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Protein

Neurotensin receptor type 2

Gene

NTSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled neurotensin receptor activity Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • regulation of membrane potential Source: Ensembl
  • sensory perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169006-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiO95665.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
Gene namesi
Name:NTSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8040. NTSR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 64CytoplasmicSequence analysis9
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 109ExtracellularSequence analysisAdd BLAST22
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 217ExtracellularSequence analysisAdd BLAST41
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini238 – 297CytoplasmicSequence analysisAdd BLAST60
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini359 – 410CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23620.
OpenTargetsiENSG00000169006.
PharmGKBiPA31822.

Chemistry databases

ChEMBLiCHEMBL2514.
DrugBankiDB01106. Levocabastine.
GuidetoPHARMACOLOGYi310.

Polymorphism and mutation databases

BioMutaiNTSR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699491 – 410Neurotensin receptor type 2Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95665.
PeptideAtlasiO95665.
PRIDEiO95665.

PTM databases

iPTMnetiO95665.
PhosphoSitePlusiO95665.

Expressioni

Tissue specificityi

Expressed in prostate (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000169006.
CleanExiHS_NTSR2.
GenevisibleiO95665. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303686.

Chemistry databases

BindingDBiO95665.

Structurei

3D structure databases

ProteinModelPortaliO95665.
SMRiO95665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO95665.
KOiK04212.
OMAiVRELCAY.
OrthoDBiEOG091G0ACG.
PhylomeDBiO95665.
TreeFamiTF337167.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN
60 70 80 90 100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP
110 120 130 140 150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR
160 170 180 190 200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR
210 220 230 240 250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST
260 270 280 290 300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
310 320 330 340 350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS
410
GFGDPPETRT
Length:410
Mass (Da):45,385
Last modified:November 2, 2010 - v2
Checksum:i8B87DFD6923CBD42
GO

Sequence cautioni

The sequence EAX00924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109 – 134Missing in AAH37776 (PubMed:15489334).CuratedAdd BLAST26
Sequence conflicti142R → C in AAH37776 (PubMed:15489334).Curated1
Sequence conflicti168L → M in AAH22501 (PubMed:15489334).Curated1
Sequence conflicti367K → R in AAH22501 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04942554A → V.3 PublicationsCorresponds to variant rs6432225dbSNPEnsembl.1
Natural variantiVAR_061225282R → K.Corresponds to variant rs34764121dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSiCCDS1681.1.
RefSeqiNP_036476.1. NM_012344.3.
UniGeneiHs.131138.

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
GeneIDi23620.
KEGGihsa:23620.
UCSCiuc002rbq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSiCCDS1681.1.
RefSeqiNP_036476.1. NM_012344.3.
UniGeneiHs.131138.

3D structure databases

ProteinModelPortaliO95665.
SMRiO95665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303686.

Chemistry databases

BindingDBiO95665.
ChEMBLiCHEMBL2514.
DrugBankiDB01106. Levocabastine.
GuidetoPHARMACOLOGYi310.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95665.
PhosphoSitePlusiO95665.

Polymorphism and mutation databases

BioMutaiNTSR2.

Proteomic databases

PaxDbiO95665.
PeptideAtlasiO95665.
PRIDEiO95665.

Protocols and materials databases

DNASUi23620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006.
GeneIDi23620.
KEGGihsa:23620.
UCSCiuc002rbq.5. human.

Organism-specific databases

CTDi23620.
DisGeNETi23620.
GeneCardsiNTSR2.
HGNCiHGNC:8040. NTSR2.
MIMi605538. gene.
neXtProtiNX_O95665.
OpenTargetsiENSG00000169006.
PharmGKBiPA31822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO95665.
KOiK04212.
OMAiVRELCAY.
OrthoDBiEOG091G0ACG.
PhylomeDBiO95665.
TreeFamiTF337167.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169006-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiO95665.

Miscellaneous databases

GeneWikiiNeurotensin_receptor_2.
GenomeRNAii23620.
PROiO95665.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169006.
CleanExiHS_NTSR2.
GenevisibleiO95665. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTR2_HUMAN
AccessioniPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5
, Q57Z87, Q8IY58, Q8TBH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.