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Protein

C-X-C motif chemokine 14

Gene

CXCL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.2 Publications

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

GO - Molecular functioni

  • chemokine activity Source: ProtInc

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • cell chemotaxis Source: GO_Central
  • chemotaxis Source: ProtInc
  • immune response Source: InterPro
  • inner ear development Source: Ensembl
  • killing of cells of other organism Source: UniProtKB
  • negative regulation of myoblast differentiation Source: Ensembl
  • positive regulation of natural killer cell chemotaxis Source: Ensembl
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 14
Alternative name(s):
Chemokine BRAK
MIP-2G
Small-inducible cytokine B14
Gene namesi
Name:CXCL14
Synonyms:MIP2G, NJAC, SCYB14
ORF Names:PSEC0212, UNQ240/PRO273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145824.12
HGNCiHGNC:10640 CXCL14
MIMi604186 gene
neXtProtiNX_O95715

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9547
OpenTargetsiENSG00000145824
PharmGKBiPA35571

Polymorphism and mutation databases

BioMutaiCXCL14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000000511535 – 111C-X-C motif chemokine 14Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 631 Publication
Disulfide bondi39 ↔ 841 Publication

Post-translational modificationi

Ubiquitinated, followed by degradation by the proteasome.1 Publication

Keywords - PTMi

Disulfide bond, Ubl conjugation

Proteomic databases

PaxDbiO95715
PeptideAtlasiO95715
PRIDEiO95715

PTM databases

iPTMnetiO95715
PhosphoSitePlusiO95715

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.3 Publications

Inductioni

Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000145824
CleanExiHS_CXCL14
ExpressionAtlasiO95715 baseline and differential
GenevisibleiO95715 HS

Organism-specific databases

HPAiCAB029996

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi114921, 6 interactors
DIPiDIP-61148N
IntActiO95715, 8 interactors
MINTiO95715
STRINGi9606.ENSP00000337065

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 44Combined sources4
Helixi48 – 50Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi63 – 65Combined sources3
Beta strandi68 – 72Combined sources5
Beta strandi74 – 76Combined sources3
Turni77 – 80Combined sources4
Beta strandi81 – 85Combined sources5
Helixi90 – 106Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HDLNMR-A35-111[»]
ProteinModelPortaliO95715
SMRiO95715
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95715

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi67 – 81D-boxAdd BLAST15

Domaini

The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0K5 Eukaryota
ENOG4111XWS LUCA
GeneTreeiENSGT00390000000618
HOGENOMiHOG000065700
HOVERGENiHBG054250
InParanoidiO95715
KOiK10033
OMAiCQEKMIF
OrthoDBiEOG091G10GY
PhylomeDBiO95715
TreeFamiTF332769

Family and domain databases

InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLPRRAPP VSMRLLAAAL LLLLLALYTA RVDGSKCKCS RKGPKIRYSD
60 70 80 90 100
VKKLEMKPKY PHCEEKMVII TTKSVSRYRG QEHCLHPKLQ STKRFIKWYN
110
AWNEKRRVYE E
Length:111
Mass (Da):13,078
Last modified:March 23, 2010 - v2
Checksum:iC9A18B2A78CACF74
GO

Sequence cautioni

The sequence AAD38944 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108V → F in AAF78449 (PubMed:10946286).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144103 mRNA Translation: AAD38944.1 Different initiation.
AF106911 mRNA Translation: AAF78449.1
AY358906 mRNA Translation: AAQ89265.1
AK075514 mRNA Translation: BAG52160.1
BT007080 mRNA Translation: AAP35743.1
AC034206 Genomic DNA No translation available.
BC003513 mRNA Translation: AAH03513.1
AF073957 mRNA Translation: AAD03839.1
CCDSiCCDS4188.1
PIRiJG0182
RefSeqiNP_004878.2, NM_004887.4
UniGeneiHs.483444

Genome annotation databases

EnsembliENST00000337225; ENSP00000337065; ENSG00000145824
GeneIDi9547
KEGGihsa:9547
UCSCiuc003lay.4 human

Similar proteinsi

Entry informationi

Entry nameiCXL14_HUMAN
AccessioniPrimary (citable) accession number: O95715
Secondary accession number(s): B3KQU8
, Q6UW97, Q86U69, Q9BTR1, Q9NS21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: April 25, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health