Diseasei

Ichthyosis, Neuropathy, Palmoplantar keratoderma

Organism-specific databases

MalaCardsiSNAP29.
MIMi609528. phenotype.
Orphaneti66631. CEDNIK syndrome.
PharmGKBiPA35981.

Polymorphism and mutation databases

BioMutaiSNAP29.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Synaptosomal-associated protein 29PRO_0000213601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei78 – 781PhosphoserineCombined sources
Modified residuei114 – 1141PhosphoserineCombined sources
Modified residuei130 – 1301PhosphothreonineCombined sources
Modified residuei137 – 1371PhosphothreonineCombined sources
Modified residuei163 – 1631PhosphoserineCombined sources
Modified residuei182 – 1821PhosphoserineCombined sources
Modified residuei185 – 1851PhosphoserineCombined sources
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95721.
MaxQBiO95721.
PaxDbiO95721.
PeptideAtlasiO95721.
PRIDEiO95721.

PTM databases

iPTMnetiO95721.
PhosphoSiteiO95721.

Expressioni

Tissue specificityi

Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000099940.
CleanExiHS_SNAP29.
ExpressionAtlasiO95721. baseline and differential.
GenevisibleiO95721. HS.

Organism-specific databases

HPAiCAB037092.
HPA031823.
HPA056492.

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with multiple syntaxins including STX6 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-490676,EBI-10175124
STX12Q86Y824EBI-490676,EBI-2691717
VAMP1P237633EBI-490676,EBI-10201335
VAMP2P630273EBI-490676,EBI-520113
VAMP4O75379-23EBI-490676,EBI-10187996
VAMP5O951833EBI-490676,EBI-10191195

GO - Molecular functioni

  • SNAP receptor activity Source: ProtInc
  • syntaxin binding Source: GO_Central

Protein-protein interaction databases

BioGridi114748. 65 interactions.
DIPiDIP-56475N.
IntActiO95721. 26 interactions.
MINTiMINT-3003155.
STRINGi9606.ENSP00000215730.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi40 – 11374Combined sources
Helixi195 – 25561Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WY4X-ray1.40C39-116[»]
D194-258[»]
ProteinModelPortaliO95721.
SMRiO95721. Positions 39-116, 194-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 25863t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 10732Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00510000048053.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiO95721.
KOiK08509.
OMAiQQEVMRT.
OrthoDBiEOG091G0GKH.
PhylomeDBiO95721.
TreeFamiTF320226.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYPKSYNP FDDDGEDEGA RPAPWRDARD LPDGPDAPAD RQQYLRQEVL
60 70 80 90 100
RRAEATAAST SRSLALMYES EKVGVASSEE LARQRGVLER TEKMVDKMDQ
110 120 130 140 150
DLKISQKHIN SIKSVFGGLV NYFKSKPVET PPEQNGTLTS QPNNRLKEAI
160 170 180 190 200
STSKEQEAKY QASHPNLRKL DDTDPVPRGA GSAMSTDAYP KNPHLRAYHQ
210 220 230 240 250
KIDSNLDELS MGLGRLKDIA LGMQTEIEEQ DDILDRLTTK VDKLDVNIKS

TERKVRQL
Length:258
Mass (Da):28,970
Last modified:May 1, 1999 - v1
Checksum:i7E1CDBA22D6F5A3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115436 mRNA. Translation: AAD11436.1.
AF278704 Genomic DNA. Translation: AAF91421.1.
CR456582 mRNA. Translation: CAG30468.1.
BT007357 mRNA. Translation: AAP36021.1.
BC009715 mRNA. Translation: AAH09715.1.
CCDSiCCDS13784.1.
RefSeqiNP_004773.1. NM_004782.3.
UniGeneiHs.108002.

Genome annotation databases

EnsembliENST00000215730; ENSP00000215730; ENSG00000099940.
GeneIDi9342.
KEGGihsa:9342.
UCSCiuc011ahw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115436 mRNA. Translation: AAD11436.1.
AF278704 Genomic DNA. Translation: AAF91421.1.
CR456582 mRNA. Translation: CAG30468.1.
BT007357 mRNA. Translation: AAP36021.1.
BC009715 mRNA. Translation: AAH09715.1.
CCDSiCCDS13784.1.
RefSeqiNP_004773.1. NM_004782.3.
UniGeneiHs.108002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WY4X-ray1.40C39-116[»]
D194-258[»]
ProteinModelPortaliO95721.
SMRiO95721. Positions 39-116, 194-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114748. 65 interactions.
DIPiDIP-56475N.
IntActiO95721. 26 interactions.
MINTiMINT-3003155.
STRINGi9606.ENSP00000215730.

PTM databases

iPTMnetiO95721.
PhosphoSiteiO95721.

Polymorphism and mutation databases

BioMutaiSNAP29.

Proteomic databases

EPDiO95721.
MaxQBiO95721.
PaxDbiO95721.
PeptideAtlasiO95721.
PRIDEiO95721.

Protocols and materials databases

DNASUi9342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215730; ENSP00000215730; ENSG00000099940.
GeneIDi9342.
KEGGihsa:9342.
UCSCiuc011ahw.3. human.

Organism-specific databases

CTDi9342.
GeneCardsiSNAP29.
HGNCiHGNC:11133. SNAP29.
HPAiCAB037092.
HPA031823.
HPA056492.
MalaCardsiSNAP29.
MIMi604202. gene.
609528. phenotype.
neXtProtiNX_O95721.
Orphaneti66631. CEDNIK syndrome.
PharmGKBiPA35981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00510000048053.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiO95721.
KOiK08509.
OMAiQQEVMRT.
OrthoDBiEOG091G0GKH.
PhylomeDBiO95721.
TreeFamiTF320226.

Enzyme and pathway databases

ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Miscellaneous databases

ChiTaRSiSNAP29. human.
GeneWikiiSNAP29.
GenomeRNAii9342.
PROiO95721.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099940.
CleanExiHS_SNAP29.
ExpressionAtlasiO95721. baseline and differential.
GenevisibleiO95721. HS.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNP29_HUMAN
AccessioniPrimary (citable) accession number: O95721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.