O95665 (NTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotensin receptor type 2
Short name=NT-R-2
Short name=NTR2

Alternative name(s):
Levocabastine-sensitive neurotensin receptor

Gene names

Name:

NTSR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
Sequence caution	The sequence EAX00924.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from electronic annotation. Source: Compara sensory perception Traceable author statement PubMed 8795617. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled neurotensin receptor activity Inferred from electronic annotation. Source: Compara G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Neurotensin receptor type 2		PRO_0000069949
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 55	23	Helical; Name=1; Potential
	Topological domain	56 – 64	9	Cytoplasmic Potential
	Transmembrane	65 – 87	23	Helical; Name=2; Potential
	Topological domain	88 – 109	22	Extracellular Potential
	Transmembrane	110 – 131	22	Helical; Name=3; Potential
	Topological domain	132 – 154	23	Cytoplasmic Potential
	Transmembrane	155 – 176	22	Helical; Name=4; Potential
	Topological domain	177 – 217	41	Extracellular Potential
	Transmembrane	218 – 237	20	Helical; Name=5; Potential
	Topological domain	238 – 297	60	Cytoplasmic Potential
	Transmembrane	298 – 318	21	Helical; Name=6; Potential
	Topological domain	319 – 337	19	Extracellular Potential
	Transmembrane	338 – 358	21	Helical; Name=7; Potential
	Topological domain	359 – 410	52	Cytoplasmic Potential
Amino acid modifications
	Lipidation	377	1	S-palmitoyl cysteine Potential
	Disulfide bond	108 ↔ 194		By similarity
Natural variations
	Natural variant	54	1	A → V. Ref.1 Ref.2 Ref.5 Corresponds to variant rs6432225 [ dbSNP | Ensembl ].		VAR_049425
	Natural variant	282	1	R → K. Corresponds to variant rs34764121 [ dbSNP | Ensembl ].		VAR_061225
Experimental info
	Sequence conflict	109 – 134	26	Missing in AAH37776. Ref.5
	Sequence conflict	142	1	R → C in AAH37776. Ref.5
	Sequence conflict	168	1	L → M in AAH22501. Ref.5
	Sequence conflict	367	1	K → R in AAH22501. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O95665 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 8B87DFD6923CBD42	FASTA	410	45,385
	10 20 30 40 50 60 METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA 70 80 90 100 110 120 RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY 130 140 150 160 170 180 ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL 190 200 210 220 230 240 ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV 250 260 270 280 290 300 PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 310 320 330 340 350 360 AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA 370 380 390 400 410 VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells." Vita N., Oury-Donat F., Chalon P., Guillemot M., Kaghad M., Bachy A., Thurneyssen S., Garcia S., Poinot-Chazel C., Casellas P., Keane P., Le Fur G., Maffrand J.-P., Shoubrie P., Caput D., Ferrara P. Eur. J. Pharmacol. 360:265-272(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-54. Tissue: Brain.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54. Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Wikipedia

Neurotensin receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y10148 mRNA. Translation: CAA71233.1. AY429107 mRNA. Translation: AAR07902.1. AC106875 Genomic DNA. Translation: AAY14691.1. AC110754 Genomic DNA. Translation: AAX82018.1. CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems. BC022501 mRNA. Translation: AAH22501.1. BC037776 mRNA. Translation: AAH37776.1.
IPI	IPI00032116.
RefSeq	NP_036476.1. NM_012344.3.
UniGene	Hs.131138.
3D structure databases
ProteinModelPortal	O95665.
SMR	O95665. Positions 30-376.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303686.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O95665.
Proteomic databases
PaxDb	O95665.
PRIDE	O95665.
Protocols and materials databases
DNASU	23620.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306928; ENSP00000303686; ENSG00000169006.
GeneID	23620.
KEGG	hsa:23620.
UCSC	uc002rbq.4. human.
Organism-specific databases
CTD	23620.
GeneCards	GC02M011715.
HGNC	HGNC:8040. NTSR2.
MIM	605538. gene.
neXtProt	NX_O95665.
PharmGKB	PA31822.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303702.
HOGENOM	HOG000231271.
HOVERGEN	HBG098285.
InParanoid	O95665.
KO	K04212.
OMA	WAKVLFT.
OrthoDB	EOG4V438D.
PhylomeDB	O95665.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O95665.
CleanEx	HS_NTSR2.
Genevestigator	O95665.
GermOnline	ENSG00000169006. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003986. NT2_rcpt. IPR003984. NT_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01479. NEUROTENSINR. PR01481. NEUROTENSN2R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O95665.
ChEMBL	CHEMBL2514.
DrugBank	DB01106. Levocabastine.
GenomeRNAi	23620.
NextBio	46352.
SOURCE	Search...

Entry information

Entry name

NTR2_HUMAN

Accession

Primary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5 , Q57Z87, Q8IY58, Q8TBH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.