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Protein

GTP-binding protein Di-Ras3

Gene

DIRAS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51GTPBy similarity8
Nucleotide bindingi63 – 69GTPBy similarity7
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi152 – 155GTPBy similarity4
Nucleotide bindingi182 – 183GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of gene expression by genetic imprinting Source: ProtInc
  • small GTPase mediated signal transduction Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras3
Alternative name(s):
Distinct subgroup of the Ras family member 3
Rho-related GTP-binding protein RhoI
Gene namesi
Name:DIRAS3
Synonyms:ARHI, NOEY2, RHOI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162595.4.
HGNCiHGNC:687. DIRAS3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9077.
OpenTargetsiENSG00000162595.
PharmGKBiPA24980.

Polymorphism and mutation databases

BioMutaiDIRAS3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916541 – 226GTP-binding protein Di-Ras3Add BLAST226
PropeptideiPRO_0000370781227 – 229Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226Cysteine methyl esterSequence analysis1
Lipidationi226S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO95661.
PeptideAtlasiO95661.
PRIDEiO95661.

PTM databases

iPTMnetiO95661.
PhosphoSitePlusiO95661.

Expressioni

Tissue specificityi

Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.

Gene expression databases

BgeeiENSG00000162595.
CleanExiHS_DIRAS3.
GenevisibleiO95661. HS.

Organism-specific databases

HPAiHPA028483.
HPA028557.
HPA029384.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407633EBI-6139214,EBI-518675

Protein-protein interaction databases

BioGridi114534. 22 interactors.
IntActiO95661. 13 interactors.
STRINGi9606.ENSP00000360020.

Structurei

3D structure databases

ProteinModelPortaliO95661.
SMRiO95661.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 74Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO95661.
KOiK07842.
OMAiWVRGNFR.
OrthoDBiEOG091G0SBH.
PhylomeDBiO95661.
TreeFamiTF313014.

Family and domain databases

Gene3Di1.20.120.430. 1 hit.
InterProiView protein in InterPro
IPR027368. MnmE_dom2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNASFGSKE QKLLKRLRLL PALLILRAFK PHRKIRDYRV VVVGTAGVGK
60 70 80 90 100
STLLHKWASG NFRHEYLPTI ENTYCQLLGC SHGVLSLHIT DSKSGDGNRA
110 120 130 140 150
LQRHVIARGH AFVLVYSVTK KETLEELKAF YELICKIKGN NLHKFPIVLV
160 170 180 190 200
GNKSDDTHRE VALNDGATCA MEWNCAFMEI SAKTDVNVQE LFHMLLNYKK
210 220
KPTTGLQEPE KKSQMPNTTE KLLDKCIIM
Length:229
Mass (Da):25,861
Last modified:May 1, 1999 - v1
Checksum:i16AEA60089A91B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96750 mRNA. Translation: AAD03164.1.
AF202543 Genomic DNA. Translation: AAG35625.1.
CR541870 mRNA. Translation: CAG46668.1.
CR541892 mRNA. Translation: CAG46690.1.
AK021882 mRNA. Translation: BAG51055.1.
AL157407 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06483.1.
BC005362 mRNA. Translation: AAH05362.1.
CCDSiCCDS641.1.
RefSeqiNP_004666.1. NM_004675.3.
XP_016858262.1. XM_017002773.1.
UniGeneiHs.194695.

Genome annotation databases

EnsembliENST00000370981; ENSP00000360020; ENSG00000162595.
GeneIDi9077.
KEGGihsa:9077.
UCSCiuc001ded.4. human.

Similar proteinsi

Entry informationi

Entry nameiDIRA3_HUMAN
AccessioniPrimary (citable) accession number: O95661
Secondary accession number(s): B3KMP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families