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O95711

- LY86_HUMAN

UniProt

O95711 - LY86_HUMAN

Protein

Lymphocyte antigen 86

Gene

LY86

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. humoral immune response Source: ProtInc
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: UniProtKB-KW
    6. positive regulation of lipopolysaccharide-mediated signaling pathway Source: MGI

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_6894. Toll Like Receptor 4 (TLR4) Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lymphocyte antigen 86
    Short name:
    Ly-86
    Alternative name(s):
    Protein MD-1
    Gene namesi
    Name:LY86
    Synonyms:MD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16837. LY86.

    Subcellular locationi

    Secretedextracellular space
    Note: Associated with CD180 at the cell surface.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 162142Lymphocyte antigen 86PRO_0000018614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 581 Publication
    Disulfide bondi45 ↔ 1541 Publication
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 1121 Publication
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO95711.

    Expressioni

    Tissue specificityi

    Highly expressed in B-cells, monocytes and tonsil.

    Inductioni

    In monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).

    Gene expression databases

    BgeeiO95711.
    CleanExiHS_LY86.
    GenevestigatoriO95711.

    Organism-specific databases

    HPAiCAB025000.
    HPA044895.

    Interactioni

    Subunit structurei

    M-shaped tetramer of two CD180-LY86 heterodimers.1 Publication

    Protein-protein interaction databases

    BioGridi114839. 2 interactions.
    DIPiDIP-59105N.
    STRINGi9606.ENSP00000230568.

    Structurei

    Secondary structure

    1
    162
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 334
    Beta strandi35 – 373
    Beta strandi39 – 446
    Beta strandi52 – 576
    Beta strandi67 – 737
    Beta strandi79 – 8911
    Beta strandi92 – 10211
    Turni110 – 1134
    Beta strandi119 – 1257
    Beta strandi135 – 14511
    Beta strandi151 – 16111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3B2DX-ray2.80C/D21-162[»]
    ProteinModelPortaliO95711.
    SMRiO95711. Positions 26-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41851.
    HOGENOMiHOG000261640.
    HOVERGENiHBG019056.
    InParanoidiO95711.
    OMAiINIRFGI.
    OrthoDBiEOG7T4MMZ.
    PhylomeDBiO95711.
    TreeFamiTF335876.

    Family and domain databases

    InterProiIPR014756. Ig_E-set.
    IPR003172. ML_dom.
    [Graphical view]
    PfamiPF02221. E1_DerP2_DerF2. 1 hit.
    [Graphical view]
    SMARTiSM00737. ML. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95711-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGFTATLFL WTLIFPSCSG GGGGKAWPTH VVCSDSGLEV LYQSCDPLQD    50
    FGFSVEKCSK QLKSNINIRF GIILREDIKE LFLDLALMSQ GSSVLNFSYP 100
    ICEAALPKFS FCGRRKGEQI YYAGPVNNPE FTIPQGEYQV LLELYTEKRS 150
    TVACANATIM CS 162
    Length:162
    Mass (Da):17,906
    Last modified:May 1, 1999 - v1
    Checksum:i3E6497E2DB4C6F27
    GO

    Sequence cautioni

    The sequence BAA76410.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti93 – 931S → P.
    Corresponds to variant rs5743649 [ dbSNP | Ensembl ].
    VAR_024531
    Natural varianti121 – 1211Y → C.
    Corresponds to variant rs5743651 [ dbSNP | Ensembl ].
    VAR_050029
    Natural varianti160 – 1601M → V.
    Corresponds to variant rs1802323 [ dbSNP | Ensembl ].
    VAR_014539

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057178 mRNA. Translation: AAC98152.2.
    AB020499 mRNA. Translation: BAA76410.1. Different initiation.
    AL031123 Genomic DNA. Translation: CAB76262.1.
    BC038846 mRNA. Translation: AAH38846.1.
    CCDSiCCDS4498.1.
    RefSeqiNP_004262.1. NM_004271.3.
    UniGeneiHs.653138.

    Genome annotation databases

    EnsembliENST00000230568; ENSP00000230568; ENSG00000112799.
    ENST00000379953; ENSP00000369286; ENSG00000112799.
    GeneIDi9450.
    KEGGihsa:9450.
    UCSCiuc003mwy.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057178 mRNA. Translation: AAC98152.2 .
    AB020499 mRNA. Translation: BAA76410.1 . Different initiation.
    AL031123 Genomic DNA. Translation: CAB76262.1 .
    BC038846 mRNA. Translation: AAH38846.1 .
    CCDSi CCDS4498.1.
    RefSeqi NP_004262.1. NM_004271.3.
    UniGenei Hs.653138.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3B2D X-ray 2.80 C/D 21-162 [» ]
    ProteinModelPortali O95711.
    SMRi O95711. Positions 26-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114839. 2 interactions.
    DIPi DIP-59105N.
    STRINGi 9606.ENSP00000230568.

    Proteomic databases

    PRIDEi O95711.

    Protocols and materials databases

    DNASUi 9450.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230568 ; ENSP00000230568 ; ENSG00000112799 .
    ENST00000379953 ; ENSP00000369286 ; ENSG00000112799 .
    GeneIDi 9450.
    KEGGi hsa:9450.
    UCSCi uc003mwy.1. human.

    Organism-specific databases

    CTDi 9450.
    GeneCardsi GC06P006588.
    HGNCi HGNC:16837. LY86.
    HPAi CAB025000.
    HPA044895.
    MIMi 605241. gene.
    neXtProti NX_O95711.
    PharmGKBi PA128394549.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41851.
    HOGENOMi HOG000261640.
    HOVERGENi HBG019056.
    InParanoidi O95711.
    OMAi INIRFGI.
    OrthoDBi EOG7T4MMZ.
    PhylomeDBi O95711.
    TreeFami TF335876.

    Enzyme and pathway databases

    Reactomei REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.

    Miscellaneous databases

    GenomeRNAii 9450.
    NextBioi 35400.
    PROi O95711.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95711.
    CleanExi HS_LY86.
    Genevestigatori O95711.

    Family and domain databases

    InterProi IPR014756. Ig_E-set.
    IPR003172. ML_dom.
    [Graphical view ]
    Pfami PF02221. E1_DerP2_DerF2. 1 hit.
    [Graphical view ]
    SMARTi SM00737. ML. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "RP105 is associated with MD-1 and transmits an activation signal in human B cells."
      Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M.
      Blood 92:2815-2822(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal liver and Spleen.
    2. "Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display."
      Begum N.A., Tsuji S., Nomura M., Shida K., Azuma I., Hayashi A., Matsumoto M., Seya T., Toyoshima K.
      Biochem. Biophys. Res. Commun. 256:325-329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-162.
      Tissue: Monocyte.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.
    6. "Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family."
      Ohto U., Miyake K., Shimizu T.
      J. Mol. Biol. 413:815-825(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 21-162 IN COMPLEX WITH CD180, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiLY86_HUMAN
    AccessioniPrimary (citable) accession number: O95711
    Secondary accession number(s): Q9UQC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3