Reviewed, UniProtKB/Swiss-Prot O95670 (VATG2_HUMAN)

Names and origin

Protein names

Recommended name:
    V-type proton ATPase subunit G 2
      Short name=V-ATPase subunit G 2
Alternative name(s):
    Vacuolar proton pump subunit G 2
    V-ATPase 13 kDa subunit 2

Gene names

Name:	ATP6V1G2
Synonyms:	ATP6G, ATP6G2, NG38

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) By similarity.
Subcellular location	Melanosome. Note: Highly enriched in late-stage melanosomes. Ref.8
Tissue specificity	Brain. Ref.7
Sequence similarities	Belongs to the V-ATPase G subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell vacuolar proton-transporting V-type ATPase complex Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATP6V1E1	P36543	1	EBI-348290,EBI-348639

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	V-type proton ATPase subunit G 2		PRO_0000192900

Sequences

	Sequence		Length	Mass (Da)
	O95670-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5D46EEE0C8D7657D	FASTA	118	13,604
	10 20 30 40 50 60 MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE REHEFQSKQQ 70 80 90 100 110 AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL GMVCDVRPQV HPNYRISA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC." Neville M.J., Campbell R.D. J. Immunol. 162:4745-4754(1999) [PubMed: 10202016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genomic structure of human ATP6G gene." Iida A., Kondo K., Mishima C., Nakamura Y. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[3]	"Polymorphism of ATP6G." Shichi D., Naruse T., Nakashima M., Kikkawa E., Ota M., Katsuyama Y., Kimura A., Matsumori A., Inoko H. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed: 12384298] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed: 17081065] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y14768 Genomic DNA. Translation: CAA75073.1. AB063177 Genomic DNA. Translation: BAC00863.1. AB102692 Genomic DNA. Translation: BAD74058.1. AB097672 Genomic DNA. Translation: BAD74057.1. BA000025 Genomic DNA. Translation: BAB63399.1. AB088115 Genomic DNA. Translation: BAC54952.1. AL662801 Genomic DNA. Translation: CAI18287.1. AL662847 Genomic DNA. Translation: CAI17673.1. BX001040 Genomic DNA. Translation: CAI18640.1. BX248516 Genomic DNA. Translation: CAI41930.1.
IPI	IPI00032147.
RefSeq	NP_569730.1.
UniGene	Hs.249227
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95670. 1 interaction.
STRING	O95670.
Proteomic databases
PRIDE	O95670.
Genome annotation databases
Ensembl	ENST00000303892; ENSP00000302194; ENSG00000213760; Homo sapiens. [Genome view] ENST00000383503; ENSP00000372995; ENSG00000206445; Homo sapiens. [Genome view] ENST00000441959; ENSP00000395436; ENSG00000227587; Homo sapiens. [Genome view] ENST00000444088; ENSP00000406389; ENSG00000234920; Homo sapiens. [Genome view] ENST00000449748; ENSP00000406372; ENSG00000226850; Homo sapiens. [Genome view] ENST00000454370; ENSP00000413222; ENSG00000234668; Homo sapiens. [Genome view] ENST00000454889; ENSP00000408670; ENSG00000230900; Homo sapiens. [Genome view]
GeneID	534.
KEGG	hsa:534.
UCSC	uc003nua.1. human.
Organism-specific databases
CTD	534.
GeneCards	GC06M031624.
HGNC	HGNC:862. ATP6V1G2.
HPA	CAB004616.
MIM	606853. gene.
PharmGKB	PA25164.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O95670.
OMA	HPNYRIA
OrthoDB	EOG92RGT7
Enzyme and pathway databases
BRENDA	3.6.3.14. 247.
Gene expression databases
CleanEx	HS_ATP6V1G2.
Genevestigator	O95670.
GermOnline	ENSG00000198563. Homo sapiens.
Family and domain databases
InterPro	IPR005124. V-ATPase_G. [Graphical view]
PANTHER	PTHR12713. V-ATPase_G. 1 hit.
Pfam	PF03179. V-ATPase_G. 1 hit. [Graphical view]
TIGRFAMs	TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	2217.
SOURCE	Search...

Entry information

Entry name

VATG2_HUMAN

Accession

Primary (citable) accession number: O95670

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.