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Protein

GTP-binding protein Di-Ras3

Gene

DIRAS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518GTPBy similarity
Nucleotide bindingi91 – 955GTPBy similarity
Nucleotide bindingi152 – 1554GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • protein transport Source: InterPro
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of gene expression by genetic imprinting Source: ProtInc
  • small GTPase mediated signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras3
Alternative name(s):
Distinct subgroup of the Ras family member 3
Rho-related GTP-binding protein RhoI
Gene namesi
Name:DIRAS3
Synonyms:ARHI, NOEY2, RHOI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:687. DIRAS3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24980.

Polymorphism and mutation databases

BioMutaiDIRAS3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226GTP-binding protein Di-Ras3PRO_0000191654Add
BLAST
Propeptidei227 – 2293Removed in mature formSequence analysisPRO_0000370781

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261Cysteine methyl esterSequence analysis
Lipidationi226 – 2261S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO95661.
PRIDEiO95661.

PTM databases

iPTMnetiO95661.
PhosphoSiteiO95661.

Expressioni

Tissue specificityi

Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.

Gene expression databases

BgeeiO95661.
CleanExiHS_DIRAS3.
GenevisibleiO95661. HS.

Organism-specific databases

HPAiHPA028483.
HPA028557.
HPA029384.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407633EBI-6139214,EBI-518675

Protein-protein interaction databases

BioGridi114534. 20 interactions.
IntActiO95661. 12 interactions.
STRINGi9606.ENSP00000360020.

Structurei

3D structure databases

ProteinModelPortaliO95661.
SMRiO95661. Positions 37-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 749Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO95661.
KOiK07842.
OMAiWVRGNFR.
OrthoDBiEOG7SBNQ3.
PhylomeDBiO95661.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNASFGSKE QKLLKRLRLL PALLILRAFK PHRKIRDYRV VVVGTAGVGK
60 70 80 90 100
STLLHKWASG NFRHEYLPTI ENTYCQLLGC SHGVLSLHIT DSKSGDGNRA
110 120 130 140 150
LQRHVIARGH AFVLVYSVTK KETLEELKAF YELICKIKGN NLHKFPIVLV
160 170 180 190 200
GNKSDDTHRE VALNDGATCA MEWNCAFMEI SAKTDVNVQE LFHMLLNYKK
210 220
KPTTGLQEPE KKSQMPNTTE KLLDKCIIM
Length:229
Mass (Da):25,861
Last modified:May 1, 1999 - v1
Checksum:i16AEA60089A91B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96750 mRNA. Translation: AAD03164.1.
AF202543 Genomic DNA. Translation: AAG35625.1.
CR541870 mRNA. Translation: CAG46668.1.
CR541892 mRNA. Translation: CAG46690.1.
AK021882 mRNA. Translation: BAG51055.1.
AL157407 Genomic DNA. Translation: CAI21991.1.
CH471059 Genomic DNA. Translation: EAX06483.1.
BC005362 mRNA. Translation: AAH05362.1.
CCDSiCCDS641.1.
RefSeqiNP_004666.1. NM_004675.3.
UniGeneiHs.194695.

Genome annotation databases

EnsembliENST00000370981; ENSP00000360020; ENSG00000162595.
ENST00000395201; ENSP00000378627; ENSG00000162595.
GeneIDi9077.
KEGGihsa:9077.
UCSCiuc001ded.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

NOEY2 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96750 mRNA. Translation: AAD03164.1.
AF202543 Genomic DNA. Translation: AAG35625.1.
CR541870 mRNA. Translation: CAG46668.1.
CR541892 mRNA. Translation: CAG46690.1.
AK021882 mRNA. Translation: BAG51055.1.
AL157407 Genomic DNA. Translation: CAI21991.1.
CH471059 Genomic DNA. Translation: EAX06483.1.
BC005362 mRNA. Translation: AAH05362.1.
CCDSiCCDS641.1.
RefSeqiNP_004666.1. NM_004675.3.
UniGeneiHs.194695.

3D structure databases

ProteinModelPortaliO95661.
SMRiO95661. Positions 37-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114534. 20 interactions.
IntActiO95661. 12 interactions.
STRINGi9606.ENSP00000360020.

PTM databases

iPTMnetiO95661.
PhosphoSiteiO95661.

Polymorphism and mutation databases

BioMutaiDIRAS3.

Proteomic databases

PaxDbiO95661.
PRIDEiO95661.

Protocols and materials databases

DNASUi9077.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370981; ENSP00000360020; ENSG00000162595.
ENST00000395201; ENSP00000378627; ENSG00000162595.
GeneIDi9077.
KEGGihsa:9077.
UCSCiuc001ded.4. human.

Organism-specific databases

CTDi9077.
GeneCardsiDIRAS3.
HGNCiHGNC:687. DIRAS3.
HPAiHPA028483.
HPA028557.
HPA029384.
MIMi605193. gene.
neXtProtiNX_O95661.
PharmGKBiPA24980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO95661.
KOiK07842.
OMAiWVRGNFR.
OrthoDBiEOG7SBNQ3.
PhylomeDBiO95661.
TreeFamiTF313014.

Miscellaneous databases

GenomeRNAii9077.
PROiO95661.
SOURCEiSearch...

Gene expression databases

BgeeiO95661.
CleanExiHS_DIRAS3.
GenevisibleiO95661. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas."
    Yu Y.H., Xu F.J., Peng H., Fang X., Zhao S., Li Y., Cuevas B., Kuo W.-L., Gray J.W., Siciliano M., Mills G.B., Bast R.C. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 96:214-219(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI."
    Luo R.Z., Peng H., Xu F., Bao J., Pang Y., Pershad R., Issa J.P., Liao W.S., Bast R.C. Jr., Yu Y.
    Biochim. Biophys. Acta 1519:216-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.

Entry informationi

Entry nameiDIRA3_HUMAN
AccessioniPrimary (citable) accession number: O95661
Secondary accession number(s): B3KMP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.