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O95665

- NTR2_HUMAN

UniProt

O95665 - NTR2_HUMAN

Protein

Neurotensin receptor type 2

Gene

NTSR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. G-protein coupled neurotensin receptor activity Source: Ensembl
    2. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    3. regulation of membrane potential Source: Ensembl
    4. sensory perception Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotensin receptor type 2
    Short name:
    NT-R-2
    Short name:
    NTR2
    Alternative name(s):
    Levocabastine-sensitive neurotensin receptor
    Gene namesi
    Name:NTSR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8040. NTSR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31822.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Neurotensin receptor type 2PRO_0000069949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
    Lipidationi377 – 3771S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO95665.
    PRIDEiO95665.

    PTM databases

    PhosphoSiteiO95665.

    Expressioni

    Tissue specificityi

    Expressed in prostate (at protein level).1 Publication

    Gene expression databases

    BgeeiO95665.
    CleanExiHS_NTSR2.
    GenevestigatoriO95665.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303686.

    Structurei

    3D structure databases

    ProteinModelPortaliO95665.
    SMRiO95665. Positions 20-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 649CytoplasmicSequence Analysis
    Topological domaini88 – 10922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21741ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 29760CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 41052CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5523Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303702.
    HOGENOMiHOG000231271.
    HOVERGENiHBG098285.
    InParanoidiO95665.
    KOiK04212.
    OMAiWAKVLFT.
    OrthoDBiEOG7S21Z8.
    PhylomeDBiO95665.
    TreeFamiTF337167.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003986. NT2_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01481. NEUROTENSN2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95665-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN    50
    ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP 100
    WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR 150
    RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR 200
    TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST 250
    PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 300
    AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS 350
    SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS 400
    GFGDPPETRT 410
    Length:410
    Mass (Da):45,385
    Last modified:November 2, 2010 - v2
    Checksum:i8B87DFD6923CBD42
    GO

    Sequence cautioni

    The sequence EAX00924.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 13426Missing in AAH37776. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti142 – 1421R → C in AAH37776. (PubMed:15489334)Curated
    Sequence conflicti168 – 1681L → M in AAH22501. (PubMed:15489334)Curated
    Sequence conflicti367 – 3671K → R in AAH22501. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541A → V.3 Publications
    Corresponds to variant rs6432225 [ dbSNP | Ensembl ].
    VAR_049425
    Natural varianti282 – 2821R → K.
    Corresponds to variant rs34764121 [ dbSNP | Ensembl ].
    VAR_061225

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10148 mRNA. Translation: CAA71233.1.
    AY429107 mRNA. Translation: AAR07902.1.
    AC106875 Genomic DNA. Translation: AAY14691.1.
    AC110754 Genomic DNA. Translation: AAX82018.1.
    CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
    BC022501 mRNA. Translation: AAH22501.1.
    BC037776 mRNA. Translation: AAH37776.1.
    CCDSiCCDS1681.1.
    RefSeqiNP_036476.1. NM_012344.3.
    UniGeneiHs.131138.

    Genome annotation databases

    EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
    GeneIDi23620.
    KEGGihsa:23620.
    UCSCiuc002rbq.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Neurotensin receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10148 mRNA. Translation: CAA71233.1 .
    AY429107 mRNA. Translation: AAR07902.1 .
    AC106875 Genomic DNA. Translation: AAY14691.1 .
    AC110754 Genomic DNA. Translation: AAX82018.1 .
    CH471053 Genomic DNA. Translation: EAX00924.1 . Sequence problems.
    BC022501 mRNA. Translation: AAH22501.1 .
    BC037776 mRNA. Translation: AAH37776.1 .
    CCDSi CCDS1681.1.
    RefSeqi NP_036476.1. NM_012344.3.
    UniGenei Hs.131138.

    3D structure databases

    ProteinModelPortali O95665.
    SMRi O95665. Positions 20-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303686.

    Chemistry

    BindingDBi O95665.
    ChEMBLi CHEMBL2514.
    DrugBanki DB01106. Levocabastine.
    GuidetoPHARMACOLOGYi 310.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O95665.

    Proteomic databases

    PaxDbi O95665.
    PRIDEi O95665.

    Protocols and materials databases

    DNASUi 23620.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306928 ; ENSP00000303686 ; ENSG00000169006 .
    GeneIDi 23620.
    KEGGi hsa:23620.
    UCSCi uc002rbq.4. human.

    Organism-specific databases

    CTDi 23620.
    GeneCardsi GC02M011715.
    HGNCi HGNC:8040. NTSR2.
    MIMi 605538. gene.
    neXtProti NX_O95665.
    PharmGKBi PA31822.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303702.
    HOGENOMi HOG000231271.
    HOVERGENi HBG098285.
    InParanoidi O95665.
    KOi K04212.
    OMAi WAKVLFT.
    OrthoDBi EOG7S21Z8.
    PhylomeDBi O95665.
    TreeFami TF337167.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Neurotensin_receptor_2.
    GenomeRNAii 23620.
    NextBioi 46352.
    PROi O95665.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95665.
    CleanExi HS_NTSR2.
    Genevestigatori O95665.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003986. NT2_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01481. NEUROTENSN2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-54.
      Tissue: Brain.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
      Tissue: Brain.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
      Tissue: Brain.
    6. "Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
      Swift S.L., Burns J.E., Maitland N.J.
      Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNTR2_HUMAN
    AccessioniPrimary (citable) accession number: O95665
    Secondary accession number(s): Q53QQ5
    , Q57Z87, Q8IY58, Q8TBH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3