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Protein

C-X-C motif chemokine 14

Gene

CXCL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.2 Publications

GO - Molecular functioni

  • chemokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • chemotaxis Source: ProtInc
  • immune response Source: InterPro
  • inner ear development Source: Ensembl
  • negative regulation of myoblast differentiation Source: Ensembl
  • positive regulation of natural killer cell chemotaxis Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 14
Alternative name(s):
Chemokine BRAK
MIP-2G
Small-inducible cytokine B14
Gene namesi
Name:CXCL14
Synonyms:MIP2G, NJAC, SCYB14
ORF Names:PSEC0212, UNQ240/PRO273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10640. CXCL14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35571.

Polymorphism and mutation databases

BioMutaiCXCL14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 11177C-X-C motif chemokine 14PRO_0000005115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 631 Publication
Disulfide bondi39 ↔ 841 Publication

Post-translational modificationi

Ubiquitinated, followed by degradation by the proteasome.1 Publication

Keywords - PTMi

Disulfide bond, Ubl conjugation

Proteomic databases

PaxDbiO95715.
PeptideAtlasiO95715.
PRIDEiO95715.

PTM databases

iPTMnetiO95715.
PhosphoSiteiO95715.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.3 Publications

Inductioni

Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000145824.
CleanExiHS_CXCL14.
ExpressionAtlasiO95715. baseline and differential.
GenevisibleiO95715. HS.

Organism-specific databases

HPAiCAB029996.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TEX11Q8IYF33EBI-2798068,EBI-742397
TRIM23P364063EBI-2798068,EBI-740098

GO - Molecular functioni

  • chemokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi114921. 4 interactions.
DIPiDIP-61148N.
IntActiO95715. 6 interactions.
MINTiMINT-4724169.
STRINGi9606.ENSP00000337065.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 444Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 566Combined sources
Beta strandi63 – 653Combined sources
Beta strandi68 – 725Combined sources
Beta strandi74 – 763Combined sources
Turni77 – 804Combined sources
Beta strandi81 – 855Combined sources
Helixi90 – 10617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDLNMR-A35-111[»]
ProteinModelPortaliO95715.
SMRiO95715. Positions 35-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95715.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 8115D-boxAdd
BLAST

Domaini

The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0K5. Eukaryota.
ENOG4111XWS. LUCA.
GeneTreeiENSGT00390000000618.
HOGENOMiHOG000065700.
HOVERGENiHBG054250.
InParanoidiO95715.
KOiK10033.
OMAiCQEKMIF.
OrthoDBiEOG091G10GY.
PhylomeDBiO95715.
TreeFamiTF332769.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLPRRAPP VSMRLLAAAL LLLLLALYTA RVDGSKCKCS RKGPKIRYSD
60 70 80 90 100
VKKLEMKPKY PHCEEKMVII TTKSVSRYRG QEHCLHPKLQ STKRFIKWYN
110
AWNEKRRVYE E
Length:111
Mass (Da):13,078
Last modified:March 23, 2010 - v2
Checksum:iC9A18B2A78CACF74
GO

Sequence cautioni

The sequence AAD38944 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081V → F in AAF78449 (PubMed:10946286).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144103 mRNA. Translation: AAD38944.1. Different initiation.
AF106911 mRNA. Translation: AAF78449.1.
AY358906 mRNA. Translation: AAQ89265.1.
AK075514 mRNA. Translation: BAG52160.1.
BT007080 mRNA. Translation: AAP35743.1.
AC034206 Genomic DNA. No translation available.
BC003513 mRNA. Translation: AAH03513.1.
AF073957 mRNA. Translation: AAD03839.1.
CCDSiCCDS4188.1.
PIRiJG0182.
RefSeqiNP_004878.2. NM_004887.4.
UniGeneiHs.483444.

Genome annotation databases

EnsembliENST00000337225; ENSP00000337065; ENSG00000145824.
GeneIDi9547.
KEGGihsa:9547.
UCSCiuc003lay.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL14 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144103 mRNA. Translation: AAD38944.1. Different initiation.
AF106911 mRNA. Translation: AAF78449.1.
AY358906 mRNA. Translation: AAQ89265.1.
AK075514 mRNA. Translation: BAG52160.1.
BT007080 mRNA. Translation: AAP35743.1.
AC034206 Genomic DNA. No translation available.
BC003513 mRNA. Translation: AAH03513.1.
AF073957 mRNA. Translation: AAD03839.1.
CCDSiCCDS4188.1.
PIRiJG0182.
RefSeqiNP_004878.2. NM_004887.4.
UniGeneiHs.483444.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDLNMR-A35-111[»]
ProteinModelPortaliO95715.
SMRiO95715. Positions 35-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114921. 4 interactions.
DIPiDIP-61148N.
IntActiO95715. 6 interactions.
MINTiMINT-4724169.
STRINGi9606.ENSP00000337065.

PTM databases

iPTMnetiO95715.
PhosphoSiteiO95715.

Polymorphism and mutation databases

BioMutaiCXCL14.

Proteomic databases

PaxDbiO95715.
PeptideAtlasiO95715.
PRIDEiO95715.

Protocols and materials databases

DNASUi9547.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337225; ENSP00000337065; ENSG00000145824.
GeneIDi9547.
KEGGihsa:9547.
UCSCiuc003lay.4. human.

Organism-specific databases

CTDi9547.
GeneCardsiCXCL14.
HGNCiHGNC:10640. CXCL14.
HPAiCAB029996.
MIMi604186. gene.
neXtProtiNX_O95715.
PharmGKBiPA35571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0K5. Eukaryota.
ENOG4111XWS. LUCA.
GeneTreeiENSGT00390000000618.
HOGENOMiHOG000065700.
HOVERGENiHBG054250.
InParanoidiO95715.
KOiK10033.
OMAiCQEKMIF.
OrthoDBiEOG091G10GY.
PhylomeDBiO95715.
TreeFamiTF332769.

Miscellaneous databases

ChiTaRSiCXCL14. human.
EvolutionaryTraceiO95715.
GenomeRNAii9547.
PROiO95715.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145824.
CleanExiHS_CXCL14.
ExpressionAtlasiO95715. baseline and differential.
GenevisibleiO95715. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXL14_HUMAN
AccessioniPrimary (citable) accession number: O95715
Secondary accession number(s): B3KQU8
, Q6UW97, Q86U69, Q9BTR1, Q9NS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.