ID   FSTL3_HUMAN             Reviewed;         263 AA.
AC   O95633;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   07-JUL-2009, entry version 76.
DE   RecName: Full=Follistatin-related protein 3;
DE   AltName: Full=Follistatin-like 3;
DE   AltName: Full=Follistatin-related gene protein;
DE   Flags: Precursor;
GN   Name=FSTL3; Synonyms=FLRG; ORFNames=UNQ674/PRO1308;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL TRANSLOCATION.
RC   TISSUE=Placenta;
RX   MEDLINE=98334491; PubMed=9671416; DOI=10.1038/sj.onc.1201807;
RA   Hayette S., Gadoux M., Martel S., Bertrand S., Tigaud I.,
RA   Magaud J.-P., Rimokh R.;
RT   "FLRG (follistatin-related gene), a new target of chromosomal
RT   rearrangement in malignant blood disorders.";
RL   Oncogene 16:2949-2954(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 27-41.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [5]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   MEDLINE=21352723; PubMed=11459787; DOI=10.1210/en.142.8.3426;
RA   Tortoriello D.V., Sidis Y., Holtzman D.A., Holmes W.E., Schneyer A.L.;
RT   "Human follistatin-related protein: a structural homologue of
RT   follistatin with nuclear localization.";
RL   Endocrinology 142:3426-3434(2001).
CC   -!- FUNCTION: Binding protein for activin and BMP2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential). Nucleus.
CC       Note=According to PubMed:11459787 it is nuclear.
CC   -!- TISSUE SPECIFICITY: Expressed in a wide range of tissues.
CC   -!- DISEASE: A chromosomal aberration involving FSTL3 is found in a
CC       case of B-cell chronic lymphocytic leukemia. Translocation
CC       t(11;19)(q13;p13) with CCDN1.
CC   -!- SIMILARITY: Contains 2 follistatin-like domains.
CC   -!- SIMILARITY: Contains 2 Kazal-like domains.
CC   -!- SIMILARITY: Contains 1 TB (TGF-beta binding) domain.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/FSTL3ID111ch19p13.html";
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DR   EMBL; U76702; AAC64321.1; -; mRNA.
DR   EMBL; AY358917; AAQ89276.1; -; mRNA.
DR   EMBL; BC005839; AAH05839.1; -; mRNA.
DR   EMBL; BC033119; AAH33119.1; -; mRNA.
DR   IPI; IPI00025155; -.
DR   RefSeq; NP_005851.1; -.
DR   UniGene; Hs.529038; -.
DR   PDB; 2KCX; NMR; -; A=97-169.
DR   PDB; 3B4V; X-ray; 2.48 A; C/D/G/H=27-263.
DR   PDBsum; 2KCX; -.
DR   PDBsum; 3B4V; -.
DR   MEROPS; I01.968; -.
DR   PeptideAtlas; O95633; -.
DR   PRIDE; O95633; -.
DR   Ensembl; ENSG00000070404; Homo sapiens.
DR   GeneID; 10272; -.
DR   KEGG; hsa:10272; -.
DR   UCSC; uc002lpk.1; human.
DR   GeneCards; GC19P000627; -.
DR   H-InvDB; HIX0014560; -.
DR   HGNC; HGNC:3973; FSTL3.
DR   MIM; 605343; gene.
DR   Orphanet; 67038; Leukemia, B-cell lymphocytic, chronic.
DR   PharmGKB; PA28390; -.
DR   HOGENOM; O95633; -.
DR   HOVERGEN; O95633; -.
DR   OMA; O95633; VTYISSC.
DR   NextBio; 38914; -.
DR   PMAP-CutDB; O95633; -.
DR   ArrayExpress; O95633; -.
DR   Bgee; O95633; -.
DR   CleanEx; HS_FSTL3; -.
DR   GermOnline; ENSG00000070404; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003645; Fol_N.
DR   InterPro; IPR015369; Follistatin/Osteonectin_EGF.
DR   InterPro; IPR012913; PRKCSH.
DR   InterPro; IPR002350; Prot_inh_Kazal.
DR   InterPro; IPR011497; Prot_Inh_Kazal_2.
DR   InterPro; IPR017878; TFG_b-bd.
DR   Pfam; PF09289; FOLN; 1.
DR   Pfam; PF00050; Kazal_1; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   Pfam; PF07915; PRKCSH; 1.
DR   SMART; SM00274; FOLN; 2.
DR   SMART; SM00280; KAZAL; 2.
DR   PROSITE; PS00282; KAZAL; FALSE_NEG.
DR   PROSITE; PS51364; TB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chromosomal rearrangement; Complete proteome;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Nucleus;
KW   Proto-oncogene; Repeat; Secreted; Signal.
FT   SIGNAL        1     26
FT   CHAIN        27    263       Follistatin-related protein 3.
FT                                /FTId=PRO_0000010115.
FT   DOMAIN       36    107       TB.
FT   DOMAIN      121    167       Kazal-like 1.
FT   DOMAIN      170    193       Follistatin-like 2.
FT   DOMAIN      195    243       Kazal-like 2.
FT   CARBOHYD     73     73       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    215    215       N-linked (GlcNAc...) (Potential).
FT   DISULFID    121    153       By similarity.
FT   DISULFID    125    146       By similarity.
FT   DISULFID    135    167       By similarity.
FT   DISULFID    195    229       By similarity.
FT   DISULFID    200    222       By similarity.
FT   DISULFID    211    243       By similarity.
SQ   SEQUENCE   263 AA;  27663 MW;  6A9AB86ADD4FD09C CRC64;
     MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL VLQTDVTRAE
     CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD GVECGPGKAC RMLGGRPRCE
     CAPDCSGLPA RLQVCGSDGA TYRDECELRA ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ
     SCVVDQTGSA HCVVCRAAPC PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA
     GSCAGTPEEP PGGESAEEEE NFV
//