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Protein

N-acetylserotonin O-methyltransferase-like protein

Gene

ASMTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Sequence analysis1
Binding sitei482S-adenosyl-L-methionineBy similarity1
Binding sitei525S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylserotonin O-methyltransferase-like protein (EC:2.1.1.-)
Short name:
ASMTL
Gene namesi
Name:ASMTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:751. ASMTL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8623.
OpenTargetsiENSG00000169093.
PharmGKBiPA25050.

Polymorphism and mutation databases

BioMutaiASMTL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647021 – 621N-acetylserotonin O-methyltransferase-like proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95671.
MaxQBiO95671.
PaxDbiO95671.
PeptideAtlasiO95671.
PRIDEiO95671.

PTM databases

iPTMnetiO95671.
PhosphoSitePlusiO95671.

Expressioni

Tissue specificityi

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Gene expression databases

BgeeiENSG00000169093.
CleanExiHS_ASMTL.
GenevisibleiO95671. HS.

Organism-specific databases

HPAiHPA003630.
HPA021865.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153235EBI-743231,EBI-948001
KRT40Q6A1623EBI-743231,EBI-10171697
PNMA1Q8ND903EBI-743231,EBI-302345
TDO2P487758EBI-743231,EBI-743494

Protein-protein interaction databases

BioGridi114178. 15 interactors.
IntActiO95671. 9 interactors.
STRINGi9606.ENSP00000370718.

Structurei

Secondary structure

1621
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 17Combined sources3
Helixi22 – 30Combined sources9
Helixi48 – 50Combined sources3
Beta strandi51 – 53Combined sources3
Helixi54 – 77Combined sources24
Beta strandi82 – 93Combined sources12
Beta strandi96 – 98Combined sources3
Helixi104 – 114Combined sources11
Beta strandi117 – 133Combined sources17
Beta strandi136 – 152Combined sources17
Helixi157 – 166Combined sources10
Helixi168 – 171Combined sources4
Helixi173 – 175Combined sources3
Beta strandi178 – 180Combined sources3
Helixi181 – 184Combined sources4
Beta strandi186 – 191Combined sources6
Helixi193 – 197Combined sources5
Helixi201 – 212Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]
ProteinModelPortaliO95671.
SMRiO95671.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95671.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 223MAF-likeAdd BLAST213
Regioni277 – 621ASMT-likeAdd BLAST345
Regioni508 – 510S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

In the N-terminal section; belongs to the maf family.Curated

Phylogenomic databases

eggNOGiKOG1509. Eukaryota.
KOG3178. Eukaryota.
COG0424. LUCA.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00530000064032.
HOGENOMiHOG000034104.
HOVERGENiHBG036737.
InParanoidiO95671.
OMAiMLWEYIN.
OrthoDBiEOG091G0PPM.
PhylomeDBiO95671.
TreeFamiTF314574.

Family and domain databases

CDDicd00555. Maf. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.150. 1 hit.
3.90.950.10. 1 hit.
HAMAPiMF_00528. Maf. 1 hit.
InterProiIPR031725. ASMT_dimerisation.
IPR029001. ITPase-like_fam.
IPR003697. Maf.
IPR016461. O-MeTrfase_COMT.
IPR001077. O_MeTrfase_2.
IPR029063. SAM-dependent_MTases.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF16864. Dimerisation2. 1 hit.
PF02545. Maf. 1 hit.
PF00891. Methyltransf_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52972. SSF52972. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00172. maf. 1 hit.
PROSITEiPS51683. SAM_OMT_II. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS
60 70 80 90 100
FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK
110 120 130 140 150
PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV
160 170 180 190 200
KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP
210 220 230 240 250
LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ
260 270 280 290 300
RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK
360 370 380 390 400
TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN
410 420 430 440 450
QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS
460 470 480 490 500
RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA
510 520 530 540 550
VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA
560 570 580 590 600
GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
Length:621
Mass (Da):68,857
Last modified:October 3, 2006 - v3
Checksum:i564C2D538F4919EC
GO
Isoform 2 (identifier: O95671-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-91: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,193
Checksum:i68D9C963275E9A36
GO
Isoform 3 (identifier: O95671-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):62,443
Checksum:i5AC40CB68911EF40
GO

Sequence cautioni

The sequence CAA75675 differs from that shown. Reason: Frameshift at position 616.Curated
The sequence CAA75676 differs from that shown. Reason: Frameshift at position 616.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228S → P in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti364Y → H in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti434G → S in BAG63287 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054802458V → M.1 PublicationCorresponds to variant rs4503285dbSNPEnsembl.1
Natural variantiVAR_054803541R → K.2 PublicationsCorresponds to variant rs1127297dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474121 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_00721376 – 91Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15521 Genomic DNA. Translation: CAA75675.1. Frameshift.
Y15521 Genomic DNA. Translation: CAA75676.1. Frameshift.
AK090498 mRNA. Translation: BAC03468.1.
AK301844 mRNA. Translation: BAG63287.1.
AL683870 Genomic DNA. Translation: CAI39847.1.
AL683870 Genomic DNA. Translation: CAI39848.1.
BC002508 mRNA. Translation: AAH02508.1.
BC010089 mRNA. Translation: AAH10089.1.
CCDSiCCDS43917.1. [O95671-1]
CCDS55362.1. [O95671-3]
CCDS55363.1. [O95671-2]
RefSeqiNP_001166944.1. NM_001173473.1. [O95671-3]
NP_001166945.1. NM_001173474.1. [O95671-2]
NP_004183.2. NM_004192.3. [O95671-1]
XP_005274491.1. XM_005274434.3. [O95671-1]
XP_005274840.1. XM_005274783.3. [O95671-1]
UniGeneiHs.533514.

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093. [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093. [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093. [O95671-3]
GeneIDi8623.
KEGGihsa:8623.
UCSCiuc004cpx.3. human. [O95671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15521 Genomic DNA. Translation: CAA75675.1. Frameshift.
Y15521 Genomic DNA. Translation: CAA75676.1. Frameshift.
AK090498 mRNA. Translation: BAC03468.1.
AK301844 mRNA. Translation: BAG63287.1.
AL683870 Genomic DNA. Translation: CAI39847.1.
AL683870 Genomic DNA. Translation: CAI39848.1.
BC002508 mRNA. Translation: AAH02508.1.
BC010089 mRNA. Translation: AAH10089.1.
CCDSiCCDS43917.1. [O95671-1]
CCDS55362.1. [O95671-3]
CCDS55363.1. [O95671-2]
RefSeqiNP_001166944.1. NM_001173473.1. [O95671-3]
NP_001166945.1. NM_001173474.1. [O95671-2]
NP_004183.2. NM_004192.3. [O95671-1]
XP_005274491.1. XM_005274434.3. [O95671-1]
XP_005274840.1. XM_005274783.3. [O95671-1]
UniGeneiHs.533514.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]
ProteinModelPortaliO95671.
SMRiO95671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114178. 15 interactors.
IntActiO95671. 9 interactors.
STRINGi9606.ENSP00000370718.

PTM databases

iPTMnetiO95671.
PhosphoSitePlusiO95671.

Polymorphism and mutation databases

BioMutaiASMTL.

Proteomic databases

EPDiO95671.
MaxQBiO95671.
PaxDbiO95671.
PeptideAtlasiO95671.
PRIDEiO95671.

Protocols and materials databases

DNASUi8623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093. [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093. [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093. [O95671-3]
GeneIDi8623.
KEGGihsa:8623.
UCSCiuc004cpx.3. human. [O95671-1]

Organism-specific databases

CTDi8623.
DisGeNETi8623.
GeneCardsiASMTL.
H-InvDBHIX0176513.
HIX0177590.
HGNCiHGNC:751. ASMTL.
HPAiHPA003630.
HPA021865.
MIMi300162. gene.
400011. gene.
neXtProtiNX_O95671.
OpenTargetsiENSG00000169093.
PharmGKBiPA25050.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1509. Eukaryota.
KOG3178. Eukaryota.
COG0424. LUCA.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00530000064032.
HOGENOMiHOG000034104.
HOVERGENiHBG036737.
InParanoidiO95671.
OMAiMLWEYIN.
OrthoDBiEOG091G0PPM.
PhylomeDBiO95671.
TreeFamiTF314574.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169093-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO95671.
GeneWikiiASMTL.
GenomeRNAii8623.
PROiO95671.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169093.
CleanExiHS_ASMTL.
GenevisibleiO95671. HS.

Family and domain databases

CDDicd00555. Maf. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.150. 1 hit.
3.90.950.10. 1 hit.
HAMAPiMF_00528. Maf. 1 hit.
InterProiIPR031725. ASMT_dimerisation.
IPR029001. ITPase-like_fam.
IPR003697. Maf.
IPR016461. O-MeTrfase_COMT.
IPR001077. O_MeTrfase_2.
IPR029063. SAM-dependent_MTases.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF16864. Dimerisation2. 1 hit.
PF02545. Maf. 1 hit.
PF00891. Methyltransf_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52972. SSF52972. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00172. maf. 1 hit.
PROSITEiPS51683. SAM_OMT_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASML_HUMAN
AccessioniPrimary (citable) accession number: O95671
Secondary accession number(s): B4DX75
, F5GXH4, J3JS33, Q5JQ53, Q8NBH5, Q96G02, Q9BUL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.