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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member D

Gene

ANP32D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member D
Alternative name(s):
Phosphoprotein 32-related protein 2
Tumorigenic protein pp32r2
Gene namesi
Name:ANP32D
Synonyms:PP32R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16676. ANP32D.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24814.

Polymorphism and mutation databases

BioMutaiANP32D.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Acidic leucine-rich nuclear phosphoprotein 32 family member DPRO_0000137598Add
BLAST

Proteomic databases

EPDiO95626.
PaxDbiO95626.
PRIDEiO95626.

PTM databases

iPTMnetiO95626.
PhosphoSiteiO95626.

Expressioni

Gene expression databases

CleanExiHS_ANP32D.
GenevisibleiO95626. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266594.

Structurei

3D structure databases

ProteinModelPortaliO95626.
SMRiO95626. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 3821LRR 1Add
BLAST
Repeati43 – 6422LRR 2Add
BLAST
Repeati65 – 8723LRR 3Add
BLAST
Repeati89 – 11022LRR 4Add
BLAST
Repeati114 – 13118LRR 5Add
BLAST

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiO95626.
KOiK18646.
OMAiMIPDIEA.
OrthoDBiEOG7TJ3KH.
PhylomeDBiO95626.
TreeFamiTF317206.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI
60 70 80 90 100
NIGLTSIANL PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI
110 120 130
KDLSTIEPLK KLENLESLDL FTCEVTNLNN Y
Length:131
Mass (Da):14,806
Last modified:October 3, 2006 - v2
Checksum:iC2B2749F83496C53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381T → A in AAD13667 (PubMed:10086381).Curated
Sequence conflicti55 – 551T → S in AAD13667 (PubMed:10086381).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461L → F.
Corresponds to variant rs7956679 [ dbSNP | Ensembl ].
VAR_027832

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71084 Genomic DNA. Translation: AAD13667.1.
BC069122 mRNA. Translation: AAH69122.1.
CCDSiCCDS31788.1.
RefSeqiNP_036536.2. NM_012404.2.
UniGeneiHs.532658.

Genome annotation databases

EnsembliENST00000266594; ENSP00000266594; ENSG00000139223.
GeneIDi23519.
KEGGihsa:23519.
UCSCiuc010slt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71084 Genomic DNA. Translation: AAD13667.1.
BC069122 mRNA. Translation: AAH69122.1.
CCDSiCCDS31788.1.
RefSeqiNP_036536.2. NM_012404.2.
UniGeneiHs.532658.

3D structure databases

ProteinModelPortaliO95626.
SMRiO95626. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266594.

PTM databases

iPTMnetiO95626.
PhosphoSiteiO95626.

Polymorphism and mutation databases

BioMutaiANP32D.

Proteomic databases

EPDiO95626.
PaxDbiO95626.
PRIDEiO95626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266594; ENSP00000266594; ENSG00000139223.
GeneIDi23519.
KEGGihsa:23519.
UCSCiuc010slt.3. human.

Organism-specific databases

CTDi23519.
GeneCardsiANP32D.
HGNCiHGNC:16676. ANP32D.
MIMi606878. gene.
neXtProtiNX_O95626.
PharmGKBiPA24814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiO95626.
KOiK18646.
OMAiMIPDIEA.
OrthoDBiEOG7TJ3KH.
PhylomeDBiO95626.
TreeFamiTF317206.

Miscellaneous databases

GeneWikiiANP32D.
GenomeRNAii23519.
PROiO95626.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ANP32D.
GenevisibleiO95626. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of oncogenic potential by alternative gene use in human prostate cancer."
    Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.
    Nat. Med. 5:275-279(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The Anp32 family of proteins containing leucine-rich repeats."
    Matilla A., Radrizzani M.
    Cerebellum 4:7-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiAN32D_HUMAN
AccessioniPrimary (citable) accession number: O95626
Secondary accession number(s): Q6NTC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.