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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member D

Gene

ANP32D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member D
Alternative name(s):
Phosphoprotein 32-related protein 2
Tumorigenic protein pp32r2
Gene namesi
Name:ANP32D
Synonyms:PP32R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139223.2.
HGNCiHGNC:16676. ANP32D.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23519.
OpenTargetsiENSG00000139223.
PharmGKBiPA24814.

Polymorphism and mutation databases

BioMutaiANP32D.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375981 – 131Acidic leucine-rich nuclear phosphoprotein 32 family member DAdd BLAST131

Proteomic databases

MaxQBiO95626.
PaxDbiO95626.
PeptideAtlasiO95626.
PRIDEiO95626.

PTM databases

iPTMnetiO95626.
PhosphoSitePlusiO95626.

Expressioni

Gene expression databases

BgeeiENSG00000139223.
CleanExiHS_ANP32D.
GenevisibleiO95626. HS.

Organism-specific databases

HPAiHPA063133.
HPA067561.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266594.

Structurei

3D structure databases

ProteinModelPortaliO95626.
SMRiO95626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 38LRR 1Add BLAST21
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Repeati114 – 131LRR 5Add BLAST18

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiO95626.
KOiK18646.
OMAiKCPNLIH.
OrthoDBiEOG091G0R8Z.
PhylomeDBiO95626.
TreeFamiTF317206.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

O95626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI
60 70 80 90 100
NIGLTSIANL PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI
110 120 130
KDLSTIEPLK KLENLESLDL FTCEVTNLNN Y
Length:131
Mass (Da):14,806
Last modified:October 3, 2006 - v2
Checksum:iC2B2749F83496C53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38T → A in AAD13667 (PubMed:10086381).Curated1
Sequence conflicti55T → S in AAD13667 (PubMed:10086381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02783246L → F. Corresponds to variant dbSNP:rs7956679Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71084 Genomic DNA. Translation: AAD13667.1.
BC069122 mRNA. Translation: AAH69122.1.
CCDSiCCDS31788.1.
RefSeqiNP_036536.2. NM_012404.2.
UniGeneiHs.532658.

Genome annotation databases

EnsembliENST00000266594; ENSP00000266594; ENSG00000139223.
GeneIDi23519.
KEGGihsa:23519.
UCSCiuc010slt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAN32D_HUMAN
AccessioniPrimary (citable) accession number: O95626
Secondary accession number(s): Q6NTC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 3, 2006
Last modified: November 22, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families