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O95677

- EYA4_HUMAN

UniProt

O95677 - EYA4_HUMAN

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Protein
Eyes absent homolog 4
Gene
EYA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Binds 1 Mg2+ ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei375 – 3751Nucleophile By similarity
Metal bindingi375 – 3751Magnesium By similarity
Active sitei377 – 3771Proton donor By similarity
Metal bindingi377 – 3771Magnesium By similarity
Metal bindingi603 – 6031Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. anatomical structure morphogenesis Source: ProtInc
  3. chromatin modification Source: UniProtKB-KW
  4. inner ear development Source: Ensembl
  5. middle ear morphogenesis Source: Ensembl
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. sensory perception of sound Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
  9. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 4 (EC:3.1.3.48)
Gene namesi
Name:EYA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:3522. EYA4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 10 (DFNA10) [MIM:601316]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Cardiomyopathy, dilated 1J (CMD1J) [MIM:605362]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD1J is characterized by the association of sensorineural hearing loss and dilated cardiomyopathy in the absence of other anomalies.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Cardiomyopathy, Deafness, Non-syndromic deafness

Organism-specific databases

MIMi601316. phenotype.
605362. phenotype.
Orphaneti90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
217622. Sensorineural deafness with dilated cardiomyopathy.
PharmGKBiPA27934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Eyes absent homolog 4
PRO_0000218651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei361 – 3611Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95677.
PaxDbiO95677.
PRIDEiO95677.

PTM databases

PhosphoSiteiO95677.

Expressioni

Tissue specificityi

Highly expressed in heart and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiO95677.
BgeeiO95677.
CleanExiHS_EYA4.
GenevestigatoriO95677.

Organism-specific databases

HPAiHPA004805.
HPA038771.
HPA038772.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347294.

Structurei

3D structure databases

ProteinModelPortaliO95677.
SMRiO95677. Positions 369-639.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG297494.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
KOiK17622.
OrthoDBiEOG7DNNTZ.
PhylomeDBiO95677.
TreeFamiTF319337.

Family and domain databases

InterProiIPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95677-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS    50
SKLEKSNLSS TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT 100
EPLNSSETTA TTGDGALDTF TGSVITSSGY SPRSAHQYSP QLYPSKPYPH 150
ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA YSQTGQPYSL PTYDLGVMLP 200
AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM PGSSFAPSST 250
IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 300
DGTPSSTSTY QLQESLPGLT NQPGEFDTMQ SPSTPIKDLD ERTCRSSGSK 350
SRGRGRKNNP SPPPDSDLER VFVWDLDETI IVFHSLLTGS YAQKYGKDPP 400
MAVTLGLRME EMIFNLADTH LFFNDLEECD QVHIDDVSSD DNGQDLSTYS 450
FATDGFHAAA SSANLCLPTG VRGGVDWMRK LAFRYRRVKE LYNTYKNNVG 500
GLLGPAKRDA WLQLRAEIEG LTDSWLTNAL KSLSIISTRS NCINVLVTTT 550
QLIPALAKVL LYSLGGAFPI ENIYSATKIG KESCFERIMQ RFGRKVVYVV 600
IGDGVEEEQA AKKHNMPFWR ISSHSDLLAL HQALELEYL 639
Length:639
Mass (Da):69,505
Last modified:July 19, 2005 - v2
Checksum:iCC59A8FB1527A0EC
GO
Isoform 2 (identifier: O95677-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-92: Missing.
     93-93: M → V

Show »
Length:616
Mass (Da):67,065
Checksum:i61BC97D2981AC16E
GO
Isoform 3 (identifier: O95677-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     447-452: STYSFA → RCKRRG
     453-639: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:452
Mass (Da):48,735
Checksum:iCE4391D2A264B937
GO
Isoform 4 (identifier: O95677-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-613: MQRFGRKVVYVVIGDGVEEEQAAKK → VSRFGTNITYVVIGDGRDEEHAANQ

Show »
Length:639
Mass (Da):69,417
Checksum:i514B81F45BD98DA2
GO
Isoform 5 (identifier: O95677-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-123: Missing.
     589-613: MQRFGRKVVYVVIGDGVEEEQAAKK → VSRFGTNITYVVIGDGRDEEHAANQ

Show »
Length:585
Mass (Da):63,911
Checksum:iF11418BAC8175189
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521L → R in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036248
Natural varianti277 – 2771G → S.1 Publication
Corresponds to variant rs9493627 [ dbSNP | Ensembl ].
VAR_022932
Natural varianti301 – 3011D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036249

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 12354Missing in isoform 5.
VSP_042160Add
BLAST
Alternative sequencei70 – 9223Missing in isoform 2.
VSP_001495Add
BLAST
Alternative sequencei93 – 931M → V in isoform 2.
VSP_001496
Alternative sequencei447 – 4526STYSFA → RCKRRG in isoform 3.
VSP_001497
Alternative sequencei453 – 639187Missing in isoform 3.
VSP_001498Add
BLAST
Alternative sequencei589 – 61325MQRFG…QAAKK → VSRFGTNITYVVIGDGRDEE HAANQ in isoform 4 and isoform 5.
VSP_001499Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771V → A in BAH13593. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17114 mRNA. Translation: CAA76636.1.
Y17847 Genomic DNA. Translation: CAA76891.1.
AJ007993 mRNA. Translation: CAA07816.1.
AJ007994 mRNA. Translation: CAA07817.1.
AK301950 mRNA. Translation: BAH13593.1.
AL121959, AL024497, AL450270 Genomic DNA. Translation: CAB92069.2.
AL024497, AL121959, AL450270 Genomic DNA. Translation: CAI42524.1.
AL450270, AL024497, AL121959 Genomic DNA. Translation: CAI41272.1.
BC041063 mRNA. Translation: AAH41063.1.
CCDSiCCDS43506.1. [O95677-2]
CCDS5165.1. [O95677-1]
CCDS5166.1. [O95677-4]
RefSeqiNP_004091.3. NM_004100.4. [O95677-1]
NP_742101.2. NM_172103.3. [O95677-2]
NP_742103.1. NM_172105.3. [O95677-4]
XP_006715436.1. XM_006715373.1. [O95677-5]
UniGeneiHs.596680.

Genome annotation databases

EnsembliENST00000355167; ENSP00000347294; ENSG00000112319. [O95677-4]
ENST00000355286; ENSP00000347434; ENSG00000112319. [O95677-2]
ENST00000367895; ENSP00000356870; ENSG00000112319. [O95677-1]
ENST00000431403; ENSP00000404558; ENSG00000112319. [O95677-4]
ENST00000452339; ENSP00000395916; ENSG00000112319. [O95677-5]
GeneIDi2070.
KEGGihsa:2070.
UCSCiuc003qec.4. human. [O95677-1]
uc003qed.4. human. [O95677-4]
uc003qee.4. human. [O95677-2]
uc011ecq.2. human. [O95677-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17114 mRNA. Translation: CAA76636.1 .
Y17847 Genomic DNA. Translation: CAA76891.1 .
AJ007993 mRNA. Translation: CAA07816.1 .
AJ007994 mRNA. Translation: CAA07817.1 .
AK301950 mRNA. Translation: BAH13593.1 .
AL121959 , AL024497 , AL450270 Genomic DNA. Translation: CAB92069.2 .
AL024497 , AL121959 , AL450270 Genomic DNA. Translation: CAI42524.1 .
AL450270 , AL024497 , AL121959 Genomic DNA. Translation: CAI41272.1 .
BC041063 mRNA. Translation: AAH41063.1 .
CCDSi CCDS43506.1. [O95677-2 ]
CCDS5165.1. [O95677-1 ]
CCDS5166.1. [O95677-4 ]
RefSeqi NP_004091.3. NM_004100.4. [O95677-1 ]
NP_742101.2. NM_172103.3. [O95677-2 ]
NP_742103.1. NM_172105.3. [O95677-4 ]
XP_006715436.1. XM_006715373.1. [O95677-5 ]
UniGenei Hs.596680.

3D structure databases

ProteinModelPortali O95677.
SMRi O95677. Positions 369-639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000347294.

PTM databases

PhosphoSitei O95677.

Proteomic databases

MaxQBi O95677.
PaxDbi O95677.
PRIDEi O95677.

Protocols and materials databases

DNASUi 2070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355167 ; ENSP00000347294 ; ENSG00000112319 . [O95677-4 ]
ENST00000355286 ; ENSP00000347434 ; ENSG00000112319 . [O95677-2 ]
ENST00000367895 ; ENSP00000356870 ; ENSG00000112319 . [O95677-1 ]
ENST00000431403 ; ENSP00000404558 ; ENSG00000112319 . [O95677-4 ]
ENST00000452339 ; ENSP00000395916 ; ENSG00000112319 . [O95677-5 ]
GeneIDi 2070.
KEGGi hsa:2070.
UCSCi uc003qec.4. human. [O95677-1 ]
uc003qed.4. human. [O95677-4 ]
uc003qee.4. human. [O95677-2 ]
uc011ecq.2. human. [O95677-5 ]

Organism-specific databases

CTDi 2070.
GeneCardsi GC06P133563.
GeneReviewsi EYA4.
HGNCi HGNC:3522. EYA4.
HPAi HPA004805.
HPA038771.
HPA038772.
MIMi 601316. phenotype.
603550. gene.
605362. phenotype.
neXtProti NX_O95677.
Orphaneti 90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
217622. Sensorineural deafness with dilated cardiomyopathy.
PharmGKBi PA27934.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297494.
HOGENOMi HOG000293149.
HOVERGENi HBG002447.
KOi K17622.
OrthoDBi EOG7DNNTZ.
PhylomeDBi O95677.
TreeFami TF319337.

Miscellaneous databases

GeneWikii EYA4.
GenomeRNAii 2070.
NextBioi 8417.
PROi O95677.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95677.
Bgeei O95677.
CleanExi HS_EYA4.
Genevestigatori O95677.

Family and domain databases

InterProi IPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view ]
PANTHERi PTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsi TIGR01658. EYA-cons_domain. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT SER-277, ALTERNATIVE SPLICING.
    Tissue: Lens epithelium and Skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus."
    Wayne S., Robertson N.G., DeClau F., Chen N., Verhoeven K., Prasad S., Tranebjaerg L., Morton C.C., Ryan A.F., Van Camp G., Smith R.J.H.
    Hum. Mol. Genet. 10:195-200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN DFNA10.
  6. "Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss."
    Schoenberger J., Wang L., Shin J.T., Kim S.D., Depreux F.F.S., Zhu H., Zon L., Pizard A., Kim J.B., Macrae C.A., Mungall A.J., Seidman J.G., Seidman C.E.
    Nat. Genet. 37:418-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CMD1J, TISSUE SPECIFICITY.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-152 AND ASN-301.

Entry informationi

Entry nameiEYA4_HUMAN
AccessioniPrimary (citable) accession number: O95677
Secondary accession number(s): B7Z7F7
, O95464, O95679, Q8IW39, Q9NTR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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