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O95625

- ZBT11_HUMAN

UniProt

O95625 - ZBT11_HUMAN

Protein

Zinc finger and BTB domain-containing protein 11

Gene

ZBTB11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri597 – 61923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri651 – 67323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri679 – 70123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri707 – 72923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri735 – 75723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri766 – 78823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri794 – 81623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri822 – 84625C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri858 – 88023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri886 – 90823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri914 – 93724C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 11
    Gene namesi
    Name:ZBTB11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16740. ZBTB11.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134907354.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10531053Zinc finger and BTB domain-containing protein 11PRO_0000047727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1050 – 10501Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95625.
    PaxDbiO95625.
    PRIDEiO95625.

    PTM databases

    PhosphoSiteiO95625.

    Expressioni

    Gene expression databases

    ArrayExpressiO95625.
    BgeeiO95625.
    CleanExiHS_ZBTB11.
    GenevestigatoriO95625.

    Organism-specific databases

    HPAiHPA015328.
    HPA024138.

    Interactioni

    Protein-protein interaction databases

    BioGridi118005. 5 interactions.
    IntActiO95625. 2 interactions.
    MINTiMINT-1185100.
    STRINGi9606.ENSP00000326200.

    Structurei

    3D structure databases

    ProteinModelPortaliO95625.
    SMRiO95625. Positions 194-310, 554-938.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini214 – 28269BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri597 – 61923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri651 – 67323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri679 – 70123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri707 – 72923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri735 – 75723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri766 – 78823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri794 – 81623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri822 – 84625C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri858 – 88023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri886 – 90823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri914 – 93724C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000155761.
    HOVERGENiHBG097138.
    InParanoidiO95625.
    KOiK10498.
    OMAiICESVHK.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiO95625.
    TreeFamiTF332263.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ     50
    RRQRHRKTFA ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY 100
    WWRGILKQVK DYIKQCSKCQ EKLDRSRPIS DVSEMLEELG LDLESGEESN 150
    ESEDDLSNFT SSPTTASKPA KKKPVSKHEL VFVDTKGVVK RSSPKHCQAV 200
    LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR DLFIEKGAVS 250
    SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV 300
    LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT 350
    TTSLPTELGD CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG 400
    CIADSHPEME SVDLITKNNQ TELETSNNRE NNTVSNIHPK LSKENVISSS 450
    PEDSGMGNDI SAEDICAEDI PKHRQKVDQP LKDQENLVAS TAKTDFGPDD 500
    DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ QVAQKLVQRG 550
    KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP 600
    LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE 650
    FICSICGRTL PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL 700
    HQSQKQFQCE LCVKSFVTKR SLQEHMSIHT GESKYLCSVC GKSFHRGSGL 750
    SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD LRQHMNKHLG VKPFQCQFCD 800
    KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH VKKATHGKKG 850
    RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS 900
    LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD 950
    TLQFHNQGTQ VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA 1000
    ATEEYPSVST LSDQSIMQVV NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS 1050
    GGE 1053
    Length:1,053
    Mass (Da):119,384
    Last modified:November 25, 2008 - v2
    Checksum:i156765B7334BF101
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti495 – 4951D → N in AAD00172. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441G → S.
    Corresponds to variant rs3749323 [ dbSNP | Ensembl ].
    VAR_021894
    Natural varianti350 – 3501T → N.
    Corresponds to variant rs33957144 [ dbSNP | Ensembl ].
    VAR_047465

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69274 mRNA. Translation: AAD00172.1.
    AK312859 mRNA. Translation: BAG35711.1.
    CH471052 Genomic DNA. Translation: EAW79786.1.
    BC111700 mRNA. Translation: AAI11701.1.
    CCDSiCCDS2943.1.
    RefSeqiNP_055230.2. NM_014415.3.
    UniGeneiHs.655286.
    Hs.743292.

    Genome annotation databases

    EnsembliENST00000312938; ENSP00000326200; ENSG00000066422.
    GeneIDi27107.
    KEGGihsa:27107.
    UCSCiuc003dve.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69274 mRNA. Translation: AAD00172.1 .
    AK312859 mRNA. Translation: BAG35711.1 .
    CH471052 Genomic DNA. Translation: EAW79786.1 .
    BC111700 mRNA. Translation: AAI11701.1 .
    CCDSi CCDS2943.1.
    RefSeqi NP_055230.2. NM_014415.3.
    UniGenei Hs.655286.
    Hs.743292.

    3D structure databases

    ProteinModelPortali O95625.
    SMRi O95625. Positions 194-310, 554-938.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118005. 5 interactions.
    IntActi O95625. 2 interactions.
    MINTi MINT-1185100.
    STRINGi 9606.ENSP00000326200.

    PTM databases

    PhosphoSitei O95625.

    Proteomic databases

    MaxQBi O95625.
    PaxDbi O95625.
    PRIDEi O95625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312938 ; ENSP00000326200 ; ENSG00000066422 .
    GeneIDi 27107.
    KEGGi hsa:27107.
    UCSCi uc003dve.4. human.

    Organism-specific databases

    CTDi 27107.
    GeneCardsi GC03M101367.
    H-InvDB HIX0003510.
    HIX0003511.
    HGNCi HGNC:16740. ZBTB11.
    HPAi HPA015328.
    HPA024138.
    neXtProti NX_O95625.
    PharmGKBi PA134907354.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000155761.
    HOVERGENi HBG097138.
    InParanoidi O95625.
    KOi K10498.
    OMAi ICESVHK.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi O95625.
    TreeFami TF332263.

    Miscellaneous databases

    GeneWikii ZBTB11.
    GenomeRNAii 27107.
    NextBioi 49774.
    PROi O95625.

    Gene expression databases

    ArrayExpressi O95625.
    Bgeei O95625.
    CleanExi HS_ZBTB11.
    Genevestigatori O95625.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tang C.M., Seto E.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1050, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZBT11_HUMAN
    AccessioniPrimary (citable) accession number: O95625
    Secondary accession number(s): Q2NKP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3