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O95631

- NET1_HUMAN

UniProt

O95631 - NET1_HUMAN

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Protein
Netrin-1
Gene
NTN1, NTN1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. anterior/posterior axon guidance Source: Ensembl
  2. apoptotic process Source: UniProtKB-KW
  3. axon guidance Source: Reactome
  4. establishment of nucleus localization Source: Ensembl
  5. inner ear morphogenesis Source: Ensembl
  6. mammary gland duct morphogenesis Source: Ensembl
  7. negative regulation of axon extension Source: Ensembl
  8. neuron migration Source: Ensembl
  9. positive regulation of axon extension Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. regulation of cell migration Source: Ensembl
  12. single organismal cell-cell adhesion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_22228. Role of second messengers in netrin-1 signaling.
REACT_22237. Netrin-1 signaling.
REACT_22351. DCC mediated attractive signaling.
REACT_22384. Netrin mediated repulsion signals.
REACT_25299. DSCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-1
Alternative name(s):
Epididymis tissue protein Li 131P
Gene namesi
Name:NTN1
Synonyms:NTN1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8029. NTN1.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 604580Netrin-1
PRO_0000017082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi119 ↔ 152 By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi285 ↔ 294 By similarity
Disulfide bondi287 ↔ 304 By similarity
Disulfide bondi306 ↔ 315 By similarity
Disulfide bondi318 ↔ 338 By similarity
Disulfide bondi341 ↔ 350 By similarity
Disulfide bondi343 ↔ 368 By similarity
Disulfide bondi371 ↔ 380 By similarity
Disulfide bondi383 ↔ 401 By similarity
Disulfide bondi404 ↔ 416 By similarity
Disulfide bondi406 ↔ 423 By similarity
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi425 ↔ 434 By similarity
Disulfide bondi437 ↔ 451 By similarity
Disulfide bondi472 ↔ 544 By similarity
Disulfide bondi491 ↔ 601 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95631.
PaxDbiO95631.
PRIDEiO95631.

PTM databases

PhosphoSiteiO95631.

Expressioni

Tissue specificityi

Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).2 Publications

Gene expression databases

ArrayExpressiO95631.
BgeeiO95631.
CleanExiHS_NTN1.
GenevestigatoriO95631.

Organism-specific databases

HPAiHPA056419.

Interactioni

Subunit structurei

Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D.2 Publications

Protein-protein interaction databases

BioGridi114816. 2 interactions.
DIPiDIP-46273N.
IntActiO95631. 1 interaction.
STRINGi9606.ENSP00000173229.

Structurei

3D structure databases

ProteinModelPortaliO95631.
SMRiO95631. Positions 41-446.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 284238Laminin N-terminal
Add
BLAST
Domaini285 – 34056Laminin EGF-like 1
Add
BLAST
Domaini341 – 40363Laminin EGF-like 2
Add
BLAST
Domaini404 – 45350Laminin EGF-like 3
Add
BLAST
Domaini472 – 601130NTR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi530 – 5323Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG244580.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiO95631.
KOiK06843.
OMAiDSYYYAV.
OrthoDBiEOG7SR4KJ.
PhylomeDBiO95631.
TreeFamiTF352481.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95631-1 [UniParc]FASTAAdd to Basket

« Hide

MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR    50
CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK 100
KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ 150
FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE 200
AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA 250
FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD 300
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC 350
RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA 400
CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP 450
CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKINMKKY CKKDYAVQIH 500
ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK 550
PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 600
CKKA 604
Length:604
Mass (Da):67,748
Last modified:May 5, 2009 - v2
Checksum:i9827C09D0D783B27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511R → H in a neuroblastoma sample. 1 Publication
VAR_014279
Natural varianti489 – 4891K → E in a neuroblastoma sample. 1 Publication
VAR_014280

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991D → T in AAD09221. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75586 mRNA. Translation: AAD09221.1.
GU727649 mRNA. Translation: ADU87650.1.
AC090610 Genomic DNA. No translation available.
AC005695 Genomic DNA. No translation available.
CCDSiCCDS11148.1.
RefSeqiNP_004813.2. NM_004822.2.
XP_006721658.1. XM_006721595.1.
UniGeneiHs.660885.

Genome annotation databases

EnsembliENST00000173229; ENSP00000173229; ENSG00000065320.
ENST00000538852; ENSP00000443259; ENSG00000065320.
ENST00000546090; ENSP00000441611; ENSG00000065320.
GeneIDi9423.
KEGGihsa:9423.
UCSCiuc002glw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75586 mRNA. Translation: AAD09221.1 .
GU727649 mRNA. Translation: ADU87650.1 .
AC090610 Genomic DNA. No translation available.
AC005695 Genomic DNA. No translation available.
CCDSi CCDS11148.1.
RefSeqi NP_004813.2. NM_004822.2.
XP_006721658.1. XM_006721595.1.
UniGenei Hs.660885.

3D structure databases

ProteinModelPortali O95631.
SMRi O95631. Positions 41-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114816. 2 interactions.
DIPi DIP-46273N.
IntActi O95631. 1 interaction.
STRINGi 9606.ENSP00000173229.

PTM databases

PhosphoSitei O95631.

Proteomic databases

MaxQBi O95631.
PaxDbi O95631.
PRIDEi O95631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000173229 ; ENSP00000173229 ; ENSG00000065320 .
ENST00000538852 ; ENSP00000443259 ; ENSG00000065320 .
ENST00000546090 ; ENSP00000441611 ; ENSG00000065320 .
GeneIDi 9423.
KEGGi hsa:9423.
UCSCi uc002glw.4. human.

Organism-specific databases

CTDi 9423.
GeneCardsi GC17P008924.
H-InvDB HIX0039241.
HGNCi HGNC:8029. NTN1.
HPAi HPA056419.
MIMi 601614. gene.
neXtProti NX_O95631.
PharmGKBi PA31813.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244580.
HOGENOMi HOG000286017.
HOVERGENi HBG006464.
InParanoidi O95631.
KOi K06843.
OMAi DSYYYAV.
OrthoDBi EOG7SR4KJ.
PhylomeDBi O95631.
TreeFami TF352481.

Enzyme and pathway databases

Reactomei REACT_22228. Role of second messengers in netrin-1 signaling.
REACT_22237. Netrin-1 signaling.
REACT_22351. DCC mediated attractive signaling.
REACT_22384. Netrin mediated repulsion signals.
REACT_25299. DSCAM interactions.

Miscellaneous databases

GeneWikii NTN1.
GenomeRNAii 9423.
NextBioi 35298.
PROi O95631.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95631.
Bgeei O95631.
CleanExi HS_NTN1.
Genevestigatori O95631.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
InterProi IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
Pfami PF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas."
    Meyerhardt J.A., Caca K., Eckstrand B.C., Hu G., Lengauer C., Banavali S., Look A.T., Fearon E.R.
    Cell Growth Differ. 10:35-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH DCC, TISSUE SPECIFICITY, VARIANTS HIS-351 AND GLU-489.
    Tissue: Brain stem and Liver.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
    Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
    Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Epididymis.
  4. "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis."
    Mazelin L., Bernet A., Bonod-Bidaud C., Pays L., Arnaud S., Gespach C., Bredesen D.E., Scoazec J.-Y., Mehlen P.
    Nature 431:80-84(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "DSCAM functions as a netrin receptor in commissural axon pathfinding."
    Liu G., Li W., Wang L., Kar A., Guan K.L., Rao Y., Wu J.Y.
    Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DSCAM.

Entry informationi

Entry nameiNET1_HUMAN
AccessioniPrimary (citable) accession number: O95631
Secondary accession number(s): E9KL51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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