O95626 (AN32D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member D

Alternative name(s):
Phosphoprotein 32-related protein 2
Tumorigenic protein pp32r2

Gene names

Name:	ANP32D
Synonyms:	PP32R2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ANP32 family. Contains 5 LRR (leucine-rich) repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Acidic leucine-rich nuclear phosphoprotein 32 family member D		PRO_0000137598
Regions
	Repeat	18 – 38	21	LRR 1
	Repeat	43 – 64	22	LRR 2
	Repeat	65 – 87	23	LRR 3
	Repeat	89 – 110	22	LRR 4
	Repeat	114 – 131	18	LRR 5
Amino acid modifications
	Modified residue	101	1	N6-acetyllysine Ref.5
Natural variations
	Natural variant	46	1	L → F. Corresponds to variant rs7956679 [ dbSNP | Ensembl ].		VAR_027832
Experimental info
	Sequence conflict	38	1	T → A in AAD13667. Ref.1
	Sequence conflict	55	1	T → S in AAD13667. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O95626 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: C2B2749F83496C53	FASTA	131	14,806
	10 20 30 40 50 60 MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI NIGLTSIANL 70 80 90 100 110 120 PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI KDLSTIEPLK KLENLESLDL 130 FTCEVTNLNN Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Modulation of oncogenic potential by alternative gene use in human prostate cancer." Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:275-279(1999) [PubMed: 10086381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	Erratum Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:1087-1087(1999) [PubMed: 10471270] [Abstract]
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The Anp32 family of proteins containing leucine-rich repeats." Matilla A., Radrizzani M. Cerebellum 4:7-18(2005) [PubMed: 15895553] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-101, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U71084 Genomic DNA. Translation: AAD13667.1. BC069122 mRNA. Translation: AAH69122.1.
IPI	IPI00172487.
RefSeq	NP_036536.2. NM_012404.2.
UniGene	Hs.532658.
3D structure databases
ProteinModelPortal	O95626.
SMR	O95626. Positions 1-131.
ModBase	Search...
PTM databases
PhosphoSite	O95626.
Proteomic databases
PRIDE	O95626.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266594; ENSP00000266594; ENSG00000139223.
GeneID	23519.
KEGG	hsa:23519.
UCSC	uc001rrq.1. human.
Organism-specific databases
CTD	23519.
GeneCards	GC12P048832.
H-InvDB	HIX0036822.
HGNC	HGNC:16676. ANP32D.
MIM	606878. gene.
neXtProt	NX_O95626.
PharmGKB	PA24814.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14917.
GeneTree	ENSGT00560000077130.
HOGENOM	HBG747960.
HOVERGEN	HBG053102.
InParanoid	O95626.
OMA	CPNLIHL.
OrthoDB	EOG4QNMXG.
PhylomeDB	O95626.
Gene expression databases
ArrayExpress	O95626.
Bgee	O95626.
CleanEx	HS_ANP32D.
Genevestigator	O95626.
GermOnline	ENSG00000139223. Homo sapiens.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. [Graphical view]
PROSITE	PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	45965.
SOURCE	Search...

Entry information

Entry name

AN32D_HUMAN

Accession

Primary (citable) accession number: O95626
Secondary accession number(s): Q6NTC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.