SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O95721

- SNP29_HUMAN

UniProt

O95721 - SNP29_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Synaptosomal-associated protein 29

Gene
SNAP29
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps.1 Publication

GO - Molecular functioni

  1. SNAP receptor activity Source: ProtInc

GO - Biological processi

  1. autophagic vacuole fusion Source: UniProtKB
  2. exocytosis Source: ProtInc
  3. membrane fusion Source: ProtInc
  4. protein transport Source: UniProtKB-KW
  5. vesicle targeting Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29
Short name:
SNAP-29
Alternative name(s):
Soluble 29 kDa NSF attachment protein
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:SNAP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:11133. SNAP29.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein. Cell junctionsynapsesynaptosome
Note: Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. centrosome Source: HPA
  3. cytoplasm Source: HPA
  4. neuron projection Source: UniProtKB-SubCell
  5. plasma membrane Source: ProtInc
  6. SNARE complex Source: UniProtKB
  7. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Involvement in diseasei

Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK) [MIM:609528]: A neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Ichthyosis, Palmoplantar keratoderma

Organism-specific databases

MIMi609528. phenotype.
Orphaneti66631. CEDNIK syndrome.
PharmGKBiPA35981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Synaptosomal-associated protein 29PRO_0000213601Add
BLAST

Proteomic databases

MaxQBiO95721.
PaxDbiO95721.
PeptideAtlasiO95721.
PRIDEiO95721.

PTM databases

PhosphoSiteiO95721.

Expressioni

Tissue specificityi

Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Gene expression databases

ArrayExpressiO95721.
BgeeiO95721.
CleanExiHS_SNAP29.
GenevestigatoriO95721.

Organism-specific databases

HPAiCAB037092.
HPA031823.
HPA056492.

Interactioni

Subunit structurei

Interacts with multiple syntaxins including STX6 By similarity. Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome.1 Publication

Protein-protein interaction databases

BioGridi114748. 25 interactions.
DIPiDIP-56475N.
IntActiO95721. 13 interactions.
MINTiMINT-3003155.
STRINGi9606.ENSP00000215730.

Structurei

3D structure databases

ProteinModelPortaliO95721.
SMRiO95721. Positions 54-110, 203-255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 25863t-SNARE coiled-coil homologyAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 10732 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244202.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiO95721.
KOiK08509.
OMAiAYPRSYN.
OrthoDBiEOG7FNC8G.
PhylomeDBiO95721.
TreeFamiTF320226.

Family and domain databases

InterProiIPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95721-1 [UniParc]FASTAAdd to Basket

« Hide

MSAYPKSYNP FDDDGEDEGA RPAPWRDARD LPDGPDAPAD RQQYLRQEVL    50
RRAEATAAST SRSLALMYES EKVGVASSEE LARQRGVLER TEKMVDKMDQ 100
DLKISQKHIN SIKSVFGGLV NYFKSKPVET PPEQNGTLTS QPNNRLKEAI 150
STSKEQEAKY QASHPNLRKL DDTDPVPRGA GSAMSTDAYP KNPHLRAYHQ 200
KIDSNLDELS MGLGRLKDIA LGMQTEIEEQ DDILDRLTTK VDKLDVNIKS 250
TERKVRQL 258
Length:258
Mass (Da):28,970
Last modified:May 1, 1999 - v1
Checksum:i7E1CDBA22D6F5A3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115436 mRNA. Translation: AAD11436.1.
AF278704 Genomic DNA. Translation: AAF91421.1.
CR456582 mRNA. Translation: CAG30468.1.
BT007357 mRNA. Translation: AAP36021.1.
BC009715 mRNA. Translation: AAH09715.1.
CCDSiCCDS13784.1.
RefSeqiNP_004773.1. NM_004782.3.
UniGeneiHs.108002.

Genome annotation databases

EnsembliENST00000215730; ENSP00000215730; ENSG00000099940.
GeneIDi9342.
KEGGihsa:9342.
UCSCiuc011ahw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115436 mRNA. Translation: AAD11436.1 .
AF278704 Genomic DNA. Translation: AAF91421.1 .
CR456582 mRNA. Translation: CAG30468.1 .
BT007357 mRNA. Translation: AAP36021.1 .
BC009715 mRNA. Translation: AAH09715.1 .
CCDSi CCDS13784.1.
RefSeqi NP_004773.1. NM_004782.3.
UniGenei Hs.108002.

3D structure databases

ProteinModelPortali O95721.
SMRi O95721. Positions 54-110, 203-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114748. 25 interactions.
DIPi DIP-56475N.
IntActi O95721. 13 interactions.
MINTi MINT-3003155.
STRINGi 9606.ENSP00000215730.

PTM databases

PhosphoSitei O95721.

Proteomic databases

MaxQBi O95721.
PaxDbi O95721.
PeptideAtlasi O95721.
PRIDEi O95721.

Protocols and materials databases

DNASUi 9342.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215730 ; ENSP00000215730 ; ENSG00000099940 .
GeneIDi 9342.
KEGGi hsa:9342.
UCSCi uc011ahw.2. human.

Organism-specific databases

CTDi 9342.
GeneCardsi GC22P021213.
HGNCi HGNC:11133. SNAP29.
HPAi CAB037092.
HPA031823.
HPA056492.
MIMi 604202. gene.
609528. phenotype.
neXtProti NX_O95721.
Orphaneti 66631. CEDNIK syndrome.
PharmGKBi PA35981.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244202.
HOGENOMi HOG000046806.
HOVERGENi HBG057045.
InParanoidi O95721.
KOi K08509.
OMAi AYPRSYN.
OrthoDBi EOG7FNC8G.
PhylomeDBi O95721.
TreeFami TF320226.

Miscellaneous databases

GeneWikii SNAP29.
GenomeRNAii 9342.
NextBioi 34991.
PROi O95721.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95721.
Bgeei O95721.
CleanExi HS_SNAP29.
Genevestigatori O95721.

Family and domain databases

InterProi IPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 2 hits.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Genomic organization of the human SNAP29 gene."
    Schardt A., Kraemer E.-M., Werner H., Nave K.-A.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma."
    Sprecher E., Ishida-Yamamoto A., Mizrahi-Koren M., Rapaport D., Goldsher D., Indelman M., Topaz O., Chefetz I., Keren H., O'brien T.J., Bercovich D., Shalev S., Geiger D., Bergman R., Horowitz M., Mandel H.
    Am. J. Hum. Genet. 77:242-251(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CEDNIK.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes."
    Itakura E., Kishi-Itakura C., Mizushima N.
    Cell 151:1256-1269(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AUTOPHAGY, INTERACTION WITH VAMP8 AND STX17.

Entry informationi

Entry nameiSNP29_HUMAN
AccessioniPrimary (citable) accession number: O95721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi