Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FGFR1 oncogene partner

Gene

FGFR1OP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385).3 Publications

Caution

Interacting region of CEP19 is conflicting: According to a report, interacts via N-terminus (PubMed:28428259). According to another report, interacts via C-terminus (PubMed:28659385).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activity Source: Reactome
  • protein tyrosine kinase inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiO95684

Names & Taxonomyi

Protein namesi
Recommended name:
FGFR1 oncogene partner
Gene namesi
Name:FGFR1OP
Synonyms:FOP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000213066.11
HGNCiHGNC:17012 FGFR1OP
MIMi605392 gene
neXtProtiNX_O95684

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity (PubMed:9949182).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74V → F: Abolishes homodimerization and leads to aggregation. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173 – 174Breakpoint for translocation to form FGFR1OP-FGFR1 or FGFR1-FGFR1OP fusion proteins2

Organism-specific databases

DisGeNETi11116
OpenTargetsiENSG00000213066
PharmGKBiPA134941638

Polymorphism and mutation databases

BioMutaiFGFR1OP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332931 – 399FGFR1 oncogene partnerAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143PhosphothreonineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei337PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95684
MaxQBiO95684
PaxDbiO95684
PeptideAtlasiO95684
PRIDEiO95684

PTM databases

iPTMnetiO95684
PhosphoSitePlusiO95684

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000213066
CleanExiHS_FGFR1OP
ExpressionAtlasiO95684 baseline and differential
GenevisibleiO95684 HS

Organism-specific databases

HPAiHPA071876

Interactioni

Subunit structurei

Homodimer (PubMed:16690081). Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1 (PubMed:16314388). Interacts with CEP19 (PubMed:28625565, PubMed:28428259, PubMed:28659385). Interacts (via N-terminus) with CEP350 (via C-terminus) (PubMed:28625565, PubMed:28428259).5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116291, 161 interactors
IntActiO95684, 146 interactors
MINTiO95684
STRINGi9606.ENSP00000355812

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi60 – 66Combined sources7
Helixi69 – 84Combined sources16
Helixi88 – 98Combined sources11
Helixi107 – 113Combined sources7
Turni120 – 124Combined sources5
Helixi127 – 134Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D68X-ray1.60A/B54-134[»]
ProteinModelPortaliO95684
SMRiO95684
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95684

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 102LisHPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the FGFR1OP family.Curated

Phylogenomic databases

eggNOGiENOG410IH12 Eukaryota
ENOG4111J6Y LUCA
GeneTreeiENSGT00390000007441
HOGENOMiHOG000007633
HOVERGENiHBG081536
InParanoidiO95684
KOiK16546
OMAiKIPRYKG
OrthoDBiEOG091G0V88
PhylomeDBiO95684
TreeFamiTF331893

Family and domain databases

InterProiView protein in InterPro
IPR018993 FOP_dimerisation-dom_N
IPR006594 LisH
PfamiView protein in Pfam
PF09398 FOP_dimer, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95684-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATAAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK
60 70 80 90 100
VENKTPLVNE SLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFQPETST
110 120 130 140 150
LQGLEGRENL ARDLGIIEAE GTVGGPLLLE VIRRCQQKEK GPTTGEGALD
160 170 180 190 200
LSDVHSPPKS PEGKTSAQTT PSKIPRYKGQ GKKKTSGQKA GDKKANDEAN
210 220 230 240 250
QSDTSVSLSE PKSKSSLHLL SHETKIGSFL SNRTLDGKDK AGLCPDEDDM
260 270 280 290 300
EGDSFFDDPI PKPEKTYGLR KEPRKQAGSL ASLSDAPPLK SGLSSLAGAP
310 320 330 340 350
SLKDSESKRG NTVLKDLKLI SDKIGSLGLG TGEDDDYVDD FNSTSHRSEK
360 370 380 390
SEISIGEEIE EDLSVEIDDI NTSDKLDDLT QDLTVSQLSD VADYLEDVA
Length:399
Mass (Da):43,065
Last modified:May 1, 1999 - v1
Checksum:i7A4B65F627B9D272
GO
Isoform 2 (identifier: O95684-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     174-193: Missing.

Show »
Length:379
Mass (Da):40,907
Checksum:iD784C5E935B62312
GO
Isoform 3 (identifier: O95684-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     376-399: LDDLTQDLTVSQLSDVADYLEDVA → TITQLECLLSIGALHFKNTADIF

Show »
Length:149
Mass (Da):16,106
Checksum:iA5D7366B2281F755
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63K → R in AAH11902 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061651190A → G. Corresponds to variant dbSNP:rs34617108Ensembl.1
Natural variantiVAR_051000271K → N1 PublicationCorresponds to variant dbSNP:rs17856382Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0181191 – 249Missing in isoform 3. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_018120174 – 193Missing in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_018121376 – 399LDDLT…LEDVA → TITQLECLLSIGALHFKNTA DIF in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18046 mRNA Translation: CAA77020.1
AK289846 mRNA Translation: BAF82535.1
AK312791 mRNA Translation: BAG35652.1
Z94721 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47509.1
CH471051 Genomic DNA Translation: EAW47510.1
BC011902 mRNA Translation: AAH11902.1
BC037785 mRNA Translation: AAH37785.1
CCDSiCCDS5296.1 [O95684-1]
CCDS5297.1 [O95684-2]
RefSeqiNP_008976.1, NM_007045.3 [O95684-1]
NP_919410.1, NM_194429.2 [O95684-2]
UniGeneiHs.487175

Genome annotation databases

EnsembliENST00000349556; ENSP00000230248; ENSG00000213066 [O95684-2]
ENST00000366847; ENSP00000355812; ENSG00000213066 [O95684-1]
GeneIDi11116
KEGGihsa:11116
UCSCiuc003qvj.5 human [O95684-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFR1OP_HUMAN
AccessioniPrimary (citable) accession number: O95684
Secondary accession number(s): A8K1D1
, B2R705, Q49AI0, Q5R3F6, Q96EW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health