Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95685

- PPR3D_HUMAN

UniProt

O95685 - PPR3D_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 3D

Gene

PPP1R3D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. glycogen metabolic process Source: UniProtKB-KW
    3. regulation of glycogen biosynthetic process Source: Ensembl
    4. regulation of glycogen catabolic process Source: Ensembl

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Protein family/group databases

    CAZyiCBM21. Carbohydrate-Binding Module Family 21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3D
    Alternative name(s):
    Protein phosphatase 1 regulatory subunit 6
    Short name:
    PP1 subunit R6
    Protein phosphatase 1-binding subunit R6
    Gene namesi
    Name:PPP1R3D
    Synonyms:PPP1R6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:9294. PPP1R3D.

    Subcellular locationi

    GO - Cellular componenti

    1. glycogen granule Source: Ensembl
    2. intracellular membrane-bounded organelle Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33654.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Protein phosphatase 1 regulatory subunit 3DPRO_0000071503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei28 – 281Phosphoserine1 Publication
    Modified residuei74 – 741Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95685.
    PaxDbiO95685.
    PeptideAtlasiO95685.
    PRIDEiO95685.

    PTM databases

    PhosphoSiteiO95685.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested. High expression in skeletal muscle and heart.

    Gene expression databases

    BgeeiO95685.
    CleanExiHS_PPP1R3D.
    GenevestigatoriO95685.

    Organism-specific databases

    HPAiHPA041146.

    Interactioni

    Subunit structurei

    Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Interacts with EPM2A; in the presence of NHLC1/malin the interaction leads to PPP1R3D ubiquitination and autophagic degradation.3 Publications

    Protein-protein interaction databases

    BioGridi111501. 5 interactions.
    IntActiO95685. 4 interactions.
    MINTiMINT-5003974.
    STRINGi9606.ENSP00000360035.

    Structurei

    3D structure databases

    ProteinModelPortaliO95685.
    SMRiO95685. Positions 155-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 278110CBM21PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi101 – 1044PP1-binding motif

    Domaini

    The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

    Sequence similaritiesi

    Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG288354.
    HOGENOMiHOG000231580.
    HOVERGENiHBG053658.
    InParanoidiO95685.
    KOiK07189.
    OMAiQCLVPDF.
    OrthoDBiEOG76HQ2B.
    PhylomeDBiO95685.
    TreeFamiTF105537.

    Family and domain databases

    InterProiIPR005036. CBM_21.
    IPR017434. Pase-1_Glycogen_target-su_met.
    [Graphical view]
    PfamiPF03370. CBM_21. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038207. PP1_GT_animal. 1 hit.
    PROSITEiPS51159. CBM21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95685-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA    50
    PPPTPAPSGC DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK 100
    LRVRFADALG LELAQVKVFN AGDDPSVPLH VLSRLAINSD LCCSSQDLEF 150
    TLHCLVPDFP PPVEAADFGE RLQRQLVCLE RVTCSDLGIS GTVRVCNVAF 200
    EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF PVPPFLLELG 250
    SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI 299
    Length:299
    Mass (Da):32,559
    Last modified:May 1, 1999 - v1
    Checksum:iDB848FB1CF55E49E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18206 mRNA. Translation: CAA77081.1.
    AL109928 Genomic DNA. Translation: CAB92096.1.
    BC074860 mRNA. Translation: AAH74860.2.
    BC074861 mRNA. Translation: AAH74861.2.
    CCDSiCCDS13483.1.
    RefSeqiNP_006233.1. NM_006242.3.
    UniGeneiHs.42215.

    Genome annotation databases

    EnsembliENST00000370996; ENSP00000360035; ENSG00000132825.
    GeneIDi5509.
    KEGGihsa:5509.
    UCSCiuc002ybb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18206 mRNA. Translation: CAA77081.1 .
    AL109928 Genomic DNA. Translation: CAB92096.1 .
    BC074860 mRNA. Translation: AAH74860.2 .
    BC074861 mRNA. Translation: AAH74861.2 .
    CCDSi CCDS13483.1.
    RefSeqi NP_006233.1. NM_006242.3.
    UniGenei Hs.42215.

    3D structure databases

    ProteinModelPortali O95685.
    SMRi O95685. Positions 155-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111501. 5 interactions.
    IntActi O95685. 4 interactions.
    MINTi MINT-5003974.
    STRINGi 9606.ENSP00000360035.

    Protein family/group databases

    CAZyi CBM21. Carbohydrate-Binding Module Family 21.

    PTM databases

    PhosphoSitei O95685.

    Proteomic databases

    MaxQBi O95685.
    PaxDbi O95685.
    PeptideAtlasi O95685.
    PRIDEi O95685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370996 ; ENSP00000360035 ; ENSG00000132825 .
    GeneIDi 5509.
    KEGGi hsa:5509.
    UCSCi uc002ybb.3. human.

    Organism-specific databases

    CTDi 5509.
    GeneCardsi GC20M058511.
    HGNCi HGNC:9294. PPP1R3D.
    HPAi HPA041146.
    MIMi 603326. gene.
    neXtProti NX_O95685.
    PharmGKBi PA33654.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288354.
    HOGENOMi HOG000231580.
    HOVERGENi HBG053658.
    InParanoidi O95685.
    KOi K07189.
    OMAi QCLVPDF.
    OrthoDBi EOG76HQ2B.
    PhylomeDBi O95685.
    TreeFami TF105537.

    Miscellaneous databases

    GenomeRNAii 5509.
    NextBioi 21308.
    PROi O95685.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95685.
    CleanExi HS_PPP1R3D.
    Genevestigatori O95685.

    Family and domain databases

    InterProi IPR005036. CBM_21.
    IPR017434. Pase-1_Glycogen_target-su_met.
    [Graphical view ]
    Pfami PF03370. CBM_21. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038207. PP1_GT_animal. 1 hit.
    PROSITEi PS51159. CBM21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1."
      Armstrong C.G., Browne G.J., Cohen P., Cohen P.T.W.
      FEBS Lett. 418:210-214(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ASSOCIATION WITH GLYCOGEN, INTERACTION WITH PPP1CC.
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-28 AND SER-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates."
      Worby C.A., Gentry M.S., Dixon J.E.
      J. Biol. Chem. 281:30412-30418(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPM2A.
    6. "Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex."
      Rubio-Villena C., Garcia-Gimeno M.A., Sanz P.
      Int. J. Biochem. Cell Biol. 45:1479-1488(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPM2A.

    Entry informationi

    Entry nameiPPR3D_HUMAN
    AccessioniPrimary (citable) accession number: O95685
    Secondary accession number(s): Q6DK02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3