Ras-related protein Rab-3D - Homo sapiens (Human)

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O95716 (RAB3D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 126. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-3D

Gene names

Name:	RAB3D
Synonyms:	GOV, RAB16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved in regulated exocytosis By similarity.
Subunit structure	Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.
Induction	Activated in myeloid differentiation.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-cysteine methylation Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle Inferred from electronic annotation. Source: Compara zymogen granule Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Ras-related protein Rab-3D

PRO_0000121088

Regions

Nucleotide binding

29 – 37

GTP

Nucleotide binding

77 – 81

GTP By similarity

Nucleotide binding

135 – 138

GTP

Nucleotide binding

165 – 167

GTP

Motif

51 – 59

Effector region By similarity

Amino acid modifications

Modified residue

219

Cysteine methyl ester By similarity

Lipidation

217

S-geranylgeranyl cysteine By similarity

Lipidation

219

S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant

V → I.
Corresponds to variant rs3969860 [ dbSNP | Ensembl ].

VAR_051710

Secondary structure

219

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

O95716 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 714754826C405EA7
Show »

FASTA

219

24,267

        10         20         30         40         50         60 
MASAGDTQAG PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 

        70         80         90        100        110        120 
VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF AAVQDWATQI 

       130        140        150        160        170        180 
KTYSWDNAQV ILVGNKCDLE DERVVPAEDG RRLADDLGFE FFEASAKENI NVKQVFERLV 

       190        200        210 
DVICEKMNES LEPSSSSGSN GKGPAVGDAP APQPSSCSC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation." Nishio H., Suda T., Sawada K., Miyamoto T., Koike T., Yamaguchi Y. Biochim. Biophys. Acta 1444:283-290(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hematopoietic.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"Crystal structure of human RAB3D in complex with GDP." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF 20-189 IN COMPLEX WITH GDP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF081353 mRNA. Translation: AAC72918.1.
AF498933 mRNA. Translation: AAM21081.1.
BC016471 mRNA. Translation: AAH16471.1.

IPI

IPI00032808.

RefSeq

NP_004274.1. NM_004283.3.

UniGene

Hs.731663.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GF9	X-ray	1.53	A	20-189	[»]

ProteinModelPortal

O95716.

ModBase

Search...

Protein-protein interaction databases

IntAct

O95716. 3 interactions.

STRING

9606.ENSP00000222120.

PTM databases

PhosphoSite

O95716.

Proteomic databases

PaxDb

O95716.

PRIDE

O95716.

Protocols and materials databases

DNASU

9545.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000222120; ENSP00000222120; ENSG00000105514.
ENST00000589655; ENSP00000466000; ENSG00000105514.

GeneID

9545.

KEGG

hsa:9545.

UCSC

uc002mqx.3. human.

Organism-specific databases

CTD

9545.

GeneCards

GC19M011435.

HGNC

HGNC:9779. RAB3D.

HPA

CAB018067.

MIM

604350. gene.

neXtProt

NX_O95716.

PharmGKB

PA34134.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1100.

HOGENOM

HOG000233968.

HOVERGEN

HBG009351.

InParanoid

O95716.

K07884.

OMA

GKGPTLG.

OrthoDB

EOG4TB4C6.

PhylomeDB

O95716.

Gene expression databases

Bgee

O95716.

CleanEx

HS_RAB3D.

Genevestigator

O95716.

GermOnline

ENSG00000105514. Homo sapiens.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00175. RAB. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51419. RAB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O95716.

GenomeRNAi

9545.

NextBio

35795.

SOURCE

Search...

Entry information

Entry name

RAB3D_HUMAN

Accession

Primary (citable) accession number: O95716

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents