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Protein

Zinc finger and BTB domain-containing protein 11

Gene

ZBTB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri569 – 591C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri822 – 846C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri858 – 880C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri886 – 908C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri914 – 937C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 11
Gene namesi
Name:ZBTB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000066422.4
HGNCiHGNC:16740 ZBTB11
neXtProtiNX_O95625

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066422
PharmGKBiPA134907354

Polymorphism and mutation databases

BioMutaiZBTB11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477271 – 1053Zinc finger and BTB domain-containing protein 11Add BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1050PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95625
MaxQBiO95625
PaxDbiO95625
PeptideAtlasiO95625
PRIDEiO95625

PTM databases

iPTMnetiO95625
PhosphoSitePlusiO95625

Expressioni

Gene expression databases

BgeeiENSG00000066422
CleanExiHS_ZBTB11
ExpressionAtlasiO95625 baseline and differential
GenevisibleiO95625 HS

Organism-specific databases

HPAiHPA015328
HPA024138

Interactioni

Protein-protein interaction databases

BioGridi118005, 24 interactors
IntActiO95625, 7 interactors
MINTiO95625
STRINGi9606.ENSP00000326200

Structurei

3D structure databases

ProteinModelPortaliO95625
SMRiO95625
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 282BTBPROSITE-ProRule annotationAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri569 – 591C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri822 – 846C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri858 – 880C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri886 – 908C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri914 – 937C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141090
HOGENOMiHOG000155761
HOVERGENiHBG097138
InParanoidiO95625
KOiK10498
OMAiNQFCDVT
OrthoDBiEOG091G02KC
PhylomeDBiO95625
TreeFamiTF332263

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

O95625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ
60 70 80 90 100
RRQRHRKTFA ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY
110 120 130 140 150
WWRGILKQVK DYIKQCSKCQ EKLDRSRPIS DVSEMLEELG LDLESGEESN
160 170 180 190 200
ESEDDLSNFT SSPTTASKPA KKKPVSKHEL VFVDTKGVVK RSSPKHCQAV
210 220 230 240 250
LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR DLFIEKGAVS
260 270 280 290 300
SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV
310 320 330 340 350
LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT
360 370 380 390 400
TTSLPTELGD CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG
410 420 430 440 450
CIADSHPEME SVDLITKNNQ TELETSNNRE NNTVSNIHPK LSKENVISSS
460 470 480 490 500
PEDSGMGNDI SAEDICAEDI PKHRQKVDQP LKDQENLVAS TAKTDFGPDD
510 520 530 540 550
DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ QVAQKLVQRG
560 570 580 590 600
KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP
610 620 630 640 650
LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE
660 670 680 690 700
FICSICGRTL PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL
710 720 730 740 750
HQSQKQFQCE LCVKSFVTKR SLQEHMSIHT GESKYLCSVC GKSFHRGSGL
760 770 780 790 800
SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD LRQHMNKHLG VKPFQCQFCD
810 820 830 840 850
KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH VKKATHGKKG
860 870 880 890 900
RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS
910 920 930 940 950
LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD
960 970 980 990 1000
TLQFHNQGTQ VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA
1010 1020 1030 1040 1050
ATEEYPSVST LSDQSIMQVV NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS

GGE
Length:1,053
Mass (Da):119,384
Last modified:November 25, 2008 - v2
Checksum:i156765B7334BF101
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495D → N in AAD00172 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02189444G → S. Corresponds to variant dbSNP:rs3749323Ensembl.1
Natural variantiVAR_047465350T → N. Corresponds to variant dbSNP:rs33957144Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69274 mRNA Translation: AAD00172.1
AK312859 mRNA Translation: BAG35711.1
CH471052 Genomic DNA Translation: EAW79786.1
BC111700 mRNA Translation: AAI11701.1
CCDSiCCDS2943.1
RefSeqiNP_055230.2, NM_014415.3
UniGeneiHs.655286
Hs.743292

Genome annotation databases

EnsembliENST00000312938; ENSP00000326200; ENSG00000066422
GeneIDi27107
KEGGihsa:27107
UCSCiuc003dve.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT11_HUMAN
AccessioniPrimary (citable) accession number: O95625
Secondary accession number(s): Q2NKP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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