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O95665 (NTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin receptor type 2

Short name=NT-R-2
Short name=NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
Gene names
Name:NTSR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in prostate (at protein level). Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.

Sequence caution

The sequence EAX00924.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Neurotensin receptor type 2
PRO_0000069949

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5523Helical; Name=1; Potential
Topological domain56 – 649Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10922Extracellular Potential
Transmembrane110 – 13122Helical; Name=3; Potential
Topological domain132 – 15423Cytoplasmic Potential
Transmembrane155 – 17622Helical; Name=4; Potential
Topological domain177 – 21741Extracellular Potential
Transmembrane218 – 23720Helical; Name=5; Potential
Topological domain238 – 29760Cytoplasmic Potential
Transmembrane298 – 31821Helical; Name=6; Potential
Topological domain319 – 33719Extracellular Potential
Transmembrane338 – 35821Helical; Name=7; Potential
Topological domain359 – 41052Cytoplasmic Potential

Amino acid modifications

Lipidation3771S-palmitoyl cysteine Potential
Disulfide bond108 ↔ 194 By similarity

Natural variations

Natural variant541A → V. Ref.1 Ref.2 Ref.5
Corresponds to variant rs6432225 [ dbSNP | Ensembl ].
VAR_049425
Natural variant2821R → K.
Corresponds to variant rs34764121 [ dbSNP | Ensembl ].
VAR_061225

Experimental info

Sequence conflict109 – 13426Missing in AAH37776. Ref.5
Sequence conflict1421R → C in AAH37776. Ref.5
Sequence conflict1681L → M in AAH22501. Ref.5
Sequence conflict3671K → R in AAH22501. Ref.5

Sequences

Sequence LengthMass (Da)Tools
O95665 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: 8B87DFD6923CBD42

FASTA41045,385
        10         20         30         40         50         60 
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA 

        70         80         90        100        110        120 
RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY 

       130        140        150        160        170        180 
ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL 

       190        200        210        220        230        240 
ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV 

       250        260        270        280        290        300 
PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 

       310        320        330        340        350        360 
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA 

       370        380        390        400        410 
VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT 

« Hide

References

« Hide 'large scale' references
[1]"Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells."
Vita N., Oury-Donat F., Chalon P., Guillemot M., Kaghad M., Bachy A., Thurneyssen S., Garcia S., Poinot-Chazel C., Casellas P., Keane P., Le Fur G., Maffrand J.-P., Shoubrie P., Caput D., Ferrara P.
Eur. J. Pharmacol. 360:265-272(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-54.
Tissue: Brain.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
Tissue: Brain.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-54.
Tissue: Brain.
[6]"Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
Swift S.L., Burns J.E., Maitland N.J.
Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Wikipedia

Neurotensin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10148 mRNA. Translation: CAA71233.1.
AY429107 mRNA. Translation: AAR07902.1.
AC106875 Genomic DNA. Translation: AAY14691.1.
AC110754 Genomic DNA. Translation: AAX82018.1.
CH471053 Genomic DNA. Translation: EAX00924.1. Sequence problems.
BC022501 mRNA. Translation: AAH22501.1.
BC037776 mRNA. Translation: AAH37776.1.
CCDSCCDS1681.1.
RefSeqNP_036476.1. NM_012344.3.
UniGeneHs.131138.

3D structure databases

ProteinModelPortalO95665.
SMRO95665. Positions 20-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303686.

Chemistry

BindingDBO95665.
ChEMBLCHEMBL2514.
DrugBankDB01106. Levocabastine.
GuidetoPHARMACOLOGY310.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO95665.

Proteomic databases

PaxDbO95665.
PRIDEO95665.

Protocols and materials databases

DNASU23620.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306928; ENSP00000303686; ENSG00000169006.
GeneID23620.
KEGGhsa:23620.
UCSCuc002rbq.4. human.

Organism-specific databases

CTD23620.
GeneCardsGC02M011715.
HGNCHGNC:8040. NTSR2.
MIM605538. gene.
neXtProtNX_O95665.
PharmGKBPA31822.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303702.
HOGENOMHOG000231271.
HOVERGENHBG098285.
InParanoidO95665.
KOK04212.
OMAWAKVLFT.
OrthoDBEOG7S21Z8.
PhylomeDBO95665.
TreeFamTF337167.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO95665.
CleanExHS_NTSR2.
GenevestigatorO95665.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeurotensin_receptor_2.
GenomeRNAi23620.
NextBio46352.
PROO95665.
SOURCESearch...

Entry information

Entry nameNTR2_HUMAN
AccessionPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5 expand/collapse secondary AC list , Q57Z87, Q8IY58, Q8TBH6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries