O95685 (PPR3D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase 1 regulatory subunit 3D

Alternative name(s):
Protein phosphatase 1 regulatory subunit 6
Short name=PP1 subunit R6
Protein phosphatase 1-binding subunit R6

Gene names

Name:	PPP1R3D
Synonyms:	PPP1R6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Subunit structure	Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Ref.1
Tissue specificity	Expressed in all tissue tested. High expression in skeletal muscle and heart.
Domain	The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
Sequence similarities	Contains 1 CBM21 (carbohydrate binding type-21) domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen metabolism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein serine/threonine phosphatase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Protein phosphatase 1 regulatory subunit 3D		PRO_0000071503
Regions
	Domain	169 – 278	110	CBM21
	Motif	101 – 104	4	PP1-binding motif
Amino acid modifications
	Modified residue	23	1	Phosphoserine Ref.5
	Modified residue	25	1	Phosphoserine Ref.5
	Modified residue	28	1	Phosphoserine Ref.5
	Modified residue	74	1	Phosphoserine Ref.4 Ref.5
	Modified residue	77	1	Phosphoserine Ref.5
	Modified residue	78	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O95685 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: DB848FB1CF55E49E	FASTA	299	32,559
	10 20 30 40 50 60 MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA PPPTPAPSGC 70 80 90 100 110 120 DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK LRVRFADALG LELAQVKVFN 130 140 150 160 170 180 AGDDPSVPLH VLSRLAINSD LCCSSQDLEF TLHCLVPDFP PPVEAADFGE RLQRQLVCLE 190 200 210 220 230 240 RVTCSDLGIS GTVRVCNVAF EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF 250 260 270 280 290 PVPPFLLELG SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1." Armstrong C.G., Browne G.J., Cohen P., Cohen P.T.W. FEBS Lett. 418:210-214(1997) [PubMed: 9414128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ASSOCIATION WITH GLYCOGEN, INTERACTION WITH PPP1CC. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-78, MASS SPECTROMETRY. Tissue: Platelet.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25; SER-28; SER-74 AND SER-77, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18206 mRNA. Translation: CAA77081.1. AL109928 Genomic DNA. Translation: CAB92096.1. BC074860 mRNA. Translation: AAH74860.2. BC074861 mRNA. Translation: AAH74861.2.
IPI	IPI00006682.
RefSeq	NP_006233.1. NM_006242.3.
UniGene	Hs.42215.
3D structure databases
ProteinModelPortal	O95685.
SMR	O95685. Positions 151-288.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95685. 1 interaction.
MINT	MINT-5003974.
STRING	O95685.
Protein family/group databases
CAZy	CBM21. Carbohydrate-Binding Module Family 21.
PTM databases
PhosphoSite	O95685.
Proteomic databases
PeptideAtlas	O95685.
PRIDE	O95685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370996; ENSP00000360035; ENSG00000132825.
GeneID	5509.
KEGG	hsa:5509.
UCSC	uc002ybb.1. human.
Organism-specific databases
CTD	5509.
GeneCards	GC20M058511.
H-InvDB	HIX0027690.
HGNC	HGNC:9294. PPP1R3D.
HPA	HPA041146.
MIM	603326. gene.
neXtProt	NX_O95685.
PharmGKB	PA33654.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19216.
HOGENOM	HBG715688.
HOVERGEN	HBG053658.
InParanoid	O95685.
OMA	VKVFNAG.
OrthoDB	EOG43BMPR.
PhylomeDB	O95685.
Gene expression databases
ArrayExpress	O95685.
Bgee	O95685.
CleanEx	HS_PPP1R3D.
Genevestigator	O95685.
GermOnline	ENSG00000132825. Homo sapiens.
Family and domain databases
InterPro	IPR005036. CBM_21. IPR017434. Pase-1_Glycogen_target-su_met. [Graphical view]
KO	K07189.
Pfam	PF03370. CBM_21. 1 hit. [Graphical view]
PIRSF	PIRSF038207. PP1_GT_animal. 1 hit.
PROSITE	PS51159. CBM21. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	21308.
SOURCE	Search...

Entry information

Entry name

PPR3D_HUMAN

Accession

Primary (citable) accession number: O95685
Secondary accession number(s): Q6DK02

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.