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O95718

- ERR2_HUMAN

UniProt

O95718 - ERR2_HUMAN

Protein

Steroid hormone receptor ERR2

Gene

ESRRB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei185 – 1851Important for stabilizing DNA-binding

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi100 – 18687Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
    3. sequence-specific DNA binding Source: UniProtKB
    4. steroid binding Source: InterPro
    5. steroid hormone receptor activity Source: InterPro
    6. transcription coactivator activity Source: BHF-UCL
    7. transcription factor binding Source: BHF-UCL
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gene expression Source: Reactome
    2. intracellular receptor signaling pathway Source: GOC
    3. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. stem cell maintenance Source: Ensembl
    6. transcription initiation from RNA polymerase II promoter Source: Reactome
    7. trophectodermal cell proliferation Source: Ensembl
    8. trophectodermal cellular morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
    SignaLinkiO95718.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid hormone receptor ERR2
    Alternative name(s):
    ERR beta-2
    Estrogen receptor-like 2
    Estrogen-related receptor beta
    Short name:
    ERR-beta
    Nuclear receptor subfamily 3 group B member 2
    Gene namesi
    Name:ESRRB
    Synonyms:ERRB2, ESRL2, NR3B2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:3473. ESRRB.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 35 (DFNB35) [MIM:608565]: A form of non-syndromic deafness characterized by non-progressive, prelingual hearing loss.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101A → V in DFNB35. 1 Publication
    VAR_043503
    Natural varianti320 – 3201L → P in DFNB35. 1 Publication
    VAR_043504
    Natural varianti342 – 3421V → L in DFNB35. 1 Publication
    VAR_043505
    Natural varianti347 – 3471L → P in DFNB35. 1 Publication
    VAR_043506
    Natural varianti389 – 3891T → M in DFNB35; uncertain pathological significance. 1 Publication
    VAR_043508

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi185 – 1851Y → A: 6-fold decrease in DNA-binding affinity. 1 Publication

    Keywords - Diseasei

    Deafness, Disease mutation, Non-syndromic deafness

    Organism-specific databases

    MIMi608565. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBiPA27889.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Steroid hormone receptor ERR2PRO_0000053662Add
    BLAST

    Post-translational modificationi

    Acetylated by PCAF/KAT2 (in vitro).1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO95718.
    PaxDbiO95718.
    PRIDEiO95718.

    PTM databases

    PhosphoSiteiO95718.

    Expressioni

    Gene expression databases

    ArrayExpressiO95718.
    BgeeiO95718.
    CleanExiHS_ESRRB.
    GenevestigatoriO95718.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000261532.

    Structurei

    Secondary structure

    1
    508
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni104 – 1074
    Beta strandi111 – 1199
    Helixi121 – 13212
    Helixi149 – 1546
    Helixi156 – 16611
    Helixi170 – 1723

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LO1NMR-A97-192[»]
    ProteinModelPortaliO95718.
    SMRiO95718. Positions 95-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95718.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282629.
    HOGENOMiHOG000233467.
    HOVERGENiHBG108344.
    KOiK08553.
    OMAiSYEDCAG.
    TreeFamiTF323751.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95718-1) [UniParc]FASTAAdd to Basket

    Also known as: ERRbeta2-delta10

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG    50
    THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK 100
    RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR 150
    RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ 200
    ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE 250
    LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV 300
    YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA 350
    NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR 400
    QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKVGQEQLRG SPKDERMSSH 450
    DGKCPFQSAA FTSRDQSNSP GIPNPRPSSP TPLNERGRQI SPSTRTPGGQ 500
    GKHLWLTM 508
    Length:508
    Mass (Da):56,208
    Last modified:January 25, 2012 - v2
    Checksum:i1BF4637DC1D45B13
    GO
    Isoform 2 (identifier: O95718-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         433-508: VGQEQLRGSP...GQGKHLWLTM → AWARADSLQE...PQRAGWPRAA

    Show »
    Length:500
    Mass (Da):55,619
    Checksum:iC219C84D914DF1C6
    GO
    Isoform 3 (identifier: O95718-3) [UniParc]FASTAAdd to Basket

    Also known as: ERRbeta-short-form

    The sequence of this isoform differs from the canonical sequence as follows:
         434-508: Missing.

    Show »
    Length:433
    Mass (Da):48,054
    Checksum:iED1D3F87E2798DD1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2481D → E in BAH02305. 1 PublicationCurated
    Sequence conflicti429 – 4291L → V in AAI31518. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101A → V in DFNB35. 1 Publication
    VAR_043503
    Natural varianti320 – 3201L → P in DFNB35. 1 Publication
    VAR_043504
    Natural varianti342 – 3421V → L in DFNB35. 1 Publication
    VAR_043505
    Natural varianti347 – 3471L → P in DFNB35. 1 Publication
    VAR_043506
    Natural varianti386 – 3861P → S.1 Publication
    Corresponds to variant rs61742642 [ dbSNP | Ensembl ].
    VAR_043507
    Natural varianti389 – 3891T → M in DFNB35; uncertain pathological significance. 1 Publication
    VAR_043508

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei433 – 50876VGQEQ…LWLTM → AWARADSLQEWRPLEQVPSP LHRATKRQHVHFLTPLPPPP SVAWVGTAQAGYHLEVFLPQ RAGWPRAA in isoform 2. 1 PublicationVSP_042211Add
    BLAST
    Alternative sequencei434 – 50875Missing in isoform 3. 2 PublicationsVSP_042212Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094517 mRNA. Translation: AAC99409.1.
    AY451389 mRNA. Translation: AAS15571.1.
    AY451390 mRNA. Translation: AAS15572.1.
    AB307714 mRNA. Translation: BAH02305.1.
    HQ692852 mRNA. Translation: ADZ17363.1.
    AC008050 Genomic DNA. Translation: AAG17472.1.
    AC016543 Genomic DNA. No translation available.
    BC131517 mRNA. Translation: AAI31518.1.
    CCDSiCCDS9850.2. [O95718-1]
    RefSeqiNP_004443.3. NM_004452.3. [O95718-1]
    XP_006720141.1. XM_006720078.1. [O95718-3]
    UniGeneiHs.435845.

    Genome annotation databases

    EnsembliENST00000380887; ENSP00000370270; ENSG00000119715. [O95718-1]
    ENST00000505752; ENSP00000423004; ENSG00000119715. [O95718-2]
    ENST00000509242; ENSP00000422488; ENSG00000119715. [O95718-1]
    ENST00000556177; ENSP00000451658; ENSG00000119715. [O95718-3]
    GeneIDi2103.
    KEGGihsa:2103.
    UCSCiuc001xsq.1. human. [O95718-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094517 mRNA. Translation: AAC99409.1 .
    AY451389 mRNA. Translation: AAS15571.1 .
    AY451390 mRNA. Translation: AAS15572.1 .
    AB307714 mRNA. Translation: BAH02305.1 .
    HQ692852 mRNA. Translation: ADZ17363.1 .
    AC008050 Genomic DNA. Translation: AAG17472.1 .
    AC016543 Genomic DNA. No translation available.
    BC131517 mRNA. Translation: AAI31518.1 .
    CCDSi CCDS9850.2. [O95718-1 ]
    RefSeqi NP_004443.3. NM_004452.3. [O95718-1 ]
    XP_006720141.1. XM_006720078.1. [O95718-3 ]
    UniGenei Hs.435845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LO1 NMR - A 97-192 [» ]
    ProteinModelPortali O95718.
    SMRi O95718. Positions 95-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000261532.

    Chemistry

    BindingDBi O95718.
    ChEMBLi CHEMBL3751.
    GuidetoPHARMACOLOGYi 623.

    PTM databases

    PhosphoSitei O95718.

    Proteomic databases

    MaxQBi O95718.
    PaxDbi O95718.
    PRIDEi O95718.

    Protocols and materials databases

    DNASUi 2103.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380887 ; ENSP00000370270 ; ENSG00000119715 . [O95718-1 ]
    ENST00000505752 ; ENSP00000423004 ; ENSG00000119715 . [O95718-2 ]
    ENST00000509242 ; ENSP00000422488 ; ENSG00000119715 . [O95718-1 ]
    ENST00000556177 ; ENSP00000451658 ; ENSG00000119715 . [O95718-3 ]
    GeneIDi 2103.
    KEGGi hsa:2103.
    UCSCi uc001xsq.1. human. [O95718-1 ]

    Organism-specific databases

    CTDi 2103.
    GeneCardsi GC14P076837.
    GeneReviewsi ESRRB.
    HGNCi HGNC:3473. ESRRB.
    MIMi 602167. gene.
    608565. phenotype.
    neXtProti NX_O95718.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBi PA27889.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282629.
    HOGENOMi HOG000233467.
    HOVERGENi HBG108344.
    KOi K08553.
    OMAi SYEDCAG.
    TreeFami TF323751.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.
    SignaLinki O95718.

    Miscellaneous databases

    ChiTaRSi ESRRB. human.
    EvolutionaryTracei O95718.
    GeneWikii Estrogen-related_receptor_beta.
    GenomeRNAii 2103.
    NextBioi 8507.
    PROi O95718.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95718.
    Bgeei O95718.
    CleanExi HS_ESRRB.
    Genevestigatori O95718.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."
      Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C., Liu Q., Caskey C.T.
      Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta."
      Zhou W., Liu Z., Wu J., Liu J.H., Hyder S.M., Antoniou E., Lubahn D.B.
      J. Clin. Endocrinol. Metab. 91:569-579(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING.
      Tissue: Heart and Testis.
    3. "Comprehensive DNA-binding analysis of human hormone nuclear receptors by fluorescence correlation spectroscopy based on cell-free system."
      Kobayashi T., Kodani Y., Sawasaki T., Endo Y.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "Isolation of cDNA coding for multiple human nuclear receptor clones."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-503 (ISOFORM 1).
    7. "Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants."
      Bombail V., Collins F., Brown P., Saunders P.T.
      Mol. Cell. Endocrinol. 314:53-61(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING.
    8. "Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."
      Cho Y., Hazen B.C., Russell A.P., Kralli A.
      J. Biol. Chem. 288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition."
      Gearhart M.D., Holmbeck S.M., Evans R.M., Dyson H.J., Wright P.E.
      J. Mol. Biol. 327:819-832(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 97-194, SUBUNIT, DNA-BINDING, MUTAGENESIS OF TYR-185.
    10. "Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle."
      Bombail V., MacPherson S., Critchley H.O., Saunders P.T.
      Hum. Reprod. 23:2782-2790(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha."
      Wilson B.J., Tremblay A.M., Deblois G., Sylvain-Drolet G., Giguere V.
      Mol. Endocrinol. 24:1349-1358(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION BY PCAF/KAT2B.
    12. Cited for: VARIANTS DFNB35 VAL-110; PRO-320; LEU-342; PRO-347 AND MET-389, VARIANT SER-386.

    Entry informationi

    Entry nameiERR2_HUMAN
    AccessioniPrimary (citable) accession number: O95718
    Secondary accession number(s): A2VDJ2
    , B6ZGU4, Q5F0P7, Q5F0P8, Q9HCB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3