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O95665

- NTR2_HUMAN

UniProt

O95665 - NTR2_HUMAN

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Protein
Neurotensin receptor type 2
Gene
NTSR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  3. regulation of membrane potential Source: Ensembl
  4. sensory perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
Gene namesi
Name:NTSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:8040. NTSR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed prediction
Add
BLAST
Transmembranei33 – 5523Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini56 – 649Cytoplasmic Reviewed prediction
Transmembranei65 – 8723Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini88 – 10922Extracellular Reviewed prediction
Add
BLAST
Transmembranei110 – 13122Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini132 – 15423Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei155 – 17622Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini177 – 21741Extracellular Reviewed prediction
Add
BLAST
Transmembranei218 – 23720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini238 – 29760Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini319 – 33719Extracellular Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini359 – 41052Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Neurotensin receptor type 2
PRO_0000069949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 194 By similarity
Lipidationi377 – 3771S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95665.
PRIDEiO95665.

PTM databases

PhosphoSiteiO95665.

Expressioni

Tissue specificityi

Expressed in prostate (at protein level).1 Publication

Gene expression databases

BgeeiO95665.
CleanExiHS_NTSR2.
GenevestigatoriO95665.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303686.

Structurei

3D structure databases

ProteinModelPortaliO95665.
SMRiO95665. Positions 20-374.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO95665.
KOiK04212.
OMAiWAKVLFT.
OrthoDBiEOG7S21Z8.
PhylomeDBiO95665.
TreeFamiTF337167.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95665-1 [UniParc]FASTAAdd to Basket

« Hide

METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN    50
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP 100
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR 150
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR 200
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST 250
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 300
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS 350
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS 400
GFGDPPETRT 410
Length:410
Mass (Da):45,385
Last modified:November 2, 2010 - v2
Checksum:i8B87DFD6923CBD42
GO

Sequence cautioni

The sequence EAX00924.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541A → V.3 Publications
Corresponds to variant rs6432225 [ dbSNP | Ensembl ].
VAR_049425
Natural varianti282 – 2821R → K.
Corresponds to variant rs34764121 [ dbSNP | Ensembl ].
VAR_061225

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 13426Missing in AAH37776. 1 Publication
Add
BLAST
Sequence conflicti142 – 1421R → C in AAH37776. 1 Publication
Sequence conflicti168 – 1681L → M in AAH22501. 1 Publication
Sequence conflicti367 – 3671K → R in AAH22501. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSiCCDS1681.1.
RefSeqiNP_036476.1. NM_012344.3.
UniGeneiHs.131138.

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
GeneIDi23620.
KEGGihsa:23620.
UCSCiuc002rbq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10148 mRNA. Translation: CAA71233.1 .
AY429107 mRNA. Translation: AAR07902.1 .
AC106875 Genomic DNA. Translation: AAY14691.1 .
AC110754 Genomic DNA. Translation: AAX82018.1 .
CH471053 Genomic DNA. Translation: EAX00924.1 . Sequence problems.
BC022501 mRNA. Translation: AAH22501.1 .
BC037776 mRNA. Translation: AAH37776.1 .
CCDSi CCDS1681.1.
RefSeqi NP_036476.1. NM_012344.3.
UniGenei Hs.131138.

3D structure databases

ProteinModelPortali O95665.
SMRi O95665. Positions 20-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000303686.

Chemistry

BindingDBi O95665.
ChEMBLi CHEMBL2514.
DrugBanki DB01106. Levocabastine.
GuidetoPHARMACOLOGYi 310.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O95665.

Proteomic databases

PaxDbi O95665.
PRIDEi O95665.

Protocols and materials databases

DNASUi 23620.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306928 ; ENSP00000303686 ; ENSG00000169006 .
GeneIDi 23620.
KEGGi hsa:23620.
UCSCi uc002rbq.4. human.

Organism-specific databases

CTDi 23620.
GeneCardsi GC02M011715.
HGNCi HGNC:8040. NTSR2.
MIMi 605538. gene.
neXtProti NX_O95665.
PharmGKBi PA31822.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303702.
HOGENOMi HOG000231271.
HOVERGENi HBG098285.
InParanoidi O95665.
KOi K04212.
OMAi WAKVLFT.
OrthoDBi EOG7S21Z8.
PhylomeDBi O95665.
TreeFami TF337167.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Neurotensin_receptor_2.
GenomeRNAii 23620.
NextBioi 46352.
PROi O95665.
SOURCEi Search...

Gene expression databases

Bgeei O95665.
CleanExi HS_NTSR2.
Genevestigatori O95665.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-54.
    Tissue: Brain.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
    Tissue: Brain.
  6. "Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
    Swift S.L., Burns J.E., Maitland N.J.
    Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNTR2_HUMAN
AccessioniPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5
, Q57Z87, Q8IY58, Q8TBH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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