ID   NTR2_HUMAN              Reviewed;         410 AA.
AC   O95665; Q53QQ5; Q57Z87; Q8IY58; Q8TBH6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 2.
DT   24-JAN-2024, entry version 173.
DE   RecName: Full=Neurotensin receptor type 2;
DE            Short=NT-R-2;
DE            Short=NTR2;
DE   AltName: Full=Levocabastine-sensitive neurotensin receptor;
GN   Name=NTSR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-54.
RC   TISSUE=Brain;
RX   PubMed=9851594; DOI=10.1016/s0014-2999(98)00678-5;
RA   Vita N., Oury-Donat F., Chalon P., Guillemot M., Kaghad M., Bachy A.,
RA   Thurneyssen S., Garcia S., Poinot-Chazel C., Casellas P., Keane P.,
RA   Le Fur G., Maffrand J.-P., Shoubrie P., Caput D., Ferrara P.;
RT   "Neurotensin is an antagonist of the human neurotensin NT2 receptor
RT   expressed in Chinese hamster ovary cells.";
RL   Eur. J. Pharmacol. 360:265-272(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-54.
RC   TISSUE=Brain;
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-54.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=20048080; DOI=10.1158/0008-5472.can-09-1252;
RA   Swift S.L., Burns J.E., Maitland N.J.;
RT   "Altered expression of neurotensin receptors is associated with the
RT   differentiation state of prostate cancer.";
RL   Cancer Res. 70:347-356(2010).
CC   -!- FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated
CC       with G proteins that activate a phosphatidylinositol-calcium second
CC       messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in prostate (at protein level).
CC       {ECO:0000269|PubMed:20048080}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Neurotensin receptor subfamily. NTSR2 sub-subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAX00924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry;
CC       URL="https://en.wikipedia.org/wiki/Neurotensin_receptor";
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DR   EMBL; Y10148; CAA71233.1; -; mRNA.
DR   EMBL; AY429107; AAR07902.1; -; mRNA.
DR   EMBL; AC106875; AAY14691.1; -; Genomic_DNA.
DR   EMBL; AC110754; AAX82018.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00924.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC022501; AAH22501.1; -; mRNA.
DR   EMBL; BC037776; AAH37776.1; -; mRNA.
DR   CCDS; CCDS1681.1; -.
DR   RefSeq; NP_036476.1; NM_012344.3.
DR   AlphaFoldDB; O95665; -.
DR   SMR; O95665; -.
DR   BioGRID; 117153; 1.
DR   STRING; 9606.ENSP00000303686; -.
DR   BindingDB; O95665; -.
DR   ChEMBL; CHEMBL2514; -.
DR   DrugBank; DB01106; Levocabastine.
DR   DrugCentral; O95665; -.
DR   GuidetoPHARMACOLOGY; 310; -.
DR   TCDB; 9.A.14.1.20; the g-protein-coupled receptor (gpcr) family.
DR   iPTMnet; O95665; -.
DR   PhosphoSitePlus; O95665; -.
DR   BioMuta; NTSR2; -.
DR   MassIVE; O95665; -.
DR   PaxDb; 9606-ENSP00000303686; -.
DR   PeptideAtlas; O95665; -.
DR   ProteomicsDB; 50982; -.
DR   Antibodypedia; 12728; 322 antibodies from 29 providers.
DR   DNASU; 23620; -.
DR   Ensembl; ENST00000306928.6; ENSP00000303686.5; ENSG00000169006.7.
DR   GeneID; 23620; -.
DR   KEGG; hsa:23620; -.
DR   MANE-Select; ENST00000306928.6; ENSP00000303686.5; NM_012344.4; NP_036476.2.
DR   UCSC; uc002rbq.5; human.
DR   AGR; HGNC:8040; -.
DR   CTD; 23620; -.
DR   DisGeNET; 23620; -.
DR   GeneCards; NTSR2; -.
DR   HGNC; HGNC:8040; NTSR2.
DR   HPA; ENSG00000169006; Tissue enriched (brain).
DR   MIM; 605538; gene.
DR   neXtProt; NX_O95665; -.
DR   OpenTargets; ENSG00000169006; -.
DR   PharmGKB; PA31822; -.
DR   VEuPathDB; HostDB:ENSG00000169006; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01100000263518; -.
DR   HOGENOM; CLU_009579_6_5_1; -.
DR   InParanoid; O95665; -.
DR   OMA; YSFRLWG; -.
DR   OrthoDB; 3471593at2759; -.
DR   PhylomeDB; O95665; -.
DR   TreeFam; TF337167; -.
DR   PathwayCommons; O95665; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   SignaLink; O95665; -.
DR   SIGNOR; O95665; -.
DR   BioGRID-ORCS; 23620; 14 hits in 1150 CRISPR screens.
DR   GeneWiki; Neurotensin_receptor_2; -.
DR   GenomeRNAi; 23620; -.
DR   Pharos; O95665; Tchem.
DR   PRO; PR:O95665; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; O95665; Protein.
DR   Bgee; ENSG00000169006; Expressed in nucleus accumbens and 83 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016492; F:G protein-coupled neurotensin receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   GO; GO:0007600; P:sensory perception; TAS:ProtInc.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR003986; NT2_rcpt.
DR   InterPro; IPR003984; NT_rcpt.
DR   PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24243:SF10; NEUROTENSIN RECEPTOR TYPE 2; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01479; NEUROTENSINR.
DR   PRINTS; PR01481; NEUROTENSN2R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O95665; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Lipoprotein;
KW   Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..410
FT                   /note="Neurotensin receptor type 2"
FT                   /id="PRO_0000069949"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..55
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..131
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..176
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..217
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..297
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..337
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        359..410
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          381..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           377
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        108..194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         54
FT                   /note="A -> V (in dbSNP:rs6432225)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:9851594, ECO:0000269|Ref.2"
FT                   /id="VAR_049425"
FT   VARIANT         282
FT                   /note="R -> K (in dbSNP:rs34764121)"
FT                   /id="VAR_061225"
FT   CONFLICT        109..134
FT                   /note="Missing (in Ref. 5; AAH37776)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142
FT                   /note="R -> C (in Ref. 5; AAH37776)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        168
FT                   /note="L -> M (in Ref. 5; AAH22501)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        367
FT                   /note="K -> R (in Ref. 5; AAH22501)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   410 AA;  45385 MW;  8B87DFD6923CBD42 CRC64;
     METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA
     RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY
     ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL
     ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV
     PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
     AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA
     VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT
//