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Protein

Bromodomain-containing protein 1

Gene

BRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100425-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 1
Alternative name(s):
BR140-like protein
Bromodomain and PHD finger-containing protein 2
Gene namesi
Name:BRD1
Synonyms:BRL, BRPF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1102. BRD1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • dendrite Source: Ensembl
  • MOZ/MORF histone acetyltransferase complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • perikaryon Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23774.
OpenTargetsiENSG00000100425.
PharmGKBiPA25413.

Chemistry databases

ChEMBLiCHEMBL2176774.
GuidetoPHARMACOLOGYi2724.

Polymorphism and mutation databases

BioMutaiBRD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111771 – 1058Bromodomain-containing protein 1Add BLAST1058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineCombined sources1
Modified residuei368N6-acetyllysineCombined sources1
Modified residuei516N6-acetyllysineCombined sources1
Modified residuei519N6-acetyllysineCombined sources1
Modified residuei803PhosphoserineCombined sources1
Modified residuei903N6-acetyllysineCombined sources1
Modified residuei1052PhosphoserineCombined sources1
Modified residuei1055PhosphoserineCombined sources1
Isoform 2 (identifier: O95696-2)
Modified residuei906PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95696.
MaxQBiO95696.
PaxDbiO95696.
PeptideAtlasiO95696.
PRIDEiO95696.

2D gel databases

OGPiO95696.

PTM databases

iPTMnetiO95696.
PhosphoSitePlusiO95696.

Miscellaneous databases

PMAP-CutDBO95696.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiENSG00000100425.
CleanExiHS_BRD1.
ExpressionAtlasiO95696. baseline and differential.
GenevisibleiO95696. HS.

Organism-specific databases

HPAiHPA000807.
HPA001063.

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys-79' on histone H3.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PBRM1Q86U862EBI-11700916,EBI-637807

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117273. 25 interactors.
IntActiO95696. 47 interactors.
MINTiMINT-1186761.
STRINGi9606.ENSP00000216267.

Chemistry databases

BindingDBiO95696.

Structurei

Secondary structure

11058
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni205 – 208Combined sources4
Beta strandi218 – 220Combined sources3
Beta strandi222 – 225Combined sources4
Beta strandi227 – 229Combined sources3
Beta strandi231 – 233Combined sources3
Beta strandi235 – 237Combined sources3
Beta strandi240 – 242Combined sources3
Helixi243 – 246Combined sources4
Helixi259 – 266Combined sources8
Turni328 – 331Combined sources4
Beta strandi338 – 340Combined sources3
Turni344 – 346Combined sources3
Beta strandi349 – 351Combined sources3
Helixi352 – 358Combined sources7
Beta strandi362 – 369Combined sources8
Turni371 – 373Combined sources3
Beta strandi376 – 383Combined sources8
Helixi386 – 388Combined sources3
Beta strandi389 – 392Combined sources4
Helixi566 – 579Combined sources14
Beta strandi586 – 589Combined sources4
Turni593 – 595Combined sources3
Helixi599 – 602Combined sources4
Helixi609 – 617Combined sources9
Helixi624 – 641Combined sources18
Beta strandi644 – 646Combined sources3
Helixi647 – 673Combined sources27
Helixi675 – 679Combined sources5
Beta strandi932 – 935Combined sources4
Beta strandi943 – 948Combined sources6
Helixi969 – 979Combined sources11
Beta strandi986 – 991Combined sources6
Beta strandi998 – 1002Combined sources5
Helixi1003 – 1005Combined sources3
Beta strandi1006 – 1011Combined sources6
Helixi1013 – 1020Combined sources8
Beta strandi1023 – 1025Combined sources3
Helixi1026 – 1046Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KU3NMR-A208-269[»]
2L43NMR-A205-269[»]
2LQ6NMR-A317-392[»]
3LYIX-ray2.10A/B925-1049[»]
3RCWX-ray2.21A/B/C/D/E/F/G/H556-688[»]
4Z02X-ray1.87A/B925-1049[»]
5AMEX-ray1.58A/B556-688[»]
5AMFX-ray1.75A/B556-688[»]
5FG6X-ray1.10A563-688[»]
ProteinModelPortaliO95696.
SMRiO95696.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95696.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini579 – 649BromoPROSITE-ProRule annotationAdd BLAST71
Domaini929 – 1012PWWPPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5076. LUCA.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiO95696.
KOiK11349.
OMAiNESHSAC.
PhylomeDBiO95696.
TreeFamiTF316118.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRKGRCHRG SAARHPSSPC SVKHSPTRET LTYAQAQRMV EIEIEGRLHR
60 70 80 90 100
ISIFDPLEII LEDDLTAQEM SECNSNKENS ERPPVCLRTK RHKNNRVKKK
110 120 130 140 150
NEALPSAHGT PASASALPEP KVRIVEYSPP SAPRRPPVYY KFIEKSAEEL
160 170 180 190 200
DNEVEYDMDE EDYAWLEIVN EKRKGDCVPA VSQSMFEFLM DRFEKESHCE
210 220 230 240 250
NQKQGEQQSL IDEDAVCCIC MDGECQNSNV ILFCDMCNLA VHQECYGVPY
260 270 280 290 300
IPEGQWLCRH CLQSRARPAD CVLCPNKGGA FKKTDDDRWG HVVCALWIPE
310 320 330 340 350
VGFANTVFIE PIDGVRNIPP ARWKLTCYLC KQKGVGACIQ CHKANCYTAF
360 370 380 390 400
HVTCAQKAGL YMKMEPVKEL TGGGTTFSVR KTAYCDVHTP PGCTRRPLNI
410 420 430 440 450
YGDVEMKNGV CRKESSVKTV RSTSKVRKKA KKAKKALAEP CAVLPTVCAP
460 470 480 490 500
YIPPQRLNRI ANQVAIQRKK QFVERAHSYW LLKRLSRNGA PLLRRLQSSL
510 520 530 540 550
QSQRSSQQRE NDEEMKAAKE KLKYWQRLRH DLERARLLIE LLRKREKLKR
560 570 580 590 600
EQVKVEQVAM ELRLTPLTVL LRSVLDQLQD KDPARIFAQP VSLKEVPDYL
610 620 630 640 650
DHIKHPMDFA TMRKRLEAQG YKNLHEFEED FDLIIDNCMK YNARDTVFYR
660 670 680 690 700
AAVRLRDQGG VVLRQARREV DSIGLEEASG MHLPERPAAA PRRPFSWEDV
710 720 730 740 750
DRLLDPANRA HLGLEEQLRE LLDMLDLTCA MKSSGSRSKR AKLLKKEIAL
760 770 780 790 800
LRNKLSQQHS QPLPTGPGLE GFEEDGAALG PEAGEEVLPR LETLLQPRKR
810 820 830 840 850
SRSTCGDSEV EEESPGKRLD AGLTNGFGGA RSEQEPGGGL GRKATPRRRC
860 870 880 890 900
ASESSISSSN SPLCDSSFNA PKCGRGKPAL VRRHTLEDRS ELISCIENGN
910 920 930 940 950
YAKAARIAAE VGQSSMWIST DAAASVLEPL KVVWAKCSGY PSYPALIIDP
960 970 980 990 1000
KMPRVPGHHN GVTIPAPPLD VLKIGEHMQT KSDEKLFLVL FFDNKRSWQW
1010 1020 1030 1040 1050
LPKSKMVPLG IDETIDKLKM MEGRNSSIRK AVRIAFDRAM NHLSRVHGEP

TSDLSDID
Length:1,058
Mass (Da):119,520
Last modified:May 1, 1999 - v1
Checksum:i6E7B07E8A030E104
GO
Isoform 2 (identifier: O95696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-786: E → EGDKSPPKLE...QLGTKTFLSV

Show »
Length:1,189
Mass (Da):133,243
Checksum:i770DB2F610CB5052
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04842438R → G.Corresponds to variant rs11549978dbSNPEnsembl.1
Natural variantiVAR_048425321A → S.Corresponds to variant rs12157714dbSNPEnsembl.1
Natural variantiVAR_048426730A → T.Corresponds to variant rs35331092dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040262786E → EGDKSPPKLEPSDALPLPSN SETNSEPPTLKPVELNPEQS KLFKRVTFDNESHSACTQSA LVSGRPPEPTRASSGDVPAA AASAVAEPASDVNRRTSVLF CKSKSVSPPKSAKNTETQPT SPQLGTKTFLSV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005067 mRNA. Translation: AAF34320.1.
CR456408 mRNA. Translation: CAG30294.1.
AK292428 mRNA. Translation: BAF85117.1.
Z98885 Genomic DNA. Translation: CAB11574.1.
Z98885 Genomic DNA. Translation: CAO72061.1.
CH471138 Genomic DNA. Translation: EAW73473.1.
CCDSiCCDS14080.1. [O95696-1]
CCDS77686.1. [O95696-2]
RefSeqiNP_001291737.1. NM_001304808.1. [O95696-2]
NP_001291738.1. NM_001304809.1. [O95696-1]
XP_016884204.1. XM_017028715.1. [O95696-2]
XP_016884205.1. XM_017028716.1. [O95696-2]
XP_016884206.1. XM_017028717.1. [O95696-2]
UniGeneiHs.127950.

Genome annotation databases

EnsembliENST00000216267; ENSP00000216267; ENSG00000100425. [O95696-1]
ENST00000404034; ENSP00000384076; ENSG00000100425. [O95696-1]
ENST00000404760; ENSP00000385858; ENSG00000100425. [O95696-2]
ENST00000457780; ENSP00000410042; ENSG00000100425. [O95696-2]
GeneIDi23774.
KEGGihsa:23774.
UCSCiuc003biu.6. human. [O95696-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005067 mRNA. Translation: AAF34320.1.
CR456408 mRNA. Translation: CAG30294.1.
AK292428 mRNA. Translation: BAF85117.1.
Z98885 Genomic DNA. Translation: CAB11574.1.
Z98885 Genomic DNA. Translation: CAO72061.1.
CH471138 Genomic DNA. Translation: EAW73473.1.
CCDSiCCDS14080.1. [O95696-1]
CCDS77686.1. [O95696-2]
RefSeqiNP_001291737.1. NM_001304808.1. [O95696-2]
NP_001291738.1. NM_001304809.1. [O95696-1]
XP_016884204.1. XM_017028715.1. [O95696-2]
XP_016884205.1. XM_017028716.1. [O95696-2]
XP_016884206.1. XM_017028717.1. [O95696-2]
UniGeneiHs.127950.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KU3NMR-A208-269[»]
2L43NMR-A205-269[»]
2LQ6NMR-A317-392[»]
3LYIX-ray2.10A/B925-1049[»]
3RCWX-ray2.21A/B/C/D/E/F/G/H556-688[»]
4Z02X-ray1.87A/B925-1049[»]
5AMEX-ray1.58A/B556-688[»]
5AMFX-ray1.75A/B556-688[»]
5FG6X-ray1.10A563-688[»]
ProteinModelPortaliO95696.
SMRiO95696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117273. 25 interactors.
IntActiO95696. 47 interactors.
MINTiMINT-1186761.
STRINGi9606.ENSP00000216267.

Chemistry databases

BindingDBiO95696.
ChEMBLiCHEMBL2176774.
GuidetoPHARMACOLOGYi2724.

PTM databases

iPTMnetiO95696.
PhosphoSitePlusiO95696.

Polymorphism and mutation databases

BioMutaiBRD1.

2D gel databases

OGPiO95696.

Proteomic databases

EPDiO95696.
MaxQBiO95696.
PaxDbiO95696.
PeptideAtlasiO95696.
PRIDEiO95696.

Protocols and materials databases

DNASUi23774.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216267; ENSP00000216267; ENSG00000100425. [O95696-1]
ENST00000404034; ENSP00000384076; ENSG00000100425. [O95696-1]
ENST00000404760; ENSP00000385858; ENSG00000100425. [O95696-2]
ENST00000457780; ENSP00000410042; ENSG00000100425. [O95696-2]
GeneIDi23774.
KEGGihsa:23774.
UCSCiuc003biu.6. human. [O95696-1]

Organism-specific databases

CTDi23774.
DisGeNETi23774.
GeneCardsiBRD1.
HGNCiHGNC:1102. BRD1.
HPAiHPA000807.
HPA001063.
MIMi604589. gene.
neXtProtiNX_O95696.
OpenTargetsiENSG00000100425.
PharmGKBiPA25413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5076. LUCA.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiO95696.
KOiK11349.
OMAiNESHSAC.
PhylomeDBiO95696.
TreeFamiTF316118.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100425-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Miscellaneous databases

ChiTaRSiBRD1. human.
EvolutionaryTraceiO95696.
GenomeRNAii23774.
PMAP-CutDBO95696.
PROiO95696.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100425.
CleanExiHS_BRD1.
ExpressionAtlasiO95696. baseline and differential.
GenevisibleiO95696. HS.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRD1_HUMAN
AccessioniPrimary (citable) accession number: O95696
Secondary accession number(s): A6ZJA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.