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Reviewed, UniProtKB/Swiss-Prot O95633 (FSTL3_HUMAN)

Last modified November 25, 2008. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Follistatin-related protein 3
Alternative name(s):
    Follistatin-like 3
    Follistatin-related gene protein
Gene names
Name: FSTL3
Synonyms: FLRG
ORF Names: UNQ674/PRO1308
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binding protein for activin and BMP2 By similarity.

Subcellular location

SecretedPotential. Nucleus. Note= According to Ref.5 it is nuclear.

Tissue specificity

Expressed in a wide range of tissues.

Involvement in disease

A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.

Sequence similarities

Contains 2 follistatin-like domains.

Contains 2 Kazal-like domains.

Contains 1 TB (TGF-beta binding) domain.

Ontologies

Keywords

   Cellular componentNucleus
Secreted
   Coding sequence diversityChromosomal rearrangement
   DiseaseProto-oncogene
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical term3D-structure
Direct protein sequencing

Gene Ontology (GO)

   Cellular componentextracellular space Ref.1

Traceable author statement. Source: ProtInc

nucleus

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 263237Follistatin-related protein 3
PRO_0000010115

Regions

Domain36 – 10772TB
Domain121 – 16747Kazal-like 1
Domain170 – 19324Follistatin-like 2
Domain195 – 24349Kazal-like 2

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 153 By similarity
Disulfide bond125 ↔ 146 By similarity
Disulfide bond135 ↔ 167 By similarity
Disulfide bond195 ↔ 229 By similarity
Disulfide bond200 ↔ 222 By similarity
Disulfide bond211 ↔ 243 By similarity

Sequences

Sequence LengthMass (Da)Tools
O95633-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6A9AB86ADD4FD09C

FASTA26327,663
        10         20         30         40         50         60 
MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL VLQTDVTRAE 

        70         80         90        100        110        120 
CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD GVECGPGKAC RMLGGRPRCE 

       130        140        150        160        170        180 
CAPDCSGLPA RLQVCGSDGA TYRDECELRA ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ 

       190        200        210        220        230        240 
SCVVDQTGSA HCVVCRAAPC PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA 

       250        260 
GSCAGTPEEP PGGESAEEEE NFV 

« Hide

References

« Hide 'large scale' references
[1]"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders."
Hayette S., Gadoux M., Martel S., Bertrand S., Tigaud I., Magaud J.-P., Rimokh R.
Oncogene 16:2949-2954(1998) [PubMed: 9671416] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION.
Tissue: Placenta.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-41.
[5]"Human follistatin-related protein: a structural homologue of follistatin with nuclear localization."
Tortoriello D.V., Sidis Y., Holtzman D.A., Holmes W.E., Schneyer A.L.
Endocrinology 142:3426-3434(2001) [PubMed: 11459787] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

U76702 mRNA. Translation: AAC64321.1.
AY358917 mRNA. Translation: AAQ89276.1.
BC005839 mRNA. Translation: AAH05839.1.
BC033119 mRNA. Translation: AAH33119.1.
RefSeqNP_005851.1.
UniGeneHs.529038

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3B4VX-ray2.48C/D/G/H27-263[»]
ModBaseSearch...

Protein family/group databases

MEROPSI01.968.

Proteomic databases

PeptideAtlasO95633.

Genome annotation databases

EnsemblENSG00000070404. Homo sapiens. [Contig view]
GeneID10272.
KEGGhsa:10272.

Organism-specific databases

H-InvDBHIX0014560.
HGNCHGNC:3973. FSTL3.
MIM605343. gene.
Orphanet67038. B-cell chronic lymphocytic leukaemia.
PharmGKBPA28390.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO95633.
HOVERGENO95633.

Gene expression databases

ArrayExpressO95633.
CleanExHS_FSTL3.
GermOnlineENSG00000070404. Homo sapiens.

Family and domain databases

InterProIPR003645. Fol_N.
IPR015204. Fol_N_sub.
IPR002350. Prot_inh_Kazal.
IPR011497. Prot_Inh_Kazal_2.
[Graphical view]
PfamPF09120. EGF-like_subdom. 1 hit.
PF00050. Kazal_1. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00274. FOLN. 2 hits.
SM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEPS00282. KAZAL. False negative.
PS51364. TB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio38914.
SOURCESearch...

Entry information

Entry nameFSTL3_HUMAN
AccessionPrimary (citable) accession number: O95633
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1999
Last modified: November 25, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents