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O95670

- VATG2_HUMAN

UniProt

O95670 - VATG2_HUMAN

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Protein

V-type proton ATPase subunit G 2

Gene

ATP6V1G2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Source: InterPro

GO - Biological processi

  1. cellular iron ion homeostasis Source: Reactome
  2. insulin receptor signaling pathway Source: Reactome
  3. interaction with host Source: Reactome
  4. phagosome maturation Source: Reactome
  5. proton transport Source: UniProtKB-KW
  6. transferrin transport Source: Reactome
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS10685-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 2
Short name:
V-ATPase subunit G 2
Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2
Gene namesi
Name:ATP6V1G2
Synonyms:ATP6G, ATP6G2, NG38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:862. ATP6V1G2.

Subcellular locationi

Melanosome 1 Publication
Note: Highly enriched in late-stage melanosomes.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. vacuolar proton-transporting V-type ATPase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 2PRO_0000192900Add
BLAST

Proteomic databases

PaxDbiO95670.
PRIDEiO95670.

PTM databases

PhosphoSiteiO95670.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiO95670.
CleanExiHS_ATP6V1G2.
ExpressionAtlasiO95670. baseline and differential.
GenevestigatoriO95670.

Organism-specific databases

HPAiCAB004616.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP6V1E1P365431EBI-348290,EBI-348639

Protein-protein interaction databases

BioGridi107017. 5 interactions.
IntActiO95670. 3 interactions.
MINTiMINT-1035852.
STRINGi9606.ENSP00000372995.

Structurei

3D structure databases

ProteinModelPortaliO95670.
SMRiO95670. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiNOG238684.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiO95670.
KOiK02152.
OMAiHPNYRIT.
OrthoDBiEOG7MWH0X.
PhylomeDBiO95670.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95670-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE
60 70 80 90 100
REHEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL
110
GMVCDVRPQV HPNYRISA
Length:118
Mass (Da):13,604
Last modified:May 1, 1999 - v1
Checksum:i5D46EEE0C8D7657D
GO
Isoform 2 (identifier: O95670-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-74: Missing.

Note: No experimental confirmation available.

Show »
Length:78
Mass (Da):8,954
Checksum:iC58F9F6252E8076A
GO
Isoform 3 (identifier: O95670-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.

Show »
Length:77
Mass (Da):8,972
Checksum:iA22322E87147DFE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521E → D in AA401769. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 3. 1 PublicationVSP_047411Add
BLAST
Alternative sequencei35 – 7440Missing in isoform 2. 1 PublicationVSP_045909Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14768 Genomic DNA. Translation: CAA75073.1.
AB063177 Genomic DNA. Translation: BAC00863.1.
AB102692 Genomic DNA. Translation: BAD74058.1.
AB097672 Genomic DNA. Translation: BAD74057.1.
BA000025 Genomic DNA. Translation: BAB63399.1.
AB088115 Genomic DNA. Translation: BAC54952.1.
AL662801 Genomic DNA. Translation: CAI18287.1.
AL662847 Genomic DNA. Translation: CAI17673.1.
BX001040 Genomic DNA. Translation: CAI18639.2.
BX001040 Genomic DNA. Translation: CAI18640.1.
BX248516 Genomic DNA. Translation: CAI41929.1.
BX248516 Genomic DNA. Translation: CAI41930.1.
CR753892 Genomic DNA. Translation: CAQ06925.1.
CR753892 Genomic DNA. Translation: CAQ06926.1.
BX927320 Genomic DNA. Translation: CAQ09987.1.
BX927320 Genomic DNA. Translation: CAQ09988.1.
CR753864 Genomic DNA. Translation: CAQ10647.1.
CR753864 Genomic DNA. Translation: CAQ10648.1.
CR753820 Genomic DNA. No translation available.
CR942185 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03414.1.
CH471081 Genomic DNA. Translation: EAX03416.1.
AB202112 Genomic DNA. Translation: BAE78636.1.
AB103621 Genomic DNA. Translation: BAF31286.1.
BC047791 mRNA. No translation available.
BC119726 mRNA. Translation: AAI19727.1.
BC119727 mRNA. Translation: AAI19728.1.
AA401769 mRNA. No translation available.
CCDSiCCDS4698.1. [O95670-1]
CCDS4699.1. [O95670-3]
CCDS56413.1. [O95670-2]
RefSeqiNP_001191007.1. NM_001204078.1. [O95670-2]
NP_569730.1. NM_130463.3. [O95670-1]
NP_612139.1. NM_138282.2. [O95670-3]
UniGeneiHs.249227.

Genome annotation databases

EnsembliENST00000303892; ENSP00000302194; ENSG00000213760. [O95670-1]
ENST00000376151; ENSP00000365321; ENSG00000213760. [O95670-2]
ENST00000383503; ENSP00000372995; ENSG00000206445. [O95670-1]
ENST00000421596; ENSP00000406575; ENSG00000234668. [O95670-2]
ENST00000434217; ENSP00000406668; ENSG00000226850. [O95670-2]
ENST00000441959; ENSP00000395436; ENSG00000227587. [O95670-1]
ENST00000443657; ENSP00000416031; ENSG00000227587. [O95670-2]
ENST00000444088; ENSP00000406389; ENSG00000234920. [O95670-1]
ENST00000447174; ENSP00000403158; ENSG00000230900. [O95670-2]
ENST00000448779; ENSP00000409104; ENSG00000234920. [O95670-2]
ENST00000449748; ENSP00000406372; ENSG00000226850. [O95670-1]
ENST00000452453; ENSP00000402430; ENSG00000206445. [O95670-2]
ENST00000454370; ENSP00000413222; ENSG00000234668. [O95670-1]
ENST00000454889; ENSP00000408670; ENSG00000230900. [O95670-1]
ENST00000483251; ENSP00000419698; ENSG00000213760. [O95670-3]
GeneIDi534.
KEGGihsa:534.
UCSCiuc003ntz.3. human. [O95670-1]
uc021yur.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14768 Genomic DNA. Translation: CAA75073.1 .
AB063177 Genomic DNA. Translation: BAC00863.1 .
AB102692 Genomic DNA. Translation: BAD74058.1 .
AB097672 Genomic DNA. Translation: BAD74057.1 .
BA000025 Genomic DNA. Translation: BAB63399.1 .
AB088115 Genomic DNA. Translation: BAC54952.1 .
AL662801 Genomic DNA. Translation: CAI18287.1 .
AL662847 Genomic DNA. Translation: CAI17673.1 .
BX001040 Genomic DNA. Translation: CAI18639.2 .
BX001040 Genomic DNA. Translation: CAI18640.1 .
BX248516 Genomic DNA. Translation: CAI41929.1 .
BX248516 Genomic DNA. Translation: CAI41930.1 .
CR753892 Genomic DNA. Translation: CAQ06925.1 .
CR753892 Genomic DNA. Translation: CAQ06926.1 .
BX927320 Genomic DNA. Translation: CAQ09987.1 .
BX927320 Genomic DNA. Translation: CAQ09988.1 .
CR753864 Genomic DNA. Translation: CAQ10647.1 .
CR753864 Genomic DNA. Translation: CAQ10648.1 .
CR753820 Genomic DNA. No translation available.
CR942185 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03414.1 .
CH471081 Genomic DNA. Translation: EAX03416.1 .
AB202112 Genomic DNA. Translation: BAE78636.1 .
AB103621 Genomic DNA. Translation: BAF31286.1 .
BC047791 mRNA. No translation available.
BC119726 mRNA. Translation: AAI19727.1 .
BC119727 mRNA. Translation: AAI19728.1 .
AA401769 mRNA. No translation available.
CCDSi CCDS4698.1. [O95670-1 ]
CCDS4699.1. [O95670-3 ]
CCDS56413.1. [O95670-2 ]
RefSeqi NP_001191007.1. NM_001204078.1. [O95670-2 ]
NP_569730.1. NM_130463.3. [O95670-1 ]
NP_612139.1. NM_138282.2. [O95670-3 ]
UniGenei Hs.249227.

3D structure databases

ProteinModelPortali O95670.
SMRi O95670. Positions 1-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107017. 5 interactions.
IntActi O95670. 3 interactions.
MINTi MINT-1035852.
STRINGi 9606.ENSP00000372995.

PTM databases

PhosphoSitei O95670.

Proteomic databases

PaxDbi O95670.
PRIDEi O95670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303892 ; ENSP00000302194 ; ENSG00000213760 . [O95670-1 ]
ENST00000376151 ; ENSP00000365321 ; ENSG00000213760 . [O95670-2 ]
ENST00000383503 ; ENSP00000372995 ; ENSG00000206445 . [O95670-1 ]
ENST00000421596 ; ENSP00000406575 ; ENSG00000234668 . [O95670-2 ]
ENST00000434217 ; ENSP00000406668 ; ENSG00000226850 . [O95670-2 ]
ENST00000441959 ; ENSP00000395436 ; ENSG00000227587 . [O95670-1 ]
ENST00000443657 ; ENSP00000416031 ; ENSG00000227587 . [O95670-2 ]
ENST00000444088 ; ENSP00000406389 ; ENSG00000234920 . [O95670-1 ]
ENST00000447174 ; ENSP00000403158 ; ENSG00000230900 . [O95670-2 ]
ENST00000448779 ; ENSP00000409104 ; ENSG00000234920 . [O95670-2 ]
ENST00000449748 ; ENSP00000406372 ; ENSG00000226850 . [O95670-1 ]
ENST00000452453 ; ENSP00000402430 ; ENSG00000206445 . [O95670-2 ]
ENST00000454370 ; ENSP00000413222 ; ENSG00000234668 . [O95670-1 ]
ENST00000454889 ; ENSP00000408670 ; ENSG00000230900 . [O95670-1 ]
ENST00000483251 ; ENSP00000419698 ; ENSG00000213760 . [O95670-3 ]
GeneIDi 534.
KEGGi hsa:534.
UCSCi uc003ntz.3. human. [O95670-1 ]
uc021yur.1. human.

Organism-specific databases

CTDi 534.
GeneCardsi GC06M031512.
GC06Mj31499.
GC06Mk31494.
GC06Ml31551.
GC06Mm31588.
GC06Mn31502.
GC06Mo31502.
HGNCi HGNC:862. ATP6V1G2.
HPAi CAB004616.
MIMi 606853. gene.
neXtProti NX_O95670.
PharmGKBi PA25164.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238684.
GeneTreei ENSGT00390000011172.
HOGENOMi HOG000186416.
HOVERGENi HBG057827.
InParanoidi O95670.
KOi K02152.
OMAi HPNYRIT.
OrthoDBi EOG7MWH0X.
PhylomeDBi O95670.
TreeFami TF313777.

Enzyme and pathway databases

BioCyci MetaCyc:HS10685-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikii ATP6V1G2.
GenomeRNAii 534.
NextBioi 2217.
PROi O95670.
SOURCEi Search...

Gene expression databases

Bgeei O95670.
CleanExi HS_ATP6V1G2.
ExpressionAtlasi O95670. baseline and differential.
Genevestigatori O95670.

Family and domain databases

InterProi IPR005124. V-ATPase_G.
[Graphical view ]
PANTHERi PTHR12713. PTHR12713. 1 hit.
TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
    Neville M.J., Campbell R.D.
    J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genomic structure of human ATP6G gene."
    Iida A., Kondo K., Mishima C., Nakamura Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  3. "Polymorphism of ATP6G."
    Shichi D., Naruse T., Nakashima M., Kikkawa E., Ota M., Katsuyama Y., Kimura A., Matsumori A., Inoko H.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
    Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Peripheral blood leukocyte.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Leiomyosarcoma.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-75 (ISOFORM 3).
  11. "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
    Smith A.N., Borthwick K.J., Karet F.E.
    Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.

Entry informationi

Entry nameiVATG2_HUMAN
AccessioniPrimary (citable) accession number: O95670
Secondary accession number(s): B5MEF0
, Q2L6F8, Q5HYU8, Q5RJ63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3