O95670 (VATG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit G 2
Short name=V-ATPase subunit G 2

Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2

Gene names

Name:	ATP6V1G2
Synonyms:	ATP6G, ATP6G2, NG38

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) By similarity.
Subcellular location	Melanosome. Note: Highly enriched in late-stage melanosomes. Ref.11
Tissue specificity	Brain. Ref.10
Sequence similarities	Belongs to the V-ATPase G subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome interaction with host Traceable author statement. Source: Reactome phagosome maturation Traceable author statement. Source: Reactome proton transport Inferred from electronic annotation. Source: UniProtKB-KW transferrin transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell vacuolar proton-transporting V-type ATPase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATP6V1E1	P36543	1	EBI-348290,EBI-348639

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95670-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95670-2)

The sequence of this isoform differs from the canonical sequence as follows:
     35-74: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	V-type proton ATPase subunit G 2		PRO_0000192900
Natural variations
	Alternative sequence	35 – 74	40	Missing in isoform 2.		VSP_045909

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5D46EEE0C8D7657D	FASTA	118	13,604
	10 20 30 40 50 60 MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE REHEFQSKQQ 70 80 90 100 110 AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL GMVCDVRPQV HPNYRISA
	Isoform 2 [UniParc]. Checksum: C58F9F6252E8076A	FASTA	78	8,954
	10 20 30 40 50 60 MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQATRRQ VQGMQSSQQR NRERVLAQLL 70 GMVCDVRPQV HPNYRISA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC." Neville M.J., Campbell R.D. J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genomic structure of human ATP6G gene." Iida A., Kondo K., Mishima C., Nakamura Y. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[3]	"Polymorphism of ATP6G." Shichi D., Naruse T., Nakashima M., Kikkawa E., Ota M., Katsuyama Y., Kimura A., Matsumori A., Inoko H. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S. Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Peripheral blood leukocyte.
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Leiomyosarcoma.
[10]	"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14768 Genomic DNA. Translation: CAA75073.1. AB063177 Genomic DNA. Translation: BAC00863.1. AB102692 Genomic DNA. Translation: BAD74058.1. AB097672 Genomic DNA. Translation: BAD74057.1. BA000025 Genomic DNA. Translation: BAB63399.1. AB088115 Genomic DNA. Translation: BAC54952.1. AL662801 Genomic DNA. Translation: CAI18287.1. AL662847 Genomic DNA. Translation: CAI17673.1. BX001040 Genomic DNA. Translation: CAI18639.2. BX001040 Genomic DNA. Translation: CAI18640.1. BX248516 Genomic DNA. Translation: CAI41929.1. BX248516 Genomic DNA. Translation: CAI41930.1. CR753892 Genomic DNA. Translation: CAQ06925.1. CR753892 Genomic DNA. Translation: CAQ06926.1. BX927320 Genomic DNA. Translation: CAQ09987.1. BX927320 Genomic DNA. Translation: CAQ09988.1. CR753864 Genomic DNA. Translation: CAQ10647.1. CR753864 Genomic DNA. Translation: CAQ10648.1. CR753820 Genomic DNA. No translation available. CR942185 Genomic DNA. No translation available. CH471081 Genomic DNA. Translation: EAX03416.1. AB202112 Genomic DNA. Translation: BAE78636.1. AB103621 Genomic DNA. Translation: BAF31286.1. BC047791 mRNA. No translation available. BC119726 mRNA. Translation: AAI19727.1. BC119727 mRNA. Translation: AAI19728.1.
IPI	IPI00032147. IPI00552247.
RefSeq	NP_001191007.1. NM_001204078.1. NP_569730.1. NM_130463.3.
UniGene	Hs.249227.
3D structure databases
ProteinModelPortal	O95670.
SMR	O95670. Positions 1-107.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95670. 3 interactions.
MINT	MINT-1035852.
STRING	9606.ENSP00000372995.
PTM databases
PhosphoSite	O95670.
Proteomic databases
PaxDb	O95670.
PRIDE	O95670.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303892; ENSP00000302194; ENSG00000213760. ENST00000376151; ENSP00000365321; ENSG00000213760. ENST00000383503; ENSP00000372995; ENSG00000206445. ENST00000421596; ENSP00000406575; ENSG00000234668. ENST00000434217; ENSP00000406668; ENSG00000226850. ENST00000441959; ENSP00000395436; ENSG00000227587. ENST00000443657; ENSP00000416031; ENSG00000227587. ENST00000444088; ENSP00000406389; ENSG00000234920. ENST00000447174; ENSP00000403158; ENSG00000230900. ENST00000448779; ENSP00000409104; ENSG00000234920. ENST00000449748; ENSP00000406372; ENSG00000226850. ENST00000452453; ENSP00000402430; ENSG00000206445. ENST00000454370; ENSP00000413222; ENSG00000234668. ENST00000454889; ENSP00000408670; ENSG00000230900.
GeneID	534.
KEGG	hsa:534.
UCSC	uc003ntz.3. human.
Organism-specific databases
CTD	534.
GeneCards	GC06M031512.
HGNC	HGNC:862. ATP6V1G2.
HPA	CAB004616.
MIM	606853. gene.
neXtProt	NX_O95670.
PharmGKB	PA25164.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG238684.
HOGENOM	HOG000186416.
HOVERGEN	HBG057827.
InParanoid	O95670.
KO	K02152.
OMA	HPNYRIT.
OrthoDB	EOG483D67.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O95670.
Bgee	O95670.
CleanEx	HS_ATP6V1G2.
Genevestigator	O95670.
GermOnline	ENSG00000198563. Homo sapiens.
Family and domain databases
InterPro	IPR005124. V-ATPase_G. [Graphical view]
PANTHER	PTHR12713. PTHR12713. 1 hit.
Pfam	PF03179. V-ATPase_G. 1 hit. [Graphical view]
TIGRFAMs	TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	534.
NextBio	2217.
SOURCE	Search...

Entry information

Entry name

VATG2_HUMAN

Accession

Primary (citable) accession number: O95670
Secondary accession number(s): Q2L6F8, Q5HYU8, Q5RJ63

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.