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O95671

- ASML_HUMAN

UniProt

O95671 - ASML_HUMAN

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Protein

N-acetylserotonin O-methyltransferase-like protein

Gene
ASMTL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441 Reviewed prediction
Binding sitei482 – 4821S-adenosyl-L-methionine By similarity
Binding sitei525 – 5251S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. O-methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylserotonin O-methyltransferase-like protein (EC:2.1.1.-)
Short name:
ASMTL
Gene namesi
Name:ASMTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:751. ASMTL.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621N-acetylserotonin O-methyltransferase-like proteinUniRule annotationPRO_0000064702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine7 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95671.
PaxDbiO95671.
PRIDEiO95671.

PTM databases

PhosphoSiteiO95671.

Expressioni

Tissue specificityi

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Gene expression databases

ArrayExpressiO95671.
BgeeiO95671.
CleanExiHS_ASMTL.
GenevestigatoriO95671.

Organism-specific databases

HPAiHPA003630.
HPA021865.

Interactioni

Protein-protein interaction databases

BioGridi114178. 8 interactions.
IntActiO95671. 2 interactions.
STRINGi9606.ENSP00000370718.

Structurei

Secondary structure

1
621
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 173
Helixi22 – 309
Helixi48 – 503
Beta strandi51 – 533
Helixi54 – 7724
Beta strandi82 – 9312
Beta strandi96 – 983
Helixi104 – 11411
Beta strandi117 – 13317
Beta strandi136 – 15217
Helixi157 – 16610
Helixi168 – 1714
Helixi173 – 1753
Beta strandi178 – 1803
Helixi181 – 1844
Beta strandi186 – 1916
Helixi193 – 1975
Helixi201 – 21212

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]
ProteinModelPortaliO95671.
SMRiO95671. Positions 10-213, 287-618.

Miscellaneous databases

EvolutionaryTraceiO95671.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 223213MAF-likeUniRule annotationAdd
BLAST
Regioni277 – 621345ASMT-likeUniRule annotationAdd
BLAST
Regioni508 – 5103S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the maf family.

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000034104.
HOVERGENiHBG036737.
InParanoidiO95671.
OMAiWEYINSG.
OrthoDBiEOG7W1557.
PhylomeDBiO95671.
TreeFamiTF314574.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.150. 1 hit.
3.90.950.10. 1 hit.
HAMAPiMF_00528. Maf.
InterProiIPR025772. ASMT-like.
IPR029001. ITPase-like_fam.
IPR003697. Maf.
IPR001077. O_MeTrfase_2.
IPR029063. SAM-dependent_MTases-like.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02545. Maf. 1 hit.
PF00891. Methyltransf_2. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00172. maf. 1 hit.
PROSITEiPS51683. SAM_OMT_II. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95671-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS    50
FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK 100
PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV 150
KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP 200
LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ 250
RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG 300
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK 350
TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN 400
QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS 450
RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA 500
VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA 550
GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH 600
QVQVVHLGGV LDAILATKVA P 621
Length:621
Mass (Da):68,857
Last modified:October 3, 2006 - v3
Checksum:i564C2D538F4919EC
GO
Isoform 2 (identifier: O95671-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-91: Missing.

Note: No experimental confirmation available.

Show »
Length:605
Mass (Da):67,193
Checksum:i68D9C963275E9A36
GO
Isoform 3 (identifier: O95671-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: No experimental confirmation available.

Show »
Length:563
Mass (Da):62,443
Checksum:i5AC40CB68911EF40
GO

Sequence cautioni

The sequence CAA75675.1 differs from that shown. Reason: Frameshift at position 616.
The sequence CAA75676.1 differs from that shown. Reason: Frameshift at position 616.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti458 – 4581V → M.1 Publication
Corresponds to variant rs4503285 [ dbSNP | Ensembl ].
VAR_054802
Natural varianti541 – 5411R → K.2 Publications
Corresponds to variant rs1127297 [ dbSNP | Ensembl ].
VAR_054803

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 3. VSP_047412Add
BLAST
Alternative sequencei76 – 9116Missing in isoform 2. VSP_007213Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281S → P in BAG63287. 1 Publication
Sequence conflicti364 – 3641Y → H in BAG63287. 1 Publication
Sequence conflicti434 – 4341G → S in BAG63287. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15521 Genomic DNA. Translation: CAA75675.1. Frameshift.
Y15521 Genomic DNA. Translation: CAA75676.1. Frameshift.
AK090498 mRNA. Translation: BAC03468.1.
AK301844 mRNA. Translation: BAG63287.1.
AL683870 Genomic DNA. Translation: CAI39847.1.
AL683870 Genomic DNA. Translation: CAI39848.1.
BC002508 mRNA. Translation: AAH02508.1.
BC010089 mRNA. Translation: AAH10089.1.
CCDSiCCDS43917.1. [O95671-1]
CCDS55362.1. [O95671-3]
CCDS55363.1. [O95671-2]
RefSeqiNP_001166944.1. NM_001173473.1. [O95671-3]
NP_001166945.1. NM_001173474.1. [O95671-2]
NP_004183.2. NM_004192.3. [O95671-1]
XP_005274491.1. XM_005274434.1. [O95671-1]
XP_005274840.1. XM_005274783.1. [O95671-1]
UniGeneiHs.533514.

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093. [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093. [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093. [O95671-3]
GeneIDi8623.
KEGGihsa:8623.
UCSCiuc004cpx.2. human. [O95671-1]
uc004cpy.2. human. [O95671-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15521 Genomic DNA. Translation: CAA75675.1 . Frameshift.
Y15521 Genomic DNA. Translation: CAA75676.1 . Frameshift.
AK090498 mRNA. Translation: BAC03468.1 .
AK301844 mRNA. Translation: BAG63287.1 .
AL683870 Genomic DNA. Translation: CAI39847.1 .
AL683870 Genomic DNA. Translation: CAI39848.1 .
BC002508 mRNA. Translation: AAH02508.1 .
BC010089 mRNA. Translation: AAH10089.1 .
CCDSi CCDS43917.1. [O95671-1 ]
CCDS55362.1. [O95671-3 ]
CCDS55363.1. [O95671-2 ]
RefSeqi NP_001166944.1. NM_001173473.1. [O95671-3 ]
NP_001166945.1. NM_001173474.1. [O95671-2 ]
NP_004183.2. NM_004192.3. [O95671-1 ]
XP_005274491.1. XM_005274434.1. [O95671-1 ]
XP_005274840.1. XM_005274783.1. [O95671-1 ]
UniGenei Hs.533514.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2P5X X-ray 2.00 A/B 10-239 [» ]
ProteinModelPortali O95671.
SMRi O95671. Positions 10-213, 287-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114178. 8 interactions.
IntActi O95671. 2 interactions.
STRINGi 9606.ENSP00000370718.

PTM databases

PhosphoSitei O95671.

Proteomic databases

MaxQBi O95671.
PaxDbi O95671.
PRIDEi O95671.

Protocols and materials databases

DNASUi 8623.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381317 ; ENSP00000370718 ; ENSG00000169093 . [O95671-1 ]
ENST00000381333 ; ENSP00000370734 ; ENSG00000169093 . [O95671-2 ]
ENST00000534940 ; ENSP00000446410 ; ENSG00000169093 . [O95671-3 ]
GeneIDi 8623.
KEGGi hsa:8623.
UCSCi uc004cpx.2. human. [O95671-1 ]
uc004cpy.2. human. [O95671-2 ]

Organism-specific databases

CTDi 8623.
GeneCardsi GC0XM001522.
H-InvDB HIX0176513.
HIX0177590.
HGNCi HGNC:751. ASMTL.
HPAi HPA003630.
HPA021865.
MIMi 300162. gene.
400011. gene.
neXtProti NX_O95671.
PharmGKBi PA25050.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0500.
HOGENOMi HOG000034104.
HOVERGENi HBG036737.
InParanoidi O95671.
OMAi WEYINSG.
OrthoDBi EOG7W1557.
PhylomeDBi O95671.
TreeFami TF314574.

Miscellaneous databases

EvolutionaryTracei O95671.
GeneWikii ASMTL.
GenomeRNAii 8623.
NextBioi 32321.
PROi O95671.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95671.
Bgeei O95671.
CleanExi HS_ASMTL.
Genevestigatori O95671.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.150. 1 hit.
3.90.950.10. 1 hit.
HAMAPi MF_00528. Maf.
InterProi IPR025772. ASMT-like.
IPR029001. ITPase-like_fam.
IPR003697. Maf.
IPR001077. O_MeTrfase_2.
IPR029063. SAM-dependent_MTases-like.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02545. Maf. 1 hit.
PF00891. Methyltransf_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00172. maf. 1 hit.
PROSITEi PS51683. SAM_OMT_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL."
    Ried K., Rao E., Schiebel K., Rappold G.A.
    Hum. Mol. Genet. 7:1771-1778(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-541.
    Tissue: Bone marrow, Colon, Fetal brain, Pancreas and Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Adrenal gland and Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-458 AND LYS-541.
    Tissue: Colon adenocarcinoma.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Crystal structure of maf domain of human N-acetylserotonin O-methyltransferase-like protein."
    Structural genomics consortium (SGC)
    Submitted (MAR-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 10-239.

Entry informationi

Entry nameiASML_HUMAN
AccessioniPrimary (citable) accession number: O95671
Secondary accession number(s): B4DX75
, F5GXH4, J3JS33, Q5JQ53, Q8NBH5, Q96G02, Q9BUL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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