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O95711 (LY86_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lymphocyte antigen 86

Short name=Ly-86
Alternative name(s):
Protein MD-1
Gene names
Name:LY86
Synonyms:MD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression By similarity.

Subunit structure

M-shaped tetramer of two CD180-LY86 heterodimers. Ref.6

Subcellular location

Secretedextracellular space. Note: Associated with CD180 at the cell surface.

Tissue specificity

Highly expressed in B-cells, monocytes and tonsil.

Induction

In monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).

Sequence caution

The sequence BAA76410.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.5
Chain21 – 162142Lymphocyte antigen 86
PRO_0000018614

Amino acid modifications

Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 58 Ref.6
Disulfide bond45 ↔ 154 Ref.6
Disulfide bond102 ↔ 112 Ref.6

Natural variations

Natural variant931S → P.
Corresponds to variant rs5743649 [ dbSNP | Ensembl ].
VAR_024531
Natural variant1211Y → C.
Corresponds to variant rs5743651 [ dbSNP | Ensembl ].
VAR_050029
Natural variant1601M → V.
Corresponds to variant rs1802323 [ dbSNP | Ensembl ].
VAR_014539

Secondary structure

....................... 162
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95711 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3E6497E2DB4C6F27

FASTA16217,906
        10         20         30         40         50         60 
MKGFTATLFL WTLIFPSCSG GGGGKAWPTH VVCSDSGLEV LYQSCDPLQD FGFSVEKCSK 

        70         80         90        100        110        120 
QLKSNINIRF GIILREDIKE LFLDLALMSQ GSSVLNFSYP ICEAALPKFS FCGRRKGEQI 

       130        140        150        160 
YYAGPVNNPE FTIPQGEYQV LLELYTEKRS TVACANATIM CS 

« Hide

References

« Hide 'large scale' references
[1]"RP105 is associated with MD-1 and transmits an activation signal in human B cells."
Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M.
Blood 92:2815-2822(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver and Spleen.
[2]"Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display."
Begum N.A., Tsuji S., Nomura M., Shida K., Azuma I., Hayashi A., Matsumoto M., Seya T., Toyoshima K.
Biochem. Biophys. Res. Commun. 256:325-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-162.
Tissue: Monocyte.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
[6]"Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family."
Ohto U., Miyake K., Shimizu T.
J. Mol. Biol. 413:815-825(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 21-162 IN COMPLEX WITH CD180, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF057178 mRNA. Translation: AAC98152.2.
AB020499 mRNA. Translation: BAA76410.1. Different initiation.
AL031123 Genomic DNA. Translation: CAB76262.1.
BC038846 mRNA. Translation: AAH38846.1.
CCDSCCDS4498.1.
RefSeqNP_004262.1. NM_004271.3.
UniGeneHs.653138.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80C/D21-162[»]
ProteinModelPortalO95711.
SMRO95711. Positions 26-162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114839. 2 interactions.
DIPDIP-59105N.
STRING9606.ENSP00000230568.

Proteomic databases

PRIDEO95711.

Protocols and materials databases

DNASU9450.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000230568; ENSP00000230568; ENSG00000112799.
ENST00000379953; ENSP00000369286; ENSG00000112799.
GeneID9450.
KEGGhsa:9450.
UCSCuc003mwy.1. human.

Organism-specific databases

CTD9450.
GeneCardsGC06P006588.
HGNCHGNC:16837. LY86.
HPACAB025000.
HPA044895.
MIM605241. gene.
neXtProtNX_O95711.
PharmGKBPA128394549.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41851.
HOGENOMHOG000261640.
HOVERGENHBG019056.
InParanoidO95711.
OMAINIRFGI.
OrthoDBEOG7T4MMZ.
PhylomeDBO95711.
TreeFamTF335876.

Gene expression databases

BgeeO95711.
CleanExHS_LY86.
GenevestigatorO95711.

Family and domain databases

InterProIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTSM00737. ML. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi9450.
NextBio35400.
PROO95711.
SOURCESearch...

Entry information

Entry nameLY86_HUMAN
AccessionPrimary (citable) accession number: O95711
Secondary accession number(s): Q9UQC4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM