Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurotensin receptor type 2

Gene

NTSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  3. regulation of membrane potential Source: Ensembl
  4. sensory perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
Gene namesi
Name:NTSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:8040. NTSR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5523Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 649CytoplasmicSequence Analysis
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 21741ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 29760CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini359 – 41052CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Neurotensin receptor type 2PRO_0000069949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377 – 3771S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95665.
PRIDEiO95665.

PTM databases

PhosphoSiteiO95665.

Expressioni

Tissue specificityi

Expressed in prostate (at protein level).1 Publication

Gene expression databases

BgeeiO95665.
CleanExiHS_NTSR2.
GenevestigatoriO95665.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303686.

Structurei

3D structure databases

ProteinModelPortaliO95665.
SMRiO95665. Positions 20-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO95665.
KOiK04212.
OMAiVRELCAY.
OrthoDBiEOG7S21Z8.
PhylomeDBiO95665.
TreeFamiTF337167.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN
60 70 80 90 100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP
110 120 130 140 150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR
160 170 180 190 200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR
210 220 230 240 250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST
260 270 280 290 300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
310 320 330 340 350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS
410
GFGDPPETRT
Length:410
Mass (Da):45,385
Last modified:November 2, 2010 - v2
Checksum:i8B87DFD6923CBD42
GO

Sequence cautioni

The sequence EAX00924.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 13426Missing in AAH37776 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti142 – 1421R → C in AAH37776 (PubMed:15489334).Curated
Sequence conflicti168 – 1681L → M in AAH22501 (PubMed:15489334).Curated
Sequence conflicti367 – 3671K → R in AAH22501 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541A → V.3 Publications
Corresponds to variant rs6432225 [ dbSNP | Ensembl ].
VAR_049425
Natural varianti282 – 2821R → K.
Corresponds to variant rs34764121 [ dbSNP | Ensembl ].
VAR_061225

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSiCCDS1681.1.
RefSeqiNP_036476.1. NM_012344.3.
UniGeneiHs.131138.

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
GeneIDi23620.
KEGGihsa:23620.
UCSCiuc002rbq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSiCCDS1681.1.
RefSeqiNP_036476.1. NM_012344.3.
UniGeneiHs.131138.

3D structure databases

ProteinModelPortaliO95665.
SMRiO95665. Positions 20-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303686.

Chemistry

BindingDBiO95665.
ChEMBLiCHEMBL2514.
DrugBankiDB01106. Levocabastine.
GuidetoPHARMACOLOGYi310.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO95665.

Proteomic databases

PaxDbiO95665.
PRIDEiO95665.

Protocols and materials databases

DNASUi23620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
GeneIDi23620.
KEGGihsa:23620.
UCSCiuc002rbq.4. human.

Organism-specific databases

CTDi23620.
GeneCardsiGC02M011798.
HGNCiHGNC:8040. NTSR2.
MIMi605538. gene.
neXtProtiNX_O95665.
PharmGKBiPA31822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO95665.
KOiK04212.
OMAiVRELCAY.
OrthoDBiEOG7S21Z8.
PhylomeDBiO95665.
TreeFamiTF337167.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiNeurotensin_receptor_2.
GenomeRNAii23620.
NextBioi46352.
PROiO95665.
SOURCEiSearch...

Gene expression databases

BgeeiO95665.
CleanExiHS_NTSR2.
GenevestigatoriO95665.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-54.
    Tissue: Brain.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
    Tissue: Brain.
  6. "Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
    Swift S.L., Burns J.E., Maitland N.J.
    Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNTR2_HUMAN
AccessioniPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5
, Q57Z87, Q8IY58, Q8TBH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.