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Protein

GTP-binding protein Di-Ras3

Gene

DIRAS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51GTPBy similarity8
Nucleotide bindingi63 – 69GTPBy similarity7
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi152 – 155GTPBy similarity4
Nucleotide bindingi182 – 183GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of gene expression by genetic imprinting Source: ProtInc
  • small GTPase mediated signal transduction Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras3
Alternative name(s):
Distinct subgroup of the Ras family member 3
Rho-related GTP-binding protein RhoI
Gene namesi
Name:DIRAS3
Synonyms:ARHI, NOEY2, RHOI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162595.4
HGNCiHGNC:687 DIRAS3
MIMi605193 gene
neXtProtiNX_O95661

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9077
OpenTargetsiENSG00000162595
PharmGKBiPA24980

Polymorphism and mutation databases

BioMutaiDIRAS3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916541 – 226GTP-binding protein Di-Ras3Add BLAST226
PropeptideiPRO_0000370781227 – 229Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226Cysteine methyl esterSequence analysis1
Lipidationi226S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO95661
PeptideAtlasiO95661
PRIDEiO95661

PTM databases

iPTMnetiO95661
PhosphoSitePlusiO95661

Expressioni

Tissue specificityi

Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.

Gene expression databases

BgeeiENSG00000162595
CleanExiHS_DIRAS3
GenevisibleiO95661 HS

Organism-specific databases

HPAiHPA028483
HPA028557
HPA029384

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407633EBI-6139214,EBI-518675

Protein-protein interaction databases

BioGridi114534, 22 interactors
IntActiO95661, 13 interactors
MINTiO95661
STRINGi9606.ENSP00000360020

Structurei

3D structure databases

ProteinModelPortaliO95661
SMRiO95661
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 74Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiO95661
KOiK07842
OMAiWVRGNFR
OrthoDBiEOG091G0SBH
PhylomeDBiO95661
TreeFamiTF313014

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNASFGSKE QKLLKRLRLL PALLILRAFK PHRKIRDYRV VVVGTAGVGK
60 70 80 90 100
STLLHKWASG NFRHEYLPTI ENTYCQLLGC SHGVLSLHIT DSKSGDGNRA
110 120 130 140 150
LQRHVIARGH AFVLVYSVTK KETLEELKAF YELICKIKGN NLHKFPIVLV
160 170 180 190 200
GNKSDDTHRE VALNDGATCA MEWNCAFMEI SAKTDVNVQE LFHMLLNYKK
210 220
KPTTGLQEPE KKSQMPNTTE KLLDKCIIM
Length:229
Mass (Da):25,861
Last modified:May 1, 1999 - v1
Checksum:i16AEA60089A91B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96750 mRNA Translation: AAD03164.1
AF202543 Genomic DNA Translation: AAG35625.1
CR541870 mRNA Translation: CAG46668.1
CR541892 mRNA Translation: CAG46690.1
AK021882 mRNA Translation: BAG51055.1
AL157407 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06483.1
BC005362 mRNA Translation: AAH05362.1
CCDSiCCDS641.1
RefSeqiNP_004666.1, NM_004675.3
XP_016858262.1, XM_017002773.1
UniGeneiHs.194695

Genome annotation databases

EnsembliENST00000370981; ENSP00000360020; ENSG00000162595
GeneIDi9077
KEGGihsa:9077
UCSCiuc001ded.4 human

Similar proteinsi

Entry informationi

Entry nameiDIRA3_HUMAN
AccessioniPrimary (citable) accession number: O95661
Secondary accession number(s): B3KMP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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