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Protein

Ribonuclease P protein subunit p29

Gene

POP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: ProtInc
  • ribonuclease P RNA binding Source: GO_Central
  • RNA binding Source: ProtInc

GO - Biological processi

  • rRNA processing Source: GO_Central
  • tRNA 5'-leader removal Source: FlyBase
  • tRNA processing Source: ProtInc

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p29 (EC:3.1.26.5)
Short name:
hPOP4
Gene namesi
Name:POP4
Synonyms:RPP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105171.9
HGNCiHGNC:30081 POP4
MIMi606114 gene
neXtProtiNX_O95707

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10775
OpenTargetsiENSG00000105171
PharmGKBiPA134987921

Polymorphism and mutation databases

BioMutaiPOP4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001284181 – 220Ribonuclease P protein subunit p29Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95707
MaxQBiO95707
PaxDbiO95707
PeptideAtlasiO95707
PRIDEiO95707

PTM databases

iPTMnetiO95707
PhosphoSitePlusiO95707

Expressioni

Gene expression databases

BgeeiENSG00000105171
CleanExiHS_POP4
ExpressionAtlasiO95707 baseline and differential
GenevisibleiO95707 HS

Organism-specific databases

HPAiHPA042748

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115993, 41 interactors
CORUMiO95707
IntActiO95707, 12 interactors
MINTiO95707
STRINGi9606.ENSP00000465213

Structurei

3D structure databases

ProteinModelPortaliO95707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 74Poly-Lys10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4046 Eukaryota
ENOG4111FUV LUCA
GeneTreeiENSGT00390000010067
HOGENOMiHOG000007746
HOVERGENiHBG002676
InParanoidiO95707
KOiK03538
OMAiPKSECVF
OrthoDBiEOG091G0O40
PhylomeDBiO95707

Family and domain databases

Gene3Di2.30.30.210, 1 hit
InterProiView protein in InterPro
IPR002730 RNase_P/MRP_p29
IPR016848 RNase_P/MRP_p29-subunit
IPR036980 RNase_P/MRP_p29_sf
IPR023534 Rof/RNase_P-like
PfamiView protein in Pfam
PF01868 UPF0086, 1 hit
PIRSFiPIRSF027081 RNase_P/MRP_p29_subunit, 1 hit
SMARTiView protein in SMART
SM00538 POP4, 1 hit
SUPFAMiSSF101744 SSF101744, 1 hit

Sequencei

Sequence statusi: Complete.

O95707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ
60 70 80 90 100
LQRKAVVLEY FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL
110 120 130 140 150
PLHELWKQYI RDLCSGLKPD TQPQMIQAKL LKADLHGAII SVTKSKCPSY
160 170 180 190 200
VGITGILLQE TKHIFKIITK EDRLKVIPKL NCVFTVETDG FISYIYGSKF
210 220
QLRSSERSAK KFKAKGTIDL
Length:220
Mass (Da):25,425
Last modified:April 3, 2002 - v2
Checksum:i26141947E9F5C61E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38 – 39ST → TS in AAD00893 (PubMed:10024167).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001176 mRNA Translation: AAD00893.2
Y18863 mRNA Translation: CAB39167.1
CR536569 mRNA Translation: CAG38806.1
AK314790 mRNA Translation: BAG37321.1
BC004438 mRNA Translation: AAH04438.1
BC006098 mRNA Translation: AAH06098.1
CCDSiCCDS12416.1
RefSeqiNP_006618.1, NM_006627.2
UniGeneiHs.412870

Genome annotation databases

EnsembliENST00000585603; ENSP00000465213; ENSG00000105171
GeneIDi10775
KEGGihsa:10775
UCSCiuc002nsf.3 human

Similar proteinsi

Entry informationi

Entry nameiRPP29_HUMAN
AccessioniPrimary (citable) accession number: O95707
Secondary accession number(s): Q5XKL7, Q6FHW9, Q9UQQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 3, 2002
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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