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O95715

- CXL14_HUMAN

UniProt

O95715 - CXL14_HUMAN

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Protein

C-X-C motif chemokine 14

Gene

CXCL14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.2 Publications

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. immune response Source: InterPro
  5. inner ear development Source: Ensembl
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 14
Alternative name(s):
Chemokine BRAK
MIP-2G
Small-inducible cytokine B14
Gene namesi
Name:CXCL14
Synonyms:MIP2G, NJAC, SCYB14
ORF Names:PSEC0212, UNQ240/PRO273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:10640. CXCL14.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. Golgi apparatus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 11177C-X-C motif chemokine 14PRO_0000005115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 631 Publication
Disulfide bondi39 ↔ 841 Publication

Post-translational modificationi

Ubiquitinated, followed by degradation by the proteasome.1 Publication

Keywords - PTMi

Disulfide bond, Ubl conjugation

Proteomic databases

PaxDbiO95715.
PRIDEiO95715.

PTM databases

PhosphoSiteiO95715.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.3 Publications

Inductioni

Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiO95715.
CleanExiHS_CXCL14.
GenevestigatoriO95715.

Organism-specific databases

HPAiCAB029996.

Interactioni

Protein-protein interaction databases

BioGridi114921. 2 interactions.
IntActiO95715. 4 interactions.
MINTiMINT-4724169.
STRINGi9606.ENSP00000337065.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 444Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 566Combined sources
Beta strandi63 – 653Combined sources
Beta strandi68 – 725Combined sources
Beta strandi74 – 763Combined sources
Turni77 – 804Combined sources
Beta strandi81 – 855Combined sources
Helixi90 – 10617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDLNMR-A35-111[»]
ProteinModelPortaliO95715.
SMRiO95715. Positions 35-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95715.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 8115D-boxAdd
BLAST

Domaini

The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72608.
GeneTreeiENSGT00390000000618.
HOGENOMiHOG000065700.
HOVERGENiHBG054250.
InParanoidiO95715.
KOiK10033.
OMAiMCLASAE.
OrthoDBiEOG7TXKK6.
PhylomeDBiO95715.
TreeFamiTF332769.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95715-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLPRRAPP VSMRLLAAAL LLLLLALYTA RVDGSKCKCS RKGPKIRYSD
60 70 80 90 100
VKKLEMKPKY PHCEEKMVII TTKSVSRYRG QEHCLHPKLQ STKRFIKWYN
110
AWNEKRRVYE E
Length:111
Mass (Da):13,078
Last modified:March 23, 2010 - v2
Checksum:iC9A18B2A78CACF74
GO

Sequence cautioni

The sequence AAD38944.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081V → F in AAF78449. (PubMed:10946286)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144103 mRNA. Translation: AAD38944.1. Different initiation.
AF106911 mRNA. Translation: AAF78449.1.
AY358906 mRNA. Translation: AAQ89265.1.
AK075514 mRNA. Translation: BAG52160.1.
BT007080 mRNA. Translation: AAP35743.1.
AC034206 Genomic DNA. No translation available.
BC003513 mRNA. Translation: AAH03513.1.
AF073957 mRNA. Translation: AAD03839.1.
CCDSiCCDS4188.1.
PIRiJG0182.
RefSeqiNP_004878.2. NM_004887.4.
UniGeneiHs.483444.

Genome annotation databases

EnsembliENST00000337225; ENSP00000337065; ENSG00000145824.
ENST00000512158; ENSP00000423783; ENSG00000145824.
GeneIDi9547.
KEGGihsa:9547.
UCSCiuc003lay.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL14 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144103 mRNA. Translation: AAD38944.1 . Different initiation.
AF106911 mRNA. Translation: AAF78449.1 .
AY358906 mRNA. Translation: AAQ89265.1 .
AK075514 mRNA. Translation: BAG52160.1 .
BT007080 mRNA. Translation: AAP35743.1 .
AC034206 Genomic DNA. No translation available.
BC003513 mRNA. Translation: AAH03513.1 .
AF073957 mRNA. Translation: AAD03839.1 .
CCDSi CCDS4188.1.
PIRi JG0182.
RefSeqi NP_004878.2. NM_004887.4.
UniGenei Hs.483444.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HDL NMR - A 35-111 [» ]
ProteinModelPortali O95715.
SMRi O95715. Positions 35-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114921. 2 interactions.
IntActi O95715. 4 interactions.
MINTi MINT-4724169.
STRINGi 9606.ENSP00000337065.

PTM databases

PhosphoSitei O95715.

Proteomic databases

PaxDbi O95715.
PRIDEi O95715.

Protocols and materials databases

DNASUi 9547.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337225 ; ENSP00000337065 ; ENSG00000145824 .
ENST00000512158 ; ENSP00000423783 ; ENSG00000145824 .
GeneIDi 9547.
KEGGi hsa:9547.
UCSCi uc003lay.3. human.

Organism-specific databases

CTDi 9547.
GeneCardsi GC05M134934.
HGNCi HGNC:10640. CXCL14.
HPAi CAB029996.
MIMi 604186. gene.
neXtProti NX_O95715.
PharmGKBi PA35571.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72608.
GeneTreei ENSGT00390000000618.
HOGENOMi HOG000065700.
HOVERGENi HBG054250.
InParanoidi O95715.
KOi K10033.
OMAi MCLASAE.
OrthoDBi EOG7TXKK6.
PhylomeDBi O95715.
TreeFami TF332769.

Miscellaneous databases

ChiTaRSi CXCL14. human.
EvolutionaryTracei O95715.
GenomeRNAii 9547.
NextBioi 35803.
PROi O95715.
SOURCEi Search...

Gene expression databases

Bgeei O95715.
CleanExi HS_CXCL14.
Genevestigatori O95715.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue."
    Frederick M.J., Henderson Y., Xu X., Deavers M.T., Sahin A.A., Wu H., Lewis D.E., El-Naggar A.K., Clayman G.L.
    Am. J. Pathol. 156:1937-1950(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Oral epithelium.
  2. "Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells."
    Cao X., Zhang W., Wan T., He L., Chen T., Yuan Z., Ma S., Yu Y., Chen G.
    J. Immunol. 165:2588-2595(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-44, FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  8. "Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells."
    Hromas R., Broxmeyer H.E., Kim C., Nakshatri H., Christopherson K. II, Azam M., Hou Y.-H.
    Biochem. Biophys. Res. Commun. 255:703-706(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-111, FUNCTION, TISSUE SPECIFICITY.
  9. "Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome."
    Peterson F.C., Thorpe J.A., Harder A.G., Volkman B.F., Schwarze S.R.
    J. Mol. Biol. 363:813-822(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 34-111, DOMAIN D-BOX MOTIF, UBIQUITINATION, DISULFIDE BONDS.

Entry informationi

Entry nameiCXL14_HUMAN
AccessioniPrimary (citable) accession number: O95715
Secondary accession number(s): B3KQU8
, Q6UW97, Q86U69, Q9BTR1, Q9NS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3