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O95625

- ZBT11_HUMAN

UniProt

O95625 - ZBT11_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 11

Gene

ZBTB11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri735 – 75723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri766 – 78823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri794 – 81623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri822 – 84625C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri858 – 88023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri886 – 90823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri914 – 93724C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 11
Gene namesi
Name:ZBTB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:16740. ZBTB11.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10531053Zinc finger and BTB domain-containing protein 11PRO_0000047727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1050 – 10501Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95625.
PaxDbiO95625.
PRIDEiO95625.

PTM databases

PhosphoSiteiO95625.

Expressioni

Gene expression databases

BgeeiO95625.
CleanExiHS_ZBTB11.
ExpressionAtlasiO95625. baseline and differential.
GenevestigatoriO95625.

Organism-specific databases

HPAiHPA015328.
HPA024138.

Interactioni

Protein-protein interaction databases

BioGridi118005. 9 interactions.
IntActiO95625. 2 interactions.
MINTiMINT-1185100.
STRINGi9606.ENSP00000326200.

Structurei

3D structure databases

ProteinModelPortaliO95625.
SMRiO95625. Positions 194-310, 554-938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini214 – 28269BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri735 – 75723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri766 – 78823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri794 – 81623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri822 – 84625C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri858 – 88023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri886 – 90823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri914 – 93724C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115614.
HOGENOMiHOG000155761.
HOVERGENiHBG097138.
InParanoidiO95625.
KOiK10498.
OMAiICESVHK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO95625.
TreeFamiTF332263.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95625-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ
60 70 80 90 100
RRQRHRKTFA ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY
110 120 130 140 150
WWRGILKQVK DYIKQCSKCQ EKLDRSRPIS DVSEMLEELG LDLESGEESN
160 170 180 190 200
ESEDDLSNFT SSPTTASKPA KKKPVSKHEL VFVDTKGVVK RSSPKHCQAV
210 220 230 240 250
LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR DLFIEKGAVS
260 270 280 290 300
SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV
310 320 330 340 350
LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT
360 370 380 390 400
TTSLPTELGD CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG
410 420 430 440 450
CIADSHPEME SVDLITKNNQ TELETSNNRE NNTVSNIHPK LSKENVISSS
460 470 480 490 500
PEDSGMGNDI SAEDICAEDI PKHRQKVDQP LKDQENLVAS TAKTDFGPDD
510 520 530 540 550
DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ QVAQKLVQRG
560 570 580 590 600
KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP
610 620 630 640 650
LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE
660 670 680 690 700
FICSICGRTL PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL
710 720 730 740 750
HQSQKQFQCE LCVKSFVTKR SLQEHMSIHT GESKYLCSVC GKSFHRGSGL
760 770 780 790 800
SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD LRQHMNKHLG VKPFQCQFCD
810 820 830 840 850
KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH VKKATHGKKG
860 870 880 890 900
RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS
910 920 930 940 950
LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD
960 970 980 990 1000
TLQFHNQGTQ VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA
1010 1020 1030 1040 1050
ATEEYPSVST LSDQSIMQVV NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS

GGE
Length:1,053
Mass (Da):119,384
Last modified:November 25, 2008 - v2
Checksum:i156765B7334BF101
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti495 – 4951D → N in AAD00172. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441G → S.
Corresponds to variant rs3749323 [ dbSNP | Ensembl ].
VAR_021894
Natural varianti350 – 3501T → N.
Corresponds to variant rs33957144 [ dbSNP | Ensembl ].
VAR_047465

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69274 mRNA. Translation: AAD00172.1.
AK312859 mRNA. Translation: BAG35711.1.
CH471052 Genomic DNA. Translation: EAW79786.1.
BC111700 mRNA. Translation: AAI11701.1.
CCDSiCCDS2943.1.
RefSeqiNP_055230.2. NM_014415.3.
UniGeneiHs.655286.
Hs.743292.

Genome annotation databases

EnsembliENST00000312938; ENSP00000326200; ENSG00000066422.
GeneIDi27107.
KEGGihsa:27107.
UCSCiuc003dve.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69274 mRNA. Translation: AAD00172.1 .
AK312859 mRNA. Translation: BAG35711.1 .
CH471052 Genomic DNA. Translation: EAW79786.1 .
BC111700 mRNA. Translation: AAI11701.1 .
CCDSi CCDS2943.1.
RefSeqi NP_055230.2. NM_014415.3.
UniGenei Hs.655286.
Hs.743292.

3D structure databases

ProteinModelPortali O95625.
SMRi O95625. Positions 194-310, 554-938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118005. 9 interactions.
IntActi O95625. 2 interactions.
MINTi MINT-1185100.
STRINGi 9606.ENSP00000326200.

PTM databases

PhosphoSitei O95625.

Proteomic databases

MaxQBi O95625.
PaxDbi O95625.
PRIDEi O95625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312938 ; ENSP00000326200 ; ENSG00000066422 .
GeneIDi 27107.
KEGGi hsa:27107.
UCSCi uc003dve.4. human.

Organism-specific databases

CTDi 27107.
GeneCardsi GC03M101367.
H-InvDB HIX0003510.
HIX0003511.
HGNCi HGNC:16740. ZBTB11.
HPAi HPA015328.
HPA024138.
neXtProti NX_O95625.
PharmGKBi PA134907354.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115614.
HOGENOMi HOG000155761.
HOVERGENi HBG097138.
InParanoidi O95625.
KOi K10498.
OMAi ICESVHK.
OrthoDBi EOG7KSX7Q.
PhylomeDBi O95625.
TreeFami TF332263.

Miscellaneous databases

GeneWikii ZBTB11.
GenomeRNAii 27107.
NextBioi 49774.
PROi O95625.

Gene expression databases

Bgeei O95625.
CleanExi HS_ZBTB11.
ExpressionAtlasi O95625. baseline and differential.
Genevestigatori O95625.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tang C.M., Seto E.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1050, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBT11_HUMAN
AccessioniPrimary (citable) accession number: O95625
Secondary accession number(s): Q2NKP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3