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O95716 (RAB3D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-3D
Gene names
Name:RAB3D
Synonyms:GOV, RAB16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Probably involved in regulated exocytosis By similarity.

Subunit structure

Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.

Induction

Activated in myeloid differentiation.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 219218Ras-related protein Rab-3D
PRO_0000121088

Regions

Nucleotide binding29 – 379GTP
Nucleotide binding77 – 815GTP By similarity
Nucleotide binding135 – 1384GTP
Nucleotide binding165 – 1673GTP
Motif51 – 599Effector region By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.5
Modified residue2191Cysteine methyl ester By similarity
Lipidation2171S-geranylgeranyl cysteine By similarity
Lipidation2191S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant641V → I.
Corresponds to variant rs3969860 [ dbSNP | Ensembl ].
VAR_051710

Secondary structure

............................. 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95716 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 714754826C405EA7

FASTA21924,267
        10         20         30         40         50         60 
MASAGDTQAG PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 

        70         80         90        100        110        120 
VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF AAVQDWATQI 

       130        140        150        160        170        180 
KTYSWDNAQV ILVGNKCDLE DERVVPAEDG RRLADDLGFE FFEASAKENI NVKQVFERLV 

       190        200        210 
DVICEKMNES LEPSSSSGSN GKGPAVGDAP APQPSSCSC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation."
Nishio H., Suda T., Sawada K., Miyamoto T., Koike T., Yamaguchi Y.
Biochim. Biophys. Acta 1444:283-290(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hematopoietic.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[6]"Crystal structure of human RAB3D in complex with GDP."
Structural genomics consortium (SGC)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF 20-189 IN COMPLEX WITH GDP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081353 mRNA. Translation: AAC72918.1.
AF498933 mRNA. Translation: AAM21081.1.
BC016471 mRNA. Translation: AAH16471.1.
RefSeqNP_004274.1. NM_004283.3.
UniGeneHs.744916.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GF9X-ray1.53A20-189[»]
ProteinModelPortalO95716.
SMRO95716. Positions 20-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114919. 12 interactions.
IntActO95716. 3 interactions.
STRING9606.ENSP00000222120.

PTM databases

PhosphoSiteO95716.

Proteomic databases

PaxDbO95716.
PRIDEO95716.

Protocols and materials databases

DNASU9545.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222120; ENSP00000222120; ENSG00000105514.
ENST00000589655; ENSP00000466000; ENSG00000105514.
GeneID9545.
KEGGhsa:9545.
UCSCuc002mqx.3. human.

Organism-specific databases

CTD9545.
GeneCardsGC19M011435.
HGNCHGNC:9779. RAB3D.
HPACAB018067.
HPA051912.
MIM604350. gene.
neXtProtNX_O95716.
PharmGKBPA34134.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidO95716.
KOK07884.
OMAEPSSCSC.
OrthoDBEOG7JQBPC.
PhylomeDBO95716.
TreeFamTF313199.

Gene expression databases

BgeeO95716.
CleanExHS_RAB3D.
GenevestigatorO95716.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO95716.
GeneWikiRAB3D.
GenomeRNAi9545.
NextBio35795.
PROO95716.
SOURCESearch...

Entry information

Entry nameRAB3D_HUMAN
AccessionPrimary (citable) accession number: O95716
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM